In a recent article published in Nature,James A.Cornwell et al.describe that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed t...In a recent article published in Nature,James A.Cornwell et al.describe that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.展开更多
基金Open Access funding enabled and organized by Projekt DEALsupported by the German Research Council(DFG),award numbers HA 1791/11-1-2,HA 1791/12-1 to MH and TG(grant numbers 440716364 and 449501615)financial support of the Open Access Publication Fund of the Martin-Luther-University Halle-Wittenberg.
文摘In a recent article published in Nature,James A.Cornwell et al.describe that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.
