Because of an unfortunate mistake during the production of this article,the Acknowledgements have been omitted.The Acknowledgements are added as follows:Sasan YAZDANI would like to thank the Scientific and Technologic...Because of an unfortunate mistake during the production of this article,the Acknowledgements have been omitted.The Acknowledgements are added as follows:Sasan YAZDANI would like to thank the Scientific and Technological Research Council of Turkey(TÜB˙ITAK)for receiving financial support for this work through the 2221 Fellowship Program for Visiting Scientists and Scientists on Sabbatical Leave(Grant ID:E 21514107-115.02-228864).Sasan YAZDANI also expresses his gratitude to Sahand University of Technology for granting him sabbatical leave to facilitate the completion of this research.展开更多
In this study,the microstructure and mechanical properties of a multi-layered 316L-TiC composite material produced by selective laser melting(SLM)additive manufacturing process are investigated.Three different layers,...In this study,the microstructure and mechanical properties of a multi-layered 316L-TiC composite material produced by selective laser melting(SLM)additive manufacturing process are investigated.Three different layers,consisting of 316L stainless steel,316L-5 wt%TiC and 316L-10 wt%TiC,were additively manufactured.The microstructure of these layers was characterized by optical microscopy(OM)and scanning electron microscopy(SEM).X-ray diffraction(XRD)was used for phase analysis,and the mechanical properties were evaluated by tensile and nanoindentation tests.The microstructural observations show epitaxial grain growth within the composite layers,with the elongated grains growing predominantly in the build direction.XRD analysis confirms the successful incorporation of the TiC particles into the 316L matrix,with no unwanted phases present.Nanoindentation results indicate a significant increase in the hardness and modulus of elasticity of the composite layers compared to pure 316L stainless steel,suggesting improved mechanical properties.Tensile tests show remarkable strength values for the 316L-TiC composite samples,which can be attributed to the embedded TiC particles.These results highlight the potential of SLM in the production of multi-layer metal-ceramic composites for applications that require high strength and ductility of metallic components in addition to the exceptional hardness of the ceramic particles.展开更多
Ice crossings have been used for several reasons.First,due to the active development of the Arctic shelf,supplies and minerals are provided and transferred on special transports on the surface of ice covers.Second,ice...Ice crossings have been used for several reasons.First,due to the active development of the Arctic shelf,supplies and minerals are provided and transferred on special transports on the surface of ice covers.Second,ice crossings across rivers are used to reduce the length of transport routes.Traditional methods of increasing the load bearing capacity of ice are ice freezing from above,ice freezing from below,and ice strengthening through a wooden copepod flooring.Practical experience shows that the physical and mechanical properties of ice covers are unreliable and changeable in time and strongly depend on various external factors.Therefore,ice covers should be strengthened through alternative methods.Thus,predicting the bearing capacity of ice crossings and exploring methods for their strengthening are important.In this study,we consider the results of experimental and numerical studies on the bearing and deformation capacity of ice beams upon destruction from pure bending.Under pure bending,ice breaks down in the ice crossing when transports move along it.Tests were carried out with a specified reinforcement scheme.The results of the model experiments were compared with numerical calculations in the ANSYS software package.Experiments on ice beams reinforced with various composite materials were also performed.Destruction of samples in all cases occurred as a result of the formation of extensive cracks in the ice caused by the bending moment in the middle of the beam span.Based on the experimental and numerical research results,the use of a surface reinforcement in ice with various materials can increase the bearing capacity from 65%to 99%for this reinforcement scheme.展开更多
Obesity, one of the most common health problems, is associated with glucose and lipid metabolism abnormalities, increased cardiovascular risk and oxidative stressI1}. Aging is also associated with an increase in oxida...Obesity, one of the most common health problems, is associated with glucose and lipid metabolism abnormalities, increased cardiovascular risk and oxidative stressI1}. Aging is also associated with an increase in oxidative stress[2]. Considering that older adults are already at risk for oxidant stress, the additional metabolic perturbations of obesity aggravated the susceptibility to oxidant stress. Modulating age-related oxidative stress via dietary interventions could reduce free radical production and significantly improve health in aging.展开更多
Background: Dietary fatty acids have important homeostatic functions in regulating the immune response and may exert beneficial effects on immune alterations during obesity. Objective: To assess the in vitro effects o...Background: Dietary fatty acids have important homeostatic functions in regulating the immune response and may exert beneficial effects on immune alterations during obesity. Objective: To assess the in vitro effects of oil fatty acids, different oils (olive, linseed, Nigel, sunflower) were tested on T-lymphocyte proliferation, Th1- and Th2-type cytokine production, and intracellular oxidant/antioxidant status in obese patients. Methods: Peripheral blood lymphocytes were isolated using Histopaque and were in vitro cultured and stimulated by Con A in the presence or absence of the oils. Cell proliferation, interleukin-2, interleukin-4 and interferon-γ (INFγ) secretions and intracellular oxidative status (glutathione (GSH), malondialdehyde (MDA), carbonyl protein levels, catalase activity and micronuclei frequency) were investigated. Results: Abnormalities in lymphocyte function and intracellular oxidative stress were observed in obesity. Linseed oil induced a reduction in T-lymphocyte proliferation and IL-2 production while Nigel oil increased them in both obese and control groups. In addition, Nigel oil enhanced IFNγ and IL-4 secretion. Olive and sunflower oils had no effect on lymphocyte proliferation and cytokine secretion in both groups. Linseed and Nigel oils induced an increase in T cell GSH concentrations and catalase activity with a concomitant decrease in MDA, carbonyl protein contents and micronuclei frequency especially in obese patients. Conclusion: Linseed and Nigel oils had beneficial effects on lymphocyte proliferation, cytokines secretions and redox status, while olive and sunflower oils had no effects on immune cell function in obesity.展开更多
Because linseed oil may influence maternal and fetal metabolisms, we investigated its role in the modulation of lipid metabolism in cafeteria diet-induced obese rats and their offspring. Female Wistar rats were fed co...Because linseed oil may influence maternal and fetal metabolisms, we investigated its role in the modulation of lipid metabolism in cafeteria diet-induced obese rats and their offspring. Female Wistar rats were fed control or cafeteria food, which were either supplemented or not supplemented with linseed oil （5%） for I month before and during gestation. At parturition, serum and tissue lipids and enzyme activities were analyzed. Cafeteria diet induced adverse metabolic alterations in both mothers and offspring. Linseed oil improved metabolic status. In conclusion, linseed oil displayed health benefits by modulating tissue enzyme activities in both obese mothers and their newborns.展开更多
With the aid of non-contact measurements of vibrating surfaces through laser scanning,operating deflection shapes(ODSs)with high spatial resolutions can be used to graphically characterize damage in plane structures.A...With the aid of non-contact measurements of vibrating surfaces through laser scanning,operating deflection shapes(ODSs)with high spatial resolutions can be used to graphically characterize damage in plane structures.Although numerous damage identification approaches relying on laser-measured ODSs have been developed for plate-type structures,they cannot be directly applied to circular cylinders due to the gap between equations of motions of plates and circular cylinders.To fill this gap,a novel approach is proposed in this study for damage identification of circular cylinders.Damage-induced discontinuities of the derivatives of ODSs can be used to gra-phically manifest the occurrence of the damage,and characterize the location and size of the damage.The approach is experimentally validated on a specimen of the circular cylinder component,whose out-of-plane ODSs in an inspection region are acquired through laser scanning using a scanning laser vibrometer.The results suggest that the occurrence,location,and size of the internal damage of the circular cylinder can be identified.展开更多
This current study focuses on the simulation of natural convection in square cavity filled with a porous medium considered homogenous, isotropic and saturated by a Newtonian fluid obeying the law of Darcy and the hypo...This current study focuses on the simulation of natural convection in square cavity filled with a porous medium considered homogenous, isotropic and saturated by a Newtonian fluid obeying the law of Darcy and the hypothesis of Boussinesq. The lower horizontal wall of the enclosure is subjected to a temperature varying sinusoidally with the space while the upper horizontal wall is maintained adiabatic. The vertical walls are kept cold isotherm. In order to generalize the results, all governing equations are put into dimensionless form, discretized by the Finite Difference Method and solved by the relaxed Gauss Seidel (SUR) Algorithm. A code has been proposed in Fortran 95, in order to solve numerically the equations of the problem. The study parameters are the Rayleigh-Darcy number (Ra) and the amplitude (Ar) of the hot wall temperature. The effects of the Rayleigh-Darcy number and amplitude on the dynamic and thermal field, the horizontal velocity distribution and the mean horizontal temperature distribution (y = 0.5) were presented and discussed. It emerges from this study that the increases of the amplitude and Rayleigh-Darcy number intensify the flow and the global transfer of heat in our physical domain.展开更多
This study enhances the application of cross-sectional warping considered mixed finite element(WMFE)formulation to accurately determine natural vibration,static displacement response,and shear and normal stress evalua...This study enhances the application of cross-sectional warping considered mixed finite element(WMFE)formulation to accurately determine natural vibration,static displacement response,and shear and normal stress evaluation with very close to the precision of solid finite elements(FEs)in two-phase/multi-phase functionally graded(FG)laminated composite beams strength using carbon nanotubes(CNTs).The principles of three dimensional(3D)elasticity theory are used to derive constitutive equations.The mixed finite element(MFE)method is improved by accounting for warping effects by displacement-based FEs within the cross-sectional domain.The MFE with two nodes has a total of 24 degrees of freedom.The two-phase material consists of a polymer matrix reinforced with aligned CNTs that are FG throughout the beam thickness.The multi-phase FG beam is modeled as a three-component composite material,consisting of CNTs,a polymer matrix,and fibers.The polymer matrix is reinforced by longitudinally aligned fibers and randomly dispersed CNT particles.The fiber volume fractions are considered to change gradually through the thickness of the beam following a power-law variation.The W-MFE achieves satisfactory results with fewer degrees of freedom than 3D solid FEs.Benchmark examples examine the effects of ply orientation,configuration,and fiber gradation on FG beam behavior.展开更多
This study proposes a decentralized urban traffic optimization approach by integrating Dijkstra’s algorithm with edge computing.The system models road networks as dynamic graphs,using real-time data from IoT sensors ...This study proposes a decentralized urban traffic optimization approach by integrating Dijkstra’s algorithm with edge computing.The system models road networks as dynamic graphs,using real-time data from IoT sensors to adapt routing decisions.A three-layer architecture reduces latency and im-proves scalability.Simulation results show a 42% decrease in response time and a 25%reduction in congestion compared to centralized systems.The ap-proach demonstrates high reliability and potential for smart city applications.展开更多
Digital twin(DT)can achieve real-time information fusion and interactive feedback between virtual space and physical space.This technology involves a digital model,real-time information management,comprehensive intell...Digital twin(DT)can achieve real-time information fusion and interactive feedback between virtual space and physical space.This technology involves a digital model,real-time information management,comprehensive intelligent perception networks,etc.,and it can drive the rapid conceptual development of intelligent construction(IC)such as smart factories,smart cities,and smart medical care.Nevertheless,the actual use of DT in IC is partially pending,with numerous scientific factors still not clarified.An overall survey on pending issues and unsolved scientific factors is needed for the development of DT-driven IC.To this end,this study aims to provide a comprehensive review of the state of the art and state of the use of DT-driven IC.The use of DT in planning,design,manufacturing,operation,and maintenance management of IC is demonstrated and analyzed,following which the driving functions of DT in IC are detailed from four aspects:information perception and analysis,data mining and modeling,state assessment and prediction,intelligent optimization and decision-making.Furthermore,the future direction of research,using DT in IC,is presented with some comments and suggestions.This work will help researchers gain in-depth and systematic understanding of the use of DT,and help practitioners to better promote its implementation in IC.展开更多
Background: The prevalence of overweight and obesity associated with oxidative stress and immune abnormalities is continuously increasing. Antioxidant supplementations might counteract potential damage caused by ROS t...Background: The prevalence of overweight and obesity associated with oxidative stress and immune abnormalities is continuously increasing. Antioxidant supplementations might counteract potential damage caused by ROS to cellular tissues. Objective: To determine the role of vitamins on immune improvement during obesity, we investigated in vitro effects of vitamins C, E, and NADH on mitogen-stimulated proliferation, Th1- and Th2-type cytokine production, and oxidant/antioxidant status of lymphocytes isolated from obese patients. Methods: Peripheral blood lymphocytes were isolated using a density gradient of Histopaque. They were in vitro cultured and stimulated by Con A in the presence or absence of vitamins. Cell proliferation was determined by MTT assay and interleukin-2, interleukin-4 and interferon-γ (INFγ) secretions. Cell oxidant/antioxidant balance was studied by assaying glutathione (GSH), malondialdehyde (MDA), carbonyl protein levels, catalase activity and micronucli frequency. Results: Obesity is associated with enhanced oxidative stress response. Indeed, vitamin C, E and NADH improved significantly lymphocyte proliferation and diminished cellular oxidative stress. Conclusion: Treatments of lymphocytes with vitamins had beneficial effects on lymphocyte proliferation, cytokines secretions and redox status, generating an anti-inflammatory profile and should be considered in therapeutic approaches for normalizing immune cell function in obesity.展开更多
The purpose of this paper is to present a simple way to approximate the dependence of the global mean air temperature at Earth＇s surface on atmospheric concentration of carbon dioxide. Current discussions include ene...The purpose of this paper is to present a simple way to approximate the dependence of the global mean air temperature at Earth＇s surface on atmospheric concentration of carbon dioxide. Current discussions include energy aspects of the greenhouse effect and the global warming. The starting point for the research are laws of thermodynamics, energy equilibrium and absorption and emission property of the atmosphere. According to the calculations, the natural and the anthropogenic changes effect the atmosphere. By the year 2100 the CO2 concentration will be doubled in comparison with the value of the pre-industrial ages. The doubled CO2 concentration will mean a temperature change about 1 ℃-1.5 ℃.展开更多
Pancreatic cancer is one of the most lethal cancers worldwide and is characterized by a poor prognosis.1,2 Due to its aggressive nature and lack of early symptoms,most patients are diagnosed at an advanced stage,and c...Pancreatic cancer is one of the most lethal cancers worldwide and is characterized by a poor prognosis.1,2 Due to its aggressive nature and lack of early symptoms,most patients are diagnosed at an advanced stage,and chemotherapy is the optimal option.3,4 Epidemiology,the incidence rate of pancreatic cancer has increased in the last two decades,from 196,000 patients in 1990 to 441,000 in 2017.Based on 2020 global cancer statistics,the annual cases of pancreatic cancer have increased to 195,773.4 Unfortunately,patients demonstrate resistance to chemotherapy,and only some of them benefit from current therapeutic strategies.展开更多
In this paper, we consider a semi-linear generalized hyperbolic boundary value problem associated to the linear elastic equations with general damping term and nonlinearities of variable exponent type. Under suitable ...In this paper, we consider a semi-linear generalized hyperbolic boundary value problem associated to the linear elastic equations with general damping term and nonlinearities of variable exponent type. Under suitable conditions, local and global existence theorems are proved. The uniqueness of the solution have been gotten by eliminating some hypotheses that have been imposed by other authors for different particular problems. We show that any solution with nontrivial initial datum becomes stable.展开更多
文摘Because of an unfortunate mistake during the production of this article,the Acknowledgements have been omitted.The Acknowledgements are added as follows:Sasan YAZDANI would like to thank the Scientific and Technological Research Council of Turkey(TÜB˙ITAK)for receiving financial support for this work through the 2221 Fellowship Program for Visiting Scientists and Scientists on Sabbatical Leave(Grant ID:E 21514107-115.02-228864).Sasan YAZDANI also expresses his gratitude to Sahand University of Technology for granting him sabbatical leave to facilitate the completion of this research.
文摘In this study,the microstructure and mechanical properties of a multi-layered 316L-TiC composite material produced by selective laser melting(SLM)additive manufacturing process are investigated.Three different layers,consisting of 316L stainless steel,316L-5 wt%TiC and 316L-10 wt%TiC,were additively manufactured.The microstructure of these layers was characterized by optical microscopy(OM)and scanning electron microscopy(SEM).X-ray diffraction(XRD)was used for phase analysis,and the mechanical properties were evaluated by tensile and nanoindentation tests.The microstructural observations show epitaxial grain growth within the composite layers,with the elongated grains growing predominantly in the build direction.XRD analysis confirms the successful incorporation of the TiC particles into the 316L matrix,with no unwanted phases present.Nanoindentation results indicate a significant increase in the hardness and modulus of elasticity of the composite layers compared to pure 316L stainless steel,suggesting improved mechanical properties.Tensile tests show remarkable strength values for the 316L-TiC composite samples,which can be attributed to the embedded TiC particles.These results highlight the potential of SLM in the production of multi-layer metal-ceramic composites for applications that require high strength and ductility of metallic components in addition to the exceptional hardness of the ceramic particles.
文摘Ice crossings have been used for several reasons.First,due to the active development of the Arctic shelf,supplies and minerals are provided and transferred on special transports on the surface of ice covers.Second,ice crossings across rivers are used to reduce the length of transport routes.Traditional methods of increasing the load bearing capacity of ice are ice freezing from above,ice freezing from below,and ice strengthening through a wooden copepod flooring.Practical experience shows that the physical and mechanical properties of ice covers are unreliable and changeable in time and strongly depend on various external factors.Therefore,ice covers should be strengthened through alternative methods.Thus,predicting the bearing capacity of ice crossings and exploring methods for their strengthening are important.In this study,we consider the results of experimental and numerical studies on the bearing and deformation capacity of ice beams upon destruction from pure bending.Under pure bending,ice breaks down in the ice crossing when transports move along it.Tests were carried out with a specified reinforcement scheme.The results of the model experiments were compared with numerical calculations in the ANSYS software package.Experiments on ice beams reinforced with various composite materials were also performed.Destruction of samples in all cases occurred as a result of the formation of extensive cracks in the ice caused by the bending moment in the middle of the beam span.Based on the experimental and numerical research results,the use of a surface reinforcement in ice with various materials can increase the bearing capacity from 65%to 99%for this reinforcement scheme.
基金supported by the French Foreign Office(International Research Extension Grant TASSILI 08MDU723)the Algerian Research Project(PNR,2011)
文摘Obesity, one of the most common health problems, is associated with glucose and lipid metabolism abnormalities, increased cardiovascular risk and oxidative stressI1}. Aging is also associated with an increase in oxidative stress[2]. Considering that older adults are already at risk for oxidant stress, the additional metabolic perturbations of obesity aggravated the susceptibility to oxidant stress. Modulating age-related oxidative stress via dietary interventions could reduce free radical production and significantly improve health in aging.
文摘Background: Dietary fatty acids have important homeostatic functions in regulating the immune response and may exert beneficial effects on immune alterations during obesity. Objective: To assess the in vitro effects of oil fatty acids, different oils (olive, linseed, Nigel, sunflower) were tested on T-lymphocyte proliferation, Th1- and Th2-type cytokine production, and intracellular oxidant/antioxidant status in obese patients. Methods: Peripheral blood lymphocytes were isolated using Histopaque and were in vitro cultured and stimulated by Con A in the presence or absence of the oils. Cell proliferation, interleukin-2, interleukin-4 and interferon-γ (INFγ) secretions and intracellular oxidative status (glutathione (GSH), malondialdehyde (MDA), carbonyl protein levels, catalase activity and micronuclei frequency) were investigated. Results: Abnormalities in lymphocyte function and intracellular oxidative stress were observed in obesity. Linseed oil induced a reduction in T-lymphocyte proliferation and IL-2 production while Nigel oil increased them in both obese and control groups. In addition, Nigel oil enhanced IFNγ and IL-4 secretion. Olive and sunflower oils had no effect on lymphocyte proliferation and cytokine secretion in both groups. Linseed and Nigel oils induced an increase in T cell GSH concentrations and catalase activity with a concomitant decrease in MDA, carbonyl protein contents and micronuclei frequency especially in obese patients. Conclusion: Linseed and Nigel oils had beneficial effects on lymphocyte proliferation, cytokines secretions and redox status, while olive and sunflower oils had no effects on immune cell function in obesity.
基金supported by the French Foreign Office(International Research Extension Grant TASSILI 08MDU723)the Algerian Research Project(PNR,2011)
文摘Because linseed oil may influence maternal and fetal metabolisms, we investigated its role in the modulation of lipid metabolism in cafeteria diet-induced obese rats and their offspring. Female Wistar rats were fed control or cafeteria food, which were either supplemented or not supplemented with linseed oil （5%） for I month before and during gestation. At parturition, serum and tissue lipids and enzyme activities were analyzed. Cafeteria diet induced adverse metabolic alterations in both mothers and offspring. Linseed oil improved metabolic status. In conclusion, linseed oil displayed health benefits by modulating tissue enzyme activities in both obese mothers and their newborns.
基金The authors are grateful for the supports from the Changzhou Policy Guidance Plan-International Science and Technology Cooperation(No.CZ20200003)the Anhui International Joint Research Center of Data Diagnosis and Smart Maintenance on Bridge Structures(No.2021AHGHYB01)+1 种基金the Nantong Science and Technology Opening Cooperation Project in 2021(No.BW2021001)the Key R&D Project of Anhui Science and Technology Department(202004b11020026).
文摘With the aid of non-contact measurements of vibrating surfaces through laser scanning,operating deflection shapes(ODSs)with high spatial resolutions can be used to graphically characterize damage in plane structures.Although numerous damage identification approaches relying on laser-measured ODSs have been developed for plate-type structures,they cannot be directly applied to circular cylinders due to the gap between equations of motions of plates and circular cylinders.To fill this gap,a novel approach is proposed in this study for damage identification of circular cylinders.Damage-induced discontinuities of the derivatives of ODSs can be used to gra-phically manifest the occurrence of the damage,and characterize the location and size of the damage.The approach is experimentally validated on a specimen of the circular cylinder component,whose out-of-plane ODSs in an inspection region are acquired through laser scanning using a scanning laser vibrometer.The results suggest that the occurrence,location,and size of the internal damage of the circular cylinder can be identified.
文摘This current study focuses on the simulation of natural convection in square cavity filled with a porous medium considered homogenous, isotropic and saturated by a Newtonian fluid obeying the law of Darcy and the hypothesis of Boussinesq. The lower horizontal wall of the enclosure is subjected to a temperature varying sinusoidally with the space while the upper horizontal wall is maintained adiabatic. The vertical walls are kept cold isotherm. In order to generalize the results, all governing equations are put into dimensionless form, discretized by the Finite Difference Method and solved by the relaxed Gauss Seidel (SUR) Algorithm. A code has been proposed in Fortran 95, in order to solve numerically the equations of the problem. The study parameters are the Rayleigh-Darcy number (Ra) and the amplitude (Ar) of the hot wall temperature. The effects of the Rayleigh-Darcy number and amplitude on the dynamic and thermal field, the horizontal velocity distribution and the mean horizontal temperature distribution (y = 0.5) were presented and discussed. It emerges from this study that the increases of the amplitude and Rayleigh-Darcy number intensify the flow and the global transfer of heat in our physical domain.
基金funding provided by the Scientific and Technological Research Council of Türkiye(TÜBİTAK).
文摘This study enhances the application of cross-sectional warping considered mixed finite element(WMFE)formulation to accurately determine natural vibration,static displacement response,and shear and normal stress evaluation with very close to the precision of solid finite elements(FEs)in two-phase/multi-phase functionally graded(FG)laminated composite beams strength using carbon nanotubes(CNTs).The principles of three dimensional(3D)elasticity theory are used to derive constitutive equations.The mixed finite element(MFE)method is improved by accounting for warping effects by displacement-based FEs within the cross-sectional domain.The MFE with two nodes has a total of 24 degrees of freedom.The two-phase material consists of a polymer matrix reinforced with aligned CNTs that are FG throughout the beam thickness.The multi-phase FG beam is modeled as a three-component composite material,consisting of CNTs,a polymer matrix,and fibers.The polymer matrix is reinforced by longitudinally aligned fibers and randomly dispersed CNT particles.The fiber volume fractions are considered to change gradually through the thickness of the beam following a power-law variation.The W-MFE achieves satisfactory results with fewer degrees of freedom than 3D solid FEs.Benchmark examples examine the effects of ply orientation,configuration,and fiber gradation on FG beam behavior.
文摘This study proposes a decentralized urban traffic optimization approach by integrating Dijkstra’s algorithm with edge computing.The system models road networks as dynamic graphs,using real-time data from IoT sensors to adapt routing decisions.A three-layer architecture reduces latency and im-proves scalability.Simulation results show a 42% decrease in response time and a 25%reduction in congestion compared to centralized systems.The ap-proach demonstrates high reliability and potential for smart city applications.
基金the financial support partially provided by The Quality Engineering Project of Anhui Province(2019sjjd58,2020sxzx36)The Ministry of Education Cooperative Education Project(201901119016)+1 种基金The Chinese(Jiangsu)-Czech Bilateral Co-funding R&D Project(SBZ2018000220)the Key R&D Project of Anhui Science and Technology Department(202004b11020026).
文摘Digital twin(DT)can achieve real-time information fusion and interactive feedback between virtual space and physical space.This technology involves a digital model,real-time information management,comprehensive intelligent perception networks,etc.,and it can drive the rapid conceptual development of intelligent construction(IC)such as smart factories,smart cities,and smart medical care.Nevertheless,the actual use of DT in IC is partially pending,with numerous scientific factors still not clarified.An overall survey on pending issues and unsolved scientific factors is needed for the development of DT-driven IC.To this end,this study aims to provide a comprehensive review of the state of the art and state of the use of DT-driven IC.The use of DT in planning,design,manufacturing,operation,and maintenance management of IC is demonstrated and analyzed,following which the driving functions of DT in IC are detailed from four aspects:information perception and analysis,data mining and modeling,state assessment and prediction,intelligent optimization and decision-making.Furthermore,the future direction of research,using DT in IC,is presented with some comments and suggestions.This work will help researchers gain in-depth and systematic understanding of the use of DT,and help practitioners to better promote its implementation in IC.
文摘Background: The prevalence of overweight and obesity associated with oxidative stress and immune abnormalities is continuously increasing. Antioxidant supplementations might counteract potential damage caused by ROS to cellular tissues. Objective: To determine the role of vitamins on immune improvement during obesity, we investigated in vitro effects of vitamins C, E, and NADH on mitogen-stimulated proliferation, Th1- and Th2-type cytokine production, and oxidant/antioxidant status of lymphocytes isolated from obese patients. Methods: Peripheral blood lymphocytes were isolated using a density gradient of Histopaque. They were in vitro cultured and stimulated by Con A in the presence or absence of vitamins. Cell proliferation was determined by MTT assay and interleukin-2, interleukin-4 and interferon-γ (INFγ) secretions. Cell oxidant/antioxidant balance was studied by assaying glutathione (GSH), malondialdehyde (MDA), carbonyl protein levels, catalase activity and micronucli frequency. Results: Obesity is associated with enhanced oxidative stress response. Indeed, vitamin C, E and NADH improved significantly lymphocyte proliferation and diminished cellular oxidative stress. Conclusion: Treatments of lymphocytes with vitamins had beneficial effects on lymphocyte proliferation, cytokines secretions and redox status, generating an anti-inflammatory profile and should be considered in therapeutic approaches for normalizing immune cell function in obesity.
文摘The purpose of this paper is to present a simple way to approximate the dependence of the global mean air temperature at Earth＇s surface on atmospheric concentration of carbon dioxide. Current discussions include energy aspects of the greenhouse effect and the global warming. The starting point for the research are laws of thermodynamics, energy equilibrium and absorption and emission property of the atmosphere. According to the calculations, the natural and the anthropogenic changes effect the atmosphere. By the year 2100 the CO2 concentration will be doubled in comparison with the value of the pre-industrial ages. The doubled CO2 concentration will mean a temperature change about 1 ℃-1.5 ℃.
基金supported by the National Natural Science Foundation of China(No.82405167)the Shenzhen Science and Technology Program(Guangdong,China)(No.GJHZ20220913143005010)the fundamental research project of the Shenzhen Science and Technology Innovation Commission(No.20231120113324002 and No.RCBS20231211090635056).
文摘Pancreatic cancer is one of the most lethal cancers worldwide and is characterized by a poor prognosis.1,2 Due to its aggressive nature and lack of early symptoms,most patients are diagnosed at an advanced stage,and chemotherapy is the optimal option.3,4 Epidemiology,the incidence rate of pancreatic cancer has increased in the last two decades,from 196,000 patients in 1990 to 441,000 in 2017.Based on 2020 global cancer statistics,the annual cases of pancreatic cancer have increased to 195,773.4 Unfortunately,patients demonstrate resistance to chemotherapy,and only some of them benefit from current therapeutic strategies.
文摘In this paper, we consider a semi-linear generalized hyperbolic boundary value problem associated to the linear elastic equations with general damping term and nonlinearities of variable exponent type. Under suitable conditions, local and global existence theorems are proved. The uniqueness of the solution have been gotten by eliminating some hypotheses that have been imposed by other authors for different particular problems. We show that any solution with nontrivial initial datum becomes stable.
