Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method...Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method.GDM diagnosis was based on a 75-g,2-h oral glucose tolerance test(OGTT)according to the criteria of the International Association of Diabetes and Pregnancy Study Groups.Logistic regression was applied to calculate the odds ratios(ORs)and 95%confidence intervals(CIs)between ABO blood types and GDM risk.Results A total of 30,740 pregnant women with a mean age of 31.81 years were enrolled in this study.The ABO blood types distribution was:type O(30.99%),type A(26.58%),type B(32.20%),and type AB(10.23%).GDM was identified in 14.44%of participants.Using blood type O as a reference,GDM risk was not significantly higher for types A(OR=1.05)or B(OR=1.04).However,women with type AB had a 19%increased risk of GDM(OR=1.19,95%CI=1.05–1.34;P<0.05),even after adjusting for various factors.This increased risk for type AB was consistent across subgroup and sensitivity analyses.Conclusion The ABO blood types may influence GDM risk,with type AB associated with a higher risk.Incorporating it—either as a single risk factor or in combination with other known factors—could help identify individuals at risk for GDM before or during early pregnancy.展开更多
China’s annual Central Economic Work Conference(CEWC),held on December 11 and 12,2024,signaled the government’s determination to sustain economic growth and expand high-level opening up.Against the backdrop of risin...China’s annual Central Economic Work Conference(CEWC),held on December 11 and 12,2024,signaled the government’s determination to sustain economic growth and expand high-level opening up.Against the backdrop of rising global economic uncertainty,stabilizing the economy and promoting highquality development not only represent a practical need for the country to achieve key goals on its socioeconomic agenda and make steady progress on the Chinese path to modernization,but will also help enhance economic resilience against external headwinds and contribute more to the global economy.展开更多
Objective: In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel...Objective: In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus(2019-nCoV), an ongoing novel coronavirus that causes pneumonia.Methods: There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology Database.Compounds meeting both requirements were subjected to absorption, distribution, metabolism and excretion(ADME) evaluation to verify that oral administration would be effective. Next, a docking analysis was used to test whether the compound had the potential for direct 2019-nCoV protein interaction.In the second step we searched Chinese herbal databases to identify plants containing the selected compounds. Plants containing 2 or more of the compounds identified in our screen were then checked against the catalogue for classic herbal usage. Finally, network pharmacology analysis was used to predict the general in vivo effects of each selected herb.Results: Of the natural compounds screened, 13 that exist in traditional Chinese medicines were also found to have potential anti-2019-nCoV activity. Further, 125 Chinese herbs were found to contain 2 or more of these 13 compounds. Of these 125 herbs, 26 are classically catalogued as treating viral respiratory infections. Network pharmacology analysis predicted that the general in vivo roles of these26 herbal plants were related to regulating viral infection, immune/inflammation reactions and hypoxia response.Conclusion: Chinese herbal treatments classically used for treating viral respiratory infection might contain direct anti-2019-nCoV compounds.展开更多
A feeding experiment was conducted to investigate the effect of Bacillus subtilis bacterium and its suitable level on survival and growth rate of juvenile Macrobrachium rosenbergii （de Man） during March 28 to May 28...A feeding experiment was conducted to investigate the effect of Bacillus subtilis bacterium and its suitable level on survival and growth rate of juvenile Macrobrachium rosenbergii （de Man） during March 28 to May 28, 2010. A B. subtilis bacterium isolated from chicken intestine was added to commercial prawn feed as a probiotic. Six diets were prepared by soaking prawn feed into the B. subtilis to achieve 10^10, 10^9, 10^8, 10^7 and 106 levels with a non-treated control. After 60 days, the prawns fed diet at level 10^8 showed a higher mean weight gain （593.45 g） or 170.29% increase in growth over control. The mean weight gain showed a decreasing trend as the B. subtilis level decreased from 10^8 to 10^6 and the B. subtilis level increased from 10^8 to 10^10 in the diets. There were significant differences （P 〈 0.05） in weight gain, feed intake, daily growth and feed conversion ratio （FCR） among treated and controlled groups. There were significant differences （P 〈 0.05） among treatments and control in survival rate but no significant differences （P 〉 0.05） in water quality and biochemical composition among treated and controlled groups. Clearly, treated with B. subtilis appeared to enhance growth and survival of M. rosenbergii. It was concluded that the tested strain may be a promising probiotics for M. rosenbergii at a level of 10^8 B. subtilis into the prawn feed.展开更多
Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(S...Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI),novel indices,reflect the body’s chronic immune-inflammatory state.This study aimed to investigate the associations between the SII or SIRI and GDM.Methods:A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020,recruiting participants in their first trimester of pregnancy.Baseline SII and SIRI values were derived from routine clinical blood results,calculated as follows:SII=neutrophil(Neut)count×platelet(PLT)count/lymphocyte(Lymph)count,SIRI=Neut count×monocyte(Mono)count/Lymph count,with participants being grouped by quartiles of their SII or SIRI values.Participants were followed up for GDM with a 75-g,2-h oral glucose tolerance test(OGTT)at 24-28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups(IADPSG).Logistic regression was used to analyze the odds ratios(ORs)(95%confidence intervals[CIs])for the the associations between SII,SIRI,and the risk of GDM.Results:Among the 28,124 women included in the study,the average age was 31.8±3.8 years,and 15.76%(4432/28,124)developed GDM.Higher SII and SIRI quartiles were correlated with increased GDM rates,with rates ranging from 12.26%(862/7031)in the lowest quartile to 20.10%(1413/7031)in the highest quartile for the SII(P_(trend)<0.001)and 11.92-19.31%for the SIRI(P_(trend)<0.001).The ORs(95%CIs)of the second,third,and fourth SII quartiles were 1.09(0.98-1.21),1.21(1.09-1.34),and 1.39(1.26-1.54),respectively.The SIRI findings paralleled the SII outcomes.For the second through fourth quartiles,the ORs(95%CIs)were 1.24(1.12-1.38),1.41(1.27-1.57),and 1.64(1.48-1.82),respectively.These associations were maintained in subgroup and sensitivity analyses.Conclusion:The SII and SIRI are potential independent risk factors contributing to the onset of GDM.展开更多
Background and Objectives:The impacts of nutritional status on clinical outcomes in children receiving umbilical cord blood stem cell transplantation(UCBT)are not fully described.We evaluated the risk for malnutrition...Background and Objectives:The impacts of nutritional status on clinical outcomes in children receiving umbilical cord blood stem cell transplantation(UCBT)are not fully described.We evaluated the risk for malnutrition before transplantation admission and influence of weight loss during hospitalization on short-term clinical outcomes in children with UCBT.Methods and Study Design:We conducted a retrospective study of pediatric patients up to age 18 years who received UCBT and were treated at the Children’s Hospital of Fudan University between January 2019 and December 2020.Results:The mean age of the 91 patients was 1.3 years,with 78(85.7%)men and 13(14.3%)women(p<0.001).UCBT was performed mostly for primary immunodeficiency disease(PID)(83,91.2%).The weight loss differences among children with different primary diseases were statistically significant(p=0.003).Children with a large amount of weight loss during hospitalization(n=24)had higher risks of skin graft-versus-host disease(GVHD)(multivariate OR=5.01,95%CI:1.35-18.65),intestinal GVHD(multivariate OR=7.27,95%CI:1.74-30.45),a longer median hospital stay(p=0.004),higher antibiotic costs(p=0.008)and higher total hospitalization costs(p=0.004).Malnutrition on admission was significantly positively correlated with longer parenteral nutrition(PN)time(p=0.008).Early nutritional intervention effects on clinical outcomes need further assessment.Conclusions:Underweight recipient child and excessive weight loss during transplantation increases the length and cost of hospital stay,and is associated with a high incidence of GVHD,which affects the prognosis of transplantation and medical resources consumption.展开更多
Background Acute myocarditis(AMC)can cause poor outcomes or even death in children.We aimed to identify AMC risk factors and create a mortality prediction model for AMC in children at hospital admission.Methods This w...Background Acute myocarditis(AMC)can cause poor outcomes or even death in children.We aimed to identify AMC risk factors and create a mortality prediction model for AMC in children at hospital admission.Methods This was a single-center retrospective cohort study of AMC children hospitalized between January 2016 and January 2020.The demographics,clinical examinations,types of AMC,and laboratory results were collected at hospital admission.In-hospital survival or death was documented.Clinical characteristics associated with death were evaluated.Results Among 67 children,51 survived,and 16 died.The most common symptom was digestive disorder(67.2%).Based on the Bayesian model averaging and Hosmer–Lemeshow test,we created a final best mortality prediction model(acute myocarditis death risk score,AMCDRS)that included ten variables(male sex,fever,congestive heart failure,left-ventricular ejection fraction<50%,pulmonary edema,ventricular tachycardia,lactic acid value>4,fulminant myocarditis,abnormal creatine kinase-MB,and hypotension).Despite differences in the characteristics of the validation cohort,the model discrimination was only marginally lower,with an AUC of 0.781(95%confidence interval=0.675–0.852)compared with the derivation cohort.Model calibration likewise indicated acceptable fit(Hosmer‒Lemeshow goodness-of-fit,P¼=0.10).Conclusions Multiple factors were associated with increased mortality in children with AMC.The prediction model AMCDRS might be used at hospital admission to accurately identify AMC in children who are at an increased risk of death.展开更多
基金supported by the Capital’s Funds for Health Improvement and Research(No.2024-2G-2118)the National Key Research and Development Program of China(2016YFC1000101)+2 种基金the Leading Talents in the Construction Project of High-Level Public Health Technical Talents in Beijing(2022-1-003)the“Green Seedling”Youth Program by the Beijing Hospitals Authority(QML20231402)the Young Elite Scientist Sponsorship Program by the Beijing Association for Science and Technology(BYESS2022200)。
文摘Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method.GDM diagnosis was based on a 75-g,2-h oral glucose tolerance test(OGTT)according to the criteria of the International Association of Diabetes and Pregnancy Study Groups.Logistic regression was applied to calculate the odds ratios(ORs)and 95%confidence intervals(CIs)between ABO blood types and GDM risk.Results A total of 30,740 pregnant women with a mean age of 31.81 years were enrolled in this study.The ABO blood types distribution was:type O(30.99%),type A(26.58%),type B(32.20%),and type AB(10.23%).GDM was identified in 14.44%of participants.Using blood type O as a reference,GDM risk was not significantly higher for types A(OR=1.05)or B(OR=1.04).However,women with type AB had a 19%increased risk of GDM(OR=1.19,95%CI=1.05–1.34;P<0.05),even after adjusting for various factors.This increased risk for type AB was consistent across subgroup and sensitivity analyses.Conclusion The ABO blood types may influence GDM risk,with type AB associated with a higher risk.Incorporating it—either as a single risk factor or in combination with other known factors—could help identify individuals at risk for GDM before or during early pregnancy.
文摘China’s annual Central Economic Work Conference(CEWC),held on December 11 and 12,2024,signaled the government’s determination to sustain economic growth and expand high-level opening up.Against the backdrop of rising global economic uncertainty,stabilizing the economy and promoting highquality development not only represent a practical need for the country to achieve key goals on its socioeconomic agenda and make steady progress on the Chinese path to modernization,but will also help enhance economic resilience against external headwinds and contribute more to the global economy.
基金supported by Shanghai Leading Talent Grants in Medicine(No.2019LG26)Shanghai Traditional Chinese Medicine Content Construction Innovation Project(No.ZY3-CCCX-3-7001)Postdoctoral Funding of Shanghai Gongil Hospital(No.GLBH2017002).
文摘Objective: In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus(2019-nCoV), an ongoing novel coronavirus that causes pneumonia.Methods: There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology Database.Compounds meeting both requirements were subjected to absorption, distribution, metabolism and excretion(ADME) evaluation to verify that oral administration would be effective. Next, a docking analysis was used to test whether the compound had the potential for direct 2019-nCoV protein interaction.In the second step we searched Chinese herbal databases to identify plants containing the selected compounds. Plants containing 2 or more of the compounds identified in our screen were then checked against the catalogue for classic herbal usage. Finally, network pharmacology analysis was used to predict the general in vivo effects of each selected herb.Results: Of the natural compounds screened, 13 that exist in traditional Chinese medicines were also found to have potential anti-2019-nCoV activity. Further, 125 Chinese herbs were found to contain 2 or more of these 13 compounds. Of these 125 herbs, 26 are classically catalogued as treating viral respiratory infections. Network pharmacology analysis predicted that the general in vivo roles of these26 herbal plants were related to regulating viral infection, immune/inflammation reactions and hypoxia response.Conclusion: Chinese herbal treatments classically used for treating viral respiratory infection might contain direct anti-2019-nCoV compounds.
文摘A feeding experiment was conducted to investigate the effect of Bacillus subtilis bacterium and its suitable level on survival and growth rate of juvenile Macrobrachium rosenbergii （de Man） during March 28 to May 28, 2010. A B. subtilis bacterium isolated from chicken intestine was added to commercial prawn feed as a probiotic. Six diets were prepared by soaking prawn feed into the B. subtilis to achieve 10^10, 10^9, 10^8, 10^7 and 106 levels with a non-treated control. After 60 days, the prawns fed diet at level 10^8 showed a higher mean weight gain （593.45 g） or 170.29% increase in growth over control. The mean weight gain showed a decreasing trend as the B. subtilis level decreased from 10^8 to 10^6 and the B. subtilis level increased from 10^8 to 10^10 in the diets. There were significant differences （P 〈 0.05） in weight gain, feed intake, daily growth and feed conversion ratio （FCR） among treated and controlled groups. There were significant differences （P 〈 0.05） among treatments and control in survival rate but no significant differences （P 〉 0.05） in water quality and biochemical composition among treated and controlled groups. Clearly, treated with B. subtilis appeared to enhance growth and survival of M. rosenbergii. It was concluded that the tested strain may be a promising probiotics for M. rosenbergii at a level of 10^8 B. subtilis into the prawn feed.
基金supported by the Capital’s Funds for Health Improvement and Research(No.2024-2G-2118)the National Key Research and Development Program of China(No.2016YFC1000100)+2 种基金the Leading Talents in the Construction Project of High Level Public Health Technical Talents in Beijing(No.20221003)the“Green Seedling”Youth Program by the Beijing Hospitals Authority(No.QML20231402)the Young Elite Scientist Sponsorship Program by the Beijing Association for Science and Technology(No.BYESS2022200).
文摘Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI),novel indices,reflect the body’s chronic immune-inflammatory state.This study aimed to investigate the associations between the SII or SIRI and GDM.Methods:A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020,recruiting participants in their first trimester of pregnancy.Baseline SII and SIRI values were derived from routine clinical blood results,calculated as follows:SII=neutrophil(Neut)count×platelet(PLT)count/lymphocyte(Lymph)count,SIRI=Neut count×monocyte(Mono)count/Lymph count,with participants being grouped by quartiles of their SII or SIRI values.Participants were followed up for GDM with a 75-g,2-h oral glucose tolerance test(OGTT)at 24-28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups(IADPSG).Logistic regression was used to analyze the odds ratios(ORs)(95%confidence intervals[CIs])for the the associations between SII,SIRI,and the risk of GDM.Results:Among the 28,124 women included in the study,the average age was 31.8±3.8 years,and 15.76%(4432/28,124)developed GDM.Higher SII and SIRI quartiles were correlated with increased GDM rates,with rates ranging from 12.26%(862/7031)in the lowest quartile to 20.10%(1413/7031)in the highest quartile for the SII(P_(trend)<0.001)and 11.92-19.31%for the SIRI(P_(trend)<0.001).The ORs(95%CIs)of the second,third,and fourth SII quartiles were 1.09(0.98-1.21),1.21(1.09-1.34),and 1.39(1.26-1.54),respectively.The SIRI findings paralleled the SII outcomes.For the second through fourth quartiles,the ORs(95%CIs)were 1.24(1.12-1.38),1.41(1.27-1.57),and 1.64(1.48-1.82),respectively.These associations were maintained in subgroup and sensitivity analyses.Conclusion:The SII and SIRI are potential independent risk factors contributing to the onset of GDM.
文摘Background and Objectives:The impacts of nutritional status on clinical outcomes in children receiving umbilical cord blood stem cell transplantation(UCBT)are not fully described.We evaluated the risk for malnutrition before transplantation admission and influence of weight loss during hospitalization on short-term clinical outcomes in children with UCBT.Methods and Study Design:We conducted a retrospective study of pediatric patients up to age 18 years who received UCBT and were treated at the Children’s Hospital of Fudan University between January 2019 and December 2020.Results:The mean age of the 91 patients was 1.3 years,with 78(85.7%)men and 13(14.3%)women(p<0.001).UCBT was performed mostly for primary immunodeficiency disease(PID)(83,91.2%).The weight loss differences among children with different primary diseases were statistically significant(p=0.003).Children with a large amount of weight loss during hospitalization(n=24)had higher risks of skin graft-versus-host disease(GVHD)(multivariate OR=5.01,95%CI:1.35-18.65),intestinal GVHD(multivariate OR=7.27,95%CI:1.74-30.45),a longer median hospital stay(p=0.004),higher antibiotic costs(p=0.008)and higher total hospitalization costs(p=0.004).Malnutrition on admission was significantly positively correlated with longer parenteral nutrition(PN)time(p=0.008).Early nutritional intervention effects on clinical outcomes need further assessment.Conclusions:Underweight recipient child and excessive weight loss during transplantation increases the length and cost of hospital stay,and is associated with a high incidence of GVHD,which affects the prognosis of transplantation and medical resources consumption.
基金Shanghai Top Priority Clinical Medical Center Project(No.2017ZZ01008-001).
文摘Background Acute myocarditis(AMC)can cause poor outcomes or even death in children.We aimed to identify AMC risk factors and create a mortality prediction model for AMC in children at hospital admission.Methods This was a single-center retrospective cohort study of AMC children hospitalized between January 2016 and January 2020.The demographics,clinical examinations,types of AMC,and laboratory results were collected at hospital admission.In-hospital survival or death was documented.Clinical characteristics associated with death were evaluated.Results Among 67 children,51 survived,and 16 died.The most common symptom was digestive disorder(67.2%).Based on the Bayesian model averaging and Hosmer–Lemeshow test,we created a final best mortality prediction model(acute myocarditis death risk score,AMCDRS)that included ten variables(male sex,fever,congestive heart failure,left-ventricular ejection fraction<50%,pulmonary edema,ventricular tachycardia,lactic acid value>4,fulminant myocarditis,abnormal creatine kinase-MB,and hypotension).Despite differences in the characteristics of the validation cohort,the model discrimination was only marginally lower,with an AUC of 0.781(95%confidence interval=0.675–0.852)compared with the derivation cohort.Model calibration likewise indicated acceptable fit(Hosmer‒Lemeshow goodness-of-fit,P¼=0.10).Conclusions Multiple factors were associated with increased mortality in children with AMC.The prediction model AMCDRS might be used at hospital admission to accurately identify AMC in children who are at an increased risk of death.
