Objective:To evaluate the efficacy of a novel coated stent in the treatment of intracranial pseudoaneurysm.Methods:MEDLINE,EMBASE,and PubMed databases were searched for literature published between 1990 and April 2022...Objective:To evaluate the efficacy of a novel coated stent in the treatment of intracranial pseudoaneurysm.Methods:MEDLINE,EMBASE,and PubMed databases were searched for literature published between 1990 and April 2022 according to PRISMA guidelines.All studies with≥10 patients reporting successful implantation of Willis covered stent,therapeutic effect,complications,and postoperative follow-up were included.The combined incidence and corresponding 95%confidence intervals were assessed using a generalized linear mixed method and random effects model.Results:Five studies(116 patients with pseudoaneurysms)were included.The experimental groups in the selected studies showed a combined technical success rate of 81.03%(OR=18.31,95%CI=9.39-35.69,I^(2)=79%,P<0.001).Clinical follow-up showed that the complete cure rate was as high as 94.4%after the follow-up(OR=106.81,95%CI=39.08-291.88,I^(2)=0%,P=0.71).Conclusions:Willis covered stent is feasible,safe,and effective in the treatment of intracranial pseudoaneurysm.展开更多
Background:The spleen plays a pivotal role in the rapid clearance of parasitized red blood cells in patients with falciparum malaria after artemisinin treatment.Prolonged parasite clearance can be found in patients wh...Background:The spleen plays a pivotal role in the rapid clearance of parasitized red blood cells in patients with falciparum malaria after artemisinin treatment.Prolonged parasite clearance can be found in patients who have had a splenectomy,or those with hemoglobin abnormalities and/or reduced immunity,which are all distinguishable from artemisinin resistance.This paper reports on a case of prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from Nigeria.Case presentation:A 35-year-old Chinese male suffered 2 days of febrile illness after returning to Zhumadian city of Henan province from Nigeria on October 1,2014.The main symptoms were febrile,including the highest axillary temperature of 40℃,headache,and chills.A peripheral blood smear showed parasitemia(53913 asexual parasites/μl)of Plasmodium falciparum.The patient had not used any chemoprophylaxis against malaria in Nigeria when he worked there as a construction worker between 2009 and 2014.The patient had three episodes of malaria in Nigeria and had a splenectomy due to a traffic accident 8 years ago from the time he was admitted to hospital.The patient was orally administrated a total of 320 mg/2.56 g dihydroartemisinin-piperaquine for 2 days and intravenously administrated a total of 3000 mg artesunate for 18 days.The axillary temperature of the patient ranged between 37.0 and 37.7℃ from Day 0 to Day 3,and blood microscopy revealed falciparum malaria parasitemia(26674 asexual parasites/μl)on Day 3.The patient was afebrile on Day 4,falciparum malaria parasitemia was continuously present and then gradually decreased on the next days,and was negative on Day 21.The patient was cured and left hospital on Day 24 after no plasmodium falciparum was found in the blood on Day 21 to Day 23.No mutation was found in the K13 propeller gene when compared with the PF3D7_1343700 K13 propeller gene reference sequence.Conclusions:This is the first reported case in China of prolonged parasite clearance in a splenectomized patient with imported falciparum malaria.Artemisinin resistance should be distinguished when prolonged parasite clearance is found in a malaria patient who has had splenectomy.展开更多
Background::Rheumatoid arthritis(RA)is a chronic autoimmune inflammatory disease.Its pathogenesis is not fully understood,and early diagnosis is challenging owing to the lack of effective biomarkers.This study aimed t...Background::Rheumatoid arthritis(RA)is a chronic autoimmune inflammatory disease.Its pathogenesis is not fully understood,and early diagnosis is challenging owing to the lack of effective biomarkers.This study aimed to analyze different samples to identify potential biomarkers and therapeutic targets.Methods::Microarray datasets of RA,osteoarthritis(OA),and healthy control(HC)were downloaded from the Gene Expression Omnibus database.R software was used to identify differentially expressed genes(DEGs),which were visualized using volcano and heat maps.Venn diagrams,principal component analysis,gene set enrichment analysis,gene ontology,and Kyoto Encyclopedia of genes and genomes were used to analyze the data.A protein–protein interaction network was constructed,and synovial tissues from patients with RA and OA were collected for verification using the collagen-induced arthritis mouse model.Results::More DEGs were found in synovial tissues than in peripheral blood mononuclear cells or fibroblast-like synoviocytes.Principal component analysis revealed significant differences between the RA and OA samples,highlighting the unique advantages of synovial tissue.Enrichment analysis revealed that metabolic and cytokine signaling pathways play crucial roles in the development of RA.Further analysis of the four synovial datasets identified 54 DEGs,of which signaling lymphocytic activation molecule family(SLAMF)8 was identified as the key molecule.SLAMF8 levels were increased in the synovial tissue of patients with RA compared to those of patients with OA(0.38±0.19 vs.12.40±1.66),and SLAMF8 levels were similarly elevated in collagen-induced arthritis model mice compared with those in the healthy mice(1.13±0.47 vs.9.05±2.52).Conclusions::This study established the unique advantages of synovial tissue for RA research and identified metabolic and cytokine signaling pathways as important for RA development.Thus,SLAMF8 may be a potential therapeutic target for RA.展开更多
基金supported by China Natural Science Funding(No.81902937)Hubei University of Science and Technology ENT special project(No.2020WG06)+1 种基金Hubei University of Science and Technology ENT special project(No.2)and Hubei province Key R&D plan(2022BCE011)and(No.2020XZ30)for SDWHubei University of Science and Technology the Second Affiliated Hospital Scientific project(No.2020LCZ001)and ENT special project(No.2021WG10).
文摘Objective:To evaluate the efficacy of a novel coated stent in the treatment of intracranial pseudoaneurysm.Methods:MEDLINE,EMBASE,and PubMed databases were searched for literature published between 1990 and April 2022 according to PRISMA guidelines.All studies with≥10 patients reporting successful implantation of Willis covered stent,therapeutic effect,complications,and postoperative follow-up were included.The combined incidence and corresponding 95%confidence intervals were assessed using a generalized linear mixed method and random effects model.Results:Five studies(116 patients with pseudoaneurysms)were included.The experimental groups in the selected studies showed a combined technical success rate of 81.03%(OR=18.31,95%CI=9.39-35.69,I^(2)=79%,P<0.001).Clinical follow-up showed that the complete cure rate was as high as 94.4%after the follow-up(OR=106.81,95%CI=39.08-291.88,I^(2)=0%,P=0.71).Conclusions:Willis covered stent is feasible,safe,and effective in the treatment of intracranial pseudoaneurysm.
基金This work was supported by Project of Science and Technique of Henan,China(No.092102310007)Project of Medical Science and Technique of Henan,China(No.201304053)+1 种基金the Special Funding of the Henan Health Science and Technology Innovation Talent Project(No.4045)The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the paper.
文摘Background:The spleen plays a pivotal role in the rapid clearance of parasitized red blood cells in patients with falciparum malaria after artemisinin treatment.Prolonged parasite clearance can be found in patients who have had a splenectomy,or those with hemoglobin abnormalities and/or reduced immunity,which are all distinguishable from artemisinin resistance.This paper reports on a case of prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from Nigeria.Case presentation:A 35-year-old Chinese male suffered 2 days of febrile illness after returning to Zhumadian city of Henan province from Nigeria on October 1,2014.The main symptoms were febrile,including the highest axillary temperature of 40℃,headache,and chills.A peripheral blood smear showed parasitemia(53913 asexual parasites/μl)of Plasmodium falciparum.The patient had not used any chemoprophylaxis against malaria in Nigeria when he worked there as a construction worker between 2009 and 2014.The patient had three episodes of malaria in Nigeria and had a splenectomy due to a traffic accident 8 years ago from the time he was admitted to hospital.The patient was orally administrated a total of 320 mg/2.56 g dihydroartemisinin-piperaquine for 2 days and intravenously administrated a total of 3000 mg artesunate for 18 days.The axillary temperature of the patient ranged between 37.0 and 37.7℃ from Day 0 to Day 3,and blood microscopy revealed falciparum malaria parasitemia(26674 asexual parasites/μl)on Day 3.The patient was afebrile on Day 4,falciparum malaria parasitemia was continuously present and then gradually decreased on the next days,and was negative on Day 21.The patient was cured and left hospital on Day 24 after no plasmodium falciparum was found in the blood on Day 21 to Day 23.No mutation was found in the K13 propeller gene when compared with the PF3D7_1343700 K13 propeller gene reference sequence.Conclusions:This is the first reported case in China of prolonged parasite clearance in a splenectomized patient with imported falciparum malaria.Artemisinin resistance should be distinguished when prolonged parasite clearance is found in a malaria patient who has had splenectomy.
基金National Natural Science Foundation of China,Grant/Award Numbers:82071834,82101896,82271839Dalian Medical University Interdisciplinary Research Cooperation Project Team Funding,Grant/Award Number:JCHZ2023010。
文摘Background::Rheumatoid arthritis(RA)is a chronic autoimmune inflammatory disease.Its pathogenesis is not fully understood,and early diagnosis is challenging owing to the lack of effective biomarkers.This study aimed to analyze different samples to identify potential biomarkers and therapeutic targets.Methods::Microarray datasets of RA,osteoarthritis(OA),and healthy control(HC)were downloaded from the Gene Expression Omnibus database.R software was used to identify differentially expressed genes(DEGs),which were visualized using volcano and heat maps.Venn diagrams,principal component analysis,gene set enrichment analysis,gene ontology,and Kyoto Encyclopedia of genes and genomes were used to analyze the data.A protein–protein interaction network was constructed,and synovial tissues from patients with RA and OA were collected for verification using the collagen-induced arthritis mouse model.Results::More DEGs were found in synovial tissues than in peripheral blood mononuclear cells or fibroblast-like synoviocytes.Principal component analysis revealed significant differences between the RA and OA samples,highlighting the unique advantages of synovial tissue.Enrichment analysis revealed that metabolic and cytokine signaling pathways play crucial roles in the development of RA.Further analysis of the four synovial datasets identified 54 DEGs,of which signaling lymphocytic activation molecule family(SLAMF)8 was identified as the key molecule.SLAMF8 levels were increased in the synovial tissue of patients with RA compared to those of patients with OA(0.38±0.19 vs.12.40±1.66),and SLAMF8 levels were similarly elevated in collagen-induced arthritis model mice compared with those in the healthy mice(1.13±0.47 vs.9.05±2.52).Conclusions::This study established the unique advantages of synovial tissue for RA research and identified metabolic and cytokine signaling pathways as important for RA development.Thus,SLAMF8 may be a potential therapeutic target for RA.
