Tuberculosis of the greater trochanter of the femur is caused by mycobacterium tuberculosis directly or indirectly invading the greater trochanter of the femur.The clinical manifestations are intermittent pain on the ...Tuberculosis of the greater trochanter of the femur is caused by mycobacterium tuberculosis directly or indirectly invading the greater trochanter of the femur.The clinical manifestations are intermittent pain on the side,low fever and night sweat all over the body.The patient was admitted to the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine on May 27,2020 with the chief complaint of"intermittent pain in the left hip for 2 years,aggravated for more than 1 month".The pre-admission examination was diagnosed as a"bone defect of the left femoral greater trochanter to be investigated."After admission,relevant examinations were actively improved,but the diagnosis could not be clearly made.The diagnosis was left with greater trochanter tuberculosis.The case report,draws the following conclusions:the disease is characterized by insidious onset,low incidence and atypical symptoms,which is prone to misdiagnosis and missed diagnosis in clinical practice.Imaging and laboratory tests can provide more diagnostic evidence before diagnosis,but pathological examination is the main basis for diagnosis.In addition,since the symptoms are not obvious and it is difficult to obtain pathological tissues in the early stage,most patients reach the advanced stage of the disease when they are first diagnosed.The diagnosis and treatment thinking of doctors is relatively fixed when they treat patients.This paper aims to improve the understanding and treatment ideas of the clinical characteristics,laboratory and imaging examination of the disease by reporting this case,which is of great significance to the diagnosis and treatment of the disease.展开更多
Objective： To assess the efficacy and safety of mouse nerve growth factor （mNGF） in patients with peripheral nerve injury. Methods： Such electronic database as Cochrane Library （Issue 1,2011）, Medline （1950-2...Objective： To assess the efficacy and safety of mouse nerve growth factor （mNGF） in patients with peripheral nerve injury. Methods： Such electronic database as Cochrane Library （Issue 1,2011）, Medline （1950-2011）, Embase （1980- 2011）, National Knowledge Infrastructure （ 1979 -2011 ） were searched and meanwhile relevant journals such as Chinese Journal of Orthopaedics, Chinese Journal of Microsurgery, Chinese Journal of Neurosurgery, ere were searched as well to collect all randomized controlled trials and quasi-randomi- zed controlled trials of mNGF on patients with peripheral nerve injury. The quality of included studies was assessed according to the criteria recommended by the Cochrane Handbook for Systematic Reviews of Interventions and the data were extracted by two reviewers independently. Meta- analysis was conducted by RevMan 5.1 software. Results： Forty-one studies involving 3 304 patients with peripheral nerve injury were included. The results of meta-analysis showed that： （1） the total effective rate ofperipheral nerve injury treatment in mNGF group was obviously higher than that in control group （OR=6.36, 95% C1 4.96-8.15, P〈0.01）; （2） the scores of activities of daily living （ADL） in mNGF group was significantly higher than that in control group （weighted mean difference=1.97, 95% CI 1.33- 2.61, P〈 0.0 l）; （3） the incidence of adverse reaction in mNGF group was higher than that in control group, （OR= 1.66, 95% CI 1.61-2.38, P=0.006）, but the adverse effects were mild, which could be relieved without specific treatment or just given symptomatic treatment, and disappeared at the end of treatment. Conclusions： The mNGF therapy is effective for peripheral nerve injury. It can obviously improve patient＇s ADL. Though the incidence of adverse reaction in mNGF treatment group is higher than that in control group, this does not influence the treatment outcomes.展开更多
基金was funded by Key Research And Development Project of Science and Technology Department of Shaanxi Province(No.2021SF419)Key Research And Development Program of Social Development of Xianyang Science and Technology Bureau(No.2020K02-109)+1 种基金Discipline Construction Innovation Team of Shaanxi University of Traditional Chinese Medicine(No.2019YL-02)Shaanxi University of Traditional Chinese Medicine Graduate Student Innovation Project of Universal-level scientific Research Project(Study on the mechanism of acupotomy in the treatment of femoral head necrosis 2021CX12)。
文摘Tuberculosis of the greater trochanter of the femur is caused by mycobacterium tuberculosis directly or indirectly invading the greater trochanter of the femur.The clinical manifestations are intermittent pain on the side,low fever and night sweat all over the body.The patient was admitted to the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine on May 27,2020 with the chief complaint of"intermittent pain in the left hip for 2 years,aggravated for more than 1 month".The pre-admission examination was diagnosed as a"bone defect of the left femoral greater trochanter to be investigated."After admission,relevant examinations were actively improved,but the diagnosis could not be clearly made.The diagnosis was left with greater trochanter tuberculosis.The case report,draws the following conclusions:the disease is characterized by insidious onset,low incidence and atypical symptoms,which is prone to misdiagnosis and missed diagnosis in clinical practice.Imaging and laboratory tests can provide more diagnostic evidence before diagnosis,but pathological examination is the main basis for diagnosis.In addition,since the symptoms are not obvious and it is difficult to obtain pathological tissues in the early stage,most patients reach the advanced stage of the disease when they are first diagnosed.The diagnosis and treatment thinking of doctors is relatively fixed when they treat patients.This paper aims to improve the understanding and treatment ideas of the clinical characteristics,laboratory and imaging examination of the disease by reporting this case,which is of great significance to the diagnosis and treatment of the disease.
文摘Objective： To assess the efficacy and safety of mouse nerve growth factor （mNGF） in patients with peripheral nerve injury. Methods： Such electronic database as Cochrane Library （Issue 1,2011）, Medline （1950-2011）, Embase （1980- 2011）, National Knowledge Infrastructure （ 1979 -2011 ） were searched and meanwhile relevant journals such as Chinese Journal of Orthopaedics, Chinese Journal of Microsurgery, Chinese Journal of Neurosurgery, ere were searched as well to collect all randomized controlled trials and quasi-randomi- zed controlled trials of mNGF on patients with peripheral nerve injury. The quality of included studies was assessed according to the criteria recommended by the Cochrane Handbook for Systematic Reviews of Interventions and the data were extracted by two reviewers independently. Meta- analysis was conducted by RevMan 5.1 software. Results： Forty-one studies involving 3 304 patients with peripheral nerve injury were included. The results of meta-analysis showed that： （1） the total effective rate ofperipheral nerve injury treatment in mNGF group was obviously higher than that in control group （OR=6.36, 95% C1 4.96-8.15, P〈0.01）; （2） the scores of activities of daily living （ADL） in mNGF group was significantly higher than that in control group （weighted mean difference=1.97, 95% CI 1.33- 2.61, P〈 0.0 l）; （3） the incidence of adverse reaction in mNGF group was higher than that in control group, （OR= 1.66, 95% CI 1.61-2.38, P=0.006）, but the adverse effects were mild, which could be relieved without specific treatment or just given symptomatic treatment, and disappeared at the end of treatment. Conclusions： The mNGF therapy is effective for peripheral nerve injury. It can obviously improve patient＇s ADL. Though the incidence of adverse reaction in mNGF treatment group is higher than that in control group, this does not influence the treatment outcomes.
