Long COVID is characterized by a group of persistent symptoms following the acute SARS-COV2 infection, which presented a multifaceted challenge to the healthcare systems all over the globe. The long COVID symptoms spa...Long COVID is characterized by a group of persistent symptoms following the acute SARS-COV2 infection, which presented a multifaceted challenge to the healthcare systems all over the globe. The long COVID symptoms span various organ systems including the respiratory, cardiovascular, gastrointestinal, and neurological manifestations. Mitochondrial dysfunction and immune dysregulation play crucial roles in the long COVID pathophysiology. Recently nutritional intervention gained much attention in managing post-viral syndromes. Effective interventions like supplementation of omega-3 fatty acid, macro and micro nutrients, and vitamins help to reduce systemic inflammation and counteract muscle wasting. Other approaches like nutritional recovery, dietetic interventions, continuous nutritional care post-hospital discharge, nutritional rehabilitation programs,whole-diet approaches like Mediterranean diet, plant-based diet, and caloric optimization, improve overall functional recovery. Physical activity and exercise regimes have been shown to improve fatigue, dyspnea, and cognitive function. Tailored exercise regimes may promote safe rehabilitation. Certain ineffective interventions,such as non-personalized approaches, high dose of antioxidants, use of herbal products that are not clinically validated need to be addressed. Dietary interventions such as personalized nutritional counseling have been demonstrated to improve physical performance in long COVID patients. Further research is needed to refine protocols and identify optimal combinations of dietary and movement-based therapies to support the recovery of long-COVID patients. This narrative review focuses on the ongoing researches that reveals the intricate relationship between nutrition and long COVID recovery and also establishes effective protocols for nutritional care.展开更多
BACKGROUND Hashimoto’s thyroiditis(HT)is an autoimmune dysfunction caused by genetic and environmental changes that attack the thyroid gland.HT affects approximately 2%to 5%of the population,being more prevalent in w...BACKGROUND Hashimoto’s thyroiditis(HT)is an autoimmune dysfunction caused by genetic and environmental changes that attack the thyroid gland.HT affects approximately 2%to 5%of the population,being more prevalent in women.It is diagnosed through a blood test(anti-thyroid peroxidase).Pharmacological treatment consists of daily administration of the synthetic hormone levothyroxine on an empty stomach.The most common signs and symptoms are:Tissue resistance to triiodothyronine T3,weight gain,dry skin,hair loss,tiredness/fatigue,and constipation,and nutritional therapy appears to help reduce these symptoms.AIM To analyze nutritional interventions for treating HT.METHODS This is an integrative review of original studies on nutritional interventions for treating Hashimoto’s disease.Articles were searched in the MEDLINE/PubMed and Latin American and Caribbean Literature on Health Sciences(LILACS)databases via virtual health library,using controlled vocabulary and free terms.A total of 70 articles were found:67 from PubMed and 3 from LILACS.After exclusions,9 articles met the eligibility criteria,including dietary interventions for maintaining and restoring the patient’s quality of life.RESULTS The reviewed articles evaluated the nutritional treatment of HT through supplementation of deficient micronutrients,anti-inflammatory diets,gluten-free diets,exclusion of foods that cause food sensitivities,lactose-free diet,paleo diet,and calorie restriction diets.However,some results were controversial regarding the beneficial effects of HT.CONCLUSION In general,it was observed that nutritional interventions for HT are based on the recovery of micronutrient deficiencies,treatment of the intestinal microbiota,diet rich in foods with anti-inflammatory properties,lifestyle changes,and encouragement of healthy habits.展开更多
Increasing access to locally produced, safe, nutritious and affordable complementary foods is essential to combat micronutrient deficiencies in young children in low- and middle-income countries. Two formulations of s...Increasing access to locally produced, safe, nutritious and affordable complementary foods is essential to combat micronutrient deficiencies in young children in low- and middle-income countries. Two formulations of sweets based on jujube, baobab fruit powder and sweet potato puree were produced, and their nutritional values and sensory properties such as taste, smell, color and acceptability were assessed. The formulation containing the most jujube powder, baobab fruit and sweet potato puree gave the best nutritional value. The sweets are rich in calcium (259.80 mg/100 g), magnesium (67.98 mg/100 g), potassium (782.04 mg/100 g), vitamin C (32.37 mg/100 g), iron (6.45 g mg/100 g) and zinc (0.97 mg/100 g). Sensory tests on the two formulations showed acceptability scores ranging from 81.26% to 84.58%, well above the minimum acceptable threshold. Candies with jujube, baobab fruit powder and sweet potato puree could be an alternative for preventing micronutrient deficiencies.展开更多
Objective:To analyze body composition measurements and explore their correlation with the nutritional risk screening score and neutrophil-to-lymphocyte ratio(NLR;an index of inflammation)to provide a basis for the per...Objective:To analyze body composition measurements and explore their correlation with the nutritional risk screening score and neutrophil-to-lymphocyte ratio(NLR;an index of inflammation)to provide a basis for the perioperative and nutritional management of patients with gynecologic malignancy.Methods:This study included 77 patients with gynecologic malignancies confirmed by surgical pathology between December 2021 and January 2023.Preoperative body composition data were obtained using bioelectrical impedance analysis.Nutritional risk screening and assessment were performed.Differences in body composition by age,nutritional status,International Federation of Gynecology and Obstetrics(FIGO)stage,systemic inflammatory response,and type of gynecologic malignancy were compared.Results:The extracellular water ratio was significantly higher in patients with a high FIGO stage than in those with a low FIGO stage(t=4.047,P<0.001).Other body composition parameters were lower in patients with a high FIGO stage than in those with a low FIGO stage(P<0.05).Regarding the NLR,the extracellular water ratio was significantly higher in patients with a high NLR than in those with a low NLR(t=2.929,P=0.005).As the nutritional condition worsened,the extracellular water ratio increased(H=12.291,P=0.002),with no significant difference in other body composition parameters between patients with different nutritional conditions(H=5.118,P=0.077).Other body composition parameters decreased with the nutritional condition,which was statistically significant(P<0.05).Conclusions:Bioelectrical impedance analysis is an easy-to-perform,noninvasive,and reproducible measurement technique that can assess changes in body composition.Body composition analysis can effectively determine an individual’s nutritional and metabolic status,providing a reference for the management of patients with gynecologic malignancy,and potentially providing predictive biomarkers to stratify these patients.展开更多
University students,transitioning from adolescence to adulthood,are at a critical stage where dietary habits and health behaviors are established,influencing long-term health outcomes.This study aimed to assess the di...University students,transitioning from adolescence to adulthood,are at a critical stage where dietary habits and health behaviors are established,influencing long-term health outcomes.This study aimed to assess the dietary intake and nutritional awareness of a population of Chinese university students(n=833),comparing their consumption with national dietary guidelines and reference intakes,while exploring subgroup differences.Results indicated that males had significantly higher amounts of most food categories compared to females.Except for whole grains and legumes,ethnic minorities had lower compliance with the recommended intakes for several food categories compared to Han Chinese.Han males consumed more energy,protein,and fat than their ethnic minority counterparts.Obese participants showed higher protein and fat intake compared to those with normal body mass index(BMI).Additionally,BMI-related trends in macronutrient contributions showed that protein and fat contributed more to the total energy intake of individuals with higher BMI.Han individuals also had higher energy contributions from protein and fat and lower carbohydrate contributions compared to ethnic minorities.Nutrient intake was generally below recommended levels,with low proportions of participants meeting the recommended intake for vitamin A,C,calcium and dietary fiber.High proportions of participants exceeded the tolerable upper intake levels for iron and manganese.Nutritional awareness scores were also significantly higher among Han students,as well as those with higher BMIs and higher income levels.This study highlights significant disparities in dietary intake and nutritional awareness among Chinese university students,with variations across sex,ethnicity,BMI,and income categories.展开更多
Deep phenotyping and genetic characterization of individuals are fundamental to assessing the metabolic status and determining nutrition-specific requirements.This study aimed to ascertain the utmost effectiveness of ...Deep phenotyping and genetic characterization of individuals are fundamental to assessing the metabolic status and determining nutrition-specific requirements.This study aimed to ascertain the utmost effectiveness of personalized interventions by aligning dietary adjustments with both the genotype and metabolotype of individuals.Therefore,we assessed here the usefulness of a polygenic score(PGS)characterizing a potential pro-inflammatory profile(PGSi)as a nutrigenetic tool to discern individuals from the Danish PREVENTOMICS cohort that could better respond to precision nutrition(PN)plans,specifically targeted at counteracting the low-grade inflammatory profile typically found in obesity.The cohort followed a PN plan to counteract the pro-inflammatory profile(PNi group)or generic dietary recommendations(Control)for 10 weeks.PGSi was applied for genetic stratification(Low/High).The effects of the intervention on anthropometrics and biomarkers related to inflammatory profile and carbohydrate metabolism were assessed.Around 30%of subjects had a high genetic predisposition to pro-inflammatory status(high-PGSi).These individuals demonstrated the most effective response to the dietary plan,experiencing improved body composition,with significant decreases in body weight(∆:-4.84%;P=0.039)and body fat(∆:-4.86%;P=0.007),and beneficial changes in pro-and anti-inflammatory biomarkers,with significant increases in IL-10(∆:71.3%;P=0.025)and decreases in TNF-α(∆:-3.0%;P=0.048),CRP(∆:-31.1%),ICAM1(∆:-5.8%),and MCP1(∆:-4.2%)circulating levels,compared to low-PGSi individuals.Both phenotypic and genetic stratification contributed to a better understanding of metabolic heterogeneity in response to diet.This approach allows for refinement of the prediction of individual requirements and potentially for better management of obesity.展开更多
Objective:It was conducted to evaluate the susceptibility to ON(orthorexia nervosa)in the students of the nutrition and dietetics department according to the variables of gender,age and BMI(body massındex).Subjects an...Objective:It was conducted to evaluate the susceptibility to ON(orthorexia nervosa)in the students of the nutrition and dietetics department according to the variables of gender,age and BMI(body massındex).Subjects and Methods:The research covers the students of Marmara University Faculty of Health Sciences,Department of Nutrition and Dietetics in September-October 2017-2018 academic year.The data were collected by survey method.Socio-demographic characteristics and anthropometric measurements of the participants were questioned.EAT-40(Eating Attitude Test),ORTO-15 test and MOCI(Maudsley Obsessive Compulsive Inventory)were used in the study.It was evaluated with SPSS(The Statistical Package for The Social Sciences)21.0 program.Results:205 people participated in the study.EAT-40 scores were found to be≤20 in 94%of the women and 95.2%of the men in the study.The EAT-40 score is≥21 in 6%of women and 4.8%of men in the study(p=0.646>0.05).The ORTO-15 score of 72.3%of women and 71.4%of men is≤40(p=0.934>0.05).EAT-40 average is 10.25±1.10 in underweight.It was found to be 9.21±0.42 in normals and 8.23±0.76 in slightly obese subjects(p=0.758>0.05).ORTO-15 average of those with BMI≤18.49 kg/m2 is 39.59±0.54;Those with 18.50-24.99 kg/m2 were found to be 38.30±0.25 and those with 25.00-29.99 kg/m2 were found to be 39.54±0.75(p=0.098>0.05).As the EAT-40 score increased,the ORTO-15 score decreased.It shows a negative,statistically significant difference between EAT-40 and ORTO-15 scores(p=0.00<0.05).Conclusion:It was concluded that orthorexic tendency is common(72.2%)in nutrition dietetic students,and ON is associated with BMI and EAT-40 scores.In terms of ON,it would be beneficial to conduct comprehensive international studies and determine DSM(Diagnostic and Statistical Manual of Mental Disorders)diagnostic criteria.展开更多
Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank...Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank,sarcopenia was diagnosed according to European and Asian Working Groups for Sarcopenia criteria.Social isolation was assessed using standardized questionnaires,including questions on solitude,frequency of social activities,contact with others,and marital status(for the CLHLS only).Results During the follow-up period,8,249 deaths occurred in the CLHLS and 26,670 deaths in the UK Biobank groups.While no significant interaction was observed between sarcopenia and social isolation in predicting all-cause mortality in the CLHLS cohort,the association between social isolation and mortality was stronger among individuals with sarcopenia in the UK Biobank(P-interaction=0.03,relative risk due to interaction:0.23,95%confidence interval[CI]:0.06–0.41).Further joint analyses showed that participants with sarcopenia and high levels of social isolation had the highest mortality risk(hazard ration[HR]:1.99;95%CI:[1.74–2.28]in the CLHLS and 1.69[1.55–1.85]in the UK Biobank)compared to those without either condition.Conclusion The combination of social isolation and sarcopenia synergistically increases the risk of mortality in middle-aged and older adults across diverse populations.展开更多
Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva a...Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva and serum samples were collected before and immediately after an incremental running-toexhaustion treadmill test in fifteen young adults(mean age [23.9 ± 2.9] years, eight females), with samples analyzed for guanidinoacetic acid, creatine, and creatinine using a liquid chromatography–tandem mass spectrometry method.Results: Following exercise, there was a substantial elevation in salivary creatine levels from(17.5 ± 14.2)μmol·L^(-1) to(43.6 ± 30.4) μmol·L^(-1)(p < 0.001), coupled with a significant increase in salivary creatinine from(11.3 ± 5.8) μmol·L^(-1) to(17.0 ± 9.3) μmol·L^(-1)(p = 0.04). In contrast, serum creatine levels were unaffected by exercise(p = 0.80), while creatinine levels exhibited a strong tendency to decrease post-exercise(from [81.8 ±17.5] μmol·L^(-1) to [73.1 ± 11.6] μmol·L^(-1);p = 0.06). A comparison of the slopes of the two regression lines(saliva vs. serum) revealed significant differences for both creatine(p = 0.01) and creatinine(p = 0.03).Conclusions: The above findings suggest a potential difference in the dynamics of creatine metabolites in these two bodily fluids, both pre and post-exercise.展开更多
Background:Although light-intensity physical activity(LPA)has been suggested to be associated with a lower risk of mortality,the minimal and optimal volumes of LPA remain unclear.We aimed to examine the minimal and op...Background:Although light-intensity physical activity(LPA)has been suggested to be associated with a lower risk of mortality,the minimal and optimal volumes of LPA remain unclear.We aimed to examine the minimal and optimal volumes of LPA associated with the risks of mortality and disease incidence(i.e.,cardiovascular diseases and cancer).Methods:Data were derived from the population-based UK Biobank cohort study,including 69,492 adults aged 43-78 years.Accelerometermeasured LPA was defined using a validated,published machine learning-based Random Forest activity method,which was categorized into 4 quartile groups.All-cause and cause-specific mortality(cardiovascular disease-and cancer-specific)were determined according to the International Classification of Diseases,10th version codes.Disease incidence was defined based on primary care,hospitalization,or death records.Results:During a median follow-up period of 8.04 years,2024 adults died from all causes,539 from cardiovascular disease,and 1175 from cancer.For all-cause mortality,compared with participants in the lowest quartile of LPA(<3.9 h/day),the hazard ratios(HRs)and 95%confidence intervals(95%CIs)were 0.82(95%CI:0.73-0.93)for those with 3.9 to<5.0 h/day,0.75(95%CI:0.66-0.85)for those with 5.0 to<6.1 h/day,and 0.77(95%CI:0.68-0.88)for those with≥6.1 h/day,respectively.There was an inverse non-linear dose-response association between LPA and all-cause mortality,with an optimal dose of 5.72 h/day(95%CI:5.45-6.41;HR=0.63,95%CI:0.56-0.71)and a minimal dose of 3.59 h/day(95%CI:3.53-8.56;HR=0.81,95%CI:0.78-0.86),with the 5th percentile as the reference.Similar patterns were observed for cause-specific mortality and disease incidence(cardiovascular disease and cancer).Conclusion:Engaging in LPA for~3.5 h/day was conservatively associated with lower risk of mortality and disease incidence,with further risk reductions observed up to an optimal dose of~6.0 h/day.These findings suggest that sufficient LPA offers important health benefits,which can inform the development of future PA guidelines.展开更多
Background:The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood.The objective of the current study was to ascertain the influence of a supervised concurrent exercise...Background:The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood.The objective of the current study was to ascertain the influence of a supervised concurrent exercise intervention from gestational Week 17 until birth on key cytokines involved in placental development and function.Secondary aims were to explore:(a)the moderating effects of fetal sex and maternal weight status;and(b)whether gestational weight gain,lifestyle behaviors(diet,sleep patterns,and physical activity),and physical fitness(strength and cardiorespiratory fitness)mediated the effects of exercise on placental cytokines.Methods:Seventy-six pregnant women(33±4 years,mean±SD),divided into exercise(n=40)and control(n=36)groups,participated in this study.The exercise group followed a 60-min,3 days/week(aerobic+resistance)training program of moderate-to-vigorous intensity.Placental cytokines—including granulocyte-macrophage colony-stimulating factor(GM-CSF),granulocyte colony-stimulating factor(G-CSF),plateletderived growth factor AA(PDGF-AA),epidermal growth factor(EGF),monocyte chemoattractant protein-1(MCP-1),fractalkine,interleukin(IL)-8,IL-6,IL-1β,interleukin 1-receptor antagonist(IL-1ra),IL-10,tumor necrosis factor alpha(TNF-a),and interferon gamma(IFN-γ)were analyzed using Luminex multi-analyte profiling(x MAP)technology.Results:The exercise group presented higher placental levels of G-CSF and lower concentrations of EGF and IL-1ra than the control group(p<0.05).Significant effects of exercise on placental G-CSF and TNF-a(p<0.05)and a trend toward lower IL-6(p=0.08)were observed only in female placentas.Additionally,a reduction in weight gain partially mediated the effects of exercise on G-CSF(p<0.05).Conclusion:Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels.Some exercise-induced effects are observed exclusively in female placentas,including increased G-CSF and lower TNF-a and IL-6 concentrations.Notably,the increased levels of G-CSF observed with exercise might be due to a more adequate gestational weight gain.展开更多
Purpose:The purpose of this study was to examine the associations between adherence to the 24-Hour Movement Guidelines and all-cause and cause-specific mortality in a large Spanish prospective cohort.Methods:We analyz...Purpose:The purpose of this study was to examine the associations between adherence to the 24-Hour Movement Guidelines and all-cause and cause-specific mortality in a large Spanish prospective cohort.Methods:We analyzed data from 14,288 participants of the Seguimiento Universidad de Navarra(SUN)Project,followed for a mean of 12.8 years(mean baseline age=38.3 years;60.1%women).Data were collected at baseline and through biennial follow-up questionnaires(up to 10 waves,depending on year of entry).The participants self-reported 24-h movement behaviors at baseline and were categorized based on the number of guidelines met(0-3).Behaviors were assessed at baseline only;changes in adherence during follow-up were not accounted for.Cox proportional hazards models were used to estimate hazard ratios(HRs)for all-cause and cause-specific mortality,adjusting for sociodemographic,lifestyle,and clinical covariates.Results:Meeting a greater number of 24-Hour Movement Guidelines at baseline was associated with a progressively lower risk of all-cause mortality.Compared with those meeting none,the multivariable-adjusted HRs were 0.52(95%confidence interval(95%CI):0.33-0.82)for meeting 1 guideline,0.47(95%CI:0.30-0.73)for meeting 2 guidelines,and 0.44(95%CI:0.28-0.71)for meeting all 3 guidelines.Only adherence to the physical activity guidelines was independently associated with a significantly lower mortality risk(HR=0.70;95%CI:0.55-0.89).A reduced risk was also observed for cancer and other-cause mortality among those meeting 2 or more guidelines.Conclusion:Adherence to the 24-Hour Movement Guidelines at baseline,particularly physical activity,was associated with a lower risk of mortality.Promoting an integrated approach to movement behaviors may be an effective strategy for improving population health and longevity.展开更多
Objective： To discuss whether nutritional risk screening 2002 （NRS2002） is appropriate for nutritional risk screening for leukemia patients before and after hematopoietic stem cell transplantation （HSCT）, and whe...Objective： To discuss whether nutritional risk screening 2002 （NRS2002） is appropriate for nutritional risk screening for leukemia patients before and after hematopoietic stem cell transplantation （HSCT）, and whether there are risk differences in other conditions, such as age, gender and matching degree; to find the methods and indicators of nutritional risk screening for these patients before and after HSCT, in order to give timely intervention to guarantee the successful completion of the entire transplantation process. Methods： Nutritional risk of 99 leukemia patients was screened with NRS2002 before and after HSCT. The ^（2 test was applied to compare the risk differences between groups such as age, gender and matching degree, while the differences of other enumeration data, such as recent （1-3 months） weight loss, reduced food intake within one week and BMI, were compared by continuity correction. Results： Of the 99 leukemia patients, 22 cases （22.2 %） had nutritional risk before HSCT, while all patients had nutritional risk after ttSCT; there is no significant difference in nutritional risk between male and female, and patients of less than 30 years old, not-full matched, recent （1-3 months） weight loss, reduced food intake within a week or BMI 〈18.5 were more likely to have nutritional risk; and 77 cases （77.8%） had weight loss, among which 49 patients （63.6%） had more than 5% weight loss within one month. Conclusions= This study showed that leukemia patients should receive the nutritional risk screening conventionally before and after HSCT, and NRS2002 was only appropriate for nutritional risk screening before HSCT. More attention should be paid to the patients less than 30 years old or not-full matched. Weight change was one of the important nutritional indicators for patients after HSCT.展开更多
Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 ...Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.展开更多
AIM： To assess the effectiveness of the current UK clinical practice in reducing hepatic fat （IHCL）.METHODS： Whole body MRI and IH MRS were obtained, before and after 6 mo nutritional counselling, from liver, sole...AIM： To assess the effectiveness of the current UK clinical practice in reducing hepatic fat （IHCL）.METHODS： Whole body MRI and IH MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease （NAFLD）.RESULTS： A 500 Kcal-restricted diet resulted in an average weight loss of 4% （-3.4 kg,） accompanied by significant reductions in most adipose tissue （AT） depots, including subcutaneous （-9.9%）, abdominal subcutaneous （-10.2%） and intra-abdominal- AT （-11.4%）. Intramyocellular lipids （IMCL） were significantly reduced in the tibialis muscle （-28.2%）. Decreases in both IHCL （-39.9%） and soleus IMCL （-12.2%） content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests： serum aspartate aminotransferase （AST） and alanine aminotransferase （ALT）. Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION： This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LETs.展开更多
The objective of this study was to evaluate the effects of adding formic acid and corn flour supplementation to banana pseudostem silages on the nutritional quality of these silages,growth,digestion,rumen fermentation...The objective of this study was to evaluate the effects of adding formic acid and corn flour supplementation to banana pseudostem silages on the nutritional quality of these silages,growth,digestion,rumen fermentation and cellulolytic bacterial community of Nubian black goats fed these silages.Banana pseudostem silage was prepared either conventionally without any additives(CON)or mixed with 0.6% formic acid(F),10% corn flour(C),or both(F+C).Four experimental diets containing 40% of the corresponding silages were designed with roughage to concentrate ratio of 50:50(dry matter(DM)basis).A total of 48 Nubian black castrated goats(body weight(BW),(22.64±1.82)kg;4-mon-old)were randomized into one of the four treatment groups with 12 replicates of one castrated goat per replicate for each treatment in a completely randomized design.Each group was fed on one of the four experimental diets for 40 days.A factorial arrangement of treatments of 2(formic acid levels:0 and 0.6%)×2(corn flour:0 and 10%)was adopted.Formic acid supplementation increased(P<0.05)average daily gain,as well as lactic acid,propionate and butyric acid and water-soluble carbohydrate concentrations,but decreased(P<0.05)the feed conversion rate,pH value,acetate/propionate ratio,and butyric acid concentration relative to the CON group.Corn flour supplementation increased(P<0.05)the apparent digestibility of crude protein,neutral detergent fiber,and non-fibrous carbohydrate and Fibrobacter succinogenes,Ruminococcus albus,and Butyrivibrio fibrisolvens populations,but decreased(P<0.05)the Ruminococcus flavefaciens population relative to the CON group.There were no F×C treatment interactions(P>0.05)for any of the other indices except for the apparent digestibility of non-fibrous carbohydrate(NFC)(P<0.05).The results demonstrated that adding 0.6% formic acid and 10% corn flour supplementation to banana pseudostem silages improved the nutritional quality of these silages and enhanced the growth performance of Nubian black castrated goats by improving apparent nutrient digestibility,and regulating ruminal fermentation and bacteria populations.展开更多
Objective This study aimed to determine the independent and joint associations of sedentary time(ST)and physical activity(PA) with metabolic syndrome(MetS) and its components among Chinese adults.Methods The study ana...Objective This study aimed to determine the independent and joint associations of sedentary time(ST)and physical activity(PA) with metabolic syndrome(MetS) and its components among Chinese adults.Methods The study analyzed data from 4,865 adults aged ≥ 18 years who participated in the 2009 and2015 China Health and Nutrition Surveys(CHNS). Four types of leisure ST and three types of PA selfreported at baseline were collected. Multivariable logistic regressions were used to determine the independent and joint associations of ST and PA with the odds of MetS or its components.Results For independent effects, higher levels of television time and total leisure ST was associated with higher MetS risk [odds ratio(OR) 1.3, 95% confidence interval(CI) 1.1–1.6, P < 0.001;OR 1.4, 95% CI1.2–1.8, P < 0.001, respectively]. The MetS risk in the computer time > 7 hours/week(h/w) group was higher than that in the < 7 h/w group in(OR 1.5, 95% CI 1.2–1.9). Higher levels of moderate-to-vigorousintensity physical activity(MVPA) and total PA were associated with a lower MetS risk(OR 0.7, 95% CI0.6–0.9, P < 0.001;OR 0.8, 95% CI 0.7–0.9, P < 0.001, respectively). For the joint effects, compared with those reporting the lowest level of total leisure ST(< 14 h/w) and the most active tertile of MVPA(≥ 61.0 MET-h/w), participants reporting the most total leisure ST(≥ 35 h/w) and the lowest level of MVPA(0 MET-h/w) had the highest odds of MetS(OR 2.0;95% CI 1.4–2.7). Except for people reporting ST(14–21 h/w) within the most active tertile of MVPA, the associations in all other groups were significant.With the increase of TV time and decreased MVPA, the odds of MetS almost showed a curve acceleration.Conclusions MVPA and total PA have independent preventive effects, and sedentary behavior(mainly watching TV) has an unsafe effect on MetS and its components. Strengthening the participation of MVPA and combining the LPA to replace the TV-based ST to increase the total PA may be necessary to reduce the prevalence of MetS in Chinese adults.展开更多
BACKGROUND Patients with gastrointestinal tumors often suffer from poor nutritional status during treatment.Surgery is the main treatment for these patients,but the long postoperative recovery period is often accompan...BACKGROUND Patients with gastrointestinal tumors often suffer from poor nutritional status during treatment.Surgery is the main treatment for these patients,but the long postoperative recovery period is often accompanied by digestive and absorption dysfunction,leading to further deterioration of the nutritional status.Early enteral nutrition support is hypothesized to be helpful in improving this situation,but the exact effects have yet to be studied in depth.AIM To observe the effect of early enteral nutritional support on postoperative recovery in patients with surgically treated gastrointestinal tract tumors,with the expectation that by improving the nutritional status of patients,the recovery process would be accelerated and the incidence of complications would be reduced,thus improving the quality of life.METHODS A retrospective analysis of 121 patients with gastrointestinal tract tumors treated in our hospital from January 2020 to January 2023 was performed.Fifty-three of these patients received complete parenteral nutrition support as the control group for this study.The other 68 patients received early enteral nutritional support as the observation group of this study.The clinical indicators comparing the two groups included time to fever,time to recovery of postoperative bowel function,time to postoperative exhaustion,and length of hospital stay.The changes in immune function and nutritional indexes in the two groups were compared.Furthermore,we utilized the SF-36 scale to compare the changes in the quality of life between the two groups of patients.Finally,the occurrence of postoperative complications between the two patient groups was also compared.RESULTS The postoperative fever time,postoperative bowel function recovery time,postoperative exhaustion time,and hospitalization time were all higher in the control group than in the observation group(P<0.05).The levels of CD3+,CD4+,immunoglobulin(Ig)A,IgM,and IgG in the observation group were significantly higher than those in the control group at 1 d and 7 d postoperatively,while CD8+was lower than in the control group(P<0.05).Total protein,albumin,prealbumin,and transferrin levels were significantly higher in the observation group than in the control group at 7 d postoperatively(P<0.05).The SF-36 scores of patients in the observation group were significantly higher than those in the control group(P<0.0001).The overall incidence of adverse reactions after the intervention was significantly lower in the control group than in the observation group(P=0.021).CONCLUSION We found that patients with gastrointestinal tumors are nutritionally vulnerable,and early enteral nutrition support programs can improve the nutritional status of patients and speed up postoperative recovery.This program can not only improve the immune function of the patient and protect the intestinal function,but it can also help to improve the quality of life of the patient.However,this program will increase the incidence of complications in patients.Caution should be taken when adopting early enteral nutrition support measures for patients with gastric cancer.The patient's condition and physical condition should be comprehensively evaluated and closely monitored to prevent possible complications.展开更多
Objectives:In the hospital setting,poor dietary intake interacts with disease and represents a major and modifiable cause of malnutrition.Understanding barriers to adequate dietary intake is an important strategy to g...Objectives:In the hospital setting,poor dietary intake interacts with disease and represents a major and modifiable cause of malnutrition.Understanding barriers to adequate dietary intake is an important strategy to guide the development of interventions to improve nutrition intake.The aim of this study reported in this paper was to explore patient,family and health care professionals'perceptions of barriers to and enablers of adequate nutrition care and dietary intake of medical inpatients.Methods:An exploratory qualitative study design incorporating group and individual interviews of patients(n=14),their family members(n=4),and health care professionals(n=18)was undertaken.Participants were recruited pragmatically,using a mix of convenience and purposive sampling.A theoretically informed,semi-structured interview schedule was based on observations of practice and the Theoretical Domains Framework.Interviews were audio-recorded,transcribed verbatim and analysed inductively using a general inductive approach.Results:Three key themes emerged from analysing participant interviews.Siloed approaches to nutrition care reflected the diverse range of health care professionals responsible for nutrition care but who often worked in isolation from their colleagues.Competing work priorities for nurses reflected the challenge in prioritise nutrition care which was often constrained because of other care needs or work-related pressures.Helping patients to eat highlighted that nurses were often the only health care professional who would provide assistance to patients at mealtimes and lack of available staff could negatively influence patients'nutrition intakes.Conclusions:We have identified many complex and interrelated barriers which preclude adequate dietary intake in acute medical patients.These predominantly reflect issues inherent in the hospital culture and environment.Multi-faceted and sustainable interventions that support a facilitating nutrition culture and multidisciplinary collaboration,inclusive of patients and families,are needed to address these underlying barriers.展开更多
Awareness of conflicts of interest(COI) in medicine began in the 1980 s. More recently, the problem has gained notoriety in nutritional sciences. COI with industry could bias study conclusions in the context of resear...Awareness of conflicts of interest(COI) in medicine began in the 1980 s. More recently, the problem has gained notoriety in nutritional sciences. COI with industry could bias study conclusions in the context of research activities and scientific publications on nutritional sciences. The issue of COI in nutritional sciences deserves more attention and requires careful analyses as biased information can negatively impact the development of dietary guidelines and, ultimately, population health. Decision-making is generally based on available, published evidence, but when the results are ambivalent, it is easier to opt for the status quo and ask for more studies. Readers might wonder if research is subsidized by industry as a counterbalancing strategy based on levels of evidence-only to slow down eminent positions and/or legislation on the food sector? How can this problem be overcome without producing paranoia and Mc Carthyism while trying to be as methodological as possible?展开更多
基金Chung Shan Medical University, Taichung city, Taiwan China, for its support。
文摘Long COVID is characterized by a group of persistent symptoms following the acute SARS-COV2 infection, which presented a multifaceted challenge to the healthcare systems all over the globe. The long COVID symptoms span various organ systems including the respiratory, cardiovascular, gastrointestinal, and neurological manifestations. Mitochondrial dysfunction and immune dysregulation play crucial roles in the long COVID pathophysiology. Recently nutritional intervention gained much attention in managing post-viral syndromes. Effective interventions like supplementation of omega-3 fatty acid, macro and micro nutrients, and vitamins help to reduce systemic inflammation and counteract muscle wasting. Other approaches like nutritional recovery, dietetic interventions, continuous nutritional care post-hospital discharge, nutritional rehabilitation programs,whole-diet approaches like Mediterranean diet, plant-based diet, and caloric optimization, improve overall functional recovery. Physical activity and exercise regimes have been shown to improve fatigue, dyspnea, and cognitive function. Tailored exercise regimes may promote safe rehabilitation. Certain ineffective interventions,such as non-personalized approaches, high dose of antioxidants, use of herbal products that are not clinically validated need to be addressed. Dietary interventions such as personalized nutritional counseling have been demonstrated to improve physical performance in long COVID patients. Further research is needed to refine protocols and identify optimal combinations of dietary and movement-based therapies to support the recovery of long-COVID patients. This narrative review focuses on the ongoing researches that reveals the intricate relationship between nutrition and long COVID recovery and also establishes effective protocols for nutritional care.
文摘BACKGROUND Hashimoto’s thyroiditis(HT)is an autoimmune dysfunction caused by genetic and environmental changes that attack the thyroid gland.HT affects approximately 2%to 5%of the population,being more prevalent in women.It is diagnosed through a blood test(anti-thyroid peroxidase).Pharmacological treatment consists of daily administration of the synthetic hormone levothyroxine on an empty stomach.The most common signs and symptoms are:Tissue resistance to triiodothyronine T3,weight gain,dry skin,hair loss,tiredness/fatigue,and constipation,and nutritional therapy appears to help reduce these symptoms.AIM To analyze nutritional interventions for treating HT.METHODS This is an integrative review of original studies on nutritional interventions for treating Hashimoto’s disease.Articles were searched in the MEDLINE/PubMed and Latin American and Caribbean Literature on Health Sciences(LILACS)databases via virtual health library,using controlled vocabulary and free terms.A total of 70 articles were found:67 from PubMed and 3 from LILACS.After exclusions,9 articles met the eligibility criteria,including dietary interventions for maintaining and restoring the patient’s quality of life.RESULTS The reviewed articles evaluated the nutritional treatment of HT through supplementation of deficient micronutrients,anti-inflammatory diets,gluten-free diets,exclusion of foods that cause food sensitivities,lactose-free diet,paleo diet,and calorie restriction diets.However,some results were controversial regarding the beneficial effects of HT.CONCLUSION In general,it was observed that nutritional interventions for HT are based on the recovery of micronutrient deficiencies,treatment of the intestinal microbiota,diet rich in foods with anti-inflammatory properties,lifestyle changes,and encouragement of healthy habits.
文摘Increasing access to locally produced, safe, nutritious and affordable complementary foods is essential to combat micronutrient deficiencies in young children in low- and middle-income countries. Two formulations of sweets based on jujube, baobab fruit powder and sweet potato puree were produced, and their nutritional values and sensory properties such as taste, smell, color and acceptability were assessed. The formulation containing the most jujube powder, baobab fruit and sweet potato puree gave the best nutritional value. The sweets are rich in calcium (259.80 mg/100 g), magnesium (67.98 mg/100 g), potassium (782.04 mg/100 g), vitamin C (32.37 mg/100 g), iron (6.45 g mg/100 g) and zinc (0.97 mg/100 g). Sensory tests on the two formulations showed acceptability scores ranging from 81.26% to 84.58%, well above the minimum acceptable threshold. Candies with jujube, baobab fruit powder and sweet potato puree could be an alternative for preventing micronutrient deficiencies.
基金funded by the Jiangsu Graduate Student Practice and Innovation Program(No.SJCX23_0665).
文摘Objective:To analyze body composition measurements and explore their correlation with the nutritional risk screening score and neutrophil-to-lymphocyte ratio(NLR;an index of inflammation)to provide a basis for the perioperative and nutritional management of patients with gynecologic malignancy.Methods:This study included 77 patients with gynecologic malignancies confirmed by surgical pathology between December 2021 and January 2023.Preoperative body composition data were obtained using bioelectrical impedance analysis.Nutritional risk screening and assessment were performed.Differences in body composition by age,nutritional status,International Federation of Gynecology and Obstetrics(FIGO)stage,systemic inflammatory response,and type of gynecologic malignancy were compared.Results:The extracellular water ratio was significantly higher in patients with a high FIGO stage than in those with a low FIGO stage(t=4.047,P<0.001).Other body composition parameters were lower in patients with a high FIGO stage than in those with a low FIGO stage(P<0.05).Regarding the NLR,the extracellular water ratio was significantly higher in patients with a high NLR than in those with a low NLR(t=2.929,P=0.005).As the nutritional condition worsened,the extracellular water ratio increased(H=12.291,P=0.002),with no significant difference in other body composition parameters between patients with different nutritional conditions(H=5.118,P=0.077).Other body composition parameters decreased with the nutritional condition,which was statistically significant(P<0.05).Conclusions:Bioelectrical impedance analysis is an easy-to-perform,noninvasive,and reproducible measurement technique that can assess changes in body composition.Body composition analysis can effectively determine an individual’s nutritional and metabolic status,providing a reference for the management of patients with gynecologic malignancy,and potentially providing predictive biomarkers to stratify these patients.
基金supported by the National Natural Science Foundation of China(82204030)the Fellowship of China Postdoctoral Science Foundation(2024T170134,2022M710675)。
文摘University students,transitioning from adolescence to adulthood,are at a critical stage where dietary habits and health behaviors are established,influencing long-term health outcomes.This study aimed to assess the dietary intake and nutritional awareness of a population of Chinese university students(n=833),comparing their consumption with national dietary guidelines and reference intakes,while exploring subgroup differences.Results indicated that males had significantly higher amounts of most food categories compared to females.Except for whole grains and legumes,ethnic minorities had lower compliance with the recommended intakes for several food categories compared to Han Chinese.Han males consumed more energy,protein,and fat than their ethnic minority counterparts.Obese participants showed higher protein and fat intake compared to those with normal body mass index(BMI).Additionally,BMI-related trends in macronutrient contributions showed that protein and fat contributed more to the total energy intake of individuals with higher BMI.Han individuals also had higher energy contributions from protein and fat and lower carbohydrate contributions compared to ethnic minorities.Nutrient intake was generally below recommended levels,with low proportions of participants meeting the recommended intake for vitamin A,C,calcium and dietary fiber.High proportions of participants exceeded the tolerable upper intake levels for iron and manganese.Nutritional awareness scores were also significantly higher among Han students,as well as those with higher BMIs and higher income levels.This study highlights significant disparities in dietary intake and nutritional awareness among Chinese university students,with variations across sex,ethnicity,BMI,and income categories.
基金supported through the European Union’s Horizon 2020 Research and Innovation Program(818318)。
文摘Deep phenotyping and genetic characterization of individuals are fundamental to assessing the metabolic status and determining nutrition-specific requirements.This study aimed to ascertain the utmost effectiveness of personalized interventions by aligning dietary adjustments with both the genotype and metabolotype of individuals.Therefore,we assessed here the usefulness of a polygenic score(PGS)characterizing a potential pro-inflammatory profile(PGSi)as a nutrigenetic tool to discern individuals from the Danish PREVENTOMICS cohort that could better respond to precision nutrition(PN)plans,specifically targeted at counteracting the low-grade inflammatory profile typically found in obesity.The cohort followed a PN plan to counteract the pro-inflammatory profile(PNi group)or generic dietary recommendations(Control)for 10 weeks.PGSi was applied for genetic stratification(Low/High).The effects of the intervention on anthropometrics and biomarkers related to inflammatory profile and carbohydrate metabolism were assessed.Around 30%of subjects had a high genetic predisposition to pro-inflammatory status(high-PGSi).These individuals demonstrated the most effective response to the dietary plan,experiencing improved body composition,with significant decreases in body weight(∆:-4.84%;P=0.039)and body fat(∆:-4.86%;P=0.007),and beneficial changes in pro-and anti-inflammatory biomarkers,with significant increases in IL-10(∆:71.3%;P=0.025)and decreases in TNF-α(∆:-3.0%;P=0.048),CRP(∆:-31.1%),ICAM1(∆:-5.8%),and MCP1(∆:-4.2%)circulating levels,compared to low-PGSi individuals.Both phenotypic and genetic stratification contributed to a better understanding of metabolic heterogeneity in response to diet.This approach allows for refinement of the prediction of individual requirements and potentially for better management of obesity.
文摘Objective:It was conducted to evaluate the susceptibility to ON(orthorexia nervosa)in the students of the nutrition and dietetics department according to the variables of gender,age and BMI(body massındex).Subjects and Methods:The research covers the students of Marmara University Faculty of Health Sciences,Department of Nutrition and Dietetics in September-October 2017-2018 academic year.The data were collected by survey method.Socio-demographic characteristics and anthropometric measurements of the participants were questioned.EAT-40(Eating Attitude Test),ORTO-15 test and MOCI(Maudsley Obsessive Compulsive Inventory)were used in the study.It was evaluated with SPSS(The Statistical Package for The Social Sciences)21.0 program.Results:205 people participated in the study.EAT-40 scores were found to be≤20 in 94%of the women and 95.2%of the men in the study.The EAT-40 score is≥21 in 6%of women and 4.8%of men in the study(p=0.646>0.05).The ORTO-15 score of 72.3%of women and 71.4%of men is≤40(p=0.934>0.05).EAT-40 average is 10.25±1.10 in underweight.It was found to be 9.21±0.42 in normals and 8.23±0.76 in slightly obese subjects(p=0.758>0.05).ORTO-15 average of those with BMI≤18.49 kg/m2 is 39.59±0.54;Those with 18.50-24.99 kg/m2 were found to be 38.30±0.25 and those with 25.00-29.99 kg/m2 were found to be 39.54±0.75(p=0.098>0.05).As the EAT-40 score increased,the ORTO-15 score decreased.It shows a negative,statistically significant difference between EAT-40 and ORTO-15 scores(p=0.00<0.05).Conclusion:It was concluded that orthorexic tendency is common(72.2%)in nutrition dietetic students,and ON is associated with BMI and EAT-40 scores.In terms of ON,it would be beneficial to conduct comprehensive international studies and determine DSM(Diagnostic and Statistical Manual of Mental Disorders)diagnostic criteria.
基金supported by grants from the National Key Research and Development Program of China(No.2023YFC3606300,No.2022YFC3600300)the National Natural Science Foundation of China(No.82325043)the National Key Research and Development Program of Hubei Province(2022BCA036)。
文摘Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank,sarcopenia was diagnosed according to European and Asian Working Groups for Sarcopenia criteria.Social isolation was assessed using standardized questionnaires,including questions on solitude,frequency of social activities,contact with others,and marital status(for the CLHLS only).Results During the follow-up period,8,249 deaths occurred in the CLHLS and 26,670 deaths in the UK Biobank groups.While no significant interaction was observed between sarcopenia and social isolation in predicting all-cause mortality in the CLHLS cohort,the association between social isolation and mortality was stronger among individuals with sarcopenia in the UK Biobank(P-interaction=0.03,relative risk due to interaction:0.23,95%confidence interval[CI]:0.06–0.41).Further joint analyses showed that participants with sarcopenia and high levels of social isolation had the highest mortality risk(hazard ration[HR]:1.99;95%CI:[1.74–2.28]in the CLHLS and 1.69[1.55–1.85]in the UK Biobank)compared to those without either condition.Conclusion The combination of social isolation and sarcopenia synergistically increases the risk of mortality in middle-aged and older adults across diverse populations.
文摘Background: We monitored changes in salivary creatine pre-and post-high-intensity exercise in young adults while also investigating the potential correlation between salivary and serum creatine levels.Method: Saliva and serum samples were collected before and immediately after an incremental running-toexhaustion treadmill test in fifteen young adults(mean age [23.9 ± 2.9] years, eight females), with samples analyzed for guanidinoacetic acid, creatine, and creatinine using a liquid chromatography–tandem mass spectrometry method.Results: Following exercise, there was a substantial elevation in salivary creatine levels from(17.5 ± 14.2)μmol·L^(-1) to(43.6 ± 30.4) μmol·L^(-1)(p < 0.001), coupled with a significant increase in salivary creatinine from(11.3 ± 5.8) μmol·L^(-1) to(17.0 ± 9.3) μmol·L^(-1)(p = 0.04). In contrast, serum creatine levels were unaffected by exercise(p = 0.80), while creatinine levels exhibited a strong tendency to decrease post-exercise(from [81.8 ±17.5] μmol·L^(-1) to [73.1 ± 11.6] μmol·L^(-1);p = 0.06). A comparison of the slopes of the two regression lines(saliva vs. serum) revealed significant differences for both creatine(p = 0.01) and creatinine(p = 0.03).Conclusions: The above findings suggest a potential difference in the dynamics of creatine metabolites in these two bodily fluids, both pre and post-exercise.
基金supported by the National Key Research and Development Plan:Real-Time Intelligent Active Intervention on Integration of Ten Important Chronic Diseases(2020YFC2003504-2,to BX)。
文摘Background:Although light-intensity physical activity(LPA)has been suggested to be associated with a lower risk of mortality,the minimal and optimal volumes of LPA remain unclear.We aimed to examine the minimal and optimal volumes of LPA associated with the risks of mortality and disease incidence(i.e.,cardiovascular diseases and cancer).Methods:Data were derived from the population-based UK Biobank cohort study,including 69,492 adults aged 43-78 years.Accelerometermeasured LPA was defined using a validated,published machine learning-based Random Forest activity method,which was categorized into 4 quartile groups.All-cause and cause-specific mortality(cardiovascular disease-and cancer-specific)were determined according to the International Classification of Diseases,10th version codes.Disease incidence was defined based on primary care,hospitalization,or death records.Results:During a median follow-up period of 8.04 years,2024 adults died from all causes,539 from cardiovascular disease,and 1175 from cancer.For all-cause mortality,compared with participants in the lowest quartile of LPA(<3.9 h/day),the hazard ratios(HRs)and 95%confidence intervals(95%CIs)were 0.82(95%CI:0.73-0.93)for those with 3.9 to<5.0 h/day,0.75(95%CI:0.66-0.85)for those with 5.0 to<6.1 h/day,and 0.77(95%CI:0.68-0.88)for those with≥6.1 h/day,respectively.There was an inverse non-linear dose-response association between LPA and all-cause mortality,with an optimal dose of 5.72 h/day(95%CI:5.45-6.41;HR=0.63,95%CI:0.56-0.71)and a minimal dose of 3.59 h/day(95%CI:3.53-8.56;HR=0.81,95%CI:0.78-0.86),with the 5th percentile as the reference.Similar patterns were observed for cause-specific mortality and disease incidence(cardiovascular disease and cancer).Conclusion:Engaging in LPA for~3.5 h/day was conservatively associated with lower risk of mortality and disease incidence,with further risk reductions observed up to an optimal dose of~6.0 h/day.These findings suggest that sufficient LPA offers important health benefits,which can inform the development of future PA guidelines.
基金funded by the Regional Ministry of Health of the Junta de Andalucıa(PI-0395-2016)the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement(No.101027215)+1 种基金supported by the PLACENTRAINING project,funded through the FEDER-UGR23 funding call(European Regional Development Fund University of Granada programGrant No.C-EXP-336UGR23)。
文摘Background:The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood.The objective of the current study was to ascertain the influence of a supervised concurrent exercise intervention from gestational Week 17 until birth on key cytokines involved in placental development and function.Secondary aims were to explore:(a)the moderating effects of fetal sex and maternal weight status;and(b)whether gestational weight gain,lifestyle behaviors(diet,sleep patterns,and physical activity),and physical fitness(strength and cardiorespiratory fitness)mediated the effects of exercise on placental cytokines.Methods:Seventy-six pregnant women(33±4 years,mean±SD),divided into exercise(n=40)and control(n=36)groups,participated in this study.The exercise group followed a 60-min,3 days/week(aerobic+resistance)training program of moderate-to-vigorous intensity.Placental cytokines—including granulocyte-macrophage colony-stimulating factor(GM-CSF),granulocyte colony-stimulating factor(G-CSF),plateletderived growth factor AA(PDGF-AA),epidermal growth factor(EGF),monocyte chemoattractant protein-1(MCP-1),fractalkine,interleukin(IL)-8,IL-6,IL-1β,interleukin 1-receptor antagonist(IL-1ra),IL-10,tumor necrosis factor alpha(TNF-a),and interferon gamma(IFN-γ)were analyzed using Luminex multi-analyte profiling(x MAP)technology.Results:The exercise group presented higher placental levels of G-CSF and lower concentrations of EGF and IL-1ra than the control group(p<0.05).Significant effects of exercise on placental G-CSF and TNF-a(p<0.05)and a trend toward lower IL-6(p=0.08)were observed only in female placentas.Additionally,a reduction in weight gain partially mediated the effects of exercise on G-CSF(p<0.05).Conclusion:Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels.Some exercise-induced effects are observed exclusively in female placentas,including increased G-CSF and lower TNF-a and IL-6 concentrations.Notably,the increased levels of G-CSF observed with exercise might be due to a more adequate gestational weight gain.
文摘Purpose:The purpose of this study was to examine the associations between adherence to the 24-Hour Movement Guidelines and all-cause and cause-specific mortality in a large Spanish prospective cohort.Methods:We analyzed data from 14,288 participants of the Seguimiento Universidad de Navarra(SUN)Project,followed for a mean of 12.8 years(mean baseline age=38.3 years;60.1%women).Data were collected at baseline and through biennial follow-up questionnaires(up to 10 waves,depending on year of entry).The participants self-reported 24-h movement behaviors at baseline and were categorized based on the number of guidelines met(0-3).Behaviors were assessed at baseline only;changes in adherence during follow-up were not accounted for.Cox proportional hazards models were used to estimate hazard ratios(HRs)for all-cause and cause-specific mortality,adjusting for sociodemographic,lifestyle,and clinical covariates.Results:Meeting a greater number of 24-Hour Movement Guidelines at baseline was associated with a progressively lower risk of all-cause mortality.Compared with those meeting none,the multivariable-adjusted HRs were 0.52(95%confidence interval(95%CI):0.33-0.82)for meeting 1 guideline,0.47(95%CI:0.30-0.73)for meeting 2 guidelines,and 0.44(95%CI:0.28-0.71)for meeting all 3 guidelines.Only adherence to the physical activity guidelines was independently associated with a significantly lower mortality risk(HR=0.70;95%CI:0.55-0.89).A reduced risk was also observed for cancer and other-cause mortality among those meeting 2 or more guidelines.Conclusion:Adherence to the 24-Hour Movement Guidelines at baseline,particularly physical activity,was associated with a lower risk of mortality.Promoting an integrated approach to movement behaviors may be an effective strategy for improving population health and longevity.
文摘Objective： To discuss whether nutritional risk screening 2002 （NRS2002） is appropriate for nutritional risk screening for leukemia patients before and after hematopoietic stem cell transplantation （HSCT）, and whether there are risk differences in other conditions, such as age, gender and matching degree; to find the methods and indicators of nutritional risk screening for these patients before and after HSCT, in order to give timely intervention to guarantee the successful completion of the entire transplantation process. Methods： Nutritional risk of 99 leukemia patients was screened with NRS2002 before and after HSCT. The ^（2 test was applied to compare the risk differences between groups such as age, gender and matching degree, while the differences of other enumeration data, such as recent （1-3 months） weight loss, reduced food intake within one week and BMI, were compared by continuity correction. Results： Of the 99 leukemia patients, 22 cases （22.2 %） had nutritional risk before HSCT, while all patients had nutritional risk after ttSCT; there is no significant difference in nutritional risk between male and female, and patients of less than 30 years old, not-full matched, recent （1-3 months） weight loss, reduced food intake within a week or BMI 〈18.5 were more likely to have nutritional risk; and 77 cases （77.8%） had weight loss, among which 49 patients （63.6%） had more than 5% weight loss within one month. Conclusions= This study showed that leukemia patients should receive the nutritional risk screening conventionally before and after HSCT, and NRS2002 was only appropriate for nutritional risk screening before HSCT. More attention should be paid to the patients less than 30 years old or not-full matched. Weight change was one of the important nutritional indicators for patients after HSCT.
文摘Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.
基金Supported by the British Medical Research Council, United Kingdom, No. MRC CEG G99000178
文摘AIM： To assess the effectiveness of the current UK clinical practice in reducing hepatic fat （IHCL）.METHODS： Whole body MRI and IH MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease （NAFLD）.RESULTS： A 500 Kcal-restricted diet resulted in an average weight loss of 4% （-3.4 kg,） accompanied by significant reductions in most adipose tissue （AT） depots, including subcutaneous （-9.9%）, abdominal subcutaneous （-10.2%） and intra-abdominal- AT （-11.4%）. Intramyocellular lipids （IMCL） were significantly reduced in the tibialis muscle （-28.2%）. Decreases in both IHCL （-39.9%） and soleus IMCL （-12.2%） content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests： serum aspartate aminotransferase （AST） and alanine aminotransferase （ALT）. Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION： This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LETs.
基金This research was supported by the China Special Fund for Agro-scientific Research in the Public Interest(Investigation on strategies of fattening and high-quality meat productive techniques for herbivores based on resources of unconventional roughage in Southern China)(201303144)the Top Talents Award Plan of Yangzhou University,China(2016,2020)+4 种基金the Cyanine Project of Yangzhou University(2020)the Technology Specialty Fund for Cooperation between Jilin Province and the Chinese Academy of Sciences,2016SYHZ0022)the National Key Research and Development Program of China(2016YFD0700201)the National Natural Science Foundation of China(31902180)the Natural Science Foundation of Jiangsu Province Research Project,China(BK20170488).
文摘The objective of this study was to evaluate the effects of adding formic acid and corn flour supplementation to banana pseudostem silages on the nutritional quality of these silages,growth,digestion,rumen fermentation and cellulolytic bacterial community of Nubian black goats fed these silages.Banana pseudostem silage was prepared either conventionally without any additives(CON)or mixed with 0.6% formic acid(F),10% corn flour(C),or both(F+C).Four experimental diets containing 40% of the corresponding silages were designed with roughage to concentrate ratio of 50:50(dry matter(DM)basis).A total of 48 Nubian black castrated goats(body weight(BW),(22.64±1.82)kg;4-mon-old)were randomized into one of the four treatment groups with 12 replicates of one castrated goat per replicate for each treatment in a completely randomized design.Each group was fed on one of the four experimental diets for 40 days.A factorial arrangement of treatments of 2(formic acid levels:0 and 0.6%)×2(corn flour:0 and 10%)was adopted.Formic acid supplementation increased(P<0.05)average daily gain,as well as lactic acid,propionate and butyric acid and water-soluble carbohydrate concentrations,but decreased(P<0.05)the feed conversion rate,pH value,acetate/propionate ratio,and butyric acid concentration relative to the CON group.Corn flour supplementation increased(P<0.05)the apparent digestibility of crude protein,neutral detergent fiber,and non-fibrous carbohydrate and Fibrobacter succinogenes,Ruminococcus albus,and Butyrivibrio fibrisolvens populations,but decreased(P<0.05)the Ruminococcus flavefaciens population relative to the CON group.There were no F×C treatment interactions(P>0.05)for any of the other indices except for the apparent digestibility of non-fibrous carbohydrate(NFC)(P<0.05).The results demonstrated that adding 0.6% formic acid and 10% corn flour supplementation to banana pseudostem silages improved the nutritional quality of these silages and enhanced the growth performance of Nubian black castrated goats by improving apparent nutrient digestibility,and regulating ruminal fermentation and bacteria populations.
基金supported by US NIH[R01-HD30880,DK056350,R24HD050924,and R01-HD38700]。
文摘Objective This study aimed to determine the independent and joint associations of sedentary time(ST)and physical activity(PA) with metabolic syndrome(MetS) and its components among Chinese adults.Methods The study analyzed data from 4,865 adults aged ≥ 18 years who participated in the 2009 and2015 China Health and Nutrition Surveys(CHNS). Four types of leisure ST and three types of PA selfreported at baseline were collected. Multivariable logistic regressions were used to determine the independent and joint associations of ST and PA with the odds of MetS or its components.Results For independent effects, higher levels of television time and total leisure ST was associated with higher MetS risk [odds ratio(OR) 1.3, 95% confidence interval(CI) 1.1–1.6, P < 0.001;OR 1.4, 95% CI1.2–1.8, P < 0.001, respectively]. The MetS risk in the computer time > 7 hours/week(h/w) group was higher than that in the < 7 h/w group in(OR 1.5, 95% CI 1.2–1.9). Higher levels of moderate-to-vigorousintensity physical activity(MVPA) and total PA were associated with a lower MetS risk(OR 0.7, 95% CI0.6–0.9, P < 0.001;OR 0.8, 95% CI 0.7–0.9, P < 0.001, respectively). For the joint effects, compared with those reporting the lowest level of total leisure ST(< 14 h/w) and the most active tertile of MVPA(≥ 61.0 MET-h/w), participants reporting the most total leisure ST(≥ 35 h/w) and the lowest level of MVPA(0 MET-h/w) had the highest odds of MetS(OR 2.0;95% CI 1.4–2.7). Except for people reporting ST(14–21 h/w) within the most active tertile of MVPA, the associations in all other groups were significant.With the increase of TV time and decreased MVPA, the odds of MetS almost showed a curve acceleration.Conclusions MVPA and total PA have independent preventive effects, and sedentary behavior(mainly watching TV) has an unsafe effect on MetS and its components. Strengthening the participation of MVPA and combining the LPA to replace the TV-based ST to increase the total PA may be necessary to reduce the prevalence of MetS in Chinese adults.
基金the Xiangshan County Science and Technology Bureau,Project Name Regional Quality Control on the Impact and Value of Endoscopic Screening for Intestinal Adenomas,No.2022C6018.
文摘BACKGROUND Patients with gastrointestinal tumors often suffer from poor nutritional status during treatment.Surgery is the main treatment for these patients,but the long postoperative recovery period is often accompanied by digestive and absorption dysfunction,leading to further deterioration of the nutritional status.Early enteral nutrition support is hypothesized to be helpful in improving this situation,but the exact effects have yet to be studied in depth.AIM To observe the effect of early enteral nutritional support on postoperative recovery in patients with surgically treated gastrointestinal tract tumors,with the expectation that by improving the nutritional status of patients,the recovery process would be accelerated and the incidence of complications would be reduced,thus improving the quality of life.METHODS A retrospective analysis of 121 patients with gastrointestinal tract tumors treated in our hospital from January 2020 to January 2023 was performed.Fifty-three of these patients received complete parenteral nutrition support as the control group for this study.The other 68 patients received early enteral nutritional support as the observation group of this study.The clinical indicators comparing the two groups included time to fever,time to recovery of postoperative bowel function,time to postoperative exhaustion,and length of hospital stay.The changes in immune function and nutritional indexes in the two groups were compared.Furthermore,we utilized the SF-36 scale to compare the changes in the quality of life between the two groups of patients.Finally,the occurrence of postoperative complications between the two patient groups was also compared.RESULTS The postoperative fever time,postoperative bowel function recovery time,postoperative exhaustion time,and hospitalization time were all higher in the control group than in the observation group(P<0.05).The levels of CD3+,CD4+,immunoglobulin(Ig)A,IgM,and IgG in the observation group were significantly higher than those in the control group at 1 d and 7 d postoperatively,while CD8+was lower than in the control group(P<0.05).Total protein,albumin,prealbumin,and transferrin levels were significantly higher in the observation group than in the control group at 7 d postoperatively(P<0.05).The SF-36 scores of patients in the observation group were significantly higher than those in the control group(P<0.0001).The overall incidence of adverse reactions after the intervention was significantly lower in the control group than in the observation group(P=0.021).CONCLUSION We found that patients with gastrointestinal tumors are nutritionally vulnerable,and early enteral nutrition support programs can improve the nutritional status of patients and speed up postoperative recovery.This program can not only improve the immune function of the patient and protect the intestinal function,but it can also help to improve the quality of life of the patient.However,this program will increase the incidence of complications in patients.Caution should be taken when adopting early enteral nutrition support measures for patients with gastric cancer.The patient's condition and physical condition should be comprehensively evaluated and closely monitored to prevent possible complications.
基金This work was generously funded through the Private Practice Trust Fund at Gold Coast Hospital and Health Service
文摘Objectives:In the hospital setting,poor dietary intake interacts with disease and represents a major and modifiable cause of malnutrition.Understanding barriers to adequate dietary intake is an important strategy to guide the development of interventions to improve nutrition intake.The aim of this study reported in this paper was to explore patient,family and health care professionals'perceptions of barriers to and enablers of adequate nutrition care and dietary intake of medical inpatients.Methods:An exploratory qualitative study design incorporating group and individual interviews of patients(n=14),their family members(n=4),and health care professionals(n=18)was undertaken.Participants were recruited pragmatically,using a mix of convenience and purposive sampling.A theoretically informed,semi-structured interview schedule was based on observations of practice and the Theoretical Domains Framework.Interviews were audio-recorded,transcribed verbatim and analysed inductively using a general inductive approach.Results:Three key themes emerged from analysing participant interviews.Siloed approaches to nutrition care reflected the diverse range of health care professionals responsible for nutrition care but who often worked in isolation from their colleagues.Competing work priorities for nurses reflected the challenge in prioritise nutrition care which was often constrained because of other care needs or work-related pressures.Helping patients to eat highlighted that nurses were often the only health care professional who would provide assistance to patients at mealtimes and lack of available staff could negatively influence patients'nutrition intakes.Conclusions:We have identified many complex and interrelated barriers which preclude adequate dietary intake in acute medical patients.These predominantly reflect issues inherent in the hospital culture and environment.Multi-faceted and sustainable interventions that support a facilitating nutrition culture and multidisciplinary collaboration,inclusive of patients and families,are needed to address these underlying barriers.
文摘Awareness of conflicts of interest(COI) in medicine began in the 1980 s. More recently, the problem has gained notoriety in nutritional sciences. COI with industry could bias study conclusions in the context of research activities and scientific publications on nutritional sciences. The issue of COI in nutritional sciences deserves more attention and requires careful analyses as biased information can negatively impact the development of dietary guidelines and, ultimately, population health. Decision-making is generally based on available, published evidence, but when the results are ambivalent, it is easier to opt for the status quo and ask for more studies. Readers might wonder if research is subsidized by industry as a counterbalancing strategy based on levels of evidence-only to slow down eminent positions and/or legislation on the food sector? How can this problem be overcome without producing paranoia and Mc Carthyism while trying to be as methodological as possible?
