In this paper,we analyze the time-series graphs of Bitcoin price and Twitter-based economic uncertainty index over the past two years and use a wavelet coherence graph to determine their relationship.We found a causal...In this paper,we analyze the time-series graphs of Bitcoin price and Twitter-based economic uncertainty index over the past two years and use a wavelet coherence graph to determine their relationship.We found a causal relationship between Bitcoin(BTC)and Twitter-based economic uncertainty(TEU)index in different frequency bands,which would help predict Bitcoin price movements in the future.Our study provides reference to academics and investors.展开更多
Objective:Diarrhea is a leading cause of morbidity and mortality among children in developing countries.The bacterial pathogen most commonly associated with childhood diarrhea is Escherichia coli.A one-year prospectiv...Objective:Diarrhea is a leading cause of morbidity and mortality among children in developing countries.The bacterial pathogen most commonly associated with childhood diarrhea is Escherichia coli.A one-year prospective study was carried out in Sanandaj to determine the prevalence and roles of the different E.coli pathotypes in children less than five years of age with acute diarrhea.Methods:Rectal swab were collected prospectively from children with acute diarrhea and transported to the Department of Microbiology,School of Medicine, KUMS,Sanandaj during 2008.The study was approved by the institutional ethics committee.Results:During this study period,rectal swabs were investigated from a total of 466 children 1 to 144 months of age(mean, 29.97 months±S.D) with diarrhea.Among the children,191(41%,191/466) were girls,and 275 (59%,275/466) were boys.The age-specific incidence rates of acute diarrhea among children 13-24 and 1 - 12 months of age were 37.37%(37/99) and 26.26%(26/99),respectively,during the study period.A total of 99 strains of E.coli were detected.EPEC 59(59.59%) and EIEC 22(22.22%),were the most commonly found Escherichia coli strains detected in stools from children.Disk diffusion testing showed E.coli strains resistance to tetracycline(89.89%),chloramphenicol(88.88%),Ampicillin(79.79%),Amoxicillin (75.75%) and Ceficime(75.75%).Among risk factors like age,sex,haemoglubin,fathers and mothers education,food and weight of children only mother's education was significant(P =0.018).Conclusion: In most of the clinical laboratories in Iran,E.coli does not considered as an etiologic agent responsible for diarrhea. Results in this study revealed that E.coli should be considered as an etiologic agent causing acute diarrhea among children.We therefore,recommend the routine isolation and identification of E.coli strains in all the clinical laboratories in Sanandaj.Guidelines for appropriate use of antibiotics in Sanandaj need updating.展开更多
A diversity of socio economic and cultural factors contributes towards maintenance and changes in dietary patterns of people. Therefore People around the world have adapted different types of dietary patterns for thei...A diversity of socio economic and cultural factors contributes towards maintenance and changes in dietary patterns of people. Therefore People around the world have adapted different types of dietary patterns for their survival. Aim of this study was to investigate the most relevant factors influencing human dietary patterns. Sample for the study was selected by using the Stratified sampling technique, which consists of 390 families residing around the Abatenna estate, Bandarawela municipal council, Sri Lanka. Principal component analysis techniques and correlation analysis were employed to identify the most relevant factors which affect human dietary patterns. Results of the study indicate that socio economic conditions, monthly income, number of children in a family, dietary patterns and weight-related behaviors are highly co-related with each other. These findings suggest that education and awareness programs on nutrition should target low income groups to enhance their knowledge on dietary patterns.展开更多
Consider the partly linear model Y = xβ ＋ g（t） ＋ e where the explanatory x is erroneously measured, and both t and the response Y are measured exactly, the random error e is a martingale difference sequence. Let ...Consider the partly linear model Y = xβ ＋ g（t） ＋ e where the explanatory x is erroneously measured, and both t and the response Y are measured exactly, the random error e is a martingale difference sequence. Let ~ be a surrogate variable observed instead of the true x in the primary survey data. Assume that in addition to the primary data set containing N observations of {（Yj, xj, tj）n＋N j=n＋1 }, the independent validation data containing n observations of {（xj, x j, tj）n j=1 } is available. In this paper, a semiparametric method with the primary data is employed to obtain the estimator ofβ and g（-） based on the least squares criterion with the help of validation data. The proposed estimators are proved to be strongly consistent. Finite sample behavior of the estimators is investigated via simulations too.展开更多
To assess, in vitro, the cellular viability in a murine macrophage cell line J774 with 9 different orthodontic wires and to evaluate the effects of its NO production. To assess cellular viability by MTT: 3-(4,5-dimeth...To assess, in vitro, the cellular viability in a murine macrophage cell line J774 with 9 different orthodontic wires and to evaluate the effects of its NO production. To assess cellular viability by MTT: 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide assay in the cell line J774 with 9 different orthodontic wires and quantify NO production by these macrophages. Cell cultures were evaluated at 24, 48 and 72 hours. There was no significant difference of the means of cellular viability between the control and the group of wires in the respective time intervals. In the comparison with the control group, there was significant difference in the NO production in groups 1, 6, and 9 at 24 hours interval. Group 8 showed significant difference in relation to the control group at final time interval. Cellular viability in all groups was higher at the final time interval than at the initial time interval. This increase was significant in the control group. In the material groups, the final mean of cellular viability at 72 hours showed no significant difference when compared with the control group. NO production in all groups was higher at the final time interval than at the initial time interval. This increase was significant in the control group. In the material groups, the final mean of NO production at 72 hours was only significant in group 8 (betatitanium) when compared with the control group.展开更多
Biomechanics is a wide interdisciplinary field, which includes all mechanical aspects from living organisms. As traditional erythrocytes viscoelastic analysis is mostly qualitative, the development of new quantitative...Biomechanics is a wide interdisciplinary field, which includes all mechanical aspects from living organisms. As traditional erythrocytes viscoelastic analysis is mostly qualitative, the development of new quantitative methods capable of analyzing at the same time biological and mechanical aspects of the cells in flow, when changing from healthy controls to glucose incubated at different concentrations, is crucial for restricting the subjectivity in the study of the cell behaviour. On the other hand, it is important to appreciate the role of mathematics in the analysis of tissues and cells. Recent developed non linear mathematical methods are particularly fruitful when they are strongly correlated with cells sensitivity to initial conditions. An optic system called Erythrodeformeter has been developed and constructed in our laboratory, in order to evaluate the erythrocytes viscoelastic properties. To analyze the erythrocytes viscoelastic dynamics we used the technique of Time Delay Coordinates suggested by Takens, False Nearest Neighbours proposed by Abarbanel and co-workers, and the forecasting procedure proposed by Sugihara and May, the so called Correlation Coefficient. The results suggest that through this random walk analysis, apparent noise associated with deterministic chaos can be used not only to distinguish but also to characterize at the same time biological and mechanical aspects of the cells in flow, when changing from healthy controls to glucose incubated at different concentrations.展开更多
The quality of the resulting pulping continuous digesters is monitored by measuring the Kappa number, which is a reference of residual lignin. The control of the kappa number is carried out mainly in the top of the di...The quality of the resulting pulping continuous digesters is monitored by measuring the Kappa number, which is a reference of residual lignin. The control of the kappa number is carried out mainly in the top of the digester, therefore it is important to get some indication of this analysis beforehand. In this context, the aim of this work was to obtain a prediction model of the kappa number in advance to the laboratory results. This paper proposes a new approach using the Box & Jenkins methodology to develop a dynamic model for predicting the kappa number from a Kamyr continuous digester from an eucalyptus Kraft pulp mill in Brazil. With a database of 1500 observations over a period of 30 days of operation, some ARMA models were studied, leading to the choice of ARMA (1, 2) as the best forecasting model. After fitting the model, we performed validation with a new set of data from 30 days of operation, achieving a model of 2.7% mean absolute percent error.展开更多
First passage time in Markov chains is defined as the first time that a chain passes a specified state or lumped states. This state or lumped states may indicate first passage time of an interesting, rare and amazing ...First passage time in Markov chains is defined as the first time that a chain passes a specified state or lumped states. This state or lumped states may indicate first passage time of an interesting, rare and amazing event. In this study, obtaining distribution of the first passage time relating to lumped states which are constructed by gathering the states through lumping method for a irreducible Markov chain whose state space is finite was deliberated. Thanks to lumping method the chain＇s Markov property has been preserved. Another benefit of lumping method in the way of practice is reduction of the state space thanks to gathering states together. As the obtained first passage distributions are continuous, it may be used in many fields such as reliability and risk analysis展开更多
BACKGROUND Hereditary non-polyposis colon cancer is a dominantly inherited syndrome of colorectal cancer(CRC),with heightened risk for younger population.Previous studies link its susceptibility to the DNA sequence po...BACKGROUND Hereditary non-polyposis colon cancer is a dominantly inherited syndrome of colorectal cancer(CRC),with heightened risk for younger population.Previous studies link its susceptibility to the DNA sequence polymorphism along with Amsterdam and Bethesda criteria.However,those fail in term of applicability.AIM To determine a clear cut-off of MSH2 gene expression for CRC heredity grouping factor.Further,the study also aims to examine the association of risk factors to the CRC heredity.METHODS The cross-sectional study observed 71 respondents from May 2018 to December 2019 in determining the CRC hereditary status through MSH2 mRNA expression using reverse transcription-polymerase chain reaction and the disease’s risk factors.Data were analyzed through Chi-Square,Fischer exact,t-test,Mann-Whitney,and multiple logistics.RESULTS There are significant differences of MSH2 within CRC group among tissue and blood;yet,negative for significance between groups.Through the blood gene expression fifth percentile,the hereditary CRC cut-off is 11059 fc,dividing the 40 CRC respondents to 32.5%with hereditary CRC.Significant risk factors include age,family history,and staging.Nonetheless,after multivariate control,age is just a confounder.Further,the study develops a probability equation with area under the curve 82.2%.CONCLUSION Numerous factors have significant relations to heredity of CRC patients.However,true important factors are staging and family history,while age and others are confounders.The study also established a definite cut-off point for heredity CRC based on mRNA MSH2 expression,11059 fc.These findings shall act as concrete foundations on further risk factors and/or genetical CRC future studies.展开更多
Urban forests are confronted with high using pressure because of the increasing demand for recreation and accessibility of these settings. For that purpose, defining and managing recreational carrying capacity is cons...Urban forests are confronted with high using pressure because of the increasing demand for recreation and accessibility of these settings. For that purpose, defining and managing recreational carrying capacity is considered as significant in ensuring ecological value’s and recreational satisfaction’s continuity. The purpose of this paper is to investigate the carrying capacity of Erzurum Urban Forest with respect to Level of Service (LOS) as a new management technique that focuses on service quality and visitor satisfaction. The data were obtained by self-administered questionnaire conducted with 166 visitors on weekends and holidays during summer season of the year 2014. Data were analyzed by dimensions/indicators of recreational satisfaction and socio-demographic characteristics with intent to identify tolerance range of visitors. The contribution and relative importance of each of the indicators to the overall satisfaction were analyzed by using Ordinal Logistic Model (OLM). The results indicated that the four indicators were at the greatest degree;“distance from picnic spot to toilets” and “quantity of children’s playground facilities” were decease of overall satisfaction while “distance from picnic spot to parking” and “level of shade at picnic spot” had a positive contribution to the overall satisfaction. The outputs from these analyses were used to calculate LOS. It was revealed that the level of service (0.40) in Erzurum Urban Forest was below the moderate level. Planning and managing strategies for optimizing the LOS were developed and discussed by considering these results.展开更多
Conilon coffee represents almost 20% of all coffee production in the Brazilian territory;however, it is inexpressive in relation to the sensory quality when compared to Arabica coffee. It is noteworthy that the coffee...Conilon coffee represents almost 20% of all coffee production in the Brazilian territory;however, it is inexpressive in relation to the sensory quality when compared to Arabica coffee. It is noteworthy that the coffee from the species Coffea canephora PIERRE has a denser sensorial profile, is less sweet, less acidic and with strong pronunciation of the body at the time of tasting. This study has unprecedentedly applied the use of starter cultures (yeast) to optimize and modify the metabolic pathways and consequently the sensorial quality perceived by Q-graders. The experiments were conducted in a randomized block design with five replicates, in the 3 × 4 factorial scheme, with three fermentation times—24, 48 and 72 hours and four wet processing tests—Washed, Yeast fermentation, Fully washed without yeast and Fully washed with yeast. The sensorial results indicate a new perspective for the application of wet processing with starter cultures for Conilon coffee. They indicate gains in sensory scale, opening a new phase of studies on spontaneous and induced fermentation for Conilon coffee in Brazil and worldwide.展开更多
The Western tragopan(Tragopan melanocephalus)is recorded in the IUCN Red List of 2017 as a vulnerable bird species in Pakistan.This study provides valuable information for the conservation of Western tragopan,which is...The Western tragopan(Tragopan melanocephalus)is recorded in the IUCN Red List of 2017 as a vulnerable bird species in Pakistan.This study provides valuable information for the conservation of Western tragopan,which is a globally threatened avian flagship species in Pakistan.This study was conducted to investigate and resolve the conservation challenges surrounding the species in two major habitat zones-Salkhala Game Reserve and Machiara National Park.The study was implemented in May-June 2020 for population density using call count data.Also,questionnaire was used for local residents’perceptions and habitat suitability modeling map was generated using the MaxEnt model based on previously recorded occurrence points as well as recorded in the survey.A total of 26 western Tragopans were identified by call count during the sampling period.Moreover,about 77.3%cited Western Tragopan they more likely to hunt while the remaining 22.6%locals recorded other pheasant.About 45.3%of this hunting for fun but only 22%for economic values and only 3%of people consider hunting as a part of their culture.Results of modeling habitat suitability of the Western tragopan showed that the species suitable habitats are small and patchy in Pakistan.We found that the Normalized Difference Vegetation Index(NDVI)with 40.6 percent contribution was the most important variable in shaping the species distribution.Our model identified some new suitable patches which can be the target of future field monitoring for finding new populations of the species and future conservation planning.展开更多
The purpose of this study was to investigate osteogenesis promoted by osteoconductive properties of bone grafting materials and the histopathological effects of ozone on osteogenesis. In total, 56 Winstar rats were eq...The purpose of this study was to investigate osteogenesis promoted by osteoconductive properties of bone grafting materials and the histopathological effects of ozone on osteogenesis. In total, 56 Winstar rats were equally divided into 4 groups. In control group, calvarial bone defect was created in 14 rats. For second group, 8 mm calvarial bone defect with ozone treatment was applied in 14 rats. For third group, an alloplastic bone graft was implanted on 8 mm calvarial bone defect. In fourth group, alloplastic bone graft was inserted in calvarial defect and ozone was treated additionally. Seven of the rats were sacrificed at the end of 4th week and the remaining 7 were sacrificed at the end of 8th week of experiment. In the study, the periosteal flaps were removed with a thin periosteal elevator and averagely 0.8 cm diameter-circular full bone defect was created with a specially designed trephine drill. The bone from the calvarial region was fixed in 10% formalin solution. After decalcification, bones were taken for routine paraffin blocking. Sections were stained with Hematoxylin-Eosin and Masson Trichrome. Histopathological findings of 4th and 8th weeks rats showed that best result for new bone formation was observed in graft + ozone treatment. It is concluded that ozone treatment increases the hemostasis in graft region, induces angiogenesis, promotes cell proliferation by preventing infiltration, induces matrix formation by influencing osteoblastic activity and has a positive effect in osteogenesis.展开更多
Due to their unique characteristics, such as the dynamic changing topology, the absence of central management, the cooperative routing mechanisms, and the resources constraints, Mobile ad hoc networks (MANETs) are rel...Due to their unique characteristics, such as the dynamic changing topology, the absence of central management, the cooperative routing mechanisms, and the resources constraints, Mobile ad hoc networks (MANETs) are relatively vulnerable to both active and passive attacks. In MANET, routing attacks try to disrupt the functions of routing protocol by intentionally or unintentionally dropping packets or propagating faked routing messages. However, due to their computation requirements, the prevention mechanisms are not powerful enough to secure MANET. In this paper, we propose a distributed and cooperative scheme using statistical methods to detect routing attacks in MANETs. Our scheme uses both direct and indirect observations to characterize the behaviors of both neighboring and remote nodes. Simple threshold and Grubb’s Test are utilized to propose our new detection methods. The scheme includes innovative methods to compute our proposed measures, Maximum Accusation Number (MAN) and Accusation Number (AN), which are used to make decision about node’s behavior. Experimental results show that our scheme performs well in detecting anomalous events in routing functions.展开更多
BACKGROUND Lactulose is approved for the symptomatic treatment of constipation,a gastrointestinal(GI)complication common in individuals with diabetes.Lactulose products contain carbohydrate impurities(e.g.,lactose,fru...BACKGROUND Lactulose is approved for the symptomatic treatment of constipation,a gastrointestinal(GI)complication common in individuals with diabetes.Lactulose products contain carbohydrate impurities(e.g.,lactose,fructose,galactose),which occur during the lactulose manufacturing process.These impurities may affect the blood glucose levels of individuals with type 2 diabetes mellitus(T2DM)using lactulose for the treatment of mild constipation.A previous study in healthy subjects revealed no increase in blood glucose levels after oral lactulose intake.However,it is still unclear whether the intake of lactulose increases blood glucose levels in individuals with diabetes.AIM To evaluate the blood glucose profile after oral lactulose intake in mildly constipated,non-insulin-dependent subjects with T2DM in an outpatient setting.METHODS This prospective,double-blind,randomized,controlled,single-center trial was conducted at the Clinical Research Center at the Medical University of Graz,Austria,in 24 adult Caucasian mildly constipated,non-insulin-dependent subjects with T2DM.Eligible subjects were randomized and assigned to one of six treatment sequences,each consisting of four treatments stratified by sex using an incomplete block design.Subjects received a single dose of 20 g or 30 g lactulose(crystal and liquid formulation),water as negative control or 30 g glucose as positive control.Capillary blood glucose concentrations were measured over a period of 180 min post dose.The primary endpoint was the baseline-corrected area under the curve of blood glucose concentrations over the complete assessment period[AUC_(baseline_c(0-180 min))].Quantitative comparisons were performed for both lactulose doses and formulations vs water for the equal lactulose dose vs glucose,as well as for liquid lactulose vs crystal lactulose.Safety parameters included GI tolerability,which was assessed at 180 min and 24 h post dose,and adverse events occurring up to 24 h post dose.In 24 randomized and analyzed subjects blood glucose concentration-time curves after intake of 20 g and 30 g lactulose were almost identical to those after water intake for both lactulose formulations despite the different amounts of carbohydrate impurities(≤3.0%for crystals and approx.30%for liquid).The primary endpoint[AUC_(baseline_c(0-180 min))]was not significantly different between lactulose and water regardless of lactulose dose and formulation.Also with regard to all secondary endpoints lactulose formulations showed comparable results to water with one exception concerning maximum glucose level.A minor increase in maximum blood glucose was observed after the 30 g dose,liquid lactulose,in comparison to water with a mean treatment difference of 0.63 mmol/L(95%confidence intervals:0.19,1.07).Intake of 30 g glucose significantly increased all blood glucose endpoints vs 30 g liquid and crystal lactulose,respectively(all P<0.0001).No differences in blood glucose response were observed between the different lactulose formulations.As expected,lactulose increased the number of bowel movements and was generally well tolerated.Subjects experienced only mild to moderate GI symptoms due to the laxative action of lactulose.CONCLUSION Blood glucose AUC_(baseline_c(0-180 min))levels in mildly constipated,non-insulin dependent subjects with T2DM are not affected by the carbohydrate impurities contained in 20 g and 30 g crystal or liquid lactulose formulations.展开更多
A fair electronic cash system is a system that allows customers to make payments anonymously. Furthermore the trusted third party can revoke the anonymity when the customers did illegal transactions. In this paper, a ...A fair electronic cash system is a system that allows customers to make payments anonymously. Furthermore the trusted third party can revoke the anonymity when the customers did illegal transactions. In this paper, a new fair electronic cash system based on group signature scheme by using elliptic curve cryptography is proposed, which satisfies properties of secure group signature scheme (correctness, unforgeability, etc). Moreover, our electronic cash contains group members (users, merchants and banks) and trusted third party which is acted by central bank as group manager.展开更多
Objective: To assess the relation between acute gastrointestinal disease and Helicobacter pylori (H. pylori) infections. Methods: Over the 18-month period, a total of 323 patients referred to three hospitals in Babol ...Objective: To assess the relation between acute gastrointestinal disease and Helicobacter pylori (H. pylori) infections. Methods: Over the 18-month period, a total of 323 patients referred to three hospitals in Babol (north of Iran) were enrolled in this cross-sectional study. H. pylori status (rapid urease test), endoscopic findings in the patients, personal habits (smoking or alcohol intake) and administration of drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs) were analyzed using standard Chi-square test and multinomial logistic regression analysis. Results: Results showed that acute gastric ulcer patients had a significant association with alcohol (P=0.001, OR=6.183), opium (P=0.022, OR=2.823), smoking (P=0.016, OR=2.579) and NSAIDs (P=0.046, OR=2.071). However, patients with in acute duodenal ulcer have a significant association with opium (P=0.023, OR=2.326) and alcohol (P=0.003, OR=3.888). As well as, gastric cancer had significant association with alcohol (P<0.05, OR=6.937), smoking (P=0.012, OR=2.738), family history (P=0.005, OR=4.380) and gender (P≤0.05, OR=5.103). Conclusions: Current investigation shows that H. pylori infection, alcoholism, male gender, age and family history have an additive impact on the incidence of gastric cancer. In addition, alcoholism, opium usage, NSAIDs and family history have more impact on the incidence of acute gastric ulcer and acute duodenal ulcer in patients.展开更多
文摘In this paper,we analyze the time-series graphs of Bitcoin price and Twitter-based economic uncertainty index over the past two years and use a wavelet coherence graph to determine their relationship.We found a causal relationship between Bitcoin(BTC)and Twitter-based economic uncertainty(TEU)index in different frequency bands,which would help predict Bitcoin price movements in the future.Our study provides reference to academics and investors.
基金The autors are thankful to Kurdistan Digestive,Liver Research Center which is affiliated to Kurdistan University of Medical Sciences,Sanandaj,for providing the financial support and necessary facilities
文摘Objective:Diarrhea is a leading cause of morbidity and mortality among children in developing countries.The bacterial pathogen most commonly associated with childhood diarrhea is Escherichia coli.A one-year prospective study was carried out in Sanandaj to determine the prevalence and roles of the different E.coli pathotypes in children less than five years of age with acute diarrhea.Methods:Rectal swab were collected prospectively from children with acute diarrhea and transported to the Department of Microbiology,School of Medicine, KUMS,Sanandaj during 2008.The study was approved by the institutional ethics committee.Results:During this study period,rectal swabs were investigated from a total of 466 children 1 to 144 months of age(mean, 29.97 months±S.D) with diarrhea.Among the children,191(41%,191/466) were girls,and 275 (59%,275/466) were boys.The age-specific incidence rates of acute diarrhea among children 13-24 and 1 - 12 months of age were 37.37%(37/99) and 26.26%(26/99),respectively,during the study period.A total of 99 strains of E.coli were detected.EPEC 59(59.59%) and EIEC 22(22.22%),were the most commonly found Escherichia coli strains detected in stools from children.Disk diffusion testing showed E.coli strains resistance to tetracycline(89.89%),chloramphenicol(88.88%),Ampicillin(79.79%),Amoxicillin (75.75%) and Ceficime(75.75%).Among risk factors like age,sex,haemoglubin,fathers and mothers education,food and weight of children only mother's education was significant(P =0.018).Conclusion: In most of the clinical laboratories in Iran,E.coli does not considered as an etiologic agent responsible for diarrhea. Results in this study revealed that E.coli should be considered as an etiologic agent causing acute diarrhea among children.We therefore,recommend the routine isolation and identification of E.coli strains in all the clinical laboratories in Sanandaj.Guidelines for appropriate use of antibiotics in Sanandaj need updating.
文摘A diversity of socio economic and cultural factors contributes towards maintenance and changes in dietary patterns of people. Therefore People around the world have adapted different types of dietary patterns for their survival. Aim of this study was to investigate the most relevant factors influencing human dietary patterns. Sample for the study was selected by using the Stratified sampling technique, which consists of 390 families residing around the Abatenna estate, Bandarawela municipal council, Sri Lanka. Principal component analysis techniques and correlation analysis were employed to identify the most relevant factors which affect human dietary patterns. Results of the study indicate that socio economic conditions, monthly income, number of children in a family, dietary patterns and weight-related behaviors are highly co-related with each other. These findings suggest that education and awareness programs on nutrition should target low income groups to enhance their knowledge on dietary patterns.
基金Supported by National Natural Science Foundation of China(Grant Nos.1127115511371168+7 种基金110011051107112611071269)Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.20110061110003)the Natural Science Foundation of Jilin Province(Grant Nos.20130101066JC20130522102JH20101596)"Twelfth Five-Year Plan"Science and Technology Research Project of the Education Department of Jilin Province(Grant No.2012186)
文摘Consider the partly linear model Y = xβ ＋ g（t） ＋ e where the explanatory x is erroneously measured, and both t and the response Y are measured exactly, the random error e is a martingale difference sequence. Let ~ be a surrogate variable observed instead of the true x in the primary survey data. Assume that in addition to the primary data set containing N observations of {（Yj, xj, tj）n＋N j=n＋1 }, the independent validation data containing n observations of {（xj, x j, tj）n j=1 } is available. In this paper, a semiparametric method with the primary data is employed to obtain the estimator ofβ and g（-） based on the least squares criterion with the help of validation data. The proposed estimators are proved to be strongly consistent. Finite sample behavior of the estimators is investigated via simulations too.
文摘To assess, in vitro, the cellular viability in a murine macrophage cell line J774 with 9 different orthodontic wires and to evaluate the effects of its NO production. To assess cellular viability by MTT: 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide assay in the cell line J774 with 9 different orthodontic wires and quantify NO production by these macrophages. Cell cultures were evaluated at 24, 48 and 72 hours. There was no significant difference of the means of cellular viability between the control and the group of wires in the respective time intervals. In the comparison with the control group, there was significant difference in the NO production in groups 1, 6, and 9 at 24 hours interval. Group 8 showed significant difference in relation to the control group at final time interval. Cellular viability in all groups was higher at the final time interval than at the initial time interval. This increase was significant in the control group. In the material groups, the final mean of cellular viability at 72 hours showed no significant difference when compared with the control group. NO production in all groups was higher at the final time interval than at the initial time interval. This increase was significant in the control group. In the material groups, the final mean of NO production at 72 hours was only significant in group 8 (betatitanium) when compared with the control group.
文摘Biomechanics is a wide interdisciplinary field, which includes all mechanical aspects from living organisms. As traditional erythrocytes viscoelastic analysis is mostly qualitative, the development of new quantitative methods capable of analyzing at the same time biological and mechanical aspects of the cells in flow, when changing from healthy controls to glucose incubated at different concentrations, is crucial for restricting the subjectivity in the study of the cell behaviour. On the other hand, it is important to appreciate the role of mathematics in the analysis of tissues and cells. Recent developed non linear mathematical methods are particularly fruitful when they are strongly correlated with cells sensitivity to initial conditions. An optic system called Erythrodeformeter has been developed and constructed in our laboratory, in order to evaluate the erythrocytes viscoelastic properties. To analyze the erythrocytes viscoelastic dynamics we used the technique of Time Delay Coordinates suggested by Takens, False Nearest Neighbours proposed by Abarbanel and co-workers, and the forecasting procedure proposed by Sugihara and May, the so called Correlation Coefficient. The results suggest that through this random walk analysis, apparent noise associated with deterministic chaos can be used not only to distinguish but also to characterize at the same time biological and mechanical aspects of the cells in flow, when changing from healthy controls to glucose incubated at different concentrations.
文摘The quality of the resulting pulping continuous digesters is monitored by measuring the Kappa number, which is a reference of residual lignin. The control of the kappa number is carried out mainly in the top of the digester, therefore it is important to get some indication of this analysis beforehand. In this context, the aim of this work was to obtain a prediction model of the kappa number in advance to the laboratory results. This paper proposes a new approach using the Box & Jenkins methodology to develop a dynamic model for predicting the kappa number from a Kamyr continuous digester from an eucalyptus Kraft pulp mill in Brazil. With a database of 1500 observations over a period of 30 days of operation, some ARMA models were studied, leading to the choice of ARMA (1, 2) as the best forecasting model. After fitting the model, we performed validation with a new set of data from 30 days of operation, achieving a model of 2.7% mean absolute percent error.
文摘First passage time in Markov chains is defined as the first time that a chain passes a specified state or lumped states. This state or lumped states may indicate first passage time of an interesting, rare and amazing event. In this study, obtaining distribution of the first passage time relating to lumped states which are constructed by gathering the states through lumping method for a irreducible Markov chain whose state space is finite was deliberated. Thanks to lumping method the chain＇s Markov property has been preserved. Another benefit of lumping method in the way of practice is reduction of the state space thanks to gathering states together. As the obtained first passage distributions are continuous, it may be used in many fields such as reliability and risk analysis
文摘BACKGROUND Hereditary non-polyposis colon cancer is a dominantly inherited syndrome of colorectal cancer(CRC),with heightened risk for younger population.Previous studies link its susceptibility to the DNA sequence polymorphism along with Amsterdam and Bethesda criteria.However,those fail in term of applicability.AIM To determine a clear cut-off of MSH2 gene expression for CRC heredity grouping factor.Further,the study also aims to examine the association of risk factors to the CRC heredity.METHODS The cross-sectional study observed 71 respondents from May 2018 to December 2019 in determining the CRC hereditary status through MSH2 mRNA expression using reverse transcription-polymerase chain reaction and the disease’s risk factors.Data were analyzed through Chi-Square,Fischer exact,t-test,Mann-Whitney,and multiple logistics.RESULTS There are significant differences of MSH2 within CRC group among tissue and blood;yet,negative for significance between groups.Through the blood gene expression fifth percentile,the hereditary CRC cut-off is 11059 fc,dividing the 40 CRC respondents to 32.5%with hereditary CRC.Significant risk factors include age,family history,and staging.Nonetheless,after multivariate control,age is just a confounder.Further,the study develops a probability equation with area under the curve 82.2%.CONCLUSION Numerous factors have significant relations to heredity of CRC patients.However,true important factors are staging and family history,while age and others are confounders.The study also established a definite cut-off point for heredity CRC based on mRNA MSH2 expression,11059 fc.These findings shall act as concrete foundations on further risk factors and/or genetical CRC future studies.
文摘Urban forests are confronted with high using pressure because of the increasing demand for recreation and accessibility of these settings. For that purpose, defining and managing recreational carrying capacity is considered as significant in ensuring ecological value’s and recreational satisfaction’s continuity. The purpose of this paper is to investigate the carrying capacity of Erzurum Urban Forest with respect to Level of Service (LOS) as a new management technique that focuses on service quality and visitor satisfaction. The data were obtained by self-administered questionnaire conducted with 166 visitors on weekends and holidays during summer season of the year 2014. Data were analyzed by dimensions/indicators of recreational satisfaction and socio-demographic characteristics with intent to identify tolerance range of visitors. The contribution and relative importance of each of the indicators to the overall satisfaction were analyzed by using Ordinal Logistic Model (OLM). The results indicated that the four indicators were at the greatest degree;“distance from picnic spot to toilets” and “quantity of children’s playground facilities” were decease of overall satisfaction while “distance from picnic spot to parking” and “level of shade at picnic spot” had a positive contribution to the overall satisfaction. The outputs from these analyses were used to calculate LOS. It was revealed that the level of service (0.40) in Erzurum Urban Forest was below the moderate level. Planning and managing strategies for optimizing the LOS were developed and discussed by considering these results.
文摘Conilon coffee represents almost 20% of all coffee production in the Brazilian territory;however, it is inexpressive in relation to the sensory quality when compared to Arabica coffee. It is noteworthy that the coffee from the species Coffea canephora PIERRE has a denser sensorial profile, is less sweet, less acidic and with strong pronunciation of the body at the time of tasting. This study has unprecedentedly applied the use of starter cultures (yeast) to optimize and modify the metabolic pathways and consequently the sensorial quality perceived by Q-graders. The experiments were conducted in a randomized block design with five replicates, in the 3 × 4 factorial scheme, with three fermentation times—24, 48 and 72 hours and four wet processing tests—Washed, Yeast fermentation, Fully washed without yeast and Fully washed with yeast. The sensorial results indicate a new perspective for the application of wet processing with starter cultures for Conilon coffee. They indicate gains in sensory scale, opening a new phase of studies on spontaneous and induced fermentation for Conilon coffee in Brazil and worldwide.
文摘The Western tragopan(Tragopan melanocephalus)is recorded in the IUCN Red List of 2017 as a vulnerable bird species in Pakistan.This study provides valuable information for the conservation of Western tragopan,which is a globally threatened avian flagship species in Pakistan.This study was conducted to investigate and resolve the conservation challenges surrounding the species in two major habitat zones-Salkhala Game Reserve and Machiara National Park.The study was implemented in May-June 2020 for population density using call count data.Also,questionnaire was used for local residents’perceptions and habitat suitability modeling map was generated using the MaxEnt model based on previously recorded occurrence points as well as recorded in the survey.A total of 26 western Tragopans were identified by call count during the sampling period.Moreover,about 77.3%cited Western Tragopan they more likely to hunt while the remaining 22.6%locals recorded other pheasant.About 45.3%of this hunting for fun but only 22%for economic values and only 3%of people consider hunting as a part of their culture.Results of modeling habitat suitability of the Western tragopan showed that the species suitable habitats are small and patchy in Pakistan.We found that the Normalized Difference Vegetation Index(NDVI)with 40.6 percent contribution was the most important variable in shaping the species distribution.Our model identified some new suitable patches which can be the target of future field monitoring for finding new populations of the species and future conservation planning.
文摘The purpose of this study was to investigate osteogenesis promoted by osteoconductive properties of bone grafting materials and the histopathological effects of ozone on osteogenesis. In total, 56 Winstar rats were equally divided into 4 groups. In control group, calvarial bone defect was created in 14 rats. For second group, 8 mm calvarial bone defect with ozone treatment was applied in 14 rats. For third group, an alloplastic bone graft was implanted on 8 mm calvarial bone defect. In fourth group, alloplastic bone graft was inserted in calvarial defect and ozone was treated additionally. Seven of the rats were sacrificed at the end of 4th week and the remaining 7 were sacrificed at the end of 8th week of experiment. In the study, the periosteal flaps were removed with a thin periosteal elevator and averagely 0.8 cm diameter-circular full bone defect was created with a specially designed trephine drill. The bone from the calvarial region was fixed in 10% formalin solution. After decalcification, bones were taken for routine paraffin blocking. Sections were stained with Hematoxylin-Eosin and Masson Trichrome. Histopathological findings of 4th and 8th weeks rats showed that best result for new bone formation was observed in graft + ozone treatment. It is concluded that ozone treatment increases the hemostasis in graft region, induces angiogenesis, promotes cell proliferation by preventing infiltration, induces matrix formation by influencing osteoblastic activity and has a positive effect in osteogenesis.
文摘Due to their unique characteristics, such as the dynamic changing topology, the absence of central management, the cooperative routing mechanisms, and the resources constraints, Mobile ad hoc networks (MANETs) are relatively vulnerable to both active and passive attacks. In MANET, routing attacks try to disrupt the functions of routing protocol by intentionally or unintentionally dropping packets or propagating faked routing messages. However, due to their computation requirements, the prevention mechanisms are not powerful enough to secure MANET. In this paper, we propose a distributed and cooperative scheme using statistical methods to detect routing attacks in MANETs. Our scheme uses both direct and indirect observations to characterize the behaviors of both neighboring and remote nodes. Simple threshold and Grubb’s Test are utilized to propose our new detection methods. The scheme includes innovative methods to compute our proposed measures, Maximum Accusation Number (MAN) and Accusation Number (AN), which are used to make decision about node’s behavior. Experimental results show that our scheme performs well in detecting anomalous events in routing functions.
文摘BACKGROUND Lactulose is approved for the symptomatic treatment of constipation,a gastrointestinal(GI)complication common in individuals with diabetes.Lactulose products contain carbohydrate impurities(e.g.,lactose,fructose,galactose),which occur during the lactulose manufacturing process.These impurities may affect the blood glucose levels of individuals with type 2 diabetes mellitus(T2DM)using lactulose for the treatment of mild constipation.A previous study in healthy subjects revealed no increase in blood glucose levels after oral lactulose intake.However,it is still unclear whether the intake of lactulose increases blood glucose levels in individuals with diabetes.AIM To evaluate the blood glucose profile after oral lactulose intake in mildly constipated,non-insulin-dependent subjects with T2DM in an outpatient setting.METHODS This prospective,double-blind,randomized,controlled,single-center trial was conducted at the Clinical Research Center at the Medical University of Graz,Austria,in 24 adult Caucasian mildly constipated,non-insulin-dependent subjects with T2DM.Eligible subjects were randomized and assigned to one of six treatment sequences,each consisting of four treatments stratified by sex using an incomplete block design.Subjects received a single dose of 20 g or 30 g lactulose(crystal and liquid formulation),water as negative control or 30 g glucose as positive control.Capillary blood glucose concentrations were measured over a period of 180 min post dose.The primary endpoint was the baseline-corrected area under the curve of blood glucose concentrations over the complete assessment period[AUC_(baseline_c(0-180 min))].Quantitative comparisons were performed for both lactulose doses and formulations vs water for the equal lactulose dose vs glucose,as well as for liquid lactulose vs crystal lactulose.Safety parameters included GI tolerability,which was assessed at 180 min and 24 h post dose,and adverse events occurring up to 24 h post dose.In 24 randomized and analyzed subjects blood glucose concentration-time curves after intake of 20 g and 30 g lactulose were almost identical to those after water intake for both lactulose formulations despite the different amounts of carbohydrate impurities(≤3.0%for crystals and approx.30%for liquid).The primary endpoint[AUC_(baseline_c(0-180 min))]was not significantly different between lactulose and water regardless of lactulose dose and formulation.Also with regard to all secondary endpoints lactulose formulations showed comparable results to water with one exception concerning maximum glucose level.A minor increase in maximum blood glucose was observed after the 30 g dose,liquid lactulose,in comparison to water with a mean treatment difference of 0.63 mmol/L(95%confidence intervals:0.19,1.07).Intake of 30 g glucose significantly increased all blood glucose endpoints vs 30 g liquid and crystal lactulose,respectively(all P<0.0001).No differences in blood glucose response were observed between the different lactulose formulations.As expected,lactulose increased the number of bowel movements and was generally well tolerated.Subjects experienced only mild to moderate GI symptoms due to the laxative action of lactulose.CONCLUSION Blood glucose AUC_(baseline_c(0-180 min))levels in mildly constipated,non-insulin dependent subjects with T2DM are not affected by the carbohydrate impurities contained in 20 g and 30 g crystal or liquid lactulose formulations.
文摘A fair electronic cash system is a system that allows customers to make payments anonymously. Furthermore the trusted third party can revoke the anonymity when the customers did illegal transactions. In this paper, a new fair electronic cash system based on group signature scheme by using elliptic curve cryptography is proposed, which satisfies properties of secure group signature scheme (correctness, unforgeability, etc). Moreover, our electronic cash contains group members (users, merchants and banks) and trusted third party which is acted by central bank as group manager.
文摘Objective: To assess the relation between acute gastrointestinal disease and Helicobacter pylori (H. pylori) infections. Methods: Over the 18-month period, a total of 323 patients referred to three hospitals in Babol (north of Iran) were enrolled in this cross-sectional study. H. pylori status (rapid urease test), endoscopic findings in the patients, personal habits (smoking or alcohol intake) and administration of drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs) were analyzed using standard Chi-square test and multinomial logistic regression analysis. Results: Results showed that acute gastric ulcer patients had a significant association with alcohol (P=0.001, OR=6.183), opium (P=0.022, OR=2.823), smoking (P=0.016, OR=2.579) and NSAIDs (P=0.046, OR=2.071). However, patients with in acute duodenal ulcer have a significant association with opium (P=0.023, OR=2.326) and alcohol (P=0.003, OR=3.888). As well as, gastric cancer had significant association with alcohol (P<0.05, OR=6.937), smoking (P=0.012, OR=2.738), family history (P=0.005, OR=4.380) and gender (P≤0.05, OR=5.103). Conclusions: Current investigation shows that H. pylori infection, alcoholism, male gender, age and family history have an additive impact on the incidence of gastric cancer. In addition, alcoholism, opium usage, NSAIDs and family history have more impact on the incidence of acute gastric ulcer and acute duodenal ulcer in patients.
