Objectives:The prevalence of cyber-aggression is increasing worldwide,resulting in significant negative impacts on both perpetrators and victims.This study aimed to investigate the relationship between cyber-ostracism...Objectives:The prevalence of cyber-aggression is increasing worldwide,resulting in significant negative impacts on both perpetrators and victims.This study aimed to investigate the relationship between cyber-ostracism and cyber-aggression among college students,clarify the role of various types of rumination in this dynamic.Methods:A total of 1198 Chinese college students(67.4%female;mean age 20.78 years;SD=1.12)were recruited through cluster random sampling and completed the Cyber-ostracism Experience Scale(COES),Positive and Negative Rumination Scale(PANRS),and Adolescent Online Aggression Behavior Scale(AOABS).Thestructural equation model(SEM)was employed to examine the relationship between cyber-ostracism,negative rumination,and cyber-aggression,as well as the moderating effect of positive rumination.Results:The results indicate that cyber-ostracism(β=0.128,p<0.001)positively predicts cyber-aggression.Negative ruminationmediates this relationship(effect size=0.027,95%CI=[0.007,0.014]).Positive rumination moderates the direct effect of cyber-ostracism on cyber-aggression(β=0.103,p<0.001).It alsomoderates both the first half(β=0.148,p<0.001)and the second half(β=0.138,p<0.001)of themediating pathway.Conclusion:This study suggests that cyber-ostracism influences cyber-aggression through negative rumination among Chinese college students.Positive rumination moderates this effect,although its impact is relatively limited.These findings offer valuable guidance for preventing and intervening in cyber-aggression among college students.展开更多
How to speed up the establishment of marine ecological compensation and the ecological compensation system is inevitable choice from ocean country to marine power.Therefore,construction of marine ecological compensati...How to speed up the establishment of marine ecological compensation and the ecological compensation system is inevitable choice from ocean country to marine power.Therefore,construction of marine ecological compensation mechanism is the effective means which incentives marine ecosystem services supply,improves the quality of marine ecology,and promotes the ocean to the green transformation.Combined with Dalian maritime case study in Liaoning Province,three dimensional interactive marine ecological compensation mechanism,the compensation frame work,path and operation mechanism were built up.Suggestions on accelerating the legislation process;perfecting the management system;establishing proper system for both incentive constraint and reward-punishment;increasing the source of Ocean Ecological Compensation funds;accelerating On the study of the Ocean Ecological Compensation Mechanism in Liaoning Area from the Angl-e of Ecological Civilization Based on Case Analysis of Dalian.展开更多
This article examines the critical integration of reflexivity,cultural sensitivity,and emergent design in qualitative psychiatry research focused on lived experiences.While quantitative methods offer essential clinica...This article examines the critical integration of reflexivity,cultural sensitivity,and emergent design in qualitative psychiatry research focused on lived experiences.While quantitative methods offer essential clinical insights,qualitative approaches provide a deeper understanding of the emotional,psychological,and social dimensions of mental health.Reflexivity enables researchers to remain aware of how their personal biases and professional backgrounds shape data interpretation.Cultural sensitivity ensures that mental health conditions are understood within their broader cultural contexts,helping avoid misrepresentation and promoting authentic participant expression.Emergent design offers flexibility in adapting the research process to evolving themes,particularly in the dynamic and multifaceted realm of psychiatric conditions.Together,these principles promote ethically sound,participant-centered research that captures the full complexity of lived experiences.The article also highlighted the practical implications of these principles for enhancing both academic knowledge and clinical practice in psychiatry.展开更多
BACKGROUND Low-grade fever during convalescence is an atypical symptom of coronavirus disease 2019(COVID-19).Reports of such cases are rare,and the mechanism and outcome of low-grade fever during COVID-19 convalescenc...BACKGROUND Low-grade fever during convalescence is an atypical symptom of coronavirus disease 2019(COVID-19).Reports of such cases are rare,and the mechanism and outcome of low-grade fever during COVID-19 convalescence are not completely clear.We report 3 cases with low-grade fever during COVID-19 convalescence and highlight the main clinical,radiographic,and laboratory characteristics,thereby increasing the level of expertise in the clinical management of COVID-19 during convalescence and facilitating individualized decision-making.CASE SUMMARY We describe 3 patients with COVID-19,two females aged 62 and 66 years and a male 55 years,who had low-grade fever during COVID-19 convalescence.All 3 patients had no other discomfort or comorbidities during low-grade process.Lesions on computed tomography in all 3 patients had resolved during this period.Two patients tested negative on two consecutive severe acute respiratory syndrome coronavirus 2 tests with an interval of at least 24 h between tests.Body temperature in all 3 patients returned to normal after several days without treatment,and fever recurrence was not observed.CONCLUSION Enhancing the knowledge of low-grade fever during COVID-19 convalescence may increase the expertise in the delivery of optimal healthcare services.展开更多
Identification and classification, as well as mapping of marine habitats, are of primary importance to plan management activities, especially in disturbed ecosystems like the ones in the marine areas of Bahrain. Remot...Identification and classification, as well as mapping of marine habitats, are of primary importance to plan management activities, especially in disturbed ecosystems like the ones in the marine areas of Bahrain. Remotely sensed Landsat-8 imagery coupled with field survey was used to identify, classify and map the benthic habitats in Bahrain marine area. The used geospatial techniques include advanced image processing procedures, which comprise of radiometric and atmospheric corrections, sun glint removal, water depth correction and image classification. Extensive ground-truthing analyses through in-situ field surveys by a team of scuba divers were conducted in October 2014 and June 2015 to inform and refine the classifications. The variables collected from this survey included physical and chemical characteristics of the water, habitat type, substrata, fauna and flora. A total of 176 field points were collected and utilized to perform an accurate assessment of the image classification. Initial habitat classification resulted in 20 habitat categories. However, due to the inability of the Landsat-8 sensors to accurately discriminate that level of classification, categories were merged into seven classes. The derived map shows that the benthic marine habitats of Bahrain consist of deep water （2,523 km2）, rock （1,738 km2）, sand （1,191 km2）, deep water/sand （1,006 km2）, algae （922 km2）, seagrass （591 km2） and corals （275.50 km2）. Although limited by the spatial and spectral resolutions of Landsat 8, the used methods produced a suitable map of the benthic habitats within the marine area of Bahrain with an overall accuracy of 84.1%. The use of very high spatial resolution satellite imagery will most likely increase such accuracy significantly.展开更多
Background:Compatibility is a characteristic of the clinical application of traditional Chinese medicine,often leading to enhanced therapeutic effects.In the treatment of cerebral ischemia,blood-activating and open or...Background:Compatibility is a characteristic of the clinical application of traditional Chinese medicine,often leading to enhanced therapeutic effects.In the treatment of cerebral ischemia,blood-activating and open orifices herbs are frequently used individually;however,their combination is not commonly practiced.This study aims to investigate the impact of combining safflower and borneol as examples of open orifices herbs and blood-activating herbs on the neurovascular unit in rats with ischemic stroke.The objective is to determine whether this combination exhibits superior therapeutic efficacy compared to using borneol or safflower alone while exploring its underlying mechanism.These findings may provide novel insights for clinical treatments.Methods:SD male rats were randomly divided into 6 groups:sham operation group,model group,borneol group(0.1 g/kg),safflower group(5 g/kg),borneol combined with safflower group(0.1 g/kg+5 g/kg)and nimodipine group(0.01 g/kg).The middle cerebral artery cerebral ischemia(MCAO)model were prepared after continuous intragastric administration for 7 days in each group,the neurological function of each group were scored 24h after operation,and water content in brain tissue were measured by weighing method.The activity of superoxide dismutase(SOD)and the contents of nitric oxide(NO)and malondialdehyde(MDA)in brain tissue and serum were determined by spectrophotometry,and the mRNA expressions of matrix metalloproteinase 2(MMP-2),tight junction protein 1(ZO-1),vascular endothelial growth factor(VEGF)and brain-derived neurotrophic factor(BDNF)were detected by Real time PCR.Result:Compared with the model group,the group treated with borneol combined with safflower exhibited a significant decrease in the neural function score of MCAO rats(P<0.01).Additionally,it led to a reduction in brain tissue water content(P<0.01),elevated SOD activity,and reduced levels of NO and MDA in both serum and brain tissue(P<0.01 or P<0.05).Moreover,this treatment resulted in a decrease in the mRNA expression of MMP-2 and an increase in ZO-1 in brain tissue,along with an increase in the mRNA expression of VEGF and BDNF(P<0.01).Conclusion:Borneol combined with safflower demonstrates a protective effect on the neurovascular unit in rats with ischemic stroke.This effect is likely associated with increased SOD activity,reduced MDA and NO content in both serum and brain tissue of MCAO rats,and a decrease in MMP-2 mRNA expression in brain tissue,coupled with an increase in ZO-1,VEGF,and BDNF mRNA expression.These effects were superior to those observed with borneol or safflower administered alone.展开更多
Traditional Hungarian method can only solve standard assignment problems, while can not solve competition assignment problems. This article emphatically discussed the difference between standard assignment problems an...Traditional Hungarian method can only solve standard assignment problems, while can not solve competition assignment problems. This article emphatically discussed the difference between standard assignment problems and competition assignment problems. The kinds of competition assignment problem algorithms based on Hungarian method and the solutions of them were studied.展开更多
Whilst most bioorthogonal reactions focus on targeting binding-site cysteine residues,proximity-induced reactivity effect ensures that reaction also occurs at nucleophilic lysine residues.We report one example here th...Whilst most bioorthogonal reactions focus on targeting binding-site cysteine residues,proximity-induced reactivity effect ensures that reaction also occurs at nucleophilic lysine residues.We report one example here that the propargylated-sulfonium center undergoes a nucleophilic reaction with lysine residue via proximity-induced conjugation.This propargylated-sulfonium tethered peptide resulting from a facile propargylation of thiolethers,enables amino-yne reaction at the selected lysine on MDM4 protein.This strategy represents a viable approach of lysine-targeted covalent inhibition in proximity.展开更多
Chinese transfer plays an important role in the teaching and learning of English grammar. Though there are many differences between English and Chinese, many rules are shared by English and Chinese, especially in term...Chinese transfer plays an important role in the teaching and learning of English grammar. Though there are many differences between English and Chinese, many rules are shared by English and Chinese, especially in terms of grammar. Therefore, in teaching of English grammar, proper use of transfer of Chinese grammar may help the learners learn English. This paper introduces Chinese positive transfer and negative transfer in learning English grammar, and discusses how to make use of Chinese transfer to improve English teaching.展开更多
Ex situ conservation is the main method for the protection of endangered wildlife.To explore the effect of ex situ conservation on the gut microbiota of the kiang(Equus kiang),metagenomic sequencing combined with bioi...Ex situ conservation is the main method for the protection of endangered wildlife.To explore the effect of ex situ conservation on the gut microbiota of the kiang(Equus kiang),metagenomic sequencing combined with bioinformatics analysis was used to investigate the composition and function of the gut microbiota of the kiang.The results showed that ex situ conservation not only protected wildlife,but also affected the composition and function of gut microbiota,as well as the health of animals.In the zoo,the ratio of the relative abundance of Firmicutes to that of Bacteroidetes(F/B)is higher,clusters of potentially pathogenic bacteria(such as Catonella,Catonella,and Mycoplasma)are more numerous,the abundance of resistance genes is higher,and the abundance of metabolic functions is increased.The dynamic changes of the gut microbiota also played an important role in the nutritional absorption,energy metabolism,and environmental adaptation of the kiang.Improving the rearing environment and increasing food diversity play important roles for increasing the diversity of gut microbiota,reducing the spread of potentially pathogenic bacteria,and reducing diseases.In the wild,especially in winter and in food-deficient areas,food supplementation can enhance the gut microbial homeostasis of wild animals and reduce the impact of crises.In depth studies of the gut microbial function of wildlife have important implications for improving ex situ conservation.展开更多
This work was devoted to synthesizingα-γAl_(2)O_(3) nanocomposite by the electrolysis method.A plate of aluminum was used as the anode,while the graphite rod was used as the counter electrode(cathode).The structure ...This work was devoted to synthesizingα-γAl_(2)O_(3) nanocomposite by the electrolysis method.A plate of aluminum was used as the anode,while the graphite rod was used as the counter electrode(cathode).The structure and morphology were investigated and characterized by X-ray diffraction(XRD)and transmission electron microscopy(TEM).The results indicated the average size ofα-γAl_(2)O_(3) nanocomposite was smaller than 10 nm.The value of inhibition zone indicated the nanocomposite’s effect on different bacteria.The results demonstrated the newly synthesized nanocomposite as promising antimicrobial agents against bacteria.展开更多
Background:Digital exclusion is a global issue that disproportionately affects older individuals especially in low-and middle-income nations.However,there is a wide gap in current research regarding the impact of digi...Background:Digital exclusion is a global issue that disproportionately affects older individuals especially in low-and middle-income nations.However,there is a wide gap in current research regarding the impact of digital exclusion on the mental health of older adults in both high-income and low-and middle-income countries.Methods:We analyzed data from 5 longitudinal cohorts:the Health and Retirement Study(HRS),the English Longitudinal Study of Aging(ELSA),the Survey of Health,Ageing and Retirement in Europe(SHARE),the China Health and Retirement Longitudinal Study(CHARLS),and the Mexican Health and Aging Study(MHAS).These cohorts consisted of nationwide samples from 24 countries.Digital exclusion was defined as the self-reported lack of access to the internet.Depressive symptoms were assessed using comparable scales across all cohorts.We used generalized estimating equation models,fitting a Poisson model,to investigate the association between the digital exclusion and depressive symptoms.We adjusted for the causal directed acyclic graph(DAG)minimal sufficient adjustment set(MSAS),which includes gender,age,retirement status,education,household wealth,social activities,and weekly contact with their children.Results:During the study period(2010–2018),122,242 participants underwent up to 5 rounds of follow-up.Digital exclusion varied greatly across countries,ranging from 21.1%in Denmark to 96.9%in China.The crude model revealed a significant association between digital exclusion and depressive symptoms.This association remained statistically significant in the MSAS-adjusted model across all cohorts:HRS[incidence rate ratio(IRR),1.37;95% confidence interval(CI),1.28 to 1.47],ELSA(IRR,1.32;95%CI,1.23 to 1.41),SHARE(IRR,1.30;95%CI,1.27 to 1.33),CHARLS(IRR,1.62;95%CI,1.38 to 1.91),and MHAS(IRR,1.31;95%CI,1.26 to 1.37);all Ps<0.001.Notably,this association was consistently stronger in individuals living in lower wealth quintile households across all 5 cohorts and among those who do not regularly interact with their children,except for ELSA.Conclusions:Digital exclusion is globally widespread among older adults.Older individuals who are digitally excluded are at a higher risk of developing depressive symptoms,particularly those with limited communication with their offspring and individuals living in lower wealth quintile households.Prioritizing the provision of internet access to older populations may help reduce the risks of depression symptoms,especially among vulnerable groups with limited familial support and with lower income.展开更多
An occasional presence of bivalent stimuli in a block of univalent trials can elicit a slowing of the response on all subsequent univalent trials.This type of modulation of cognitive control is termed the bivalency ef...An occasional presence of bivalent stimuli in a block of univalent trials can elicit a slowing of the response on all subsequent univalent trials.This type of modulation of cognitive control is termed the bivalency effect.To explore whether this modulation is task specific,this study used a triplet task switching paradigm,with three following tasks that were presented concussively:a shape color judgment(red vs.blue),a number parity judgment(odd vs.even),and a letter case judgment(lowercase vs.upper-case).The event-related potential(ERP)results showed that(1)the bivalency effect was reflected by the decreased amplitude of N2 and P3a over the frontal region for both the color and letter tasks;(2)the bivalency effect occurred earlier for the color task compared with that for the letter task;(3)for the number parity task,the bivalency effect was observed in the increased N1 and the decreased P2p over the parietal region.These findings indicate that the modulation of cognitive control is task-specific after the presentation of bivalent stimuli in task switching.展开更多
The impact of insecure attachment on hoarding behavior(HB)has been supported by empirical evidence.However,scant literature has focused on how anthropomorphism(attributing human-like traits,characteristics,or emotions...The impact of insecure attachment on hoarding behavior(HB)has been supported by empirical evidence.However,scant literature has focused on how anthropomorphism(attributing human-like traits,characteristics,or emotions to nonhuman objects)and hoarding beliefs(motivations for ownership)affect the relationship between insecure attachment and HB,especially among Chinese adolescents.Using a cross-sectional study,we reserved 903 participants(561 males,342 females,M=20.20,SD=1.85,age range=18-24 years)to complete self-report questionnaires about close relationships,anthropomorphism,saving beliefs,and saving inventory to investigate the mediating role of anthropomorphism and the moderating role of hoarding beliefs in the relationship between insecure attachment and HB.Attachment anxiety and avoidance had a positive relationship with HB,and anthropomorphism is a mediating factor in the association between attachment anxiety and HB.In addition,hoarding beliefs moderated the relationship between attachment anxiety and HB.This study further elaborated on the relationships between insecure attachment,anthropomorphism,hoarding beliefs,and HB,which might shed some light on adolescent clinical interventions.展开更多
The study aimed to examine the indirect factors underlying the association between work–family conflict and posttraumatic stress symptoms(PTSS)in college teachers during the COVID-19 pandemic.Three potential indirect...The study aimed to examine the indirect factors underlying the association between work–family conflict and posttraumatic stress symptoms(PTSS)in college teachers during the COVID-19 pandemic.Three potential indirect factors were examined:perceived stress,basic psychological needs,and rumination.A total of 274 college teachers were recruited.All participants completed an electronic questionnaire that assessed their exposure to the pandemic,work–family conflict,perceived stress,basic psychological needs,rumination,and PTSS.The results showed that after controlling for pandemic exposure,gender,and age,work–family conflict was associated with PTSS via perceived stress alone,rumination alone,a path from perceived stress to basic psychological needs,and a path from perceived stress to rumination.These results indicate that work–family conflict is positively associated with PTSS indirectly via perceived stress,rumination,and basic psychological needs during the COVID-19 pandemic.These three mediators may completely explain the relation of work–family conflict to PTSS.展开更多
基金supported by the Key Research Base Project of Humanities and Social Sciences in Jiangxi Colleges and Universities(JD23056)the Characteristic Programmers of Mental Health Education for Students,University of Tibetan Medicine(2024XLJKZD01).
文摘Objectives:The prevalence of cyber-aggression is increasing worldwide,resulting in significant negative impacts on both perpetrators and victims.This study aimed to investigate the relationship between cyber-ostracism and cyber-aggression among college students,clarify the role of various types of rumination in this dynamic.Methods:A total of 1198 Chinese college students(67.4%female;mean age 20.78 years;SD=1.12)were recruited through cluster random sampling and completed the Cyber-ostracism Experience Scale(COES),Positive and Negative Rumination Scale(PANRS),and Adolescent Online Aggression Behavior Scale(AOABS).Thestructural equation model(SEM)was employed to examine the relationship between cyber-ostracism,negative rumination,and cyber-aggression,as well as the moderating effect of positive rumination.Results:The results indicate that cyber-ostracism(β=0.128,p<0.001)positively predicts cyber-aggression.Negative ruminationmediates this relationship(effect size=0.027,95%CI=[0.007,0.014]).Positive rumination moderates the direct effect of cyber-ostracism on cyber-aggression(β=0.103,p<0.001).It alsomoderates both the first half(β=0.148,p<0.001)and the second half(β=0.138,p<0.001)of themediating pathway.Conclusion:This study suggests that cyber-ostracism influences cyber-aggression through negative rumination among Chinese college students.Positive rumination moderates this effect,although its impact is relatively limited.These findings offer valuable guidance for preventing and intervening in cyber-aggression among college students.
基金supported by the National Social Science Foundation: Research on Fiscal and Tax Policy Innovation and Mechanism of Coordinated Development of Regional Economy (14BJY003)Liaoning Social Science Foundation: Study on Ecological Compensation Mechanism of Liaoning Province (L13djy057)the Second Batch School of Marxism Major Research Direction Foundation Items of Liaoning Province: Study on Liaoning Province Ocean Strengthening Strategic Issues with Five Concepts Leading
文摘How to speed up the establishment of marine ecological compensation and the ecological compensation system is inevitable choice from ocean country to marine power.Therefore,construction of marine ecological compensation mechanism is the effective means which incentives marine ecosystem services supply,improves the quality of marine ecology,and promotes the ocean to the green transformation.Combined with Dalian maritime case study in Liaoning Province,three dimensional interactive marine ecological compensation mechanism,the compensation frame work,path and operation mechanism were built up.Suggestions on accelerating the legislation process;perfecting the management system;establishing proper system for both incentive constraint and reward-punishment;increasing the source of Ocean Ecological Compensation funds;accelerating On the study of the Ocean Ecological Compensation Mechanism in Liaoning Area from the Angl-e of Ecological Civilization Based on Case Analysis of Dalian.
文摘This article examines the critical integration of reflexivity,cultural sensitivity,and emergent design in qualitative psychiatry research focused on lived experiences.While quantitative methods offer essential clinical insights,qualitative approaches provide a deeper understanding of the emotional,psychological,and social dimensions of mental health.Reflexivity enables researchers to remain aware of how their personal biases and professional backgrounds shape data interpretation.Cultural sensitivity ensures that mental health conditions are understood within their broader cultural contexts,helping avoid misrepresentation and promoting authentic participant expression.Emergent design offers flexibility in adapting the research process to evolving themes,particularly in the dynamic and multifaceted realm of psychiatric conditions.Together,these principles promote ethically sound,participant-centered research that captures the full complexity of lived experiences.The article also highlighted the practical implications of these principles for enhancing both academic knowledge and clinical practice in psychiatry.
基金Supported by Emergency Special Project on Prevention and Treatment of COVID-19 with Traditional Chinese Medicine,No.2020YBBGWL007.
文摘BACKGROUND Low-grade fever during convalescence is an atypical symptom of coronavirus disease 2019(COVID-19).Reports of such cases are rare,and the mechanism and outcome of low-grade fever during COVID-19 convalescence are not completely clear.We report 3 cases with low-grade fever during COVID-19 convalescence and highlight the main clinical,radiographic,and laboratory characteristics,thereby increasing the level of expertise in the clinical management of COVID-19 during convalescence and facilitating individualized decision-making.CASE SUMMARY We describe 3 patients with COVID-19,two females aged 62 and 66 years and a male 55 years,who had low-grade fever during COVID-19 convalescence.All 3 patients had no other discomfort or comorbidities during low-grade process.Lesions on computed tomography in all 3 patients had resolved during this period.Two patients tested negative on two consecutive severe acute respiratory syndrome coronavirus 2 tests with an interval of at least 24 h between tests.Body temperature in all 3 patients returned to normal after several days without treatment,and fever recurrence was not observed.CONCLUSION Enhancing the knowledge of low-grade fever during COVID-19 convalescence may increase the expertise in the delivery of optimal healthcare services.
文摘Identification and classification, as well as mapping of marine habitats, are of primary importance to plan management activities, especially in disturbed ecosystems like the ones in the marine areas of Bahrain. Remotely sensed Landsat-8 imagery coupled with field survey was used to identify, classify and map the benthic habitats in Bahrain marine area. The used geospatial techniques include advanced image processing procedures, which comprise of radiometric and atmospheric corrections, sun glint removal, water depth correction and image classification. Extensive ground-truthing analyses through in-situ field surveys by a team of scuba divers were conducted in October 2014 and June 2015 to inform and refine the classifications. The variables collected from this survey included physical and chemical characteristics of the water, habitat type, substrata, fauna and flora. A total of 176 field points were collected and utilized to perform an accurate assessment of the image classification. Initial habitat classification resulted in 20 habitat categories. However, due to the inability of the Landsat-8 sensors to accurately discriminate that level of classification, categories were merged into seven classes. The derived map shows that the benthic marine habitats of Bahrain consist of deep water （2,523 km2）, rock （1,738 km2）, sand （1,191 km2）, deep water/sand （1,006 km2）, algae （922 km2）, seagrass （591 km2） and corals （275.50 km2）. Although limited by the spatial and spectral resolutions of Landsat 8, the used methods produced a suitable map of the benthic habitats within the marine area of Bahrain with an overall accuracy of 84.1%. The use of very high spatial resolution satellite imagery will most likely increase such accuracy significantly.
基金This work was supported by Project of Natural Science Foundation of Shandong province(No.ZR2020MH343).
文摘Background:Compatibility is a characteristic of the clinical application of traditional Chinese medicine,often leading to enhanced therapeutic effects.In the treatment of cerebral ischemia,blood-activating and open orifices herbs are frequently used individually;however,their combination is not commonly practiced.This study aims to investigate the impact of combining safflower and borneol as examples of open orifices herbs and blood-activating herbs on the neurovascular unit in rats with ischemic stroke.The objective is to determine whether this combination exhibits superior therapeutic efficacy compared to using borneol or safflower alone while exploring its underlying mechanism.These findings may provide novel insights for clinical treatments.Methods:SD male rats were randomly divided into 6 groups:sham operation group,model group,borneol group(0.1 g/kg),safflower group(5 g/kg),borneol combined with safflower group(0.1 g/kg+5 g/kg)and nimodipine group(0.01 g/kg).The middle cerebral artery cerebral ischemia(MCAO)model were prepared after continuous intragastric administration for 7 days in each group,the neurological function of each group were scored 24h after operation,and water content in brain tissue were measured by weighing method.The activity of superoxide dismutase(SOD)and the contents of nitric oxide(NO)and malondialdehyde(MDA)in brain tissue and serum were determined by spectrophotometry,and the mRNA expressions of matrix metalloproteinase 2(MMP-2),tight junction protein 1(ZO-1),vascular endothelial growth factor(VEGF)and brain-derived neurotrophic factor(BDNF)were detected by Real time PCR.Result:Compared with the model group,the group treated with borneol combined with safflower exhibited a significant decrease in the neural function score of MCAO rats(P<0.01).Additionally,it led to a reduction in brain tissue water content(P<0.01),elevated SOD activity,and reduced levels of NO and MDA in both serum and brain tissue(P<0.01 or P<0.05).Moreover,this treatment resulted in a decrease in the mRNA expression of MMP-2 and an increase in ZO-1 in brain tissue,along with an increase in the mRNA expression of VEGF and BDNF(P<0.01).Conclusion:Borneol combined with safflower demonstrates a protective effect on the neurovascular unit in rats with ischemic stroke.This effect is likely associated with increased SOD activity,reduced MDA and NO content in both serum and brain tissue of MCAO rats,and a decrease in MMP-2 mRNA expression in brain tissue,coupled with an increase in ZO-1,VEGF,and BDNF mRNA expression.These effects were superior to those observed with borneol or safflower administered alone.
文摘Traditional Hungarian method can only solve standard assignment problems, while can not solve competition assignment problems. This article emphatically discussed the difference between standard assignment problems and competition assignment problems. The kinds of competition assignment problem algorithms based on Hungarian method and the solutions of them were studied.
基金financial support from the National Key Research and Development Program"Synthetic Biology"Key Special Project of China(No.2018YFA0902504)the Natural Science Foundation of China(Nos.21778009 and 21977010)+6 种基金the Natural Science Foundation ofGuangdongProvince(Nos.2020A1515010766,2020A1515010522,2019A1515111184 and 2019A1515110489)the Shenzhen Science and Technology Innovation Committee(Nos.JCYJ20180507181527112,JCYJ20180508152213145,and JCYJ20170817172023838)financial support from Beijing National Laboratory of Molecular Science Open Grant(No.BNLMS20160112)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(No.2019SHIBS0004)supported by Proteomic Platform of Pingshan Translational Medicine CenterShenzhen Bay Laboratorythe high-performance computing platform of Peking University.
文摘Whilst most bioorthogonal reactions focus on targeting binding-site cysteine residues,proximity-induced reactivity effect ensures that reaction also occurs at nucleophilic lysine residues.We report one example here that the propargylated-sulfonium center undergoes a nucleophilic reaction with lysine residue via proximity-induced conjugation.This propargylated-sulfonium tethered peptide resulting from a facile propargylation of thiolethers,enables amino-yne reaction at the selected lysine on MDM4 protein.This strategy represents a viable approach of lysine-targeted covalent inhibition in proximity.
文摘Chinese transfer plays an important role in the teaching and learning of English grammar. Though there are many differences between English and Chinese, many rules are shared by English and Chinese, especially in terms of grammar. Therefore, in teaching of English grammar, proper use of transfer of Chinese grammar may help the learners learn English. This paper introduces Chinese positive transfer and negative transfer in learning English grammar, and discusses how to make use of Chinese transfer to improve English teaching.
基金We would like to express our heartfelt thanks to the keepers of the Qinghai-Tibet Plateau Wildlife Park for their help in collecting fecal samples from the Tibetan wild ass in zoo.This study was financially supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA23060602 and XDA2002030302)the Qinghai Province Science and Technology Plan(2021-ZJ-951Q)+3 种基金the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(2019QZKK0501)Qinghai Key R&D and Transformation Program(2019-SF-150)the Joint Grant from Chinese Academy of Sciences-People’s Government of Qinghai Province on Sanjiangyuan National Park(LHZX-2020-01)the Science and Technology Department of Qinghai Province Major Project“Sanjiangyaun National Park Animal Genome Program.”。
文摘Ex situ conservation is the main method for the protection of endangered wildlife.To explore the effect of ex situ conservation on the gut microbiota of the kiang(Equus kiang),metagenomic sequencing combined with bioinformatics analysis was used to investigate the composition and function of the gut microbiota of the kiang.The results showed that ex situ conservation not only protected wildlife,but also affected the composition and function of gut microbiota,as well as the health of animals.In the zoo,the ratio of the relative abundance of Firmicutes to that of Bacteroidetes(F/B)is higher,clusters of potentially pathogenic bacteria(such as Catonella,Catonella,and Mycoplasma)are more numerous,the abundance of resistance genes is higher,and the abundance of metabolic functions is increased.The dynamic changes of the gut microbiota also played an important role in the nutritional absorption,energy metabolism,and environmental adaptation of the kiang.Improving the rearing environment and increasing food diversity play important roles for increasing the diversity of gut microbiota,reducing the spread of potentially pathogenic bacteria,and reducing diseases.In the wild,especially in winter and in food-deficient areas,food supplementation can enhance the gut microbial homeostasis of wild animals and reduce the impact of crises.In depth studies of the gut microbial function of wildlife have important implications for improving ex situ conservation.
文摘This work was devoted to synthesizingα-γAl_(2)O_(3) nanocomposite by the electrolysis method.A plate of aluminum was used as the anode,while the graphite rod was used as the counter electrode(cathode).The structure and morphology were investigated and characterized by X-ray diffraction(XRD)and transmission electron microscopy(TEM).The results indicated the average size ofα-γAl_(2)O_(3) nanocomposite was smaller than 10 nm.The value of inhibition zone indicated the nanocomposite’s effect on different bacteria.The results demonstrated the newly synthesized nanocomposite as promising antimicrobial agents against bacteria.
基金supported by the National Key R&D Program of China(2023YFC3606400 and 2023YFB4603200)Major Project of the National Social Science Fund of China(23&ZD188)National Natural Science Foundation of China(72374013).
文摘Background:Digital exclusion is a global issue that disproportionately affects older individuals especially in low-and middle-income nations.However,there is a wide gap in current research regarding the impact of digital exclusion on the mental health of older adults in both high-income and low-and middle-income countries.Methods:We analyzed data from 5 longitudinal cohorts:the Health and Retirement Study(HRS),the English Longitudinal Study of Aging(ELSA),the Survey of Health,Ageing and Retirement in Europe(SHARE),the China Health and Retirement Longitudinal Study(CHARLS),and the Mexican Health and Aging Study(MHAS).These cohorts consisted of nationwide samples from 24 countries.Digital exclusion was defined as the self-reported lack of access to the internet.Depressive symptoms were assessed using comparable scales across all cohorts.We used generalized estimating equation models,fitting a Poisson model,to investigate the association between the digital exclusion and depressive symptoms.We adjusted for the causal directed acyclic graph(DAG)minimal sufficient adjustment set(MSAS),which includes gender,age,retirement status,education,household wealth,social activities,and weekly contact with their children.Results:During the study period(2010–2018),122,242 participants underwent up to 5 rounds of follow-up.Digital exclusion varied greatly across countries,ranging from 21.1%in Denmark to 96.9%in China.The crude model revealed a significant association between digital exclusion and depressive symptoms.This association remained statistically significant in the MSAS-adjusted model across all cohorts:HRS[incidence rate ratio(IRR),1.37;95% confidence interval(CI),1.28 to 1.47],ELSA(IRR,1.32;95%CI,1.23 to 1.41),SHARE(IRR,1.30;95%CI,1.27 to 1.33),CHARLS(IRR,1.62;95%CI,1.38 to 1.91),and MHAS(IRR,1.31;95%CI,1.26 to 1.37);all Ps<0.001.Notably,this association was consistently stronger in individuals living in lower wealth quintile households across all 5 cohorts and among those who do not regularly interact with their children,except for ELSA.Conclusions:Digital exclusion is globally widespread among older adults.Older individuals who are digitally excluded are at a higher risk of developing depressive symptoms,particularly those with limited communication with their offspring and individuals living in lower wealth quintile households.Prioritizing the provision of internet access to older populations may help reduce the risks of depression symptoms,especially among vulnerable groups with limited familial support and with lower income.
基金supported by the National Natural Science Foundation of China(Grant Nos.32360201,31860278 and 31760285).
文摘An occasional presence of bivalent stimuli in a block of univalent trials can elicit a slowing of the response on all subsequent univalent trials.This type of modulation of cognitive control is termed the bivalency effect.To explore whether this modulation is task specific,this study used a triplet task switching paradigm,with three following tasks that were presented concussively:a shape color judgment(red vs.blue),a number parity judgment(odd vs.even),and a letter case judgment(lowercase vs.upper-case).The event-related potential(ERP)results showed that(1)the bivalency effect was reflected by the decreased amplitude of N2 and P3a over the frontal region for both the color and letter tasks;(2)the bivalency effect occurred earlier for the color task compared with that for the letter task;(3)for the number parity task,the bivalency effect was observed in the increased N1 and the decreased P2p over the parietal region.These findings indicate that the modulation of cognitive control is task-specific after the presentation of bivalent stimuli in task switching.
文摘The impact of insecure attachment on hoarding behavior(HB)has been supported by empirical evidence.However,scant literature has focused on how anthropomorphism(attributing human-like traits,characteristics,or emotions to nonhuman objects)and hoarding beliefs(motivations for ownership)affect the relationship between insecure attachment and HB,especially among Chinese adolescents.Using a cross-sectional study,we reserved 903 participants(561 males,342 females,M=20.20,SD=1.85,age range=18-24 years)to complete self-report questionnaires about close relationships,anthropomorphism,saving beliefs,and saving inventory to investigate the mediating role of anthropomorphism and the moderating role of hoarding beliefs in the relationship between insecure attachment and HB.Attachment anxiety and avoidance had a positive relationship with HB,and anthropomorphism is a mediating factor in the association between attachment anxiety and HB.In addition,hoarding beliefs moderated the relationship between attachment anxiety and HB.This study further elaborated on the relationships between insecure attachment,anthropomorphism,hoarding beliefs,and HB,which might shed some light on adolescent clinical interventions.
基金High Education Research Project of Zhejiang Higher Education Association,Grant/Award Number:KT2020051。
文摘The study aimed to examine the indirect factors underlying the association between work–family conflict and posttraumatic stress symptoms(PTSS)in college teachers during the COVID-19 pandemic.Three potential indirect factors were examined:perceived stress,basic psychological needs,and rumination.A total of 274 college teachers were recruited.All participants completed an electronic questionnaire that assessed their exposure to the pandemic,work–family conflict,perceived stress,basic psychological needs,rumination,and PTSS.The results showed that after controlling for pandemic exposure,gender,and age,work–family conflict was associated with PTSS via perceived stress alone,rumination alone,a path from perceived stress to basic psychological needs,and a path from perceived stress to rumination.These results indicate that work–family conflict is positively associated with PTSS indirectly via perceived stress,rumination,and basic psychological needs during the COVID-19 pandemic.These three mediators may completely explain the relation of work–family conflict to PTSS.
