Introduction:Infants born to HBsAg-positive mothers are exposed to hepatitis B virus(HBV)during childbirth and require timely hepatitis B vaccination(HepB)and hepatitis B immunoglobulin(HBIG)to prevent vertical transm...Introduction:Infants born to HBsAg-positive mothers are exposed to hepatitis B virus(HBV)during childbirth and require timely hepatitis B vaccination(HepB)and hepatitis B immunoglobulin(HBIG)to prevent vertical transmission.Post-vaccination serological testing(PVST)determines whether HBVexposed infants are protected,infected,or need revaccination.This study evaluated PVST implementation among HBV-exposed infants and the effectiveness of the recommended strategy to prevent mother-to-child transmission(MTCT)of HBV.Methods:This observational study of infants born to HBsAg-positive mothers evaluated implementation of the MTCT prevention strategy and PVST follow-up across five provinces in China.Chi-square tests assessed timely HepB1 and HBIG administration and HepB series completion.PVST was used to evaluate MTCT prevention effectiveness.Bivariate analyses explored factors influencing infection and protection rates among HBV-exposed infants.Results:Among 7,425 infants born to HBsAgpositive mothers,94.8%received timely HepB1 and HBIG,and 99.5%completed the full HepB vaccination series.PVST was conducted in 3,243(43.7%)infants;the median interval between HepB3 and PVST was 66 days(interquartile range:47–114).26(0.8%)infants tested HBsAg-positive;3,147(97.0%)developed protective antibody levels;and 72(2.2%)were neither infected nor protected,requiring revaccination.Maternal HBeAg positivity was a significant risk factor for MTCT prevention failure[adjusted odds ratio(aOR)=12.7,95%confidence interval(CI):4.7,34.1].Conclusions:The MTCT prevention strategy was highly effective.PVST for infants born to HBsAgpositive mothers enables evaluation of MTCT prevention strategies and improvement of strategy their effectiveness.PVST utilization should be expanded to test all HBV-exposed infants to ensure their protection and to further enhance the MTCT prevention.展开更多
基金funded by the Major Science and Technology Special Project of China’s 13th 5-Year Plan(grant no.2017ZX10105015).
文摘Introduction:Infants born to HBsAg-positive mothers are exposed to hepatitis B virus(HBV)during childbirth and require timely hepatitis B vaccination(HepB)and hepatitis B immunoglobulin(HBIG)to prevent vertical transmission.Post-vaccination serological testing(PVST)determines whether HBVexposed infants are protected,infected,or need revaccination.This study evaluated PVST implementation among HBV-exposed infants and the effectiveness of the recommended strategy to prevent mother-to-child transmission(MTCT)of HBV.Methods:This observational study of infants born to HBsAg-positive mothers evaluated implementation of the MTCT prevention strategy and PVST follow-up across five provinces in China.Chi-square tests assessed timely HepB1 and HBIG administration and HepB series completion.PVST was used to evaluate MTCT prevention effectiveness.Bivariate analyses explored factors influencing infection and protection rates among HBV-exposed infants.Results:Among 7,425 infants born to HBsAgpositive mothers,94.8%received timely HepB1 and HBIG,and 99.5%completed the full HepB vaccination series.PVST was conducted in 3,243(43.7%)infants;the median interval between HepB3 and PVST was 66 days(interquartile range:47–114).26(0.8%)infants tested HBsAg-positive;3,147(97.0%)developed protective antibody levels;and 72(2.2%)were neither infected nor protected,requiring revaccination.Maternal HBeAg positivity was a significant risk factor for MTCT prevention failure[adjusted odds ratio(aOR)=12.7,95%confidence interval(CI):4.7,34.1].Conclusions:The MTCT prevention strategy was highly effective.PVST for infants born to HBsAgpositive mothers enables evaluation of MTCT prevention strategies and improvement of strategy their effectiveness.PVST utilization should be expanded to test all HBV-exposed infants to ensure their protection and to further enhance the MTCT prevention.
