To evaluate the clinical significance of clinical staging and magnetic resonance imaging (MRI) staging for prostate cancer before radical prostatectomy. Methods: Thirty-two patients with organ confined prostate cancer...To evaluate the clinical significance of clinical staging and magnetic resonance imaging (MRI) staging for prostate cancer before radical prostatectomy. Methods: Thirty-two patients with organ confined prostate cancer were reviewed to assess the accuracy of clinical staging and MRI staging to correlate with pathological staging results after radical prostatectomy. Results: 33.3% (10/30) prostate cancer patients with staging C and 3.3% (1/30) prostate cancer patients with staging D were diagnosed by pathology after radical prostatectomy in 30 patients with prostate cancer with clinical staging B, and 36.7% (11/30) under staging; Only one patient was over staging in clinical staging C. 19.1% (4/21) prostate cancer patients with staging C were diagnosed in 21 patients with prostate cancer and under staging with MRI staging B; 11.1% (1/9) was over staging with MRI staging C. The clinical staging and MRI staging had more correlation with pathological staging results (P=0.002), and PPV of the organ confined prostate cancer by clinical staging and MRI staging were 63.3% and 80.9% respectively, and NPV of nonorgan confined prostate cancer by clinical staging and MRI staging were 50% and 88.9% respectively. MRI staging was more specificity and accuracy than that of clinical staging to predict pathological staging results before radical prostatectomy (P=0.023). Conclusion: The MRI staging was more accuracy than that of clinical staging to predict pathological staging results in organ confined and nonorgan confined prostate cancer before radical prostatectomy.展开更多
Whether the secondary motor areas are involved in simple voluntary movements remains controversial. Differences in the neural substrates of movements with the dominant and the non-dominant hands have not been well doc...Whether the secondary motor areas are involved in simple voluntary movements remains controversial. Differences in the neural substrates of movements with the dominant and the non-dominant hands have not been well documented. In the present study, functional magnetic resonance imaging (fMRI) was used to investigate the hemodynamic response in the primary motor cortex (M1), supplementary motor area (SMA) and premotor cortex (PMC) in six healthy right-handed subjects while performing a visually-guided finger-tapping task with their dominant or non-dominant hands. Significant activation was observed in M1, SMA and PMC during this externally triggered simple voluntary movement task. While dominant hand movements only activated contralateral motor areas, non-domi- nant hand movements also activated ipsilateral SMA and PMC. The results provide strong evidence for the involvement of the secondary motor areas in simple voluntary movements, and also suggest that movements of the dominant hand primarily engage the contralateral secondary motor areas, whereas movements of the non-dominant hand engage bilateral secondary motor areas.展开更多
To evaluate the imaging method and clinical application of CT virtual bronchoscopy (CTVB) Methods Fifty two patients with bronchial and pulmonary diseases were studied with CTVB All patients underwent fiberoptic ...To evaluate the imaging method and clinical application of CT virtual bronchoscopy (CTVB) Methods Fifty two patients with bronchial and pulmonary diseases were studied with CTVB All patients underwent fiberoptic bronchoscopy and patients with lung cancers were confirmed pathologically Lung cancer of center type was found in 46 patients, postoperative lung cancer in 4, tracheal adenoidcystic carcinoma in 1, and bronchial diverticulum in 1 CTVB was performed using Navigator Smooth software on the workstation(Advantage Windows 3 1, GE Medical Systems) Source images included slice thickness of 3?mm or 5?mm, pitch of 1 0 or 1 5, 1 0?mm or 2 0?mm interval (overlap more than 60%) reconstruction Results CTVB could reveal vividly the tracheo^bronchial lumens, the cartilage rings, the carina and the left and right main bronchi, down to the fourth order of bronchial orifices, mimicing fiberoptic bronchoscopy Among 46 patients with lung cancers of center type, fiberoptic bronchoscopy showed the masses in 45 patients and CTVB displayed the masses in 42 The sensitivity of CTVB was 93 3% and its accuracy was 93 5% (χ 2=1 33, 0 10< P <0 25) The tumors appeared as masses or nodules, causing bronchial stenosis (n=35) or occlusion (n=7). The bronchial rings near the masses were blurred, smooth or absent in contrast to the findings of fiberoptic endoscopy Postoperative bronchial stump (n=4) appeared to be smooth Bronchial diverticulum exhibited a local concavity on CTVB and local protrusion on surface shadow display (SSD) CTVB could pass through the stenotic bronchi and detect the occlusive bronchi from the distal end Conclusions The sensitivity of CTVB in detecting bronchial masses was higher than that of fiberoptic bronchoscopy Combined with multiplanar reconstruction (MPR) and CTVB can demonstrate the extraluminal extension of tumors As a noninvasive examining method, however, CTVB is limited to observe mucosal abnormalities and to obtain histologic samples展开更多
文摘To evaluate the clinical significance of clinical staging and magnetic resonance imaging (MRI) staging for prostate cancer before radical prostatectomy. Methods: Thirty-two patients with organ confined prostate cancer were reviewed to assess the accuracy of clinical staging and MRI staging to correlate with pathological staging results after radical prostatectomy. Results: 33.3% (10/30) prostate cancer patients with staging C and 3.3% (1/30) prostate cancer patients with staging D were diagnosed by pathology after radical prostatectomy in 30 patients with prostate cancer with clinical staging B, and 36.7% (11/30) under staging; Only one patient was over staging in clinical staging C. 19.1% (4/21) prostate cancer patients with staging C were diagnosed in 21 patients with prostate cancer and under staging with MRI staging B; 11.1% (1/9) was over staging with MRI staging C. The clinical staging and MRI staging had more correlation with pathological staging results (P=0.002), and PPV of the organ confined prostate cancer by clinical staging and MRI staging were 63.3% and 80.9% respectively, and NPV of nonorgan confined prostate cancer by clinical staging and MRI staging were 50% and 88.9% respectively. MRI staging was more specificity and accuracy than that of clinical staging to predict pathological staging results before radical prostatectomy (P=0.023). Conclusion: The MRI staging was more accuracy than that of clinical staging to predict pathological staging results in organ confined and nonorgan confined prostate cancer before radical prostatectomy.
基金supported by the National Natural Science Foundation of China (Grant Nos.30128005,30170325 and 30070250)the State Key Basic Research and Development Progrom(Grant No.G1999054000)the Technology Fund from the Ministry of Education of China (Grant No.20010284021)
文摘Whether the secondary motor areas are involved in simple voluntary movements remains controversial. Differences in the neural substrates of movements with the dominant and the non-dominant hands have not been well documented. In the present study, functional magnetic resonance imaging (fMRI) was used to investigate the hemodynamic response in the primary motor cortex (M1), supplementary motor area (SMA) and premotor cortex (PMC) in six healthy right-handed subjects while performing a visually-guided finger-tapping task with their dominant or non-dominant hands. Significant activation was observed in M1, SMA and PMC during this externally triggered simple voluntary movement task. While dominant hand movements only activated contralateral motor areas, non-domi- nant hand movements also activated ipsilateral SMA and PMC. The results provide strong evidence for the involvement of the secondary motor areas in simple voluntary movements, and also suggest that movements of the dominant hand primarily engage the contralateral secondary motor areas, whereas movements of the non-dominant hand engage bilateral secondary motor areas.
文摘To evaluate the imaging method and clinical application of CT virtual bronchoscopy (CTVB) Methods Fifty two patients with bronchial and pulmonary diseases were studied with CTVB All patients underwent fiberoptic bronchoscopy and patients with lung cancers were confirmed pathologically Lung cancer of center type was found in 46 patients, postoperative lung cancer in 4, tracheal adenoidcystic carcinoma in 1, and bronchial diverticulum in 1 CTVB was performed using Navigator Smooth software on the workstation(Advantage Windows 3 1, GE Medical Systems) Source images included slice thickness of 3?mm or 5?mm, pitch of 1 0 or 1 5, 1 0?mm or 2 0?mm interval (overlap more than 60%) reconstruction Results CTVB could reveal vividly the tracheo^bronchial lumens, the cartilage rings, the carina and the left and right main bronchi, down to the fourth order of bronchial orifices, mimicing fiberoptic bronchoscopy Among 46 patients with lung cancers of center type, fiberoptic bronchoscopy showed the masses in 45 patients and CTVB displayed the masses in 42 The sensitivity of CTVB was 93 3% and its accuracy was 93 5% (χ 2=1 33, 0 10< P <0 25) The tumors appeared as masses or nodules, causing bronchial stenosis (n=35) or occlusion (n=7). The bronchial rings near the masses were blurred, smooth or absent in contrast to the findings of fiberoptic endoscopy Postoperative bronchial stump (n=4) appeared to be smooth Bronchial diverticulum exhibited a local concavity on CTVB and local protrusion on surface shadow display (SSD) CTVB could pass through the stenotic bronchi and detect the occlusive bronchi from the distal end Conclusions The sensitivity of CTVB in detecting bronchial masses was higher than that of fiberoptic bronchoscopy Combined with multiplanar reconstruction (MPR) and CTVB can demonstrate the extraluminal extension of tumors As a noninvasive examining method, however, CTVB is limited to observe mucosal abnormalities and to obtain histologic samples
