The study aimed to evaluate the instrumental and clinical properties of an innovative gel formulation for anti-aging treatment. This was an open, non-controlled study, where the eligible subjects, divided into three s...The study aimed to evaluate the instrumental and clinical properties of an innovative gel formulation for anti-aging treatment. This was an open, non-controlled study, where the eligible subjects, divided into three subgroups according to age, had to perform a single dose application of the gel on the face for a short-term evaluation and a 4-week repeated use, twice a day, for a long-term evaluation. Instrumental and clinical evaluations had to be performed mono-laterally at the level of the face (right or left side according to a predisposed randomization list) in basal conditions (T0), 20 minutes after the first dose application (T20min) and after 2 and 4 weeks of treatment (T2wks - T4wks). Thirty-three subjects completed the study showing, after only 20 minutes from the 1st product application, a clinically important and statistically significant improvement of crow’s feet, skin dullness clinical score and cutaneous microrelief clinical score (p < 0.05), after 2 weeks of treatment an improvement of skin tonicity (p < 0.05) and after 4 weeks of treatment having a significant decrease of nasolabial folds clinical score (p < 0.05). The study showed the great efficacy of an innovative anti-aging gel in reducing the skin roughness and skin dryness, improving the skin firmness and, in general, providing a global skin rejuvenation.展开更多
Background: Vulvovaginal atrophy is an inflammatory condition linked with estrogenic deficiency, as well as decreased lubrication. The study aimed at the objective measurements of vaginal moisture (RH%), in fertile wo...Background: Vulvovaginal atrophy is an inflammatory condition linked with estrogenic deficiency, as well as decreased lubrication. The study aimed at the objective measurements of vaginal moisture (RH%), in fertile women and in postmenopausal women before and during treatment with a non-estrogenic moisturizing gel. Methods: The study followed a stepwise design. Acute: 5 women with postmenopausal vaginal dryness were measured their RH% at baseline and 30 minutes after the application of a moisturizer. Fertile Controls: 20 women were measured in the follicular phase and20 inthe luteal phase. Chronic: Forty postmenopausal women with mild/moderate vaginal dryness were randomly assigned to treatment (once/day for the first week and twice/week for the following 11 weeks) or untreated control group. Primary parameter was RH%, done by means of a vaginal hygrometer manufactured and validated for the specific purpose. Secondary parameters were the evaluation of erythema and oedema, scored for severity. Results: Fertile women showed an average 93/95 RH%, independently on the cycle phase. Postmenopausal women had 49/69 RH% in absence of any treatment. A 37% increased RH% was observed 30 min after a single application. During chronic treatment, RH% measured not earlier than 2 hours after the application of the product, resulted 7.8% to 10.4% higher than baseline (p < 0.05). Erythema improved accordingly. Conclusions: The vaginal moisturizer proved to be safe and to increase vaginal moisture short after treatment initiation;moreover, its effect proved to be long lasting.展开更多
Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was ...Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was an open-label, controlled study in 21 volunteers. The participants applied once, on the volar surface of both forearms, five formulations with elasticising properties (test products 1 to 5) and a reference standard (test product 6). The formulations were applied on three sites on each forearm that were randomly assigned. Skin elasticising parameters were evaluated using the Dermal Torque Meter, at baseline and 30 minutes after application. Results: Among the test products, only test product 2 significantly increased skin elasticity compared with the baseline value, with a trend toward superiority?versus the reference standard (+24% vs.?+13%, respectively). There was a significant increase in elastic recovery of 23% with test product 2, compared with a significant increase of 13% with the reference standard. Conclusion: Test product 2, comprising a thiolated compound and a mixture of esters of fatty acids, had the greatest elasticising effect. Compared with the other tested formulations, product 2 led to a greater increase in extensibility and faster elastic recovery of the skin on the volar surface of the forearm.展开更多
Background: The incidence of cutaneous malignant melanoma has been rising ste adily in Caucasian populations for several decades, with a doubling time of 10- 14 years. An increase in incidence of about 5% per year has...Background: The incidence of cutaneous malignant melanoma has been rising ste adily in Caucasian populations for several decades, with a doubling time of 10- 14 years. An increase in incidence of about 5% per year has been reported in most Caucasian populations since the early 1960s. Objectives: This study was des igned to determine the changing incidence of primary cutaneous malignant melanom a in Northern Ireland and to examine changes in survival rates from cutaneous ma lignant melanoma in two 5- year periods, 1984- 88 and 1994- 98. Methods: One thousand three hundred and twenty-six patients with invasive primary cutaneous melanoma were included in the study. Results: The age standardized rate of mela noma rose from 4- 3 per 100 000 population per year in men and 8.6 per 100 000 population per year in women to 7.7 and 11.8, respectively, p er 100 000 population per year in the 1994- 98 period. Overall, the absolute 5 - year survival for the 1984- 88 period was 71.0% (95% confidence interval (CI) 66.9- 75.1% ) and 77.4% (95% CI 73.4- 81.4% ) for the 1994- 98 pe riod. Women consistently showed better survival at all ages and within almost al l categories of thickness of primary tumour. Younger patients of both sexes show ed better survival rates. Conclusions: When survival rates between the 1984- 88 and 1994- 98 periods were compared using multivariate analysis, we found that patients diagnosed in the second period had a one-third lower risk of dying th an those in the earlier period. Much of this reduction was explained by changes in the number of melanomas of thin Breslow depth and ulcerated melanomas.展开更多
Background. Lichen nitidus is a rare condition, which may be a cause of palmop lantar hyperkeratosis. We report two cases. Case reports. A 53 year-old woman p resented with a dry and fissured palmoplantar hyperkeratos...Background. Lichen nitidus is a rare condition, which may be a cause of palmop lantar hyperkeratosis. We report two cases. Case reports. A 53 year-old woman p resented with a dry and fissured palmoplantar hyperkeratosis. Histological exami nation of a biopsy showed the typical features of lichen nitidus. Significant im provement was obtained with acitretin. A few months later, multiple lichen nitid us papules appeared on the limbs and the abdomen. A 67 year-old woman was refer red to us for a fissured, disabling palmoplantar hyperkeratosis refractory to to pical steroids. Histological examination led to the diagnosis of lichen nitidus. Local PUVAtherapy resulted in the cleaning of her lesions. Later, typical papul es of lichen nitidus appeared on her elbows. Discussion. Nineteen cases of palmoplantar localization of lich en nitidus have been described. The features are usually tiny yellow papules ’b ut sometimes a nonspecific keratoderma resembling chronic eczema. Palmoplantar i nvolvement of lichen nitidus maybe isolated or associated with cutaneous lesions on unusual sites. Oral retinoids and local PUVA are effective treatments.展开更多
Polycythemia vera is classified with myelogenous leukaemia, agnogenic myeloid metaplasia and primary thrombocythemia as a myeloproliferative syndrome. Cutane ous symptoms have been reported with polycythemia vera, inc...Polycythemia vera is classified with myelogenous leukaemia, agnogenic myeloid metaplasia and primary thrombocythemia as a myeloproliferative syndrome. Cutane ous symptoms have been reported with polycythemia vera, including facial plethor a, aquagenic pruritus, urticaria, purpura, Sweet’s syndrome and pyoderma gangr enosum. However, polycythemia vera associated with systemic sarcoidosis has been rarely reported. An unusual case of polycythemia vera associated with cutaneous sarcoidosis is described.展开更多
Background:Topical tacrolimus has been reported to be effective for the treatme nt of oral lichen planus. This article describes our experience with topical tac rolimus in patients treated for symptomatic oral lichen ...Background:Topical tacrolimus has been reported to be effective for the treatme nt of oral lichen planus. This article describes our experience with topical tac rolimus in patients treated for symptomatic oral lichen planus. Observations:A survey was mailed to 40 patients with symptomatic oral lichen planus treated wit h topical tacrolimus. Surveys were completed by 37 patients (93%) a mean of 1.3 years after initiation of treatment. Thirty-three (89%) of the 37 patients re ported symptomatic improvement, and 31 (84%) reported partial to complete lesio n clearance while using topical tacrolimus. On average, patients noted improveme nt in 1 month. Twelve patients(32%) reported adverse effects consistent with th ose reported previously (ie, burning, irritation, and tingling). Among the 28 pa tients still using the medication, 15 patients (54%) apply it at least once dai ly. Of the 9 patients who discontinued using the medication, 5 experienced recur rence. Conclusions:Topical tacrolimus is effective for the treatment of oral li chen planus. Most patients experienced symptomatic improvement in less than 1 mo nth. However, the effect is temporary; when topical tacrolimus is discontinued, oral lichen planus may flare again.展开更多
The extracellular matrix(ECM)occupies the space between cell and cell,and serves as a sort of intranet which connects the whole organism.Current research is focused on the ECM and,it is now possible to develop increas...The extracellular matrix(ECM)occupies the space between cell and cell,and serves as a sort of intranet which connects the whole organism.Current research is focused on the ECM and,it is now possible to develop increasingly effective strategies for the prevention and treatment of degenerative diseases and even,cutaneous ageing.In fact,the most advanced anti-aging treatments are those that regenerate the ECM,which is now regarded as the main player in the physical support of,and exchange with and between cells of nutrients,cellular mediators and growth factors.展开更多
Atopic dermatitis(AD)is a common disease clinically characterized by chronic recurrent eczematous lesions,dry skin,and pruritus.AD can negatively impact patients’quality of life.The prevalence of AD in China has been...Atopic dermatitis(AD)is a common disease clinically characterized by chronic recurrent eczematous lesions,dry skin,and pruritus.AD can negatively impact patients’quality of life.The prevalence of AD in China has been increasing during the past few decades.Based on the most recent advances in the treatment of AD,we updated the 2014 version of the Guidelines for Diagnosis and Treatment of Atopic Dermatitis in China regarding the definition,epidemiology,pathogenesis,clinical classification,diagnosis,prevention,and treatment of AD.展开更多
The collection of big data on skin and appendage phenotypes has revolutionized the field of personalized diagnosis and treatment by enabling the evaluation of individual characteristics and early detection of abnormal...The collection of big data on skin and appendage phenotypes has revolutionized the field of personalized diagnosis and treatment by enabling the evaluation of individual characteristics and early detection of abnormalities.To establish a standardized system for collecting and measuring big data on phenotypes,a systematic categorization of measurement entries has been undertaken,accompanied by recommendations on measurement entries,environmental equipment requirements,and collection processes,tailored to the needs of different usage scenarios.Specific collection sites have also been recommended based on different index characteristics.A multi-center,multi-regional collaboration has been initiated to collect big date on phenotypes of healthy and diseased skin in the Chinese population.This data will be correlated with patient disease information,exploring the factors influencing skin phenotype,analyzing the phenotypic data features that can predict prognosis,and ultimately promoting the exploration of the pathophysiology and pathogenesis of skin diseases and therapeutic approaches.Non-invasive skin measurement robots are also in development.This consensus aims to provide a reference for the study of phenomics and the standardization of phenotypic measurements of skin and appendages in China.展开更多
Aminolevulinic acid-based photodynamic therapy(ALA-PDT)is a safe and effective physical therapy for acne vulgaris that is widely used in clinical practice.To further standardize the clinical application of ALA-PDT in ...Aminolevulinic acid-based photodynamic therapy(ALA-PDT)is a safe and effective physical therapy for acne vulgaris that is widely used in clinical practice.To further standardize the clinical application of ALA-PDT in the treatment of acne,we created this updated consensus based on the 2011 version of the consensus on ALA-PDT for the treatment of acne vulgaris.In this document,we summarize the mechanisms of action of ALA-PDT and provide practical standards for patient selection,treatment parameters,administration procedures,and management of adverse reactions.Our aim was to provide guidance and treatment regimens for using ALA-PDT for acne vulgaris in clinical practice.展开更多
文摘The study aimed to evaluate the instrumental and clinical properties of an innovative gel formulation for anti-aging treatment. This was an open, non-controlled study, where the eligible subjects, divided into three subgroups according to age, had to perform a single dose application of the gel on the face for a short-term evaluation and a 4-week repeated use, twice a day, for a long-term evaluation. Instrumental and clinical evaluations had to be performed mono-laterally at the level of the face (right or left side according to a predisposed randomization list) in basal conditions (T0), 20 minutes after the first dose application (T20min) and after 2 and 4 weeks of treatment (T2wks - T4wks). Thirty-three subjects completed the study showing, after only 20 minutes from the 1st product application, a clinically important and statistically significant improvement of crow’s feet, skin dullness clinical score and cutaneous microrelief clinical score (p < 0.05), after 2 weeks of treatment an improvement of skin tonicity (p < 0.05) and after 4 weeks of treatment having a significant decrease of nasolabial folds clinical score (p < 0.05). The study showed the great efficacy of an innovative anti-aging gel in reducing the skin roughness and skin dryness, improving the skin firmness and, in general, providing a global skin rejuvenation.
文摘Background: Vulvovaginal atrophy is an inflammatory condition linked with estrogenic deficiency, as well as decreased lubrication. The study aimed at the objective measurements of vaginal moisture (RH%), in fertile women and in postmenopausal women before and during treatment with a non-estrogenic moisturizing gel. Methods: The study followed a stepwise design. Acute: 5 women with postmenopausal vaginal dryness were measured their RH% at baseline and 30 minutes after the application of a moisturizer. Fertile Controls: 20 women were measured in the follicular phase and20 inthe luteal phase. Chronic: Forty postmenopausal women with mild/moderate vaginal dryness were randomly assigned to treatment (once/day for the first week and twice/week for the following 11 weeks) or untreated control group. Primary parameter was RH%, done by means of a vaginal hygrometer manufactured and validated for the specific purpose. Secondary parameters were the evaluation of erythema and oedema, scored for severity. Results: Fertile women showed an average 93/95 RH%, independently on the cycle phase. Postmenopausal women had 49/69 RH% in absence of any treatment. A 37% increased RH% was observed 30 min after a single application. During chronic treatment, RH% measured not earlier than 2 hours after the application of the product, resulted 7.8% to 10.4% higher than baseline (p < 0.05). Erythema improved accordingly. Conclusions: The vaginal moisturizer proved to be safe and to increase vaginal moisture short after treatment initiation;moreover, its effect proved to be long lasting.
文摘Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was an open-label, controlled study in 21 volunteers. The participants applied once, on the volar surface of both forearms, five formulations with elasticising properties (test products 1 to 5) and a reference standard (test product 6). The formulations were applied on three sites on each forearm that were randomly assigned. Skin elasticising parameters were evaluated using the Dermal Torque Meter, at baseline and 30 minutes after application. Results: Among the test products, only test product 2 significantly increased skin elasticity compared with the baseline value, with a trend toward superiority?versus the reference standard (+24% vs.?+13%, respectively). There was a significant increase in elastic recovery of 23% with test product 2, compared with a significant increase of 13% with the reference standard. Conclusion: Test product 2, comprising a thiolated compound and a mixture of esters of fatty acids, had the greatest elasticising effect. Compared with the other tested formulations, product 2 led to a greater increase in extensibility and faster elastic recovery of the skin on the volar surface of the forearm.
文摘Background: The incidence of cutaneous malignant melanoma has been rising ste adily in Caucasian populations for several decades, with a doubling time of 10- 14 years. An increase in incidence of about 5% per year has been reported in most Caucasian populations since the early 1960s. Objectives: This study was des igned to determine the changing incidence of primary cutaneous malignant melanom a in Northern Ireland and to examine changes in survival rates from cutaneous ma lignant melanoma in two 5- year periods, 1984- 88 and 1994- 98. Methods: One thousand three hundred and twenty-six patients with invasive primary cutaneous melanoma were included in the study. Results: The age standardized rate of mela noma rose from 4- 3 per 100 000 population per year in men and 8.6 per 100 000 population per year in women to 7.7 and 11.8, respectively, p er 100 000 population per year in the 1994- 98 period. Overall, the absolute 5 - year survival for the 1984- 88 period was 71.0% (95% confidence interval (CI) 66.9- 75.1% ) and 77.4% (95% CI 73.4- 81.4% ) for the 1994- 98 pe riod. Women consistently showed better survival at all ages and within almost al l categories of thickness of primary tumour. Younger patients of both sexes show ed better survival rates. Conclusions: When survival rates between the 1984- 88 and 1994- 98 periods were compared using multivariate analysis, we found that patients diagnosed in the second period had a one-third lower risk of dying th an those in the earlier period. Much of this reduction was explained by changes in the number of melanomas of thin Breslow depth and ulcerated melanomas.
文摘Background. Lichen nitidus is a rare condition, which may be a cause of palmop lantar hyperkeratosis. We report two cases. Case reports. A 53 year-old woman p resented with a dry and fissured palmoplantar hyperkeratosis. Histological exami nation of a biopsy showed the typical features of lichen nitidus. Significant im provement was obtained with acitretin. A few months later, multiple lichen nitid us papules appeared on the limbs and the abdomen. A 67 year-old woman was refer red to us for a fissured, disabling palmoplantar hyperkeratosis refractory to to pical steroids. Histological examination led to the diagnosis of lichen nitidus. Local PUVAtherapy resulted in the cleaning of her lesions. Later, typical papul es of lichen nitidus appeared on her elbows. Discussion. Nineteen cases of palmoplantar localization of lich en nitidus have been described. The features are usually tiny yellow papules ’b ut sometimes a nonspecific keratoderma resembling chronic eczema. Palmoplantar i nvolvement of lichen nitidus maybe isolated or associated with cutaneous lesions on unusual sites. Oral retinoids and local PUVA are effective treatments.
文摘Polycythemia vera is classified with myelogenous leukaemia, agnogenic myeloid metaplasia and primary thrombocythemia as a myeloproliferative syndrome. Cutane ous symptoms have been reported with polycythemia vera, including facial plethor a, aquagenic pruritus, urticaria, purpura, Sweet’s syndrome and pyoderma gangr enosum. However, polycythemia vera associated with systemic sarcoidosis has been rarely reported. An unusual case of polycythemia vera associated with cutaneous sarcoidosis is described.
文摘Background:Topical tacrolimus has been reported to be effective for the treatme nt of oral lichen planus. This article describes our experience with topical tac rolimus in patients treated for symptomatic oral lichen planus. Observations:A survey was mailed to 40 patients with symptomatic oral lichen planus treated wit h topical tacrolimus. Surveys were completed by 37 patients (93%) a mean of 1.3 years after initiation of treatment. Thirty-three (89%) of the 37 patients re ported symptomatic improvement, and 31 (84%) reported partial to complete lesio n clearance while using topical tacrolimus. On average, patients noted improveme nt in 1 month. Twelve patients(32%) reported adverse effects consistent with th ose reported previously (ie, burning, irritation, and tingling). Among the 28 pa tients still using the medication, 15 patients (54%) apply it at least once dai ly. Of the 9 patients who discontinued using the medication, 5 experienced recur rence. Conclusions:Topical tacrolimus is effective for the treatment of oral li chen planus. Most patients experienced symptomatic improvement in less than 1 mo nth. However, the effect is temporary; when topical tacrolimus is discontinued, oral lichen planus may flare again.
文摘The extracellular matrix(ECM)occupies the space between cell and cell,and serves as a sort of intranet which connects the whole organism.Current research is focused on the ECM and,it is now possible to develop increasingly effective strategies for the prevention and treatment of degenerative diseases and even,cutaneous ageing.In fact,the most advanced anti-aging treatments are those that regenerate the ECM,which is now regarded as the main player in the physical support of,and exchange with and between cells of nutrients,cellular mediators and growth factors.
文摘Atopic dermatitis(AD)is a common disease clinically characterized by chronic recurrent eczematous lesions,dry skin,and pruritus.AD can negatively impact patients’quality of life.The prevalence of AD in China has been increasing during the past few decades.Based on the most recent advances in the treatment of AD,we updated the 2014 version of the Guidelines for Diagnosis and Treatment of Atopic Dermatitis in China regarding the definition,epidemiology,pathogenesis,clinical classification,diagnosis,prevention,and treatment of AD.
基金sponsored by the Project of Intelligent Management Software for Multimodal Medical Big Data for New Generation Information Technology,Ministry of Industry and Information Technology of People’s Republic of China(TC210804V)the Research on the Precision Prevention and Treatment System for Skin Malignant Tumors,National Key Research and Development Program of China(2022YFC2504701,2022YFC2504705).
文摘The collection of big data on skin and appendage phenotypes has revolutionized the field of personalized diagnosis and treatment by enabling the evaluation of individual characteristics and early detection of abnormalities.To establish a standardized system for collecting and measuring big data on phenotypes,a systematic categorization of measurement entries has been undertaken,accompanied by recommendations on measurement entries,environmental equipment requirements,and collection processes,tailored to the needs of different usage scenarios.Specific collection sites have also been recommended based on different index characteristics.A multi-center,multi-regional collaboration has been initiated to collect big date on phenotypes of healthy and diseased skin in the Chinese population.This data will be correlated with patient disease information,exploring the factors influencing skin phenotype,analyzing the phenotypic data features that can predict prognosis,and ultimately promoting the exploration of the pathophysiology and pathogenesis of skin diseases and therapeutic approaches.Non-invasive skin measurement robots are also in development.This consensus aims to provide a reference for the study of phenomics and the standardization of phenotypic measurements of skin and appendages in China.
文摘Aminolevulinic acid-based photodynamic therapy(ALA-PDT)is a safe and effective physical therapy for acne vulgaris that is widely used in clinical practice.To further standardize the clinical application of ALA-PDT in the treatment of acne,we created this updated consensus based on the 2011 version of the consensus on ALA-PDT for the treatment of acne vulgaris.In this document,we summarize the mechanisms of action of ALA-PDT and provide practical standards for patient selection,treatment parameters,administration procedures,and management of adverse reactions.Our aim was to provide guidance and treatment regimens for using ALA-PDT for acne vulgaris in clinical practice.
