AIM: To determine the efficacy and long-term outcome of biofeedback treatment for chronic idiopathic constipation and to compare the efficacy of two modes of biofeedback (EMG-based and manometry-based biofeedback).MET...AIM: To determine the efficacy and long-term outcome of biofeedback treatment for chronic idiopathic constipation and to compare the efficacy of two modes of biofeedback (EMG-based and manometry-based biofeedback).METHODS: Fifty consecutive contactable patients included 8 cases of slow transit constipation, 36 cases of anorectic outlet obstruction and 6 cases of mixed constipation. Two modes of biofeedback were used for these 50 patients, 30 of whom had EMG-based biofeedback, and 20 had manometrybased biofeedback. Before treatment, a consultation and physical examination were done for all the patients, related information such as bowel function and gut transit time was documented, psychological test (symptom checkJist 90, SCL90)and anorectic physiological test and defecography were applied. After biofeedback management, all the patients were followed up. The Student′s t-test, chi-squared test and Logistic regression were used for statistical analysis.RESULTS: The period of following up ranged from 12 to 24months (Median 18 months). 70% of patients felt that biofeedback was helpful, and 62.5% of patients with constipation were improved. Clinical manifestations including straining, abdominal pain, bloating, were relieved, and less oral laxative was used. Spontaneous bowel frequency and psychological state were improved significantly after treatment. Patients with slow and normal transit, and those with and without paradoxical contraction of the anal sphincter on straining, benefited equally from the treatment. The psychological status rather than anorectal test could predict outcome. The efficacy of the two modes of biofeedback was similar without side effects.CONCLUSION: This study suggests that biofeedback has a long-term effect with no side effects, for the majority of patients with chronic idiopathic constipation unresponsive to traditional treatment. Pelvic floor abnormalities and transit time should not be the selection criteria for treatment.展开更多
AIM: To investigate the association between cytochrome P450 2C19 (CYP2C19) gene polymorphism and cancer susceptibility by genotyping of CYP2C19 poor metabolizers (PMs) in cancer patients.METHODS: One hundred and thirt...AIM: To investigate the association between cytochrome P450 2C19 (CYP2C19) gene polymorphism and cancer susceptibility by genotyping of CYP2C19 poor metabolizers (PMs) in cancer patients.METHODS: One hundred and thirty-five cases of esophagus cancer, 148 cases of stomach cancer, 212 cases of lung cancer, 112 cases of bladder cancer and 372 controls were genotyped by allele specific amplification-polymerase chain reaction (ASA-PCR) for CYP2C19 PMs. The frequencies of PMs in cancer groups and control group were compared.RESULTS: The frequencies of PMs of CYP2C19 were 34.1% (46/135) in the group of esophagus cancer patients, 31.8% (47/148) in the stomach cancer patients, 34.4%(73/212) in the group of lung cancer patients, only 4.5%(5/112) in the bladder cancer patients and 14.0%(52/372) in control group.There were statistical differences between the cancer groups and control group (esophagus cancer, X^2=25.65, P<0.005,OR=-3.18, 95%C/=2.005-5.042, stomach cancer, X^2=21.70,P<0.005, OR=2.86, 95%CI=1.820-4.501; lung cancer,X^2=33.58, P<0.005, OR=-3.23, 95%C/=1.503-6.906; bladder cancer, X^2=7.50, P<0.01, OR=-0.288, 95%C/=0.112-0.740).CONCLUSION: CYP2C19 PMs have a high incidence of esophagus cancer, stomach cancer and lung cancer, conversely they have a low incidence of bladder cancer. It suggests that CYP2C19 may participate in the activation of procarcinogen of esophagus cancer, stomach cancer and lung cancer, but may involve in the detoxification of carcinogens of bladder cancer.展开更多
Objective: To study the relationship between Ca 2+ intake,Ca 2+ absorption and Ca 2+ retention. Methods; Thirty-six weaning rats were firstly fed with Ca-poor diet for a 3-week Ca 2+ depletion period,and ...Objective: To study the relationship between Ca 2+ intake,Ca 2+ absorption and Ca 2+ retention. Methods; Thirty-six weaning rats were firstly fed with Ca-poor diet for a 3-week Ca 2+ depletion period,and then randomly divided into 3 groups to receive diet with low,adequate and high Ca 2+ contents.The experiment lasted 12 weeks,with a 3-day metabolism experiment conducted in the 5th week. Results:Supplement with adequate amount of Ca 2+ increased bone Ca 2+,bone mineral density(BMD),bone mineral content(BMC)and the weight of femur(P<0.05).Higher doses of Ca 2+ failed to further improve the efficiency.Analysis showed that Ca 2+ intake was positively correlated to bone Ca 2+,BND and BMC,and negatively correlated to the rates of Ca 2+ absorption and retention.Dose-effect study revealed that the Ca 2+ absorption rate()was a hyperbola function of Ca 2+ intake(X),i.e.=e 6.8068×X -0.8821+20(F=47.3154,P<0.0001).It was found from the results that bone Ca 2+ content(determined by atom absorption spectrophotometer)had a linear correlation to BMC(determined with uni-photon bone mineral densitometer). Conclusion:The rate of Ca 2+ absorption is a hyperbola function of Ca 2+ intake.The increment of Ca 2+ absorption will be minimal when Ca 2+ intake exceeds 3d 250 mg in rats.BMC,better than BMD,may substitute for the ideal bone Ca 2+ content as the index to assess the efficacy of Ca 2+ supplement.展开更多
Latex glove used in healthcare settings has risen dramatically since around 1987. The increased threat of contracting HIV, hepatitis B, and other infectious agents during the course of delivering health care to patien...Latex glove used in healthcare settings has risen dramatically since around 1987. The increased threat of contracting HIV, hepatitis B, and other infectious agents during the course of delivering health care to patients has created the need for barrier protection. Studies have estimated that the prevalence of latex allergy in healthcare workers ranged from 2. 9% up to 17%.展开更多
基金the Natural Science Foundation of Tianjin Health Bureau,No.99KY2D07
文摘AIM: To determine the efficacy and long-term outcome of biofeedback treatment for chronic idiopathic constipation and to compare the efficacy of two modes of biofeedback (EMG-based and manometry-based biofeedback).METHODS: Fifty consecutive contactable patients included 8 cases of slow transit constipation, 36 cases of anorectic outlet obstruction and 6 cases of mixed constipation. Two modes of biofeedback were used for these 50 patients, 30 of whom had EMG-based biofeedback, and 20 had manometrybased biofeedback. Before treatment, a consultation and physical examination were done for all the patients, related information such as bowel function and gut transit time was documented, psychological test (symptom checkJist 90, SCL90)and anorectic physiological test and defecography were applied. After biofeedback management, all the patients were followed up. The Student′s t-test, chi-squared test and Logistic regression were used for statistical analysis.RESULTS: The period of following up ranged from 12 to 24months (Median 18 months). 70% of patients felt that biofeedback was helpful, and 62.5% of patients with constipation were improved. Clinical manifestations including straining, abdominal pain, bloating, were relieved, and less oral laxative was used. Spontaneous bowel frequency and psychological state were improved significantly after treatment. Patients with slow and normal transit, and those with and without paradoxical contraction of the anal sphincter on straining, benefited equally from the treatment. The psychological status rather than anorectal test could predict outcome. The efficacy of the two modes of biofeedback was similar without side effects.CONCLUSION: This study suggests that biofeedback has a long-term effect with no side effects, for the majority of patients with chronic idiopathic constipation unresponsive to traditional treatment. Pelvic floor abnormalities and transit time should not be the selection criteria for treatment.
基金Supported by Research funding from Health Bureau of Zhejiang Province(G20030697)and Research Fund from Hangzhou Tobacco Factory
文摘AIM: To investigate the association between cytochrome P450 2C19 (CYP2C19) gene polymorphism and cancer susceptibility by genotyping of CYP2C19 poor metabolizers (PMs) in cancer patients.METHODS: One hundred and thirty-five cases of esophagus cancer, 148 cases of stomach cancer, 212 cases of lung cancer, 112 cases of bladder cancer and 372 controls were genotyped by allele specific amplification-polymerase chain reaction (ASA-PCR) for CYP2C19 PMs. The frequencies of PMs in cancer groups and control group were compared.RESULTS: The frequencies of PMs of CYP2C19 were 34.1% (46/135) in the group of esophagus cancer patients, 31.8% (47/148) in the stomach cancer patients, 34.4%(73/212) in the group of lung cancer patients, only 4.5%(5/112) in the bladder cancer patients and 14.0%(52/372) in control group.There were statistical differences between the cancer groups and control group (esophagus cancer, X^2=25.65, P<0.005,OR=-3.18, 95%C/=2.005-5.042, stomach cancer, X^2=21.70,P<0.005, OR=2.86, 95%CI=1.820-4.501; lung cancer,X^2=33.58, P<0.005, OR=-3.23, 95%C/=1.503-6.906; bladder cancer, X^2=7.50, P<0.01, OR=-0.288, 95%C/=0.112-0.740).CONCLUSION: CYP2C19 PMs have a high incidence of esophagus cancer, stomach cancer and lung cancer, conversely they have a low incidence of bladder cancer. It suggests that CYP2C19 may participate in the activation of procarcinogen of esophagus cancer, stomach cancer and lung cancer, but may involve in the detoxification of carcinogens of bladder cancer.
文摘Objective: To study the relationship between Ca 2+ intake,Ca 2+ absorption and Ca 2+ retention. Methods; Thirty-six weaning rats were firstly fed with Ca-poor diet for a 3-week Ca 2+ depletion period,and then randomly divided into 3 groups to receive diet with low,adequate and high Ca 2+ contents.The experiment lasted 12 weeks,with a 3-day metabolism experiment conducted in the 5th week. Results:Supplement with adequate amount of Ca 2+ increased bone Ca 2+,bone mineral density(BMD),bone mineral content(BMC)and the weight of femur(P<0.05).Higher doses of Ca 2+ failed to further improve the efficiency.Analysis showed that Ca 2+ intake was positively correlated to bone Ca 2+,BND and BMC,and negatively correlated to the rates of Ca 2+ absorption and retention.Dose-effect study revealed that the Ca 2+ absorption rate()was a hyperbola function of Ca 2+ intake(X),i.e.=e 6.8068×X -0.8821+20(F=47.3154,P<0.0001).It was found from the results that bone Ca 2+ content(determined by atom absorption spectrophotometer)had a linear correlation to BMC(determined with uni-photon bone mineral densitometer). Conclusion:The rate of Ca 2+ absorption is a hyperbola function of Ca 2+ intake.The increment of Ca 2+ absorption will be minimal when Ca 2+ intake exceeds 3d 250 mg in rats.BMC,better than BMD,may substitute for the ideal bone Ca 2+ content as the index to assess the efficacy of Ca 2+ supplement.
基金British Heart Foundation grant number PG/95130. The guarantor accepts full responsibility for the conduct of the study+1 种基金 had access to the data and controlled the decision to publish.
文摘Latex glove used in healthcare settings has risen dramatically since around 1987. The increased threat of contracting HIV, hepatitis B, and other infectious agents during the course of delivering health care to patients has created the need for barrier protection. Studies have estimated that the prevalence of latex allergy in healthcare workers ranged from 2. 9% up to 17%.
基金The NZCMS is primarily funded by the Health Research Council of New Zealand with further funding from the Ministry of Health. Funding for SEH's salary came from the New Zealand Population Health Charitable Trust.
