Background International students contribute to the academic and economic vitality of US higher education while facing exacerbated mental health challenges.Little is known about national trends in anxiety,depression,s...Background International students contribute to the academic and economic vitality of US higher education while facing exacerbated mental health challenges.Little is known about national trends in anxiety,depression,suicidal ideation and mental health service utilisation in this population.Aims This study examined national trends in the prevalence of clinically significant anxiety,depression,suicidal ideation and service utilisation among international students in US higher education from 2015 to 2024.Methods This repeated cross-sectional study analysed annual data from the Healthy Minds Study,a national survey of collegiate mental health,including 44560 international students.Weighted prevalence estimates were calculated,and multivariable logistic regression models were used to examine temporal trends,controlling for demographic characteristics.Results The weighted annual prevalence of anxiety increased by 78.25%(from 20.46%in 2015-2016 to 36.47%in 2023-2024),depression increased by 73.04%(from 20.44%to 35.37%),suicidal ideation increased by 92.52%(from 5.35%to 10.30%)and service utilisation increased by 45.82%(from 5.26%to 7.67%).In logistic models controlling for demographic characteristics,the increasing trends in anxiety(adjusted odds ratio(aOR)2.21;95%CI 2.07 to 2.36;p<0.001),depression(aOR 1.93;95%CI 1.80 to 2.06;p<0.001),suicidal ideation(aOR 1.57;95%CI 1.41 to 1.74;p<0.001)and service utilisation(aOR 2.01;95%CI 1.79 to 2.26;p<0.001)remained statistically significant over time.Conclusions The prevalence of anxiety,depression and suicidal ideation nearly doubled among international students from 2015 to 2024,while counselling service utilisation increased at a slower rate,indicating persistent gaps in mental healthcare.These findings suggest the need for proactive interventions,culturally competent services and expanded outreach efforts to bridge the mental health service gap for international students.展开更多
Purpose:The aim of this study was to investigate the influence of the cardiorespiratory fitness level on the response to high-intensity interval training(HIIT)with an individually adjusted running speed of the same re...Purpose:The aim of this study was to investigate the influence of the cardiorespiratory fitness level on the response to high-intensity interval training(HIIT)with an individually adjusted running speed of the same relative intensity.The evaluation focused on acute cardiorespiratory response,postexercise cardiac autonomic modulation(heart rate variability(HRV))and biochemical markers of inflammation,oxidative stress,and muscle damage.Methods:Thirty participants were divided into 3 subgroups:well trained,moderately trained,and untrained.All the participants performed30 min HIIT composed of 6×2 min interval exercise with work-to-relief ratio=1 and work intensity 100%of individual velocity at maximal oxygen consumption(VO2max).Acute cardiorespiratory variables,postexercise HRV,lactate,interleukin-6(IL-6),total antioxidant capacity(TAC),creatine kinase,and myoglobin up to 4h after HIIT were monitored.Results:The differences in relatively expressed cardiorespiratory variables(heart rate,VO2)during HIIT were at most moderate,with the most pronounced between-group differences in absolute VO2 values.The disruption of the postexercise HRV was the most pronounced in untrained individuals,and this difference persisted 1 h after HIIT.The highest postexercise IL-6 and TAC concentrations and the lowest changes in creatine kinase and myoglobin were revealed in well-trained individuals.Conclusion:The higher fitness level was associated with the less pronounced postexercise cardiac autonomic changes and their faster restoration,even when there were similar acute cardiorespiratory responses.These findings were simultaneously accompanied by the higher postexercise IL-6 and TAC concentrations and less significant changes in muscle damage biochemical markers in well-trained individuals.展开更多
Purpose: This study aims to compare the load and the length of previously ruptured and healthy Achilles tendon(AT) of a recreational runner who used different footfall patterns on each limb during running.Methods: A 4...Purpose: This study aims to compare the load and the length of previously ruptured and healthy Achilles tendon(AT) of a recreational runner who used different footfall patterns on each limb during running.Methods: A 41-year-old recreational athlete with a ruptured AT participated in this report. Two force plates and a high-speed motion capture system were used to collect ground reaction force and kinematic data in shod and barefoot running conditions. AT length was measured using ultrasonography and an infrared camera system. AT force was estimated as the active plantar flexion moment divided by AT moment arm during stance phase.Results: The participant used a rearfoot pattern on the affected limb and a forefoot/midfoot pattern on the unaffected limb during shod running,and a forefoot/midfoot pattern during barefoot running. There was no difference between the length of the affected and the unaffected AT. During shod running, the maximal AT force and loading rate were lower in the affected AT versus the unaffected AT. During barefoot running, the affected maximal AT force and loading rate were greater than the unaffected AT.Conclusion: Footfall patterns can be an adaptation to reduce the loading on a previously injured AT. It appears that runners may consider using a rearfoot footfall pattern during running to reduce the stress on the AT.展开更多
Given the protective roles of 25-hydroxyvitamin D (25(OH)D or vitamin D) in musculoskeletal health and the potential beneficial effects of vitamin D supplementation in reducing the risk of various chronic diseases, in...Given the protective roles of 25-hydroxyvitamin D (25(OH)D or vitamin D) in musculoskeletal health and the potential beneficial effects of vitamin D supplementation in reducing the risk of various chronic diseases, intensive repletion of vitamin D has been widely advocated. Of note, CD8 T cells have the highest levels of the vitamin D receptor compared with other major immune cells. The effects of vitamin D on CD8 T cells during aging, however, remain unclear. This study determined the relationship between vitamin D levels and CD8 T cell status in 34 healthy female subjects (all >60 years old). The CD8 T-cell phenotype was defined by the surface expression of CD28 and CD95. The low-25(OH)D serum groups (≤30 ng/ml) had higher percentages of CD28+CD95–CD8+ (na?ve) T cells and lower percentages of CD28+CD95+CD8+ (effector) T cells. By contrast, subjects with high levels of 25(OH)D had very low percentages of na?ve CD8 T cells but very high percentages of effector CD8 T cells. There was a significant inverse correlation between 25(OH)D levels and the frequency of na?ve CD8 T cells. The results show that higher levels of vitamin D are correlated with decreased frequencies of na?ve CD8 T cells during early aging, suggesting that higher levels of 25(OH)D accelerate CD8 T cell senescence. These results warrant further evaluation of the effects of vitamin D supplementation in immune aging.展开更多
Much of Italy is characterised by two features： an increased risk of seismic activity and a profusion of old and historic buildings. These factors force us to consider the relationship between building safety and pra...Much of Italy is characterised by two features： an increased risk of seismic activity and a profusion of old and historic buildings. These factors force us to consider the relationship between building safety and practices of conservation and protection, and as such have a direct bearing on our approach to preserving the country＇s cultural heritage in general. The guidelines issued on the assessment and reduction of seismic risk to cultural heritage assets in the Prime Ministerial Decree （DPCM） of 9 February 201 l underline the importance of studying such properties in terms of their vulnerability to seismic activity, using ＂factors of confidence＂ （FC） to translate the qualitative assessments produced during previous phases into quantitative measurements. In addition to the building survey, which describes the precise three-dimensional form of a structure and the relationships between its constituent parts, a substantial part of our knowledge of a building is provided by stratigraphic analysis of the above-ground elements. Similarly, a great deal of useful information can be derived from historical analysis. This paper outlines an archaeoseismological study developed by archaeologists from the University of L＇Aquila and researchers from the ITC-CNR in the same city, which applies a multi-disciplinary approach to the study of historic buildings in areas of seismic activity.展开更多
Background:Mental health conditions are known to increase susceptibility to infectious diseases,including coronavirus disease 2019(COVID-19).Health behaviors play a crucial role in mitigating this susceptibility.We ai...Background:Mental health conditions are known to increase susceptibility to infectious diseases,including coronavirus disease 2019(COVID-19).Health behaviors play a crucial role in mitigating this susceptibility.We aim to examine the differential effectiveness of COVID-19 preventive health behaviors among individuals,considering the presence or absence of specific mental health disorders.Methods:Multivariable logistic regression with interaction terms was performed to examine whether associations between adherence to health behaviors and COVID-19 infection were conditional on depression,anxiety,or eating disorders in a national sample of adults(N=61,891)from 140 US universities,2020–2021.Results:Adjusting for age,race/ethnicity,and gender/sex,the effectiveness of mask-wearing was significant and comparable among individuals with and without depression,anxiety,or eating disorders.Social distancing provided significantly less protection among individuals with depression,anxiety,or eating disorders.Hygiene practice provided significantly less protection among individuals with anxiety.Conclusion:Mask-wearing is robustly effective in the prevention of COVID-19 among individuals.However,social distancing and hygiene practice provide less significant protection among individuals with certain mental health conditions,suggesting the importance of prioritizing these individuals for additional preventive measures(e.g.,vaccines targeting variants)and mitigation strategies(e.g.,financial assistance,targeted mental health care,health education).展开更多
Despite the recent development in radiometric dating of numerous zircons by LA-ICPMS, mineral separation still remains a major obstacle, particularly in the search for the oldest material on Earth. To improve the effi...Despite the recent development in radiometric dating of numerous zircons by LA-ICPMS, mineral separation still remains a major obstacle, particularly in the search for the oldest material on Earth. To improve the efficiency in zircon separation by an order of magnitude, we have designed/developed a new machine-an automatic zircon separator（AZS）. This is designed particularly for automatic pick-up of100 μm-sized zircon grains out of a heavy mineral fraction after conventional separation procedures. The AZS operates in three modes：（1） image processing to choose targeted individual zircon grains out of all heavy minerals spread on a tray,（2） automatic capturing of the individual zircon grains with microtweezers, and（3） placing them one-by-one in a coordinated alignment on a receiving tray. The automatic capturing was designed/created for continuous mineral selecting without human presence for many hours. This software also enables the registration of each separated zircon grain for dating, by recording digital photo-image, optical（color） indices, and coordinates on a receiving tray. We developed two new approaches for the dating; i.e.（1） direct dating of zircons selected by LA-ICPMS without conventional resin-mounting/polishing,（2） high speed U-Pb dating, combined with conventional sample preparation procedures using the new equipment with multiple-ion counting detectors（LA-MIC-ICPMS）.With the first approach, Pb-Pb ages obtained from the surface of a mineral were crosschecked with the interior of the same grain after resin-mounting/polishing. With the second approach, the amount of time required for dating one zircon grain is ca. 20 s, and a sample throughput of 〉150 grains per hour can be achieved with sufficient precision（ca. 0.5%）.We tested the practical efficiency of the AZS, by analyzing an Archean Jack Hills conglomerate in Western Australia with the known oldest（〉4.3 Ga） zircon on Earth. Preliminary results are positive; we were able to obtain more than 194 zircons that are over 4.0 Ga out of ca. 3800 checked grains, and 9 grains were over 4300 Ma with the oldest at 4371 ± 7 Ma. This separation system by AZS, combined with the new approaches, guarantees much higher yield in the hunt for old zircons.展开更多
Technologies such as 3-dimensional body scanners and thermal cameras are currently being investigated to eliminate the traditional means of assessing anthropometrics in the overweight and obese population. The purpose...Technologies such as 3-dimensional body scanners and thermal cameras are currently being investigated to eliminate the traditional means of assessing anthropometrics in the overweight and obese population. The purpose of this study was to determine the potential for thermal imaging to assess the relationship between thermal patterning and anthropometrics in young adults. Participants were 18 - 24 year old men (n = 176) and women (n = 260) with different Body Mass Indices (BMI), somatotypes, and activity levels. Participants were weighed, body scanned and thermally imaged. Statistical treatment included descriptive statistics and ANOVA. Statistically significant differences between mean thermal ratings were found between the normal and abnormal groups as categorized by waist circumference for both males (p < 0.003) and females (p < 0.001). The mean ratings of the contour regions between normal and overweight/ obese groups were also found to be statistically different for both males展开更多
Immersive Virtual Learning Environments(IVLEs)are an increasingly popular tool used extensively in modern training techniques,but little is known about the learning transfer process accompanying curricula based on the...Immersive Virtual Learning Environments(IVLEs)are an increasingly popular tool used extensively in modern training techniques,but little is known about the learning transfer process accompanying curricula based on these methods and the ability of the technique to teach procedures.As an advantageous instrument in teaching and developing psychomotor and spatial activities,further research and assessment into the strengths and applications of IVLE in training activities is needed to evaluate the contributions of this tool in transportation training and development.Using a highway flagman IVLE training program,the purpose of this study was to evaluate the learning experience and learning gains of participants enrolled in the training.The training program’s successes in reaching a wide range of learners and recreating real-world situations support the use of IVLE-based learning to increase engagement and knowledge transfer.展开更多
文摘Background International students contribute to the academic and economic vitality of US higher education while facing exacerbated mental health challenges.Little is known about national trends in anxiety,depression,suicidal ideation and mental health service utilisation in this population.Aims This study examined national trends in the prevalence of clinically significant anxiety,depression,suicidal ideation and service utilisation among international students in US higher education from 2015 to 2024.Methods This repeated cross-sectional study analysed annual data from the Healthy Minds Study,a national survey of collegiate mental health,including 44560 international students.Weighted prevalence estimates were calculated,and multivariable logistic regression models were used to examine temporal trends,controlling for demographic characteristics.Results The weighted annual prevalence of anxiety increased by 78.25%(from 20.46%in 2015-2016 to 36.47%in 2023-2024),depression increased by 73.04%(from 20.44%to 35.37%),suicidal ideation increased by 92.52%(from 5.35%to 10.30%)and service utilisation increased by 45.82%(from 5.26%to 7.67%).In logistic models controlling for demographic characteristics,the increasing trends in anxiety(adjusted odds ratio(aOR)2.21;95%CI 2.07 to 2.36;p<0.001),depression(aOR 1.93;95%CI 1.80 to 2.06;p<0.001),suicidal ideation(aOR 1.57;95%CI 1.41 to 1.74;p<0.001)and service utilisation(aOR 2.01;95%CI 1.79 to 2.26;p<0.001)remained statistically significant over time.Conclusions The prevalence of anxiety,depression and suicidal ideation nearly doubled among international students from 2015 to 2024,while counselling service utilisation increased at a slower rate,indicating persistent gaps in mental healthcare.These findings suggest the need for proactive interventions,culturally competent services and expanded outreach efforts to bridge the mental health service gap for international students.
基金supported by Ostrava University under Grant SGS06/PdF2014
文摘Purpose:The aim of this study was to investigate the influence of the cardiorespiratory fitness level on the response to high-intensity interval training(HIIT)with an individually adjusted running speed of the same relative intensity.The evaluation focused on acute cardiorespiratory response,postexercise cardiac autonomic modulation(heart rate variability(HRV))and biochemical markers of inflammation,oxidative stress,and muscle damage.Methods:Thirty participants were divided into 3 subgroups:well trained,moderately trained,and untrained.All the participants performed30 min HIIT composed of 6×2 min interval exercise with work-to-relief ratio=1 and work intensity 100%of individual velocity at maximal oxygen consumption(VO2max).Acute cardiorespiratory variables,postexercise HRV,lactate,interleukin-6(IL-6),total antioxidant capacity(TAC),creatine kinase,and myoglobin up to 4h after HIIT were monitored.Results:The differences in relatively expressed cardiorespiratory variables(heart rate,VO2)during HIIT were at most moderate,with the most pronounced between-group differences in absolute VO2 values.The disruption of the postexercise HRV was the most pronounced in untrained individuals,and this difference persisted 1 h after HIIT.The highest postexercise IL-6 and TAC concentrations and the lowest changes in creatine kinase and myoglobin were revealed in well-trained individuals.Conclusion:The higher fitness level was associated with the less pronounced postexercise cardiac autonomic changes and their faster restoration,even when there were similar acute cardiorespiratory responses.These findings were simultaneously accompanied by the higher postexercise IL-6 and TAC concentrations and less significant changes in muscle damage biochemical markers in well-trained individuals.
基金supported by a grant from the University of Ostrava (SGS 6148), Czech Republic
文摘Purpose: This study aims to compare the load and the length of previously ruptured and healthy Achilles tendon(AT) of a recreational runner who used different footfall patterns on each limb during running.Methods: A 41-year-old recreational athlete with a ruptured AT participated in this report. Two force plates and a high-speed motion capture system were used to collect ground reaction force and kinematic data in shod and barefoot running conditions. AT length was measured using ultrasonography and an infrared camera system. AT force was estimated as the active plantar flexion moment divided by AT moment arm during stance phase.Results: The participant used a rearfoot pattern on the affected limb and a forefoot/midfoot pattern on the unaffected limb during shod running,and a forefoot/midfoot pattern during barefoot running. There was no difference between the length of the affected and the unaffected AT. During shod running, the maximal AT force and loading rate were lower in the affected AT versus the unaffected AT. During barefoot running, the affected maximal AT force and loading rate were greater than the unaffected AT.Conclusion: Footfall patterns can be an adaptation to reduce the loading on a previously injured AT. It appears that runners may consider using a rearfoot footfall pattern during running to reduce the stress on the AT.
基金National Institute of HealthDeep South Resource Center for Minority Aging Research (1P30AG031054-01, provided by the National Institute on Aging)
文摘Given the protective roles of 25-hydroxyvitamin D (25(OH)D or vitamin D) in musculoskeletal health and the potential beneficial effects of vitamin D supplementation in reducing the risk of various chronic diseases, intensive repletion of vitamin D has been widely advocated. Of note, CD8 T cells have the highest levels of the vitamin D receptor compared with other major immune cells. The effects of vitamin D on CD8 T cells during aging, however, remain unclear. This study determined the relationship between vitamin D levels and CD8 T cell status in 34 healthy female subjects (all >60 years old). The CD8 T-cell phenotype was defined by the surface expression of CD28 and CD95. The low-25(OH)D serum groups (≤30 ng/ml) had higher percentages of CD28+CD95–CD8+ (na?ve) T cells and lower percentages of CD28+CD95+CD8+ (effector) T cells. By contrast, subjects with high levels of 25(OH)D had very low percentages of na?ve CD8 T cells but very high percentages of effector CD8 T cells. There was a significant inverse correlation between 25(OH)D levels and the frequency of na?ve CD8 T cells. The results show that higher levels of vitamin D are correlated with decreased frequencies of na?ve CD8 T cells during early aging, suggesting that higher levels of 25(OH)D accelerate CD8 T cell senescence. These results warrant further evaluation of the effects of vitamin D supplementation in immune aging.
文摘Much of Italy is characterised by two features： an increased risk of seismic activity and a profusion of old and historic buildings. These factors force us to consider the relationship between building safety and practices of conservation and protection, and as such have a direct bearing on our approach to preserving the country＇s cultural heritage in general. The guidelines issued on the assessment and reduction of seismic risk to cultural heritage assets in the Prime Ministerial Decree （DPCM） of 9 February 201 l underline the importance of studying such properties in terms of their vulnerability to seismic activity, using ＂factors of confidence＂ （FC） to translate the qualitative assessments produced during previous phases into quantitative measurements. In addition to the building survey, which describes the precise three-dimensional form of a structure and the relationships between its constituent parts, a substantial part of our knowledge of a building is provided by stratigraphic analysis of the above-ground elements. Similarly, a great deal of useful information can be derived from historical analysis. This paper outlines an archaeoseismological study developed by archaeologists from the University of L＇Aquila and researchers from the ITC-CNR in the same city, which applies a multi-disciplinary approach to the study of historic buildings in areas of seismic activity.
文摘Background:Mental health conditions are known to increase susceptibility to infectious diseases,including coronavirus disease 2019(COVID-19).Health behaviors play a crucial role in mitigating this susceptibility.We aim to examine the differential effectiveness of COVID-19 preventive health behaviors among individuals,considering the presence or absence of specific mental health disorders.Methods:Multivariable logistic regression with interaction terms was performed to examine whether associations between adherence to health behaviors and COVID-19 infection were conditional on depression,anxiety,or eating disorders in a national sample of adults(N=61,891)from 140 US universities,2020–2021.Results:Adjusting for age,race/ethnicity,and gender/sex,the effectiveness of mask-wearing was significant and comparable among individuals with and without depression,anxiety,or eating disorders.Social distancing provided significantly less protection among individuals with depression,anxiety,or eating disorders.Hygiene practice provided significantly less protection among individuals with anxiety.Conclusion:Mask-wearing is robustly effective in the prevention of COVID-19 among individuals.However,social distancing and hygiene practice provide less significant protection among individuals with certain mental health conditions,suggesting the importance of prioritizing these individuals for additional preventive measures(e.g.,vaccines targeting variants)and mitigation strategies(e.g.,financial assistance,targeted mental health care,health education).
基金supported by the Grant-in-Aid from Japan Society of the Promotion for Science (JSPS KAKAENHI New Academic Research No. 26106005)
文摘Despite the recent development in radiometric dating of numerous zircons by LA-ICPMS, mineral separation still remains a major obstacle, particularly in the search for the oldest material on Earth. To improve the efficiency in zircon separation by an order of magnitude, we have designed/developed a new machine-an automatic zircon separator（AZS）. This is designed particularly for automatic pick-up of100 μm-sized zircon grains out of a heavy mineral fraction after conventional separation procedures. The AZS operates in three modes：（1） image processing to choose targeted individual zircon grains out of all heavy minerals spread on a tray,（2） automatic capturing of the individual zircon grains with microtweezers, and（3） placing them one-by-one in a coordinated alignment on a receiving tray. The automatic capturing was designed/created for continuous mineral selecting without human presence for many hours. This software also enables the registration of each separated zircon grain for dating, by recording digital photo-image, optical（color） indices, and coordinates on a receiving tray. We developed two new approaches for the dating; i.e.（1） direct dating of zircons selected by LA-ICPMS without conventional resin-mounting/polishing,（2） high speed U-Pb dating, combined with conventional sample preparation procedures using the new equipment with multiple-ion counting detectors（LA-MIC-ICPMS）.With the first approach, Pb-Pb ages obtained from the surface of a mineral were crosschecked with the interior of the same grain after resin-mounting/polishing. With the second approach, the amount of time required for dating one zircon grain is ca. 20 s, and a sample throughput of 〉150 grains per hour can be achieved with sufficient precision（ca. 0.5%）.We tested the practical efficiency of the AZS, by analyzing an Archean Jack Hills conglomerate in Western Australia with the known oldest（〉4.3 Ga） zircon on Earth. Preliminary results are positive; we were able to obtain more than 194 zircons that are over 4.0 Ga out of ca. 3800 checked grains, and 9 grains were over 4300 Ma with the oldest at 4371 ± 7 Ma. This separation system by AZS, combined with the new approaches, guarantees much higher yield in the hunt for old zircons.
文摘Technologies such as 3-dimensional body scanners and thermal cameras are currently being investigated to eliminate the traditional means of assessing anthropometrics in the overweight and obese population. The purpose of this study was to determine the potential for thermal imaging to assess the relationship between thermal patterning and anthropometrics in young adults. Participants were 18 - 24 year old men (n = 176) and women (n = 260) with different Body Mass Indices (BMI), somatotypes, and activity levels. Participants were weighed, body scanned and thermally imaged. Statistical treatment included descriptive statistics and ANOVA. Statistically significant differences between mean thermal ratings were found between the normal and abnormal groups as categorized by waist circumference for both males (p < 0.003) and females (p < 0.001). The mean ratings of the contour regions between normal and overweight/ obese groups were also found to be statistically different for both males
文摘Immersive Virtual Learning Environments(IVLEs)are an increasingly popular tool used extensively in modern training techniques,but little is known about the learning transfer process accompanying curricula based on these methods and the ability of the technique to teach procedures.As an advantageous instrument in teaching and developing psychomotor and spatial activities,further research and assessment into the strengths and applications of IVLE in training activities is needed to evaluate the contributions of this tool in transportation training and development.Using a highway flagman IVLE training program,the purpose of this study was to evaluate the learning experience and learning gains of participants enrolled in the training.The training program’s successes in reaching a wide range of learners and recreating real-world situations support the use of IVLE-based learning to increase engagement and knowledge transfer.
