Selenium is an essential trace element for human beings and it plays a significant role for the health of human nervous system.The strong antioxidant effect of selenium endows the element with the ability to treat var...Selenium is an essential trace element for human beings and it plays a significant role for the health of human nervous system.The strong antioxidant effect of selenium endows the element with the ability to treat various diseases,including Alzheimer's disease(AD).In the body,selenium exists in the forms of selenoproteins,which could treat AD through various pathways,such as inhibiting peroxidation,inhibiting apoptosis signal pathway,reducing the levels of Aβin neurons and alleviating Tau protein caused by pathological damage.This article aims to comprehensively elaborate on the relationship between selenium and AD.展开更多
Dear Editor,Varicocele(VC)is a vascular condition characterized by abnormal tortuosity and dilation of the pampiniform plexus veins within the spermatic cord.VC is commonly observed in young adults,predominantly on th...Dear Editor,Varicocele(VC)is a vascular condition characterized by abnormal tortuosity and dilation of the pampiniform plexus veins within the spermatic cord.VC is commonly observed in young adults,predominantly on the left side;it is a frequent cause of male infertility and can lead to testicular hypofunction,pain,and discomfort.Microsurgical varicocelectomy is the gold standard for treating infertility caused by VC.VC repair is strongly recommended for couple infertility,oligoasthenoteratozoospermia(OAT),Grade 2 or 3 clinical VC,partner age<37 years,patient age<40 years,or testicular hypotrophy in children and adolescents.展开更多
Uronic acids are prevalent components of crucial glycoconjugates,pivotal in various biological processes.In nature,NDP-uronic acids,the nucleosides-activated uronic acids,serve as glycosylation donors catalyzed by uro...Uronic acids are prevalent components of crucial glycoconjugates,pivotal in various biological processes.In nature,NDP-uronic acids,the nucleosides-activated uronic acids,serve as glycosylation donors catalyzed by uronosyltransferases(UATs)to construct glycans containing uronic acids.Despite their biological importance,the synthesis of naturally occurring NDP-uronic acids on a large scale remains challenging.Here,we developed an oxidation reaction insertion strategy for the efficient synthesis of NDP-uronic acids,and 11 NDP-uronic acids were successfully prepared in good yield and on a large scale.The prepared NDP-uronic acids can be used to explore new uronosyltransferases and synthesize uronic acids containing carbohydrates for fundamental research.展开更多
Acupuncture can intervene with and treat vascular dementia(VD)through multiple targets and pathways.The mechanisms of its action involve inhibiting central inflammatory responses,regulating neuronal synaptic plasticit...Acupuncture can intervene with and treat vascular dementia(VD)through multiple targets and pathways.The mechanisms of its action involve inhibiting central inflammatory responses,regulating neuronal synaptic plasticity,modulating oxidative stress,reducing neuronal apoptosis,and adjusting cellular autophagy.This paper summarizes researches on the mechanisms of acupuncture treatment for vD over the past decade,aiming to provide theoretical support for the clinical application of acupuncture in treating VD and offer a reference for future in-depth research in this field.展开更多
Coral-like structures of the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were synthesized using the sol-gel method. Structural investigation certified the YIG cubic crystal struct...Coral-like structures of the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were synthesized using the sol-gel method. Structural investigation certified the YIG cubic crystal structure formation, without any secondary phase. It is shown that, the relatively large ionic radius of the dopant cations results in an expansion of the lattice parameter, variations in the Iona-O-Iondangle, Iona-O,Iond-O and Ionc-O bond distances and decrease in the average crystallite size. Fourier transform infrared(FTIR) and Raman measurements are essential to testify the single-phase formation of YIG crystal structure and are observed changes in the stretching and vibrational modes, respectively. The morphological study, energy dispersive spectroscopy(EDS) spectra and textural properties show corallike structures, peaks associated with Pr^(3+) and Yb^(3+) atoms and the effect of dopants on surface area,diameter, and pore volume, respectively. The optical analysis from diffuse reflectance spectra witnessed an increase in the optical gap band, a decrease in Urbach energy and blue shift in the charge transfer,correlated with the expansion of the unit cell due to the dopant's insertion in the YIG structure. A typical ferrimagnetic behavior is exhibited by the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12)compound. The saturation magnetization(M_(s)), cubic anisotropy constant(K_(1)) and coercive field(H_(c)) increase with the Pr^(3+)cations content, as consequence of their magnetic nature and distribution around of Fe^(3+)ions due to the coexistence with the Yb^(3+). Finally, for the first time, antibacterial tests by mean of the direct contact method were performed for YIG co-doped with Pr^(3+)and Yb^(3+)and it is shown that, relatively high dosages of Pr^(3+) cations favored the activity against S. aureus, therefore, a new biological property for YIG doped with rare earths is presented.展开更多
Most behavioral traits are known to be weakly heritable,possibly due to their extreme complexity and flexibility.Despite this general pattern,within-species variation in avian colony size choice has been reported to h...Most behavioral traits are known to be weakly heritable,possibly due to their extreme complexity and flexibility.Despite this general pattern,within-species variation in avian colony size choice has been reported to have a strong additive genetic component,but we are aware of no attempts to assess the heritability of avian sociality at the finer spatial scale.Here,we used an animal model and parent-offspring regression to quantify additive genetic variance in social phenotype(local nesting density)in a nonpasserine waterbird,the common tern Sterna hirundo.For this purpose,we used a novel experimental framework,where variation in the social environment was generated by providing birds with artificial patches of attractive nesting substrate that markedly varied in size.During 2011-2019,we collected data on social preferences for either low or high nesting density in over 250 individuals,either kin(mostly parent-offspring relationships)or non-kin recorded breeding multiple times across years.All heritability estimates of local nesting density were low(<0.10),irrespectively of fixed effects(sex and year)included in the models,data used in the modeling(all individuals vs.early recruits),or methodological approach(animal model vs.parent-offspring regression).We conclude that avian sociality,as measured at the local scale,may be much less heritable than colony size choice,as measured at the landscape level.Our study adds to the understanding of additive genetic variance in avian behavior,and it underlines a scale dependency in the heritability of behavioral traits.展开更多
The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial ...The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 months.Treatment-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and headache.Significant improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,respectively.Global Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,respectively.The quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month 24.Two-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.展开更多
A core assumption of sexual selection theory is that sexually selected weapons,specialized morphological structures used directly in male con-tests,can improve an individual's reproductive success but only if the ...A core assumption of sexual selection theory is that sexually selected weapons,specialized morphological structures used directly in male con-tests,can improve an individual's reproductive success but only if the bearer can overcome associated costs,the negative effects on the bear-er's fitness components.However,recent studies have shown that producing and wielding exaggerated weapons may not necessarily be costly.Rather,some traits can be selected for supporting,or compensating for,the expense of producing and wielding such exaggerated weapons.n the ant-mimicking jumping spider Myrmarachne gisti,exaggerated chelicerae are borne only by adult males and not females,showing sexual dimorphism and steep positive allometry with body size.Here,we determine the potential benefits of bearing exaggerated chelicerae during male contests and explore the potential for costs in terms of prey-capture efficiency and compensation between chelicera size and neighboring trait size.While males with longer chelicerae won most of their male-male contests,we found no significant differences in prey-capture effi-ciency between males and females regardless of whether prey was winged or flightless.Males'elongated chelicerae thus do not impede their efficiency at capturing prey.Furthermore,we found that the sizes of all neighboring traits are positively correlated with chelicera size,suggesting that these traits may be under correlational selection.Taken together,our findings suggest that M.gisti males armed with the exaggerated chelicerae that function as weapons win more fights at limited cost for performance in prey capture and compensate for neighboring structures.展开更多
The Faleme River, a West Africa long transboundary stream (625 km) and abundant flow (>1100 million m<sup>3</sup>) is affected by severe erosion because of mining activities that takes place throughout ...The Faleme River, a West Africa long transboundary stream (625 km) and abundant flow (>1100 million m<sup>3</sup>) is affected by severe erosion because of mining activities that takes place throughout the riverbed. To preserve this important watercourse and ensure the sustainability of its services, selecting and implementing appropriates restorations techniques is vital. In this context, the purpose of this paper was to present an overview of the actions and techniques that can be implemented for the restoration/rehabilitation of the Faleme. The methodological approach includes field investigation, water sampling, literature review with cases studies and SWOT analysis of the four methods presented: river dredging, constructed wetlands, floating treatment wetlands and chemical precipitation (coagulation and flocculation). The study confirmed the pollution of the river by suspended solids (TSS > 1100 mg/L) and heavy metals such as iron, zinc, aluminium, and arsenic. For the restoration methods, it was illustrated through description of their mode of operation and through some case studies presented, that all the four methods have proven their effectiveness in treating rivers but have differences in their costs, their sustainability (detrimental to living organisms or causing a second pollution) and social acceptance. They also have weaknesses and issues that must be addressed to ensure success of rehabilitation. For the case of the Faleme river, after analysis, floating treatment wetlands are highly recommended for their low cost, good removal efficiency if the vulnerability of the raft and buoyancy to strong waves and flow is under control.展开更多
INTRODUCTION Artificial intelligence(AI)has brought about revolutionary changes in the medical field,including clinical practice,basic research and health monitoring.The powerful computing capabilities and intelligent...INTRODUCTION Artificial intelligence(AI)has brought about revolutionary changes in the medical field,including clinical practice,basic research and health monitoring.The powerful computing capabilities and intelligent algorithms enable it to process and analyse largescale medical data.展开更多
Cardiovascular Diseases (CVDs) pose a significant global health challenge, necessitating accurate risk prediction for effective preventive measures. This comprehensive comparative study explores the performance of tra...Cardiovascular Diseases (CVDs) pose a significant global health challenge, necessitating accurate risk prediction for effective preventive measures. This comprehensive comparative study explores the performance of traditional Machine Learning (ML) and Deep Learning (DL) models in predicting CVD risk, utilizing a meticulously curated dataset derived from health records. Rigorous preprocessing, including normalization and outlier removal, enhances model robustness. Diverse ML models (Logistic Regression, Random Forest, Support Vector Machine, K-Nearest Neighbor, Decision Tree, and Gradient Boosting) are compared with a Long Short-Term Memory (LSTM) neural network for DL. Evaluation metrics include accuracy, ROC AUC, computation time, and memory usage. Results identify the Gradient Boosting Classifier and LSTM as top performers, demonstrating high accuracy and ROC AUC scores. Comparative analyses highlight model strengths and limitations, contributing valuable insights for optimizing predictive strategies. This study advances predictive analytics for cardiovascular health, with implications for personalized medicine. The findings underscore the versatility of intelligent systems in addressing health challenges, emphasizing the broader applications of ML and DL in disease identification beyond cardiovascular health.展开更多
基金the Yangzhou City and Yangzhou University Cooperation Program(No.YZ2023209)the Sele Valley Scholars Basic Research Project(No.2301)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)for support。
文摘Selenium is an essential trace element for human beings and it plays a significant role for the health of human nervous system.The strong antioxidant effect of selenium endows the element with the ability to treat various diseases,including Alzheimer's disease(AD).In the body,selenium exists in the forms of selenoproteins,which could treat AD through various pathways,such as inhibiting peroxidation,inhibiting apoptosis signal pathway,reducing the levels of Aβin neurons and alleviating Tau protein caused by pathological damage.This article aims to comprehensively elaborate on the relationship between selenium and AD.
文摘Dear Editor,Varicocele(VC)is a vascular condition characterized by abnormal tortuosity and dilation of the pampiniform plexus veins within the spermatic cord.VC is commonly observed in young adults,predominantly on the left side;it is a frequent cause of male infertility and can lead to testicular hypofunction,pain,and discomfort.Microsurgical varicocelectomy is the gold standard for treating infertility caused by VC.VC repair is strongly recommended for couple infertility,oligoasthenoteratozoospermia(OAT),Grade 2 or 3 clinical VC,partner age<37 years,patient age<40 years,or testicular hypotrophy in children and adolescents.
基金financially supported by National Natural Science Foundation of China(No.22207113 to J.Zhang)Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110588to J.Zhang)Natural Science Foundation of Shanghai Municipality(No.22ZR1474000 to L.Wen)。
文摘Uronic acids are prevalent components of crucial glycoconjugates,pivotal in various biological processes.In nature,NDP-uronic acids,the nucleosides-activated uronic acids,serve as glycosylation donors catalyzed by uronosyltransferases(UATs)to construct glycans containing uronic acids.Despite their biological importance,the synthesis of naturally occurring NDP-uronic acids on a large scale remains challenging.Here,we developed an oxidation reaction insertion strategy for the efficient synthesis of NDP-uronic acids,and 11 NDP-uronic acids were successfully prepared in good yield and on a large scale.The prepared NDP-uronic acids can be used to explore new uronosyltransferases and synthesize uronic acids containing carbohydrates for fundamental research.
基金Supported by National Natural Science Foundation of ChinaGeneral Program:82074530Heilongjiang Provincial Natural Science Foundation Project:ZD2021H007Heilongjiang Provincial Traditional Chinese Medicine Research Project:ZHY2023-189,ZHY2023-209。
文摘Acupuncture can intervene with and treat vascular dementia(VD)through multiple targets and pathways.The mechanisms of its action involve inhibiting central inflammatory responses,regulating neuronal synaptic plasticity,modulating oxidative stress,reducing neuronal apoptosis,and adjusting cellular autophagy.This paper summarizes researches on the mechanisms of acupuncture treatment for vD over the past decade,aiming to provide theoretical support for the clinical application of acupuncture in treating VD and offer a reference for future in-depth research in this field.
基金The authors are grateful to the Brazilian Agencies:Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES),Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq),(CNPq N 4/2021-Bolsa de Produtividade em Pesquisa-PQ 307659/2021-6),(Chamada CNPq/MCTI/FNDCT N°18/2021-Faixa A,407796/2021-5)Financiadora de Estudos e Projetos(FINEP)and Fundacao de Amparo a Ciencia e Tecnologia de Pernambuco(FACEPE)(APQ-0635-3.03/21-Jovens Pesquisadores).
文摘Coral-like structures of the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were synthesized using the sol-gel method. Structural investigation certified the YIG cubic crystal structure formation, without any secondary phase. It is shown that, the relatively large ionic radius of the dopant cations results in an expansion of the lattice parameter, variations in the Iona-O-Iondangle, Iona-O,Iond-O and Ionc-O bond distances and decrease in the average crystallite size. Fourier transform infrared(FTIR) and Raman measurements are essential to testify the single-phase formation of YIG crystal structure and are observed changes in the stretching and vibrational modes, respectively. The morphological study, energy dispersive spectroscopy(EDS) spectra and textural properties show corallike structures, peaks associated with Pr^(3+) and Yb^(3+) atoms and the effect of dopants on surface area,diameter, and pore volume, respectively. The optical analysis from diffuse reflectance spectra witnessed an increase in the optical gap band, a decrease in Urbach energy and blue shift in the charge transfer,correlated with the expansion of the unit cell due to the dopant's insertion in the YIG structure. A typical ferrimagnetic behavior is exhibited by the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12)compound. The saturation magnetization(M_(s)), cubic anisotropy constant(K_(1)) and coercive field(H_(c)) increase with the Pr^(3+)cations content, as consequence of their magnetic nature and distribution around of Fe^(3+)ions due to the coexistence with the Yb^(3+). Finally, for the first time, antibacterial tests by mean of the direct contact method were performed for YIG co-doped with Pr^(3+)and Yb^(3+)and it is shown that, relatively high dosages of Pr^(3+) cations favored the activity against S. aureus, therefore, a new biological property for YIG doped with rare earths is presented.
基金supported by the research grant of the National Science Centre in Poland(2016/23/B/NZ8/02374).
文摘Most behavioral traits are known to be weakly heritable,possibly due to their extreme complexity and flexibility.Despite this general pattern,within-species variation in avian colony size choice has been reported to have a strong additive genetic component,but we are aware of no attempts to assess the heritability of avian sociality at the finer spatial scale.Here,we used an animal model and parent-offspring regression to quantify additive genetic variance in social phenotype(local nesting density)in a nonpasserine waterbird,the common tern Sterna hirundo.For this purpose,we used a novel experimental framework,where variation in the social environment was generated by providing birds with artificial patches of attractive nesting substrate that markedly varied in size.During 2011-2019,we collected data on social preferences for either low or high nesting density in over 250 individuals,either kin(mostly parent-offspring relationships)or non-kin recorded breeding multiple times across years.All heritability estimates of local nesting density were low(<0.10),irrespectively of fixed effects(sex and year)included in the models,data used in the modeling(all individuals vs.early recruits),or methodological approach(animal model vs.parent-offspring regression).We conclude that avian sociality,as measured at the local scale,may be much less heritable than colony size choice,as measured at the landscape level.Our study adds to the understanding of additive genetic variance in avian behavior,and it underlines a scale dependency in the heritability of behavioral traits.
基金sponsored by A.Menarini China Holding Co.,Ltd.(Shanghai,China).A.Menarini China had no influence on the data and no competinginterests.
文摘The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 months.Treatment-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and headache.Significant improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,respectively.Global Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,respectively.The quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month 24.Two-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.
基金supported by the grants from the National Natural Sciences Foundation of China(NSFC)(31572276,31872229,32270531,31801979)the Singapore Ministry of Education AcRF Tier 1(A-0004443-00-00,A-0008516-00-00).
文摘A core assumption of sexual selection theory is that sexually selected weapons,specialized morphological structures used directly in male con-tests,can improve an individual's reproductive success but only if the bearer can overcome associated costs,the negative effects on the bear-er's fitness components.However,recent studies have shown that producing and wielding exaggerated weapons may not necessarily be costly.Rather,some traits can be selected for supporting,or compensating for,the expense of producing and wielding such exaggerated weapons.n the ant-mimicking jumping spider Myrmarachne gisti,exaggerated chelicerae are borne only by adult males and not females,showing sexual dimorphism and steep positive allometry with body size.Here,we determine the potential benefits of bearing exaggerated chelicerae during male contests and explore the potential for costs in terms of prey-capture efficiency and compensation between chelicera size and neighboring trait size.While males with longer chelicerae won most of their male-male contests,we found no significant differences in prey-capture effi-ciency between males and females regardless of whether prey was winged or flightless.Males'elongated chelicerae thus do not impede their efficiency at capturing prey.Furthermore,we found that the sizes of all neighboring traits are positively correlated with chelicera size,suggesting that these traits may be under correlational selection.Taken together,our findings suggest that M.gisti males armed with the exaggerated chelicerae that function as weapons win more fights at limited cost for performance in prey capture and compensate for neighboring structures.
文摘The Faleme River, a West Africa long transboundary stream (625 km) and abundant flow (>1100 million m<sup>3</sup>) is affected by severe erosion because of mining activities that takes place throughout the riverbed. To preserve this important watercourse and ensure the sustainability of its services, selecting and implementing appropriates restorations techniques is vital. In this context, the purpose of this paper was to present an overview of the actions and techniques that can be implemented for the restoration/rehabilitation of the Faleme. The methodological approach includes field investigation, water sampling, literature review with cases studies and SWOT analysis of the four methods presented: river dredging, constructed wetlands, floating treatment wetlands and chemical precipitation (coagulation and flocculation). The study confirmed the pollution of the river by suspended solids (TSS > 1100 mg/L) and heavy metals such as iron, zinc, aluminium, and arsenic. For the restoration methods, it was illustrated through description of their mode of operation and through some case studies presented, that all the four methods have proven their effectiveness in treating rivers but have differences in their costs, their sustainability (detrimental to living organisms or causing a second pollution) and social acceptance. They also have weaknesses and issues that must be addressed to ensure success of rehabilitation. For the case of the Faleme river, after analysis, floating treatment wetlands are highly recommended for their low cost, good removal efficiency if the vulnerability of the raft and buoyancy to strong waves and flow is under control.
文摘INTRODUCTION Artificial intelligence(AI)has brought about revolutionary changes in the medical field,including clinical practice,basic research and health monitoring.The powerful computing capabilities and intelligent algorithms enable it to process and analyse largescale medical data.
文摘Cardiovascular Diseases (CVDs) pose a significant global health challenge, necessitating accurate risk prediction for effective preventive measures. This comprehensive comparative study explores the performance of traditional Machine Learning (ML) and Deep Learning (DL) models in predicting CVD risk, utilizing a meticulously curated dataset derived from health records. Rigorous preprocessing, including normalization and outlier removal, enhances model robustness. Diverse ML models (Logistic Regression, Random Forest, Support Vector Machine, K-Nearest Neighbor, Decision Tree, and Gradient Boosting) are compared with a Long Short-Term Memory (LSTM) neural network for DL. Evaluation metrics include accuracy, ROC AUC, computation time, and memory usage. Results identify the Gradient Boosting Classifier and LSTM as top performers, demonstrating high accuracy and ROC AUC scores. Comparative analyses highlight model strengths and limitations, contributing valuable insights for optimizing predictive strategies. This study advances predictive analytics for cardiovascular health, with implications for personalized medicine. The findings underscore the versatility of intelligent systems in addressing health challenges, emphasizing the broader applications of ML and DL in disease identification beyond cardiovascular health.
