Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide ...Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.展开更多
Background:The advent of the self-media age,digital humanities,and artificial intelligence(AI)technologies is gradually reshaping the narrative frameworks of the history of science and technology in general and the hi...Background:The advent of the self-media age,digital humanities,and artificial intelligence(AI)technologies is gradually reshaping the narrative frameworks of the history of science and technology in general and the history of medicine in particular,as it transforms the specific shape of contemporary medical science and health communication practice with the help of interactive,scenario-based communication ecosystems.Methods:This paper focuses on the interactive relationship between the history of science and science communication,employing historical tracing and case study comparison as research methods to explore the pathways and innovative models for reintegrating the history of science and technology including the history of medicine into contemporary scientific discourse.Results:The study finds that in the Chinese context,three key pathways facilitate the engagement of the history of science and technology including the history of medicine in science communication:administrative intervention,value reconstruction,and personalized adaptation.Specifically,administrative intervention promotes the integration of the history of science education into talent development through policy design;value reconstruction,centered on the scientific spirit,enhances societal cultural recognition of technological progress;and personalized adaptation leverages big data and social media technologies to enable precise and tailored knowledge dissemination.Conclusion:The rise of the“web-based knowledge brokering model”in the era of social media has introduced professional knowledge brokers,ensuring the accuracy and accessibility of science communication.These innovations not only serve as decision-making simulation tools for medical science and health communication,linking historical insights with contemporary practice,but also provide theoretical foundations and practical paradigms for realizing the value of the history of science and technology in the digital era.展开更多
This article investigates the word Du(毒)in premodern Chinese medicine and culture.It highlights the paradoxical meaning of the word that served as a foundation for the therapeutic use of poisons in traditional Chines...This article investigates the word Du(毒)in premodern Chinese medicine and culture.It highlights the paradoxical meaning of the word that served as a foundation for the therapeutic use of poisons in traditional Chinese medicine.The article then situates the study in a comparative framework.By comparing the Chinese notion of Du with the Greek concept of pharmakon,it demonstrates significant similarities on the medical use of poisons in the two cultures.It further identifies a striking difference:While the European pharmacy started to separate poisons from medicines in the medieval era,poisons remained an integral part of healing repertoire throughout imperial China.The article ends with offering some cultural explanations for this divergence,and more broadly,a distinct worldview as revealed by the intimate relationship between poisons and medicines in traditional Chinese pharmacy.展开更多
Based on archival materials discovered in America,Britain,and China,this paper carefully examines the history of the short-lived and completely overlooked Department of Physics in the Premedical School of Peking Union...Based on archival materials discovered in America,Britain,and China,this paper carefully examines the history of the short-lived and completely overlooked Department of Physics in the Premedical School of Peking Union Medical College(PUMC),and uncovers this department’s extensive interconnections with its counterpart at Yenching University.This project also looks into the Master of Science(MS)program in the Department of Physics at Yenching University,which,founded in 1927,was the first graduate program in physics in China.It was this MS program that transformed the Yenching Department from a largely premedical training center serving the PUMC into a prominent cradle of Chinese physics research.This Yenching Department,despite its small faculty and brief existence,nurtured many eminent Chinese physicists,such as Chao-Ying Meng孟昭英,Wen-Yu Chang张文裕,Ming-Chen Wang王明贞,Chia-Liu Luke Yuan袁家骝,Cheng-Shu Wang(Chang)王承书,Ho-Fu Lu卢鹤绂,Ting-Sui Ke葛庭燧,Kun Huang黄昆,and Chia-Lin Hsieh谢家麟.It would have been impossible to achieve these outstanding accomplishments without the effective leadership and pioneering work of C.H.Corbett,P.A.Anderson,Y.M.Hsieh,and W.Band—the first four Department Chairs—in combination with relatively abundant private funding,mostly from America,and extensive educational connections with Western institutions.This paper not only introduces in detail these four department heads and their contributions,but also discloses the unique role played by the Rockefeller Foundation via the China Medical Board and the PUMC in the development of the Yenching Department of Physics.展开更多
According to historical evidence, the abuse of opium has been reported all over the globe-specifically throughout Eastern nations-since the sixteenth century. Before that, opium had mostly been applied as medication. ...According to historical evidence, the abuse of opium has been reported all over the globe-specifically throughout Eastern nations-since the sixteenth century. Before that, opium had mostly been applied as medication. Reference has been made in traditional Persian medical literature to the method of cultivation, properties, side effects and toxicity. In sixteenth century Iran, during the reign of the Safavids, opium abuse began. It was from then that prominent Persian scholars started to think of solutions to this societal problem. One of the most famous scholars was Imad al-Din Mahmud ibn Mas＇ud Shirazi, who composed a book concerning addiction-Afyunieh, a comprehensive book on the topic of opium and all issues of opium. Furthermore, he recommended methods for reducing opium dose as well as substitution with other medications that had a narrower range of side effects, in order to eradicate dependency upon opium and opium-derived materials. This is most likely the first book that comprehensively addressed opium and discussed drug rehabilitation methodology, in traditional Persian medical literature. In this historical review, the authors have introduced the book Afyunieh, which presents methods for treating addiction to and giving up opium; the text comprises a synthesis of the author＇s opinions, professional experience and references to the work of other famous physicians.展开更多
The globalization of Chinese medicine, forged through successive waves of migration, cultural exchanges, and economic imperatives, constitutes a nuanced and intricate process with historical roots extending over mille...The globalization of Chinese medicine, forged through successive waves of migration, cultural exchanges, and economic imperatives, constitutes a nuanced and intricate process with historical roots extending over millennia. It stands as the culmination of interconnected historical events that reverberated beyond the confines of China, emerging as a phenomenon characterized by the adjustment of Chinese medical theories, clinical practices, and materia medica to indigenous customs and healthcare traditions prevalent in both proximate and distant regions. In these glocalized processes, the global and the local intersect and mix. The frameworks of globalization and glocalization allow a critical interpretation of the many hybridizations that have shaped overseas Chinese medicine's history and present.展开更多
The mass communication model and interactive ritual chain theory,which serve as communication paradigms in the new media era,facilitate and enhance the synergy between the fields of social history of medicine and heal...The mass communication model and interactive ritual chain theory,which serve as communication paradigms in the new media era,facilitate and enhance the synergy between the fields of social history of medicine and health communication.This study employs a comprehensive framework based on the five elements of the mass communication model:information source,communication subject,communication object,message content,and post-communication feedback.Additionally,it incorporates the interactive ritual chain theory to examine the evolving dynamics and developmental trajectory of research in the social history of medicine during the new media era.Conclusively,this paper acknowledges the existing interaction gaps in the interaction between health communication and the social history of medicine research while outlining the challenges for fostering collaboration and proposing strategic optimizations for effective integration.展开更多
China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic ...China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic groups,with limited research on the genetic formation of the hereditary elite family,especially considering their abundant archaeological record and clear material identity.In this study,we obtain the ancient genome of a hereditary elite family,Gao Bin(高宾,503 AD–572 AD),at 0.6473-fold coverage with 475,132 single-nucleotide polymorphisms(SNPs)on the 1240k panel.His mitochondrial haplogroup belongs to Z4 and Y-haplogroup to O1a1a2b-F2444∗.The genetic profile of Gao Bin is most similar to that of the northern Han Chinese.He can be modeled as deriving all his ancestry from Late Neolithic to Iron Age Yellow River farmers without influence from Northeast Asia,Korea,or the Mongolian Plateau.Our study sheds light on the genetic formation of hereditary elite families in the context of the Southern and Northern Dynasties ethnic integration.展开更多
Political memorials remain being a developing chapter of the current heritage boom in China,with evolving heritage narratives that resonate with inner political changes.Analysing the Site of the First National Congres...Political memorials remain being a developing chapter of the current heritage boom in China,with evolving heritage narratives that resonate with inner political changes.Analysing the Site of the First National Congress of the Communist Party of China in Shanghai,I argue that the search for the'origins'of the place is rooted in authorised heritage discourses that motivate constant arrangements of heritage conservation and architectural and urban design around Shanghai's vernacular residential type:the shikumen.Using qualitative methods like architectural analysis,site observation and semi-structured interviews,this paper analyses the sublimation of the Shanghai shikumen through three different stages,put in place at the site of the First National Congress since 1949 until today.Doing so,the paper puts forward the argument that interventions at the site do not follow a straightforward route to appropriate the shikumen type,but one that is subject to varying political orientations within the Party-State.Also,that politically motivated attention towards the vernacular origins of the site stresses the rising consideration towards the historic built environment in China,and related processes of heritage conservation and monumentalisation.展开更多
1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western med...1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.展开更多
This article examines the transmission and influence of Tang-period foreign astrology in China through two representative texts:the Futian Calendar(Futian li符天历)and the Yusi Scripture(Yusi jing聿斯经).The Tang and ...This article examines the transmission and influence of Tang-period foreign astrology in China through two representative texts:the Futian Calendar(Futian li符天历)and the Yusi Scripture(Yusi jing聿斯经).The Tang and Song official and private bibliographies,which record numerous works belonging to the Futian system and the Yusi system,indicate that,after the Futian Calendar and the Yusi Scripture were introduced into China in the Jianzhong and Zhenyuan eras,respectively,they were widely disseminated through the practices and manipulations of folk diviners.An analysis of the surviving scattered records that reflect the contents of these two texts suggests that the Futian Calendar and the Yusi Scripture represent two sides of the same coin in the foreign astrology introduced to China:the Futian Calendar supplied the mathematical methods for calculating planetary positions for the fortune-telling aspect of astrology,which is mathematically demanding,while the Yusi Scripture provided the rules for astrological calculations,predicting an individual’s fate based on the configuration of celestial bodies in the ecliptic at the time of the person’s birth as determined by the Futian Calendar.The Yusi Scripture likely underwent multiple translations,reintroductions,and localizations,transforming the practice from predicting fate based on the seven luminaries to doing so with the eleven luminaries.The Tangperiod foreign astrology represented by the Futian Calendar and the Yusi Scripture exerted a profound influence on China’s indigenous astronomy and even its indigenous culture.This influence not only functioned at the broad social and cultural levels but also permeated from the civilian to the official sphere,eventually becoming an integral part of traditional Chinese culture.The study highlights how knowledge exchange and transmission drive civilizational development,and argues that necessary encounters and fusion between local culture and foreign knowledge constitute a healthy condition for preserving cultural independence and diversity.展开更多
The creation of a national unified textbook on acupuncture was a critical effort by China to standardize traditional Chinese medicine.In the early People’s Republic of China,the development of acupuncture textbooks f...The creation of a national unified textbook on acupuncture was a critical effort by China to standardize traditional Chinese medicine.In the early People’s Republic of China,the development of acupuncture textbooks followed a complex trajectory.It began with Zhu Lian’s(朱琏)Xin Zhen Jiu Xue(《新针灸学》New Acupuncture and Moxibustion),extending the Yan’an(延安)tradition,and moved to Zhen Jiu Xue(《针灸学》Acupuncture and Moxibustion,1957),a localized effort from the Jiangsu Provincial Chinese Medicine School.This culminated in the national Zhen Jiu Xue Jiang Yi(《针灸学讲义》Lectures on Acupuncture and Moxibustion).This process reflects a shift from regional teaching to a standardized national model,as well as a pedagogical transformation from a scientific approach to a return to classical sources.The textbook centers on Bian Zheng Lun Zhi(辨证论治treatment based on pattern differentiation),blending systematic,scientific,and practical elements,and represents the era’s fusion of Chinese and Western medicine,helping to shape a modern acupuncture framework.展开更多
Background:Vaccine hesitancy remains a pressing global challenge,impacting the acceptance and distribution of both long-established and newly developed vaccines.This paper investigates the multifaceted nature of vacci...Background:Vaccine hesitancy remains a pressing global challenge,impacting the acceptance and distribution of both long-established and newly developed vaccines.This paper investigates the multifaceted nature of vaccine hesitancy,focusing on the development of the measles vaccine as a historical case study,while drawing comparisons to the coronavirus disease 2019(COVID-19)pandemic.Methods:The study employs a historical and comparative approach to analyze vaccine hesitancy.It examines how technological advances,public policy,and communication strategies have influenced vaccine acceptance.Key lessons from the development of the measles vaccine are compared with challenges encountered during the rapid development and deployment of COVID-19 vaccines.Results:Both historical and contemporary examples reveal commonalities and differences in addressing vaccine hesitancy.While the measles vaccine demonstrated the importance of long-term safety evaluations and public trust-building,the COVID-19 vaccine highlighted the challenges of rapid development timelines and combating misinformation in a digital age.The findings underscore the necessity of transparent communication,equitable access,and proactive engagement in overcoming hesitancy.Conclusion:Understanding the historical and contemporary dynamics of vaccine hesitancy is crucial for promoting public trust and equitable vaccination in an evolving global health landscape.Effective strategies,combining historical lessons with modern innovations,can address public concerns and enhance vaccine acceptance.展开更多
Radial growth of trees is highly sensitive to environmental changes,but the effect of climate on tree rings in Qinghai spruce(Picea crassifolia),a widely distributed endemic conifer in western China,is more complex th...Radial growth of trees is highly sensitive to environmental changes,but the effect of climate on tree rings in Qinghai spruce(Picea crassifolia),a widely distributed endemic conifer in western China,is more complex than in many other conifers.A comprehensive understanding of the spatiotemporal climatic responses of its rings is needed to develop theoretical basis for designing strategies for its conservation and management.Here,our synthesis of the literature on responses of radial growth of Qinghai spruce to monthly climate variables in different environmental conditions by meta-analysis showed that precipitation and drought severity are the main limiting factors for Qinghai spruce radial growth in the semiarid region of northwestern China.In warmer and drier areas,radial growth of Qinghai spruce is mainly limited by drought.In the areas north of the 600-mm annual precipitation isoline,the tree-ring width(TRW)was significantly positively correlated with precipitation and significantly negatively correlated with temperature during the growing season(June-August).The limiting effect of drought on Qinghai spruce is also gradually increasing from southeast to northwest,to the west of 103°E and within 37°N-39°N.展开更多
AIMTo analyze the research activity on liver abscess (LA) and identify the main topic clusters in the area.METHODSWe identified all documents using the medical subject heading “LA” indexed in t...AIMTo analyze the research activity on liver abscess (LA) and identify the main topic clusters in the area.METHODSWe identified all documents using the medical subject heading “LA” indexed in the MEDLINE database between 2001 and 2015. We performed a descriptive bibliometric analysis, characterizing the evolution of scientific activity, the publication types of the documents, the document categories of clinical interest (case reports, clinical trials, evaluation studies, meta-analysis, observational studies, practice guidelines and validation studies) and the geographic distribution of the research. We also carried out an analysis of networks and research clusters in order to identify the main topic areas of research.RESULTSOur search yielded a total of 1278 documents, showing a stable scientific production over the study period and a marked multidisciplinary nature. The research was dominated by case reports (65.9% of the documents analyzed). In terms of geographic distribution, researchers from the United States led in the number of signatures (n = 229), followed by those from Taiwan (n = 185), India (n = 145), Japan (n = 144), South Korea (n = 100), and China (n = 84). With regard to amebic LA, the top-producing countries were India and Mexico (n = 69 each), followed by the United States (n = 29). In the case of pyogenic LA, Taiwan Residents researchers led scientific production (n = 71), followed by the United States (n = 39) and China (n = 29). The most active areas of research in the field are diagnosis via computerized tomography scan, differential diagnosis with regard to liver cancer, treatment with antimicrobial agents, and Klebsiella infections (including bacteremia).CONCLUSIONClinical case reports associated with diagnosis and treatment are the main topic of study, highlighting the importance of this document type in advancing knowledge.展开更多
To identify impact factors on the distribution and characters of natural plants community in reclamation area, with survey data from 67 plant quadrats in July 2009, soil properties data from 216 sampling points in Apr...To identify impact factors on the distribution and characters of natural plants community in reclamation area, with survey data from 67 plant quadrats in July 2009, soil properties data from 216 sampling points in April 2009, and TM (30 m) data in 2006, the composition and characteristics of natural plants community in different time of the Fengxian area in the Changjiang (Yangtze) River estuary were analyzed with two-way indicator species analysis (TWINSPAN), multivariate analysis of variance (MANOVA), detrended canonical correspondence analysis (DCCA) and canonical correspondence analysis (CCA). The results show that: 1) The plant communities in the reclaimed area are mainly mesophytes and helophytic-mesophytic transitional communities, showing a gradient distribution trend with the change in reclamation years. Species richness (MA), species diversity (H) and above-ground biomass also increase with the increase of reclamation years. Nevertheless, they appear to decline slightly in the middle and late reclamation period (> 30 years). 2) With the rise in land use levels, the changes in species richness and species diversity tend to increase at first and then decrease; species dominance (D), however, tends to decline; and above-ground biomass increases slightly. 3) The distribution of the plant community is mainly influenced by the following factors: land use levels (R = 0.55, p < 0.05), soil moisture (R = 0.53, p < 0.05), soil salinity (R = 0.43, p < 0.05) and reclamation time (R = 0.40, p < 0.05).展开更多
This paper investigates some of the ways that Chinese medicine has been transferred to the Western world and to Islamic territories. During the Golden Age of Islam （8th to 13th century CE）, the herbal drug trade pro...This paper investigates some of the ways that Chinese medicine has been transferred to the Western world and to Islamic territories. During the Golden Age of Islam （8th to 13th century CE）, the herbal drug trade promoted significant commercial and scientific exchange between China and the Muslim world. Chinese herbal drugs have been described by medieval Muslim medical scholars such as Tabari （870 CE）, Rhazes （925 CE）, Haly Abbas （982 CE）, Avicenna （1037 CE） and Jurjani （1137 CE）. The term al-sin （the Arabic word for China） is used 46 times in Avicenna＇s Canon of Medicine in reference to herbal drugs imported from China. Cinnamon （dar sini; ＂Chinese herb＂）, wild ginger （asaron）, rhubarb （rivand-e sini）, nutmeg （basbasa）, incense tree wood （ood）, cubeb （kababe） and sandalwood （sandal） were the most frequently mentioned Chinese herbs in Islamic medical books. There are also multiple similarities between the clinical uses of these herbs in both medical systems. It appears that Chinese herbal drugs were a major component of the exchange of goods and knowledge between China and the Islamic and later to the Western world amid this era.展开更多
In the theory of traditional Chinese medicine, aging is mainly thought renal deficiency caused renal failure, mainly involving decline of kidney-Yang and deficiency of kidney-essence. Huanshaodan, a Chinese traditiona...In the theory of traditional Chinese medicine, aging is mainly thought renal deficiency caused renal failure, mainly involving decline of kidney-Yang and deficiency of kidney-essence. Huanshaodan, a Chinese traditional preparation for kidney-replenishing essence, was used to be the preparation for reinforcing renal deficiency and preventing aging for aged people. OBJECTIVE： To observe the effects of Huanshaodan on swimming durance and the abilities of catalase （CAT） in serum and monoamine oxidase-B （MAO-B） in brain tissue as well as in vitro anti-oxidative ability of aging mouse. DESIGN： A controlled animal experiment. SETTING： College of Basic Medicine, Hunan University of Traditional Chinese Medicine. MATERIALS： Fifty-four healthy NIH mice, aged 18 months old, of either gender, weighing （48.9±5.4） g, and one SD male rat, aged 16 months old, weighing 51.7 g, were provided by Animal Experimental Center, Hunan University of Traditional Chinese Medicine. Thirty NIH mice were randomly chosen for swimming test, and divided into experimental group and control group, with 15 in each; The other 24 NIH mice were used for enzyme activity assay, and also divided into experimental group and control group, with 12 in each. SD rat was used for in vitro anti-oxidative ability test, Huanshaodan water decoction was composed of Cheqianzi, Wuweizi, Huaishan, Danggui, Huangbai, Shudi, Baizhi, Niuxi, Baishen, Tusizi, Buguzhi, Roucongrong and Heshouwu 13 Chinese herbs. METHODS： This study was carried out in the Second Laboratory, Department of Biochemistry, Hunan University of Traditional Chinese Medicine in June 2006. Swimming and enzyme activity assay： Mice in the two experimental groups were intragastrically administrated with l0 μL/g Huanshaodan water decoction. Mice in the two control groups were intragastrically administrated with the same amount of normal saline. All the mice were intragastrically administrated for 5 days, and they were free to access to medicine in the other 2 days in a week. Each mouse was administrated for 8 weeks. MAIN OUTCOME MEASURES： ① Forty days after administration, mice in the experimental group and control group for swimming test were loaded at tails and allowed to swim in the water-tank. Swimming durance was recorded. ② Following the method of Chen Qi, the activities of CAT in serum and MAO-B in brain tissue as well as the inhibitory rate of each medicine on malonaldehyde （MDA） content in the in vitro rat hepatic tissue were determined; Meanwhile, the inhibitory rate of different doses of Tusizi liquid to MDA content in the rat hepatic tissue in vitro was also assayed. RESULTS： Fifty-four NIH mice and one SD rat were recruited in this experiment. Three mice died in the swimming test, and all the other animals were involved in the final analysis. ① Swimming durance of mice in the experimental group was significantly longer than that in the control group （ t =7.502, P 〈 0.01 ） . The activity of CAT in serum of mice in the experimental group was significantly higher than that in the control group （ t =13.307, P 〈 0.01 ） . ② The activity of MAO-B in brain tissue of mice in the experimental group was significantly lower than that in the control group （t =l3.27, P 〈 0.01 ） . ③The inhibitory rate of Cheqianzi, Wuweizi, Huaishan, Danggui, Huangbai, Shudi, Baizhi, Niuxi, Baishen, Tusizi, Buguzhi, Roucongrong and Heshouwu 13 Chinese herbs of Huanshaodan to MDA in the rat hepatic tissue in vitro was - 62.9, - 95.1, - 34.9, - 65.1, - 99.1, - 87.2, - 94.1, - 20.0, - 67.0, - 83.7, - 91.0, - 98.4, - 93.0, respectively. ④ The inhibitory rate of low to high dose of Tusizi liquid to MDA content in the rat hepatic tissue in vitro was - 3.41, - 18.1, - 26.6, - 83.7, respectively. CONCLUSION： Huanshaodan enhances swimming endurance, anti-oxygen free radical and anti-oxidativeabilities, and thus, it can delay aging.展开更多
During the COVID-19 pandemic,a multitude of narratives saturated the print,audiovisual,and electronic media.Improvised,uninformed,apocalyptic and voluntarist approaches abounded.These notes-written during the pandemic...During the COVID-19 pandemic,a multitude of narratives saturated the print,audiovisual,and electronic media.Improvised,uninformed,apocalyptic and voluntarist approaches abounded.These notes-written during the pandemic and delivered in the conference series-address the proliferation of such discourses,emphasizing a series of issues.First,the widespread ignorance about the history of epidemics.Then,the inability to deal with the uncertainties that reign during pandemic times,as well as the announcements that this extraordinary health/sanitary event would produce a profound watershed in all walks of life and in all corners of the world.Finally,and against the general assertion that“one learns from the past to understand the present,”these notes seek to point out how the present can illuminate the study of the past-or,more personally,what I think I have learned as a historian in the times of the COVID-19 pandemic.展开更多
The process of food digestion is one of the most important physiologic processes in human body. In this review, we are seeking the views of Avicenna, the most distinguished Persian medical scholar about digestion and ...The process of food digestion is one of the most important physiologic processes in human body. In this review, we are seeking the views of Avicenna, the most distinguished Persian medical scholar about digestion and indigestion. Avicenna’s view was based on the humoral theory. Avicenna has focused scrutiny on the process of digestion. He divided this process into four phases including gastric, hepatic, intravascular and intra-organ digestion. A defect in any of these phases can lead to disturbance in other stages. Avicenna approached the problem of indigestion through factors of diet, lifestyle and inherent structural characteristics of digestive organs. Modern medicine confirms Avicenna's opinion about the start of digestion from the mouth, the role of the stomach in digestion and the role of the liver in the metabolism of foods. Overeating or eating certain foods, snacking between meals, eating variety of different foods together, intense physical activity, sexual activity after a meal, stress and sleep insufficiency are among factors that may be linked to indigestion in modern medicine viewpoints and also have been mentioned in Avicenna's teachings. It seems rational to consider the medical approaches recommended by Avicenna for future studies in the field of digestive disorders.展开更多
基金supported by the National Key Research and Development Program(Grant No.2024YFA0917200)the Projects of the Chinese Center for Disease Control and Prevention(Grant No.BB2110240093)World Medical History under the Education Innovation Plan of the University of Science and Technology of China(Grant No.2024YCHX07).
文摘Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.
基金The National Key R&D project granted by the Ministry of Science and Technology(2024YFA0917200)Digital Museum Construction Project of Chinese Centre for Disease Control and Prevention(BB2110240080)Science Communication Project of Chinese Academy of Sciences(CX2090000008).
文摘Background:The advent of the self-media age,digital humanities,and artificial intelligence(AI)technologies is gradually reshaping the narrative frameworks of the history of science and technology in general and the history of medicine in particular,as it transforms the specific shape of contemporary medical science and health communication practice with the help of interactive,scenario-based communication ecosystems.Methods:This paper focuses on the interactive relationship between the history of science and science communication,employing historical tracing and case study comparison as research methods to explore the pathways and innovative models for reintegrating the history of science and technology including the history of medicine into contemporary scientific discourse.Results:The study finds that in the Chinese context,three key pathways facilitate the engagement of the history of science and technology including the history of medicine in science communication:administrative intervention,value reconstruction,and personalized adaptation.Specifically,administrative intervention promotes the integration of the history of science education into talent development through policy design;value reconstruction,centered on the scientific spirit,enhances societal cultural recognition of technological progress;and personalized adaptation leverages big data and social media technologies to enable precise and tailored knowledge dissemination.Conclusion:The rise of the“web-based knowledge brokering model”in the era of social media has introduced professional knowledge brokers,ensuring the accuracy and accessibility of science communication.These innovations not only serve as decision-making simulation tools for medical science and health communication,linking historical insights with contemporary practice,but also provide theoretical foundations and practical paradigms for realizing the value of the history of science and technology in the digital era.
文摘This article investigates the word Du(毒)in premodern Chinese medicine and culture.It highlights the paradoxical meaning of the word that served as a foundation for the therapeutic use of poisons in traditional Chinese medicine.The article then situates the study in a comparative framework.By comparing the Chinese notion of Du with the Greek concept of pharmakon,it demonstrates significant similarities on the medical use of poisons in the two cultures.It further identifies a striking difference:While the European pharmacy started to separate poisons from medicines in the medieval era,poisons remained an integral part of healing repertoire throughout imperial China.The article ends with offering some cultural explanations for this divergence,and more broadly,a distinct worldview as revealed by the intimate relationship between poisons and medicines in traditional Chinese pharmacy.
文摘Based on archival materials discovered in America,Britain,and China,this paper carefully examines the history of the short-lived and completely overlooked Department of Physics in the Premedical School of Peking Union Medical College(PUMC),and uncovers this department’s extensive interconnections with its counterpart at Yenching University.This project also looks into the Master of Science(MS)program in the Department of Physics at Yenching University,which,founded in 1927,was the first graduate program in physics in China.It was this MS program that transformed the Yenching Department from a largely premedical training center serving the PUMC into a prominent cradle of Chinese physics research.This Yenching Department,despite its small faculty and brief existence,nurtured many eminent Chinese physicists,such as Chao-Ying Meng孟昭英,Wen-Yu Chang张文裕,Ming-Chen Wang王明贞,Chia-Liu Luke Yuan袁家骝,Cheng-Shu Wang(Chang)王承书,Ho-Fu Lu卢鹤绂,Ting-Sui Ke葛庭燧,Kun Huang黄昆,and Chia-Lin Hsieh谢家麟.It would have been impossible to achieve these outstanding accomplishments without the effective leadership and pioneering work of C.H.Corbett,P.A.Anderson,Y.M.Hsieh,and W.Band—the first four Department Chairs—in combination with relatively abundant private funding,mostly from America,and extensive educational connections with Western institutions.This paper not only introduces in detail these four department heads and their contributions,but also discloses the unique role played by the Rockefeller Foundation via the China Medical Board and the PUMC in the development of the Yenching Department of Physics.
文摘According to historical evidence, the abuse of opium has been reported all over the globe-specifically throughout Eastern nations-since the sixteenth century. Before that, opium had mostly been applied as medication. Reference has been made in traditional Persian medical literature to the method of cultivation, properties, side effects and toxicity. In sixteenth century Iran, during the reign of the Safavids, opium abuse began. It was from then that prominent Persian scholars started to think of solutions to this societal problem. One of the most famous scholars was Imad al-Din Mahmud ibn Mas＇ud Shirazi, who composed a book concerning addiction-Afyunieh, a comprehensive book on the topic of opium and all issues of opium. Furthermore, he recommended methods for reducing opium dose as well as substitution with other medications that had a narrower range of side effects, in order to eradicate dependency upon opium and opium-derived materials. This is most likely the first book that comprehensively addressed opium and discussed drug rehabilitation methodology, in traditional Persian medical literature. In this historical review, the authors have introduced the book Afyunieh, which presents methods for treating addiction to and giving up opium; the text comprises a synthesis of the author＇s opinions, professional experience and references to the work of other famous physicians.
文摘The globalization of Chinese medicine, forged through successive waves of migration, cultural exchanges, and economic imperatives, constitutes a nuanced and intricate process with historical roots extending over millennia. It stands as the culmination of interconnected historical events that reverberated beyond the confines of China, emerging as a phenomenon characterized by the adjustment of Chinese medical theories, clinical practices, and materia medica to indigenous customs and healthcare traditions prevalent in both proximate and distant regions. In these glocalized processes, the global and the local intersect and mix. The frameworks of globalization and glocalization allow a critical interpretation of the many hybridizations that have shaped overseas Chinese medicine's history and present.
基金University of Science and Technology of China Quality Project History of Medicine(2023YCZX02)Digital Museum Construction Project of Chinese Centre for Disease Control and Prevention(BB2110240080)The National Key R&D project granted by the Ministry of Science and Technology(2018YFA0902400).
文摘The mass communication model and interactive ritual chain theory,which serve as communication paradigms in the new media era,facilitate and enhance the synergy between the fields of social history of medicine and health communication.This study employs a comprehensive framework based on the five elements of the mass communication model:information source,communication subject,communication object,message content,and post-communication feedback.Additionally,it incorporates the interactive ritual chain theory to examine the evolving dynamics and developmental trajectory of research in the social history of medicine during the new media era.Conclusively,this paper acknowledges the existing interaction gaps in the interaction between health communication and the social history of medicine research while outlining the challenges for fostering collaboration and proposing strategic optimizations for effective integration.
基金funded by the National Natural Science Foundation of China(32070576,31801040,and 32270667)Lantai Young Scholars Program of Chinese History Institute(2022LTQN602)+11 种基金the National Social Science Fund of China(19VJX074 and 21CKG022)Priority Research Program of the Chinese Academy of Sciences:Pan-Third Pole Environment Study for a Green Silk Road(Pan-TPE)(XDA2004010101)the National Key Research and Development Program(2023YFC3303701-02)the Natural Science Foundation of Fujian Province of China(2023J06013)the Science and Technology Commission of Shanghai Municipality(18490750300)the National Key Research and Development Program(2020YFE0201600)Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)the Major Project of National Social Science Foundation of China granted to C.C.W.(21&ZD285),S.W.(20&ZD212),and D.L.(21&ZD237)Major Special Project of Philosophy and Social Sciences Research of the Ministry of Education(2022JZDZ023)Open Research Fund of State Key Laboratory of Genetic Engineering at Fudan University(SKLGE-2310)Open Research Fund of Forensic Genetics Key Laboratory of the Ministry of Public Security(2023FGKFKT07)European Research Council(ERC)grant(ERC-2019-ADG-883700-TRAM).
文摘China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic groups,with limited research on the genetic formation of the hereditary elite family,especially considering their abundant archaeological record and clear material identity.In this study,we obtain the ancient genome of a hereditary elite family,Gao Bin(高宾,503 AD–572 AD),at 0.6473-fold coverage with 475,132 single-nucleotide polymorphisms(SNPs)on the 1240k panel.His mitochondrial haplogroup belongs to Z4 and Y-haplogroup to O1a1a2b-F2444∗.The genetic profile of Gao Bin is most similar to that of the northern Han Chinese.He can be modeled as deriving all his ancestry from Late Neolithic to Iron Age Yellow River farmers without influence from Northeast Asia,Korea,or the Mongolian Plateau.Our study sheds light on the genetic formation of hereditary elite families in the context of the Southern and Northern Dynasties ethnic integration.
文摘Political memorials remain being a developing chapter of the current heritage boom in China,with evolving heritage narratives that resonate with inner political changes.Analysing the Site of the First National Congress of the Communist Party of China in Shanghai,I argue that the search for the'origins'of the place is rooted in authorised heritage discourses that motivate constant arrangements of heritage conservation and architectural and urban design around Shanghai's vernacular residential type:the shikumen.Using qualitative methods like architectural analysis,site observation and semi-structured interviews,this paper analyses the sublimation of the Shanghai shikumen through three different stages,put in place at the site of the First National Congress since 1949 until today.Doing so,the paper puts forward the argument that interventions at the site do not follow a straightforward route to appropriate the shikumen type,but one that is subject to varying political orientations within the Party-State.Also,that politically motivated attention towards the vernacular origins of the site stresses the rising consideration towards the historic built environment in China,and related processes of heritage conservation and monumentalisation.
文摘1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.
基金the General Program of the National Natural Science Foundation of China entitled“A Study on Foreign Astronomy Introduced to China and Its Influence During the Tang and Song Dynasties”唐宋时期域外来华天文学及其影响之研究(Project No.12273039).
文摘This article examines the transmission and influence of Tang-period foreign astrology in China through two representative texts:the Futian Calendar(Futian li符天历)and the Yusi Scripture(Yusi jing聿斯经).The Tang and Song official and private bibliographies,which record numerous works belonging to the Futian system and the Yusi system,indicate that,after the Futian Calendar and the Yusi Scripture were introduced into China in the Jianzhong and Zhenyuan eras,respectively,they were widely disseminated through the practices and manipulations of folk diviners.An analysis of the surviving scattered records that reflect the contents of these two texts suggests that the Futian Calendar and the Yusi Scripture represent two sides of the same coin in the foreign astrology introduced to China:the Futian Calendar supplied the mathematical methods for calculating planetary positions for the fortune-telling aspect of astrology,which is mathematically demanding,while the Yusi Scripture provided the rules for astrological calculations,predicting an individual’s fate based on the configuration of celestial bodies in the ecliptic at the time of the person’s birth as determined by the Futian Calendar.The Yusi Scripture likely underwent multiple translations,reintroductions,and localizations,transforming the practice from predicting fate based on the seven luminaries to doing so with the eleven luminaries.The Tangperiod foreign astrology represented by the Futian Calendar and the Yusi Scripture exerted a profound influence on China’s indigenous astronomy and even its indigenous culture.This influence not only functioned at the broad social and cultural levels but also permeated from the civilian to the official sphere,eventually becoming an integral part of traditional Chinese culture.The study highlights how knowledge exchange and transmission drive civilizational development,and argues that necessary encounters and fusion between local culture and foreign knowledge constitute a healthy condition for preserving cultural independence and diversity.
基金financed by the grant from major bidding project of National Social Science Foundation of China Major Historical Issues Research Project of Chinese Academy of History in 2024(No.24VLS013).
文摘The creation of a national unified textbook on acupuncture was a critical effort by China to standardize traditional Chinese medicine.In the early People’s Republic of China,the development of acupuncture textbooks followed a complex trajectory.It began with Zhu Lian’s(朱琏)Xin Zhen Jiu Xue(《新针灸学》New Acupuncture and Moxibustion),extending the Yan’an(延安)tradition,and moved to Zhen Jiu Xue(《针灸学》Acupuncture and Moxibustion,1957),a localized effort from the Jiangsu Provincial Chinese Medicine School.This culminated in the national Zhen Jiu Xue Jiang Yi(《针灸学讲义》Lectures on Acupuncture and Moxibustion).This process reflects a shift from regional teaching to a standardized national model,as well as a pedagogical transformation from a scientific approach to a return to classical sources.The textbook centers on Bian Zheng Lun Zhi(辨证论治treatment based on pattern differentiation),blending systematic,scientific,and practical elements,and represents the era’s fusion of Chinese and Western medicine,helping to shape a modern acupuncture framework.
基金supported by The National Key Research and Development Program(Grant No.2024YFA0917200)University of Science and Technology of China(Grant No.2024YCHX07)Chinese Academy of Sciences(Grant No.CX2110240028).
文摘Background:Vaccine hesitancy remains a pressing global challenge,impacting the acceptance and distribution of both long-established and newly developed vaccines.This paper investigates the multifaceted nature of vaccine hesitancy,focusing on the development of the measles vaccine as a historical case study,while drawing comparisons to the coronavirus disease 2019(COVID-19)pandemic.Methods:The study employs a historical and comparative approach to analyze vaccine hesitancy.It examines how technological advances,public policy,and communication strategies have influenced vaccine acceptance.Key lessons from the development of the measles vaccine are compared with challenges encountered during the rapid development and deployment of COVID-19 vaccines.Results:Both historical and contemporary examples reveal commonalities and differences in addressing vaccine hesitancy.While the measles vaccine demonstrated the importance of long-term safety evaluations and public trust-building,the COVID-19 vaccine highlighted the challenges of rapid development timelines and combating misinformation in a digital age.The findings underscore the necessity of transparent communication,equitable access,and proactive engagement in overcoming hesitancy.Conclusion:Understanding the historical and contemporary dynamics of vaccine hesitancy is crucial for promoting public trust and equitable vaccination in an evolving global health landscape.Effective strategies,combining historical lessons with modern innovations,can address public concerns and enhance vaccine acceptance.
基金supported by the National Natural Science Foundation of China(Grants Nos.42130511,42261134537 and 41602192)funded by the Russian Science Foundation(Grant No.23-44-00067)+2 种基金supported by the Swedish Research Council(Vetenskaps lijeradet,Grant No.2023-00605)the Marianne and Marcus Wallenberg Foundation(Grant No.MMW 2022-0114)the Centre for Advanced Study(CAS)at the Norwegian Academy of Science and Letters,which funded and hosted the research project“The Nordic Little Ice Age”during the 2024-2025 academic year。
文摘Radial growth of trees is highly sensitive to environmental changes,but the effect of climate on tree rings in Qinghai spruce(Picea crassifolia),a widely distributed endemic conifer in western China,is more complex than in many other conifers.A comprehensive understanding of the spatiotemporal climatic responses of its rings is needed to develop theoretical basis for designing strategies for its conservation and management.Here,our synthesis of the literature on responses of radial growth of Qinghai spruce to monthly climate variables in different environmental conditions by meta-analysis showed that precipitation and drought severity are the main limiting factors for Qinghai spruce radial growth in the semiarid region of northwestern China.In warmer and drier areas,radial growth of Qinghai spruce is mainly limited by drought.In the areas north of the 600-mm annual precipitation isoline,the tree-ring width(TRW)was significantly positively correlated with precipitation and significantly negatively correlated with temperature during the growing season(June-August).The limiting effect of drought on Qinghai spruce is also gradually increasing from southeast to northwest,to the west of 103°E and within 37°N-39°N.
文摘AIMTo analyze the research activity on liver abscess (LA) and identify the main topic clusters in the area.METHODSWe identified all documents using the medical subject heading “LA” indexed in the MEDLINE database between 2001 and 2015. We performed a descriptive bibliometric analysis, characterizing the evolution of scientific activity, the publication types of the documents, the document categories of clinical interest (case reports, clinical trials, evaluation studies, meta-analysis, observational studies, practice guidelines and validation studies) and the geographic distribution of the research. We also carried out an analysis of networks and research clusters in order to identify the main topic areas of research.RESULTSOur search yielded a total of 1278 documents, showing a stable scientific production over the study period and a marked multidisciplinary nature. The research was dominated by case reports (65.9% of the documents analyzed). In terms of geographic distribution, researchers from the United States led in the number of signatures (n = 229), followed by those from Taiwan (n = 185), India (n = 145), Japan (n = 144), South Korea (n = 100), and China (n = 84). With regard to amebic LA, the top-producing countries were India and Mexico (n = 69 each), followed by the United States (n = 29). In the case of pyogenic LA, Taiwan Residents researchers led scientific production (n = 71), followed by the United States (n = 39) and China (n = 29). The most active areas of research in the field are diagnosis via computerized tomography scan, differential diagnosis with regard to liver cancer, treatment with antimicrobial agents, and Klebsiella infections (including bacteremia).CONCLUSIONClinical case reports associated with diagnosis and treatment are the main topic of study, highlighting the importance of this document type in advancing knowledge.
基金Under the auspices of Ministry of Education, China (No. 108148)State Key Laboratory of Urban and Regional Ecology (No. SKLURE2010-2-2)+1 种基金National Basic Research Program of China (No. 2010CB951203)Key Research Program of Shanghai Science & Technology (No. 08231200700, 08231200702)
文摘To identify impact factors on the distribution and characters of natural plants community in reclamation area, with survey data from 67 plant quadrats in July 2009, soil properties data from 216 sampling points in April 2009, and TM (30 m) data in 2006, the composition and characteristics of natural plants community in different time of the Fengxian area in the Changjiang (Yangtze) River estuary were analyzed with two-way indicator species analysis (TWINSPAN), multivariate analysis of variance (MANOVA), detrended canonical correspondence analysis (DCCA) and canonical correspondence analysis (CCA). The results show that: 1) The plant communities in the reclaimed area are mainly mesophytes and helophytic-mesophytic transitional communities, showing a gradient distribution trend with the change in reclamation years. Species richness (MA), species diversity (H) and above-ground biomass also increase with the increase of reclamation years. Nevertheless, they appear to decline slightly in the middle and late reclamation period (> 30 years). 2) With the rise in land use levels, the changes in species richness and species diversity tend to increase at first and then decrease; species dominance (D), however, tends to decline; and above-ground biomass increases slightly. 3) The distribution of the plant community is mainly influenced by the following factors: land use levels (R = 0.55, p < 0.05), soil moisture (R = 0.53, p < 0.05), soil salinity (R = 0.43, p < 0.05) and reclamation time (R = 0.40, p < 0.05).
文摘This paper investigates some of the ways that Chinese medicine has been transferred to the Western world and to Islamic territories. During the Golden Age of Islam （8th to 13th century CE）, the herbal drug trade promoted significant commercial and scientific exchange between China and the Muslim world. Chinese herbal drugs have been described by medieval Muslim medical scholars such as Tabari （870 CE）, Rhazes （925 CE）, Haly Abbas （982 CE）, Avicenna （1037 CE） and Jurjani （1137 CE）. The term al-sin （the Arabic word for China） is used 46 times in Avicenna＇s Canon of Medicine in reference to herbal drugs imported from China. Cinnamon （dar sini; ＂Chinese herb＂）, wild ginger （asaron）, rhubarb （rivand-e sini）, nutmeg （basbasa）, incense tree wood （ood）, cubeb （kababe） and sandalwood （sandal） were the most frequently mentioned Chinese herbs in Islamic medical books. There are also multiple similarities between the clinical uses of these herbs in both medical systems. It appears that Chinese herbal drugs were a major component of the exchange of goods and knowledge between China and the Islamic and later to the Western world amid this era.
文摘In the theory of traditional Chinese medicine, aging is mainly thought renal deficiency caused renal failure, mainly involving decline of kidney-Yang and deficiency of kidney-essence. Huanshaodan, a Chinese traditional preparation for kidney-replenishing essence, was used to be the preparation for reinforcing renal deficiency and preventing aging for aged people. OBJECTIVE： To observe the effects of Huanshaodan on swimming durance and the abilities of catalase （CAT） in serum and monoamine oxidase-B （MAO-B） in brain tissue as well as in vitro anti-oxidative ability of aging mouse. DESIGN： A controlled animal experiment. SETTING： College of Basic Medicine, Hunan University of Traditional Chinese Medicine. MATERIALS： Fifty-four healthy NIH mice, aged 18 months old, of either gender, weighing （48.9±5.4） g, and one SD male rat, aged 16 months old, weighing 51.7 g, were provided by Animal Experimental Center, Hunan University of Traditional Chinese Medicine. Thirty NIH mice were randomly chosen for swimming test, and divided into experimental group and control group, with 15 in each; The other 24 NIH mice were used for enzyme activity assay, and also divided into experimental group and control group, with 12 in each. SD rat was used for in vitro anti-oxidative ability test, Huanshaodan water decoction was composed of Cheqianzi, Wuweizi, Huaishan, Danggui, Huangbai, Shudi, Baizhi, Niuxi, Baishen, Tusizi, Buguzhi, Roucongrong and Heshouwu 13 Chinese herbs. METHODS： This study was carried out in the Second Laboratory, Department of Biochemistry, Hunan University of Traditional Chinese Medicine in June 2006. Swimming and enzyme activity assay： Mice in the two experimental groups were intragastrically administrated with l0 μL/g Huanshaodan water decoction. Mice in the two control groups were intragastrically administrated with the same amount of normal saline. All the mice were intragastrically administrated for 5 days, and they were free to access to medicine in the other 2 days in a week. Each mouse was administrated for 8 weeks. MAIN OUTCOME MEASURES： ① Forty days after administration, mice in the experimental group and control group for swimming test were loaded at tails and allowed to swim in the water-tank. Swimming durance was recorded. ② Following the method of Chen Qi, the activities of CAT in serum and MAO-B in brain tissue as well as the inhibitory rate of each medicine on malonaldehyde （MDA） content in the in vitro rat hepatic tissue were determined; Meanwhile, the inhibitory rate of different doses of Tusizi liquid to MDA content in the rat hepatic tissue in vitro was also assayed. RESULTS： Fifty-four NIH mice and one SD rat were recruited in this experiment. Three mice died in the swimming test, and all the other animals were involved in the final analysis. ① Swimming durance of mice in the experimental group was significantly longer than that in the control group （ t =7.502, P 〈 0.01 ） . The activity of CAT in serum of mice in the experimental group was significantly higher than that in the control group （ t =13.307, P 〈 0.01 ） . ② The activity of MAO-B in brain tissue of mice in the experimental group was significantly lower than that in the control group （t =l3.27, P 〈 0.01 ） . ③The inhibitory rate of Cheqianzi, Wuweizi, Huaishan, Danggui, Huangbai, Shudi, Baizhi, Niuxi, Baishen, Tusizi, Buguzhi, Roucongrong and Heshouwu 13 Chinese herbs of Huanshaodan to MDA in the rat hepatic tissue in vitro was - 62.9, - 95.1, - 34.9, - 65.1, - 99.1, - 87.2, - 94.1, - 20.0, - 67.0, - 83.7, - 91.0, - 98.4, - 93.0, respectively. ④ The inhibitory rate of low to high dose of Tusizi liquid to MDA content in the rat hepatic tissue in vitro was - 3.41, - 18.1, - 26.6, - 83.7, respectively. CONCLUSION： Huanshaodan enhances swimming endurance, anti-oxygen free radical and anti-oxidativeabilities, and thus, it can delay aging.
文摘During the COVID-19 pandemic,a multitude of narratives saturated the print,audiovisual,and electronic media.Improvised,uninformed,apocalyptic and voluntarist approaches abounded.These notes-written during the pandemic and delivered in the conference series-address the proliferation of such discourses,emphasizing a series of issues.First,the widespread ignorance about the history of epidemics.Then,the inability to deal with the uncertainties that reign during pandemic times,as well as the announcements that this extraordinary health/sanitary event would produce a profound watershed in all walks of life and in all corners of the world.Finally,and against the general assertion that“one learns from the past to understand the present,”these notes seek to point out how the present can illuminate the study of the past-or,more personally,what I think I have learned as a historian in the times of the COVID-19 pandemic.
文摘The process of food digestion is one of the most important physiologic processes in human body. In this review, we are seeking the views of Avicenna, the most distinguished Persian medical scholar about digestion and indigestion. Avicenna’s view was based on the humoral theory. Avicenna has focused scrutiny on the process of digestion. He divided this process into four phases including gastric, hepatic, intravascular and intra-organ digestion. A defect in any of these phases can lead to disturbance in other stages. Avicenna approached the problem of indigestion through factors of diet, lifestyle and inherent structural characteristics of digestive organs. Modern medicine confirms Avicenna's opinion about the start of digestion from the mouth, the role of the stomach in digestion and the role of the liver in the metabolism of foods. Overeating or eating certain foods, snacking between meals, eating variety of different foods together, intense physical activity, sexual activity after a meal, stress and sleep insufficiency are among factors that may be linked to indigestion in modern medicine viewpoints and also have been mentioned in Avicenna's teachings. It seems rational to consider the medical approaches recommended by Avicenna for future studies in the field of digestive disorders.
