<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Retinoblastoma is one of the pediatric malignancies and its treatment is s...<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Retinoblastoma is one of the pediatric malignancies and its treatment is still challenging. The objective of this study was to highlight the sociodemographic, clinical, and therapeutic aspects of retinoblastoma at the Donka Paediatric Haematology/Oncology unit in Donka university hospital, Guinea, and thereby highlight the conditions of this malignancy in this country. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a retrospective study over 3 years (January 1, 2017 to December 31, 2019). The study population was all retinoblastoma patients who were treated in this unit. Socio-demographic, clinical, and therapeutic data were analyzed. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Out of 210 pediatric patients followed up for cancer in this unit during the period, retinoblastoma accounted for 46 (22%). The patient age at diagnosis was 35.17 months (range: 3 - 132 months). At admission, metastases were observed in 16 patients (35%): 14 with brain metastases and 2 with lymph node metastases. Preoperative chemotherapy was employed in 38 (83%), tumor resection was performed in 20 patients (43%), and postoperative chemotherapy was performed in 19 patients. As for the prognosis, remission in 9, death in 14, and treatment discontinuation in 15. Only one patient had health insurance (2%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> In this region of Guinea, retinoblastoma is the most common ocular tumor in children. Its diagnosis is easy: strabismus and leukocoria are the early signs of retinoblastoma. The prognosis depends on how early the diagnosis is made. Physicians, care-givers, and family members should be aware of the nature of this malignancy and social education/message as such is necessary.</span></span>展开更多
Objective This study aimed to explore the scene-trait coping style of military rescuers in Wenchuan earthquake in an effort to provide scientific evidences for mental intervention program for Chinese military personne...Objective This study aimed to explore the scene-trait coping style of military rescuers in Wenchuan earthquake in an effort to provide scientific evidences for mental intervention program for Chinese military personnel.Methods By cluster sampling,a total of 151 military rescuers and 331 control servicemen were administered the military personnel scene-trait coping style scale(MPSTCSS).Results All active coping factor scores,and passive coping factor scores of affection,health and economy in the rescuer group were significantly higher than those in control group(P<0.05).The 21-above age subgroup,the3-year plus service subgroup,and the officer subgroup had significantly higher active coping factor scores on military tasks,military experience and personal development than those of the 21-below age subgroup,3-year minus service subgroup and the soldier subgroup,respectively(P<0.05 or P<0.01).Conclusion The earthquake relief servicemen can cope with stressful situations better than control group by taking active coping style.The officers,servicemen older than 21 years,and servicemen with more service duration than3 years could usually take active coping style.展开更多
We describe the case of a 2-year-old boy with disseminated infection by a rapidly growing,poorly pathogenic mycobacterial species that belonged to the Mycobacterium fortuitum-Mycobacterium peregrinum complex. He had a...We describe the case of a 2-year-old boy with disseminated infection by a rapidly growing,poorly pathogenic mycobacterial species that belonged to the Mycobacterium fortuitum-Mycobacterium peregrinum complex. He had a severe course characterized by a poor response to treatment and recurrent lymph node abscess formation. Sequencing of the interferon-γreceptor 1 gene (IFNγR1) revealed that he was homozygous for a novel null mutation,453delT. Patients presenting with disseminated infections by rapidly growing environmental mycobacteria must be investigated for complete IFNγR1 deficiency. The spectrum of IFNγR1 genotypes associated with this immunological disorder is expanding.展开更多
Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We eval...Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We evaluated whether:(i)the level of sleep loss correlates with pruritus and(ii)the level of pruritus correlates with the extent or severity of AD in children according to the SCORing Atopic Dermatitis(SCORAD)index.Method:Patients with AD younger than 18 years old were recruited from the pediatric dermatology clinic of a university teaching hospital,and AD severity was evaluated by the SCORAD index.Results:One hundred and eighty-two Chinese children with AD(107 boys and 75 girls)[mean(SD)age of 9.6(4.2)years] were recruited.Their mean(SD)overall SCORAD was 30.1(19.2).Sleep loss was strongly correlated with pruritus(r=0.57,P < 0.001).However,the two subjective symptoms were only weakly correlated with the objective signs(extent and intensity)of AD.The correlations between pruritus and extent and intensity were 0.42(P < 0.001)and 0.38(P < 0.001),respectively,and the correlations between sleep loss and extent and intensity were 0.38(P < 0.001)and 0.34(P < 0.001),respectively.Conclusion:We speculate that the lack of a better correlation was either because pruritus and sleep loss as reported by parents were imprecise,or that mechanisms other than disease extent or severity are responsible for the pathogenesis of these subjective symptoms.展开更多
Objective:To assess early circulatory status in very low birthweight(VLBW)infants with suspected intrauterine infections.Patients:Thirteen VLBW infants who were diagnosed with prenatal infections because of raised ser...Objective:To assess early circulatory status in very low birthweight(VLBW)infants with suspected intrauterine infections.Patients:Thirteen VLBW infants who were diagnosed with prenatal infections because of raised serum IgM at birth(infectious group),and 39 infants matched for gestational age and birth weight(control group).Methods:Echocardiographic assessments were performed consecutively from birth to day 28 in all VLBW infants.Left ventricular output(LVO)and left ventricular stroke volume(LVSV)were measured using Doppler echocardiography.Pulsed Doppler assessment of pulmonary artery pressure(PAP)was performed using the corrected ratio of the pulmonary artery acceleration time to the right ventricular ejection time(AT/RVET(c)).Blood flow in the superior mesenteric artery(SAAA)was also evaluated by Doppler ultrasound.Results:Mean LVO and LVSV were both significantly higher in the infectious group than in the control group at 12 hours(LVO;188 v 154 ml/kg/min)and 72 hours(LVO;216 v 173 ml/kg/min)of life.Pulsed Doppler assessment of PAP showed that mean AT/RVET(c)values were significantly lower in the infectious group than in the control group at 48 hours,96 hours,day 14,and day 28.In the analysis of SMA flow velocities,both peak systolic velocities and time averaged velocities had decreased significantly in the infectious group compared with the control group at 24 hours,36 hours,96 hours,and day 28.Conclusions:VLBW infants with suspected prenatal infection showed a unique circulation status,namely high cardiac output,latency of high PAP,and low organ flow.展开更多
文摘<strong>Introduction:</strong><span style="font-family:""><span style="font-family:Verdana;"> Retinoblastoma is one of the pediatric malignancies and its treatment is still challenging. The objective of this study was to highlight the sociodemographic, clinical, and therapeutic aspects of retinoblastoma at the Donka Paediatric Haematology/Oncology unit in Donka university hospital, Guinea, and thereby highlight the conditions of this malignancy in this country. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a retrospective study over 3 years (January 1, 2017 to December 31, 2019). The study population was all retinoblastoma patients who were treated in this unit. Socio-demographic, clinical, and therapeutic data were analyzed. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Out of 210 pediatric patients followed up for cancer in this unit during the period, retinoblastoma accounted for 46 (22%). The patient age at diagnosis was 35.17 months (range: 3 - 132 months). At admission, metastases were observed in 16 patients (35%): 14 with brain metastases and 2 with lymph node metastases. Preoperative chemotherapy was employed in 38 (83%), tumor resection was performed in 20 patients (43%), and postoperative chemotherapy was performed in 19 patients. As for the prognosis, remission in 9, death in 14, and treatment discontinuation in 15. Only one patient had health insurance (2%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> In this region of Guinea, retinoblastoma is the most common ocular tumor in children. Its diagnosis is easy: strabismus and leukocoria are the early signs of retinoblastoma. The prognosis depends on how early the diagnosis is made. Physicians, care-givers, and family members should be aware of the nature of this malignancy and social education/message as such is necessary.</span></span>
文摘Objective This study aimed to explore the scene-trait coping style of military rescuers in Wenchuan earthquake in an effort to provide scientific evidences for mental intervention program for Chinese military personnel.Methods By cluster sampling,a total of 151 military rescuers and 331 control servicemen were administered the military personnel scene-trait coping style scale(MPSTCSS).Results All active coping factor scores,and passive coping factor scores of affection,health and economy in the rescuer group were significantly higher than those in control group(P<0.05).The 21-above age subgroup,the3-year plus service subgroup,and the officer subgroup had significantly higher active coping factor scores on military tasks,military experience and personal development than those of the 21-below age subgroup,3-year minus service subgroup and the soldier subgroup,respectively(P<0.05 or P<0.01).Conclusion The earthquake relief servicemen can cope with stressful situations better than control group by taking active coping style.The officers,servicemen older than 21 years,and servicemen with more service duration than3 years could usually take active coping style.
文摘We describe the case of a 2-year-old boy with disseminated infection by a rapidly growing,poorly pathogenic mycobacterial species that belonged to the Mycobacterium fortuitum-Mycobacterium peregrinum complex. He had a severe course characterized by a poor response to treatment and recurrent lymph node abscess formation. Sequencing of the interferon-γreceptor 1 gene (IFNγR1) revealed that he was homozygous for a novel null mutation,453delT. Patients presenting with disseminated infections by rapidly growing environmental mycobacteria must be investigated for complete IFNγR1 deficiency. The spectrum of IFNγR1 genotypes associated with this immunological disorder is expanding.
文摘Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep disturbance.It is not known how well these symptoms correlate with the extent and intensity of eczematous involvement.We evaluated whether:(i)the level of sleep loss correlates with pruritus and(ii)the level of pruritus correlates with the extent or severity of AD in children according to the SCORing Atopic Dermatitis(SCORAD)index.Method:Patients with AD younger than 18 years old were recruited from the pediatric dermatology clinic of a university teaching hospital,and AD severity was evaluated by the SCORAD index.Results:One hundred and eighty-two Chinese children with AD(107 boys and 75 girls)[mean(SD)age of 9.6(4.2)years] were recruited.Their mean(SD)overall SCORAD was 30.1(19.2).Sleep loss was strongly correlated with pruritus(r=0.57,P < 0.001).However,the two subjective symptoms were only weakly correlated with the objective signs(extent and intensity)of AD.The correlations between pruritus and extent and intensity were 0.42(P < 0.001)and 0.38(P < 0.001),respectively,and the correlations between sleep loss and extent and intensity were 0.38(P < 0.001)and 0.34(P < 0.001),respectively.Conclusion:We speculate that the lack of a better correlation was either because pruritus and sleep loss as reported by parents were imprecise,or that mechanisms other than disease extent or severity are responsible for the pathogenesis of these subjective symptoms.
文摘Objective:To assess early circulatory status in very low birthweight(VLBW)infants with suspected intrauterine infections.Patients:Thirteen VLBW infants who were diagnosed with prenatal infections because of raised serum IgM at birth(infectious group),and 39 infants matched for gestational age and birth weight(control group).Methods:Echocardiographic assessments were performed consecutively from birth to day 28 in all VLBW infants.Left ventricular output(LVO)and left ventricular stroke volume(LVSV)were measured using Doppler echocardiography.Pulsed Doppler assessment of pulmonary artery pressure(PAP)was performed using the corrected ratio of the pulmonary artery acceleration time to the right ventricular ejection time(AT/RVET(c)).Blood flow in the superior mesenteric artery(SAAA)was also evaluated by Doppler ultrasound.Results:Mean LVO and LVSV were both significantly higher in the infectious group than in the control group at 12 hours(LVO;188 v 154 ml/kg/min)and 72 hours(LVO;216 v 173 ml/kg/min)of life.Pulsed Doppler assessment of PAP showed that mean AT/RVET(c)values were significantly lower in the infectious group than in the control group at 48 hours,96 hours,day 14,and day 28.In the analysis of SMA flow velocities,both peak systolic velocities and time averaged velocities had decreased significantly in the infectious group compared with the control group at 24 hours,36 hours,96 hours,and day 28.Conclusions:VLBW infants with suspected prenatal infection showed a unique circulation status,namely high cardiac output,latency of high PAP,and low organ flow.
