Non-alcoholic fatty liver disease(NAFLD)encompasses a spectrum of liver disorders of varying severity,ultimately leading to fibrosis.This spectrum primarily consists of NAFL and non-alcoholic steatohepatitis.The patho...Non-alcoholic fatty liver disease(NAFLD)encompasses a spectrum of liver disorders of varying severity,ultimately leading to fibrosis.This spectrum primarily consists of NAFL and non-alcoholic steatohepatitis.The pathogenesis of NAFLD is closely associated with disturbances in the gut micr-obiota and impairment of the intestinal barrier.Non-gut commensal flora,particularly bacteria,play a pivotal role in the progression of NAFLD.Notably,Porphyromonas gingivalis,a principal bacterium involved in periodontitis,is known to facilitate lipid accumulation,augment immune responses,and induce insulin resistance,thereby exacerbating fibrosis in cases of periodontitis-associated NAFLD.The influence of oral microbiota on NAFLD via the“oral-gut-liver”axis is gaining recognition,offering a novel perspective for NAFLD management through microbial imbalance correction.This review endeavors to encapsulate the intricate roles of oral bacteria in NAFLD and explore underlying mechanisms,emphasizing microbial control strategies as a viable therapeutic avenue for NAFLD.展开更多
After teeth are replanted,there are two possible healing responses：periodontal ligament healing or ankylosis with subsequent replacement resorption.The purpose of this study was to compare the fatigue resistance of v...After teeth are replanted,there are two possible healing responses：periodontal ligament healing or ankylosis with subsequent replacement resorption.The purpose of this study was to compare the fatigue resistance of vertically fractured teeth after bonding the fragments under conditions simulating both healing modes.Thirty-two human premolars were vertically fractured and the fragments were bonded together with Super-Bond C＆B.They were then randomly distributed into four groups（BP,CP,CA,BA）.The BP and CP groups were used to investigate the periodontal ligament healing mode whilst the BA and CA groups simulated ankylosis.All teeth had root canal treatment performed.Metal crowns were constructed for the CP and CA groups.The BP and BA groups only had composite resin restorations in the access cavities.All specimens were subjected to a 260 N load at 4 Hz until failure of the bond or until 2 x 106 cycles had been reached if no fracture occurred.Cracks were detected by stereomicroscope imaging and also assessed via dye penetration tests.Finally,interfaces of the resin luting agent were examined by scanning electron microscope.The results confirmed that the fatigue resistance was higher in the groups with simulated periodontal ligament healing.Periodontal reattachment showed important biomechanical role in bonded and replanted vertically fractured teeth.展开更多
Polydichlorophosphazene(PDCP)was synthesized from PCl5 and NH4Cl via a one-pot approach,and then further reacted with glycine ethyl ester and methylparaben via a two-step nucleophilic substitution approach to give pol...Polydichlorophosphazene(PDCP)was synthesized from PCl5 and NH4Cl via a one-pot approach,and then further reacted with glycine ethyl ester and methylparaben via a two-step nucleophilic substitution approach to give poly(methylparaben/glycine ethyl ester)phosphazene(PMGP),which was a kind of mix-substituted biodegradable polymer.NMR and FT-IR were used to characterize its structure.A series of experiments were conducted to study the effects of the ratio of methylparaben to glycine ethyl ester and the experimental conditions to the degradability of PMGP samples.The degradability of PMGP can be adjusted by altering the ratio of methylparaben to glycine ethyl ester easily.展开更多
This study aimed to propose a novel biomimetic design strategy of an oral implant and to numerically examine its biomechanical effect according to clinical interests.The designed implant conceptually mimicked the morp...This study aimed to propose a novel biomimetic design strategy of an oral implant and to numerically examine its biomechanical effect according to clinical interests.The designed implant conceptually mimicked the morphology and elastic modulus of the mandibular bone.Basing on a CT-image-based patient-specific reconstruction of the tumor-excised mandible,the biomechanical effects of the implants with three materials(PEEK/n-HA/CF,PEEK/HA and Ti6Al4V),two surgical conditions(removed and retained muscles),and two postoperative stages(early and late)were fully investigated by a static finite element analysis.Moreover,according to clinical interests(e.g.failure and stability of the implant and rivets),maximum von Mises stresses and strains of the implant and rivets,maximum implant-bone gap in the early postoperative stage,and maximum von Mises stress of the mandible were mainly analyzed.The results showed that the implant composed of Ti6Al4V material was suitable for the current design strategy with respect to the other two PEEK-based materials.Although the implants in the muscle-retained surgical condition had relative greater indices compared to the muscle-removed surgical condition,the index difference between the two conditions was slight.The biomechanical indices indicating the failure and loosening risks of implant and rivets were much reduced in the late postoperative stage with respect to the early postoperative stage due to the osteointegration at the implant-bone interface.Generally,the proposed novel design strategy could be useful to guide the design of the oral implant addressing different implant materials and surgical conditions,and further made proper suggestion to clinicians and patients.展开更多
文摘Non-alcoholic fatty liver disease(NAFLD)encompasses a spectrum of liver disorders of varying severity,ultimately leading to fibrosis.This spectrum primarily consists of NAFL and non-alcoholic steatohepatitis.The pathogenesis of NAFLD is closely associated with disturbances in the gut micr-obiota and impairment of the intestinal barrier.Non-gut commensal flora,particularly bacteria,play a pivotal role in the progression of NAFLD.Notably,Porphyromonas gingivalis,a principal bacterium involved in periodontitis,is known to facilitate lipid accumulation,augment immune responses,and induce insulin resistance,thereby exacerbating fibrosis in cases of periodontitis-associated NAFLD.The influence of oral microbiota on NAFLD via the“oral-gut-liver”axis is gaining recognition,offering a novel perspective for NAFLD management through microbial imbalance correction.This review endeavors to encapsulate the intricate roles of oral bacteria in NAFLD and explore underlying mechanisms,emphasizing microbial control strategies as a viable therapeutic avenue for NAFLD.
基金supported by the Jiangsu Province's Outstanding Medical Academic Leader Program(No.LJ201110)the National Natural Scientific Foundation of China(81070839)Key Project supported by Medical Science and Technology Development Foundation,Nanjing Department of Health(ZKX10030)
文摘After teeth are replanted,there are two possible healing responses：periodontal ligament healing or ankylosis with subsequent replacement resorption.The purpose of this study was to compare the fatigue resistance of vertically fractured teeth after bonding the fragments under conditions simulating both healing modes.Thirty-two human premolars were vertically fractured and the fragments were bonded together with Super-Bond C＆B.They were then randomly distributed into four groups（BP,CP,CA,BA）.The BP and CP groups were used to investigate the periodontal ligament healing mode whilst the BA and CA groups simulated ankylosis.All teeth had root canal treatment performed.Metal crowns were constructed for the CP and CA groups.The BP and BA groups only had composite resin restorations in the access cavities.All specimens were subjected to a 260 N load at 4 Hz until failure of the bond or until 2 x 106 cycles had been reached if no fracture occurred.Cracks were detected by stereomicroscope imaging and also assessed via dye penetration tests.Finally,interfaces of the resin luting agent were examined by scanning electron microscope.The results confirmed that the fatigue resistance was higher in the groups with simulated periodontal ligament healing.Periodontal reattachment showed important biomechanical role in bonded and replanted vertically fractured teeth.
文摘Polydichlorophosphazene(PDCP)was synthesized from PCl5 and NH4Cl via a one-pot approach,and then further reacted with glycine ethyl ester and methylparaben via a two-step nucleophilic substitution approach to give poly(methylparaben/glycine ethyl ester)phosphazene(PMGP),which was a kind of mix-substituted biodegradable polymer.NMR and FT-IR were used to characterize its structure.A series of experiments were conducted to study the effects of the ratio of methylparaben to glycine ethyl ester and the experimental conditions to the degradability of PMGP samples.The degradability of PMGP can be adjusted by altering the ratio of methylparaben to glycine ethyl ester easily.
基金This work is partially supported by the National Nature Science Foundation of China(32171307,11972118,11772093)ARC(DP200103492,DP200101970).
文摘This study aimed to propose a novel biomimetic design strategy of an oral implant and to numerically examine its biomechanical effect according to clinical interests.The designed implant conceptually mimicked the morphology and elastic modulus of the mandibular bone.Basing on a CT-image-based patient-specific reconstruction of the tumor-excised mandible,the biomechanical effects of the implants with three materials(PEEK/n-HA/CF,PEEK/HA and Ti6Al4V),two surgical conditions(removed and retained muscles),and two postoperative stages(early and late)were fully investigated by a static finite element analysis.Moreover,according to clinical interests(e.g.failure and stability of the implant and rivets),maximum von Mises stresses and strains of the implant and rivets,maximum implant-bone gap in the early postoperative stage,and maximum von Mises stress of the mandible were mainly analyzed.The results showed that the implant composed of Ti6Al4V material was suitable for the current design strategy with respect to the other two PEEK-based materials.Although the implants in the muscle-retained surgical condition had relative greater indices compared to the muscle-removed surgical condition,the index difference between the two conditions was slight.The biomechanical indices indicating the failure and loosening risks of implant and rivets were much reduced in the late postoperative stage with respect to the early postoperative stage due to the osteointegration at the implant-bone interface.Generally,the proposed novel design strategy could be useful to guide the design of the oral implant addressing different implant materials and surgical conditions,and further made proper suggestion to clinicians and patients.
