Over the past three decades,a variety of complex structures mimicking intermetallic compounds have been discovered in soft matter systems.However,a complete understanding of the mechanisms that govern the self-assembl...Over the past three decades,a variety of complex structures mimicking intermetallic compounds have been discovered in soft matter systems.However,a complete understanding of the mechanisms that govern the self-assembly of these complex structures in aqueous solution is still lacking.Herein,we investigate the formation of mesoscale complex crystal structures with micelle packing of nonionic amphiphilic molecules in aqueous solutions using small-angle X-ray scattering(SAXS).The SAXS measurements revealed both unary-micelle and binary-micelles liquid crystalline phases,including face-centered cubic(FCC),body-centered cubic(BCC),Frank-Kasper(FK)σ,and FK A15 and NaZn_(13),FK C14,and FK C15 phases,respectively,which arise from the interplay of composition,temperature,and time.Quantitative SAXS analyses with Le Bail refinements and electron density reconstruction indicated that EO hydration,the interfacial curvature of micelles,and micellar packing play important roles in the formation of mesoscale complex crystalline structures during the self-assembly process of the nonionic ternary system.This study is the first demonstration of binary mesoscale complex crystalline structures with quasispherical close packing in nonionic amphiphilic aqueous solution,offering broader insights for the self-assembly mechanism of the complex crystalline structures on soft materials.展开更多
Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface friction.However,achieving effective prevention of both bloodstream-...Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface friction.However,achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities,specifically regarding electrostatic interactions.This study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan(ZW@CMC)with antibacterial and antithrombotic activities for use in catheters.The ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties,which facilitate the formation of a stable hydration layer with low friction.The zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl group.This augmentation enhances electrostatic repulsion and facilitates the formation of hydration layer.This leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm formation.Subsequently,the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity,hemolysis,and catheter friction.Furthermore,in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis treatment.This study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.展开更多
基金supported by the Korea Basic Science Institute(National Research Facilities and Equipment Center)grant funded by the Ministry of Educationthe National Research Foundation of Korea(NRF)+1 种基金the Commercialization Promotion Agency for R&D Outcomes(COMPA)grants funded by the Korean government(NRF-2020M2D6A1044636,NRF-2020R1I1A3A04036603,NRF-2021R1A6C101B383,RS-2023-00304743)supported by the BK21 FOUR Program by Jeonbuk National University Research Grant.
文摘Over the past three decades,a variety of complex structures mimicking intermetallic compounds have been discovered in soft matter systems.However,a complete understanding of the mechanisms that govern the self-assembly of these complex structures in aqueous solution is still lacking.Herein,we investigate the formation of mesoscale complex crystal structures with micelle packing of nonionic amphiphilic molecules in aqueous solutions using small-angle X-ray scattering(SAXS).The SAXS measurements revealed both unary-micelle and binary-micelles liquid crystalline phases,including face-centered cubic(FCC),body-centered cubic(BCC),Frank-Kasper(FK)σ,and FK A15 and NaZn_(13),FK C14,and FK C15 phases,respectively,which arise from the interplay of composition,temperature,and time.Quantitative SAXS analyses with Le Bail refinements and electron density reconstruction indicated that EO hydration,the interfacial curvature of micelles,and micellar packing play important roles in the formation of mesoscale complex crystalline structures during the self-assembly process of the nonionic ternary system.This study is the first demonstration of binary mesoscale complex crystalline structures with quasispherical close packing in nonionic amphiphilic aqueous solution,offering broader insights for the self-assembly mechanism of the complex crystalline structures on soft materials.
基金supported by the Korea Evaluation Institute of Industrial Technology(KEIT)grant funded by the South Korea government(MOTIE)(No.1415187426,RS-2023-00238181)supported by the institutional program funded by the Korea Institute of Industrial Technology(JA230007)the National Research Foundation of Korea(NRF)grant funded by the South Korea government(MSIT)(No.2022R1F1A1074255,No.RS-2022-00144435).
文摘Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface friction.However,achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities,specifically regarding electrostatic interactions.This study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan(ZW@CMC)with antibacterial and antithrombotic activities for use in catheters.The ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties,which facilitate the formation of a stable hydration layer with low friction.The zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl group.This augmentation enhances electrostatic repulsion and facilitates the formation of hydration layer.This leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm formation.Subsequently,the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity,hemolysis,and catheter friction.Furthermore,in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis treatment.This study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.
