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Black tea in chemo-prevention of cancer and other human diseases 被引量:20
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作者 Min-Hsiung Pan Ching-Shu Lai +3 位作者 Hong Wang Chih-Yu Lo Chi-Tang Ho Shiming Li 《Food Science and Human Wellness》 SCIE 2013年第1期12-21,共10页
Tea is the most popular functional beverage in the world and has been gaining more and more attention for its health beneficial properties.Among common teas,black tea is consumed more than green tea and oolong tea wor... Tea is the most popular functional beverage in the world and has been gaining more and more attention for its health beneficial properties.Among common teas,black tea is consumed more than green tea and oolong tea worldwide.Numerous studies have shown the biological activities of black tea and its polyphenols that include anti-oxidant,anti-tumor,anti-inflammation and metabolic regulation.Tea polyphenols such as theaflavins and catechins are considered to be multifunctional compounds that could be effective in the prevention or treatment of various cancers,cardiovascular disease,chronic inflammation,obesity,metabolic syndrome,and neurodegenerative diseases.In this review,we summarized the up-to-date research and underlying molecular mechanisms of black tea and its polyphenols.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. 展开更多
关键词 Black tea THEAFLAVINS CATECHINS Human disease Molecular mechanism CANCER
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Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice 被引量:7
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作者 Min-Hsiung Pan Shiming Li +3 位作者 Ching-Shu Lai Yutaka Miyauchi Michiko Suzawa Chi-Tang Ho 《Food Science and Human Wellness》 SCIE 2012年第1期65-73,共9页
The inhibitory effects of a formulated product from citrus peel extract,Gold Lotion(GL),on 12-O-tetradecanoylphorbol 13-acetate(TPA)-induced expression of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-... The inhibitory effects of a formulated product from citrus peel extract,Gold Lotion(GL),on 12-O-tetradecanoylphorbol 13-acetate(TPA)-induced expression of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)in mouse skin was reported in this study.It is found that in the TPA-induced skin inflammation model,the topical application of GL effectively inhibited the transcriptional activation of iNOS and its mRNA and protein in mouse skin.It is also discovered that GL significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory gene parameters.Furthermore,GL dramatically inhibited 7,12-dimethylbenez[a]anthracene(DMBA)/TPA-induced skin tumor formation and reduced tumor incidence,tumor weight and tumor multiplicity of papillomas at 20 weeks.In essence,these in vivo data have revealed that GL is an effective anti-tumor agent that functions by down-regulating the protein levels of COX-2,ornithine decarboxylase(ODC),and vascular endothelial growth factor(VEGF)in mouse skin,suggesting that GL is a novel functional natural product capable of preventing inflammation-associated tumorigenesis.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. 展开更多
关键词 INHIBITION Skin cancer Citrus flavonoids Inflammation TUMORIGENESIS
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Enzymes in the bioconversion of food waste into valuable bioproducts:A circular economy perspective
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作者 Parushi Nargotra Rhessa Grace Guanga Ortizo +6 位作者 Jia-Xiang Wang Mei-Ling Tsai Cheng-Di Dong Pei-Pei Sun Bijender Kumar Bajaj Chia-Hung Kuo Vishal Sharma 《Systems Microbiology and Biomanufacturing》 2024年第3期850-868,共19页
The escalating global challenges of food security,waste management,and environmental sustainability have necessitated the application of novel green approaches to utilize agro-industrial food waste as a valuable biore... The escalating global challenges of food security,waste management,and environmental sustainability have necessitated the application of novel green approaches to utilize agro-industrial food waste as a valuable bioresource.Enzymatic conversion of food waste into high-value bioproducts emerges as one of the promising solutions to address these issues.The current review explores the critical role of enzymes in facilitating the conversion of diverse agro-industrial residues,including those from plants and animals,into biochemicals and functional ingredients.The current review evaluates the environmental and economic benefits of enzyme-mediated bioconversion processes,underlining the circular economy paradigm,which prioritizes resource efficiency and waste minimization.The enzyme production from diverse plant and animal-based food wastes as raw materials has been highlighted beside the description of different bioproducts from food waste using enzymes and the integration of enzymatic bioprocessing.The economic analysis and case studies of the enzyme-mediated processes for biochemical production from food waste have also been emphasized.By harnessing the synergistic potential of enzymes and circular economy principles,the bioconversion of agro-industrial food waste into novel bioproducts presents a viable pathway toward sustainable resource utilization and a circular bioeconomy. 展开更多
关键词 Circular economy Sustainable development goals Food processing waste ENZYMES Industrial applications Life cycle analysis
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Hepatocarcinoma Single Cell Migration on Micropatterned PDMS Substrates
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作者 Bin Zheng Shu-Ling Hsieh +7 位作者 Chih-Chung Wu Chun-Hsin Wu Pei-Ying Lin Chiung-Wen Hsieh I-Tin Li Yun-Shan Huang Huay-Min Wang Shuchen Hsieh 《Nano Biomedicine & Engineering》 2011年第2期99-106,共8页
Cell migration influences many normal and pathological processes and is one of key issues addressed in cancer research studies.In this report,a plasma patterned polydimethylsiloxane(PDMS)substrate was used to selectiv... Cell migration influences many normal and pathological processes and is one of key issues addressed in cancer research studies.In this report,a plasma patterned polydimethylsiloxane(PDMS)substrate was used to selectively position hepatocarcinoma cells in order to characterize their migration behavior.We observed that cell mobility was directly related to the differentiation stage of the cells,with poorly-differentiated(SK-Hep-1)cells exhibiting higher mobility that well-differentiated(Hep-G2)cells.We propose that this difference occurs due to a loss of adhesion molecules presented at the apical membranes of the poorly-differentiated SK-Hep-1 cells,thereby reducing their adhesion to the surface.Our results provide new insight into the relationship between carcinoma cell differentiation grade and mobility.Further this experimental process may provide a simple and effective model for universal cell biology studies and applications in microsystems technology. 展开更多
关键词 Cell adhesion Cell spreading Hepatocyte Micropatterning Polydimethylsiloxane
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