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内皮功能紊乱的生物学标志与2型糖尿病的发病危险 被引量:2
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作者 JamesB.Meigs FrankB.Hu +3 位作者 NaderRifai JoAnnE.Manson 姚军 郭晓蕙 《美国医学会杂志(中文版)》 2005年第3期138-146,共9页
背景:内皮功能紊乱见于已确诊的2型糖尿病,也有可能在发展为糖尿病之前出现。目的:在最初无糖尿病的妇女中,明确血浆内皮功能紊乱的生物学标志(E-选择素、细胞问粘附分子1[intercellular adhesion molecule 1,ICAM-1]和血管细胞粘... 背景:内皮功能紊乱见于已确诊的2型糖尿病,也有可能在发展为糖尿病之前出现。目的:在最初无糖尿病的妇女中,明确血浆内皮功能紊乱的生物学标志(E-选择素、细胞问粘附分子1[intercellular adhesion molecule 1,ICAM-1]和血管细胞粘附分子1[vascular cell adhesion molecule1,VCAM-1])水平升高是否可预测2型糖尿病的发生。设计和地点:护士健康研究(Nurses’Health Study)中之前瞻性、窠式病例对照研究。护士健康研究于1976年启动,目前仍在进行中。参试者:在1989—1990年最初入选的121700名妇女中,有32826人提供了血标本。基线时无糖尿病、心血管疾病或癌症的参试者中,至2000年有737人发生糖尿病。根据年龄、空腹状态以及种族情况选择匹配的对照组(n=785)。主要观察指标:通过不同基线E-选择素、ICAM-1和VCAM-1水平确定临床诊断2型糖尿病的危险性。结果:基线时病例组生物学标志的中位值与对照组比较明显升高(E-选择素,61.2比45.4ng/mL;ICAM-1,264.9比247.0 ng/mL;VCAM-1:545.4比526.0 ng/mL[P值均≤0.004])。在logistic回归分析模型中,在匹配标准条件下,在校正体重指数(body mass index,BMI)、糖尿病家族史、吸烟、饮食积分、酒精摄入、活动指数以及绝经后使用激素情况后,发现E-选择素和ICAM-1水平升高可以预测糖尿病的发生。最高5分位与最低5分位比较,校正后发生糖尿病的相对危险度E-选择素为5.43(95%可信区间[confidence interval,CI],3.47~8.50),ICAM-1为3.56(95% CI,2.28~5.58),VCAM-1为1.12(95%,CI,0.76—1.66)。以腰围取代BMI进行校正或进一步校正基线C-反应蛋白、空腹胰岛素和糖化血红蛋白A1c水平,或排除于最初4年期间随访诊断糖尿病的病例,均未改变其相关性。结论:内皮功能紊乱可以预测女性2型糖尿病的发生,而且独立于其他已知的危险因素(包括肥胖和亚临床炎症)。 展开更多
关键词 内皮功能紊乱 2型糖尿病 生物学标志 发病危险 ICAM-1 VCAM-1 糖化血红蛋白A1C E-选择素 molecule 血管细胞粘附分子 logistic interval 细胞问粘附分子 Health 病例对照研究 回归分析模型 糖尿病家族史 C-反应蛋白 健康研究
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Mortality and Other Risk Factors among Infants Born to Teenage Mothers
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作者 YURong-bin YANGWei StanleyTOmaye 《Journal of Nanjing Medical University》 2004年第5期228-234,共7页
Objective: To describe the profiles and changing tendency of infant mortality born to teenage mother in the state of Nevada, 1980-2000, and explore the risk factors of infant mortality. Methods: The Nevada Linked Birt... Objective: To describe the profiles and changing tendency of infant mortality born to teenage mother in the state of Nevada, 1980-2000, and explore the risk factors of infant mortality. Methods: The Nevada Linked Birth/Infant Death data sets in 1980-2000 was analyzed. Total of 421964 live births were registered, which included 55419 live births born to teenage mother aged 10-20 years old. Multivariate binary logistic regression model was used to explore the risk factors of infant mortality and estimate the strength of association. Results: Infant mortality rate (IMR) born to teenage mother varied from 5.69 to 14.72 per 1000 live births in 1980-2000, mean IMR was 9.51 per 1000 live births during these 21 years, which were higher than IMRs born to 20 years or older mothers every year. IMRs in two groups seem to have an overall decline by year during this period. The infant mortality rate born to black teenage mother reached to 16.07 per 1000 live births, which was the highest one and significantly higher than those born to white, native American, Asian and other race mothers. Infant mortality rate generally appeared to decline by the increase of mothers age and 16 years old should be an important cut point. This study showed that Congenital anomalies: Club foot, Abnormal conditions of newborn: Meconium aspiration syndrome, Congenital anomaly: Heart malformation, Method of delivery: Repeat Csection, Abnormal conditions of newborn: Assisted ventilation <30min, Birth weight group, Tobacco use, The time mother prenatal care began were significantly positively associated with infant mortality born to teenage mothers, their odds ratios were 24.25, 10.68, 10.23, 4.73, 2.49, 2.00, 1.99 and 1.19 respectively. The clinical gestation estimates was significantly negatively associated with infant mortality as odds ratio of 0.79. Conclusion: Infant mortality born to teenage mother is one of important public problem in Nevada, there are different risk factors related to infant death born to teenage and adult mother. Teenage pregnancy and its outcome should be paid more attention to study. 展开更多
关键词 死亡率 风险因素 婴儿出生 青年母亲 IMR
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Zinc deficiency inhibited the proliferation and differentiation of rat osteoblast in vitro
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作者 CENZiaobo 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1999年第3期237-238,共2页
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Effects of High Erucic Acid Rapeseed Oil on Fatty Acid Oxidation in Rat Liver
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作者 ZHANGLISHI TNAYIN 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1991年第3期262-267,共6页
The effects of high erucic acid rapeseed oil (HER) on fatty acid oxidation in rat liver compared with low erucic acid rapeseed oil (LER) were studied. Weanling male SD rats were fed diets containing 20% HER or LER for... The effects of high erucic acid rapeseed oil (HER) on fatty acid oxidation in rat liver compared with low erucic acid rapeseed oil (LER) were studied. Weanling male SD rats were fed diets containing 20% HER or LER for 1 week or 4 weeks, or 5% HER diet for 4 weeks. The hepatic oxidation capacity of butyric acid or palmitic acid was determined by titrating the propanone produced by their oxidation. The results showed that feeding HER to rats led to an increase in the weight of liver and a decrease in the hepatic oxidation capacity of palmitic acid. Hepatic oxidation of butyric acid was not influenced by the intake of HER. The inhibitory action of HER on the oxidation of long-chain fatty acids probably resulted from the incorporation of erucic acid into mitochondrial membranes, interfering the fatty acyl-CoA transfering system on the membranes, but not from the β-oxidation enzyme system in mitochondria being directly inhibited. 展开更多
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