Objective:To study the changes of serum vaspin levels in hyperthyroidism and hypothyroidism,and the correlation between serum vaspin and FT3,FT4,TSH and HOMA-IR.Methods:According to the diagnostic criteria of hyperthy...Objective:To study the changes of serum vaspin levels in hyperthyroidism and hypothyroidism,and the correlation between serum vaspin and FT3,FT4,TSH and HOMA-IR.Methods:According to the diagnostic criteria of hyperthyroidism and hypothyroidism published in the 8th edition of internal medicine,the patients were divided into hyperthyroidism group(n=47),male 14,female 33,average age(35+9)years;hypothyroidism group:23 hypothyroidism patients,7 males and 16 females,with an average age of(38+10)years.The blood pressure,height and weight of all the participants were measured by a specially assigned person,and the body mass index(BMI-weight(kg)/height(M)and ankle brachial index(ABI)were calculated.Venous blood samples were drawn from all subjects after fasting for 8 hours in the moring to determine biochemical indexes.Fasting insulin(fins)was measured by chemiluminescence method,insulin resistance index(HOMA-IR,HOMA-IR==FPGx fins/22.5)was calculated by homeostasis model assessment(HOMA-IR),and HbA1c was determined by high-pressure liquid chromatography.The levels of FT3,FT4 and TSH were detected by radioimmunoassay.Serum vaspin levels were measured by ELISA Results:The level of BMI in hypothyroidism group was significantly higher than that in hyperthyroidism group and control group(P<0.01),BMI level in hyperthyroidism group was significantly lower than that in control group(P<0.05),FT3 and FT41evels in hyperthyroidism group were significantly higher than those in hypothyroidism group and control group(P<0.01),TSH level in hypothyroidism group was significantly higher than that in control group and hyperthyroidism group(P<0.01).The level of FPG in byperthyroidism group was significantly higher than that in contro1 group(P<0.01),but there was no significant difference between bhyperthyroidism group and hypothyroidism group.and fins level in hypothyroidism group was significantly higher than that in contro1 group and hyperthyroidism group(P<0.01).The leve1 of HOMA-IR in hyperthyroidism and hypothyroidism group was significantly higher than that in control group(P<0.01).Compared with the control group and the control group,the blood 1ipid indexes(TC,LDL-Q)in the hyperthyroidism group were lower than tlose in the control group and hypothyroidism group(P<0.01),and all the blood 1ipid indexes in the hypothyroidism group were significantly different from those in the control group(P<0.01).The vaspin level of hyperthyroidism group was significantly higher than that of control group and bypothyroidism group,and the latter two groups showed that the level of vaspin in hypothyroidism group was significantly lower than that of control group(P<0.05).Correlation analysis showed that serum vaspin was positively correlated with FT3 and FT4(r=0.255,P=0.005;r=0.327,P=0.001),and negatively correlated with BMI,TC and HDL(r=-0.250,P=0.006;r=-0.244,P=0.007;r=0.258,P=0.004).).Conclusion:Serum vaspin 1eve1 is related to thyroid function.The 1evel of serum vaspin increases in hyperthyroidism and decreases in hypothyroidism.Abnormal changes of fat factor vaspin are associated with thyroid dysfunction.展开更多
Background:The fetal growth charts in widest use in China were published by Hadlock>35 years ago and were established on data from several hundred of American pregnant women.After that,>100 fetal growth charts w...Background:The fetal growth charts in widest use in China were published by Hadlock>35 years ago and were established on data from several hundred of American pregnant women.After that,>100 fetal growth charts were published around the world.We attempted to assess the impact of applying the long-standing Hadlock charts and other charts in a Chinese population and to compare their ability to predict newborn small for gestational age(SGA).Methods:For this retrospective observational study,we reviewed all pregnant women(n=106,455)who booked prenatal care with ultrasound measurements for fetal biometry at the Shenzhen Maternity and Child Healthcare Hospital between 2012 and 2019.A fractional polynomial regression model was applied to generate Shenzhen fetal growth chart ranges for head circumference(HC),biparietal diameter(BPD),abdominal circumference(AC),and femur length(FL).The differences between Shenzhen charts and published charts were quantified by calculating the Z-score.The impact of applying these published charts was quantifed by calculating the proportions of fetuses with biometric measurements below the 3rd centile of these charts.The sensitivity and area under the receiver operating characteristic curves of published charts to predict neonatal SGA(birthweight<10th centile)were assessed..Results:Following selection,169,980 scans of fetal biometry contributed by 41,032 pregnancies with reliable gestational age were analyzed.When using Hadlock references(<3rd centile),the proportions of small heads and short femurs were as high as 8.9%and 6.6%in late gestation,respectively.The INTERGROWTH-21st standards matched those of our observed curves better than other charts,in particular for fat-free biometry(HC and FL).When using AC<10th centile,all of these references were poor at predicting neonatal SGA.Conclusions:Applying long-standing Hadlock references could misclassify a large proportion of fetuses as SGA.INTERGROWTH-21st standard appears to be a safe option in China.For fat-based biometry,AC,a reference based on the Chinese population is needed.In addition,when applying published charts,particular care should be taken due to the discrepancy of measurement methods.展开更多
基金The authors are grateful to the Key Laboratory of Cardiovascular Remodeling and Function Research Center,Qilu Hospital of Shandong University for technical assistance.The work was supported by a grant from Shandong Province medical and health science and technology development program(No.2015ws0446).
文摘Objective:To study the changes of serum vaspin levels in hyperthyroidism and hypothyroidism,and the correlation between serum vaspin and FT3,FT4,TSH and HOMA-IR.Methods:According to the diagnostic criteria of hyperthyroidism and hypothyroidism published in the 8th edition of internal medicine,the patients were divided into hyperthyroidism group(n=47),male 14,female 33,average age(35+9)years;hypothyroidism group:23 hypothyroidism patients,7 males and 16 females,with an average age of(38+10)years.The blood pressure,height and weight of all the participants were measured by a specially assigned person,and the body mass index(BMI-weight(kg)/height(M)and ankle brachial index(ABI)were calculated.Venous blood samples were drawn from all subjects after fasting for 8 hours in the moring to determine biochemical indexes.Fasting insulin(fins)was measured by chemiluminescence method,insulin resistance index(HOMA-IR,HOMA-IR==FPGx fins/22.5)was calculated by homeostasis model assessment(HOMA-IR),and HbA1c was determined by high-pressure liquid chromatography.The levels of FT3,FT4 and TSH were detected by radioimmunoassay.Serum vaspin levels were measured by ELISA Results:The level of BMI in hypothyroidism group was significantly higher than that in hyperthyroidism group and control group(P<0.01),BMI level in hyperthyroidism group was significantly lower than that in control group(P<0.05),FT3 and FT41evels in hyperthyroidism group were significantly higher than those in hypothyroidism group and control group(P<0.01),TSH level in hypothyroidism group was significantly higher than that in control group and hyperthyroidism group(P<0.01).The level of FPG in byperthyroidism group was significantly higher than that in contro1 group(P<0.01),but there was no significant difference between bhyperthyroidism group and hypothyroidism group.and fins level in hypothyroidism group was significantly higher than that in contro1 group and hyperthyroidism group(P<0.01).The leve1 of HOMA-IR in hyperthyroidism and hypothyroidism group was significantly higher than that in control group(P<0.01).Compared with the control group and the control group,the blood 1ipid indexes(TC,LDL-Q)in the hyperthyroidism group were lower than tlose in the control group and hypothyroidism group(P<0.01),and all the blood 1ipid indexes in the hypothyroidism group were significantly different from those in the control group(P<0.01).The vaspin level of hyperthyroidism group was significantly higher than that of control group and bypothyroidism group,and the latter two groups showed that the level of vaspin in hypothyroidism group was significantly lower than that of control group(P<0.05).Correlation analysis showed that serum vaspin was positively correlated with FT3 and FT4(r=0.255,P=0.005;r=0.327,P=0.001),and negatively correlated with BMI,TC and HDL(r=-0.250,P=0.006;r=-0.244,P=0.007;r=0.258,P=0.004).).Conclusion:Serum vaspin 1eve1 is related to thyroid function.The 1evel of serum vaspin increases in hyperthyroidism and decreases in hypothyroidism.Abnormal changes of fat factor vaspin are associated with thyroid dysfunction.
基金supported by grants from the Shenzhen Science and Technology Project(No.JCYJ20210324130812035)The National Key Research and Development Program of China(No.2018YFC1002200).
文摘Background:The fetal growth charts in widest use in China were published by Hadlock>35 years ago and were established on data from several hundred of American pregnant women.After that,>100 fetal growth charts were published around the world.We attempted to assess the impact of applying the long-standing Hadlock charts and other charts in a Chinese population and to compare their ability to predict newborn small for gestational age(SGA).Methods:For this retrospective observational study,we reviewed all pregnant women(n=106,455)who booked prenatal care with ultrasound measurements for fetal biometry at the Shenzhen Maternity and Child Healthcare Hospital between 2012 and 2019.A fractional polynomial regression model was applied to generate Shenzhen fetal growth chart ranges for head circumference(HC),biparietal diameter(BPD),abdominal circumference(AC),and femur length(FL).The differences between Shenzhen charts and published charts were quantified by calculating the Z-score.The impact of applying these published charts was quantifed by calculating the proportions of fetuses with biometric measurements below the 3rd centile of these charts.The sensitivity and area under the receiver operating characteristic curves of published charts to predict neonatal SGA(birthweight<10th centile)were assessed..Results:Following selection,169,980 scans of fetal biometry contributed by 41,032 pregnancies with reliable gestational age were analyzed.When using Hadlock references(<3rd centile),the proportions of small heads and short femurs were as high as 8.9%and 6.6%in late gestation,respectively.The INTERGROWTH-21st standards matched those of our observed curves better than other charts,in particular for fat-free biometry(HC and FL).When using AC<10th centile,all of these references were poor at predicting neonatal SGA.Conclusions:Applying long-standing Hadlock references could misclassify a large proportion of fetuses as SGA.INTERGROWTH-21st standard appears to be a safe option in China.For fat-based biometry,AC,a reference based on the Chinese population is needed.In addition,when applying published charts,particular care should be taken due to the discrepancy of measurement methods.
