Objective To describe secular trends on physical growth of children in China during the year of 1985‐2005 and to analyze the urban‐suburban‐rural difference and its change. Methods The measurements of height, weigh...Objective To describe secular trends on physical growth of children in China during the year of 1985‐2005 and to analyze the urban‐suburban‐rural difference and its change. Methods The measurements of height, weight and chest circumference obtained from two serial national cross‐sectional surveys for children aged 0 to 7 years in China were used to analyze the secular trends, and the growth differences among urban, suburban and rural children were compared. Results The average weight and height for both boys and girls from urban, suburban and rural areas have significantly increased in most age groups during the past 20 years; The average chest circumference increased slightly, ranging from 0.0 to 2.0 cm. From 1985 to 2005, the urban‐suburban difference in height had become smaller, and that in weight showed similar trend for children under 3 years old but became larger after 3 years old; the suburban‐rural difference both in height and weight became larger after 6 months old. The increment per decade in height was the greatest in the suburban group while the greatest increment in weight was the urban group. Conclusion Positive secular trends were observed among urban, suburban and rural areas in Chinese children under 7 years old during the 1980s and the 2000s, reflecting a rapid socio‐economic development in China.展开更多
Growth reflects the general condition of society,and is a measure of the nutritional and hygienic status of a population[1,2].Nutrition is one of the most important components of children’s well-being[3].The Chinese ...Growth reflects the general condition of society,and is a measure of the nutritional and hygienic status of a population[1,2].Nutrition is one of the most important components of children’s well-being[3].The Chinese government attaches great importance to children’s health and development,with a clear statement and consistent practice for“Children are the future and hope of the motherland”.展开更多
Large-gap peripheral nerve injuries(PNI)are often treated with autografts,allografts,or synthetic grafts to facilitate nerve regeneration,but these options are often limited in their availability or functionality.To a...Large-gap peripheral nerve injuries(PNI)are often treated with autografts,allografts,or synthetic grafts to facilitate nerve regeneration,but these options are often limited in their availability or functionality.To address these issues,we developed ionically conductive(IC)nerve guidance conduits(NGCs)of sufficient biodegrad-ability,mechanical strength,and bioactivity to support large-gap nerve regeneration.These chitosan-based NGCs release 4-aminopyridine(4-AP)from embedded halloysite nanotubes,and the NGC’s IC properties enable transcutaneous electrical stimulation(ES)without invasive electrodes.In vitro,we found scaffolds with ES+4-AP synergistically enhanced Schwann cell adhesion,proliferation,and neurotrophin secretion,significantly improving axonal growth and neurite extension.In vivo,these scaffolds in large-gap PNI boosted neurotrophin levels,myelination,nerve function,and muscle weight while promoting angiogenesis and reducing fibrosis.Upregulated Trk receptors and PI3K/Akt and MAPK pathway highlight the regenerative potential.This study advances understanding of ES-mediated regeneration and supports innovative strategies for nerve and muscu-loskeletal repair.展开更多
Background INTERGROWTH-21 st Newborn Cross-Sectional Study(NCSS)charts were established and recommended for global application.However,whether one international reference is appropriate for all populations is still un...Background INTERGROWTH-21 st Newborn Cross-Sectional Study(NCSS)charts were established and recommended for global application.However,whether one international reference is appropriate for all populations is still unclear.We aim to compare the updated Chinese birth size charts by gestational age with INTERGROWTH-21st NCSS charts.Methods A cross-sectional survey was carried out,and the birth weight,length and head circumference of 24,375 infants born after uncomplicated pregnancies at gestational age ranging from 24+0 to 42+6 weeks were measured in 13 cities in China from 2015 to 2018.Growth charts were constructed.The measurements of all these infants were evaluated by the methods of calculating their Z scores using the INTERGROWTH-21 st standards.The prevalence of small for gestational age(SGA)and large for gestational age(LGA)based on birth weight was analyzed using Chinese charts and INTERGROWTH-21st charts.Results The mean Z scores were 0.10 for birth weight,0.35 for length and-0.02 for head circumference.Compared to the INTERGROWTH-21st charts,the Chinese birth weight percentile curves were higher except for the 90th percentile at 29-37 weeks gestational age,and the length percentile curves were higher after 33 weeks gestational age,while the 10th percentile of the head circumference was lower and the other percentiles were similar.The prevalence of SGA was 10.1%[95%confidence interval(CI)=9.7%-10.5%]using the Chinese birth weight chart and 6.5%(95%CI=6.2%-6.8%)using the INTERGROWTH-21 st birth weight chart.The prevalence of LGA was 9.9%(95%CI=9.5%-10.2%)and 8.2%(95%CI=7.9%-8.6%)using the Chinese and INTERGROWTH-21st birth weight charts,respectively.Conclusions Chinese birth size charts based on infants born after uncomplicated pregnancies were different from the INTER-GROWTH-21st charts.Differences in the classification of newborns by the two charts should receive attention,and whether the application of INTERGROWTH-21st in Chinese newborns will lead to misclassification needs to be validated in future clinical practice.展开更多
Background A more comprehensive assessment of growth and nutrition in children is required in China due to rapid socioeconomic processes.We aimed to investigate height and body mass index(BMI)trajectories from 1975 to...Background A more comprehensive assessment of growth and nutrition in children is required in China due to rapid socioeconomic processes.We aimed to investigate height and body mass index(BMI)trajectories from 1975 to 2015 and the prevalence of stunting and obesity in 2016 among children in Chinese cities.Methods A total of 904,263 children from birth to 6.9 years were collected from a series of nationally representative surveys in China.Height and BMI trajectories and prevalence of stunting,underweight,overweight and obesity were assessed.Results The average height level of Chinese urban children under 7 years presented a positive secular trend from 1975 to 2015;however,a slowing tendency occurred in 2005‒2015.An apparent increase was observed at the 5th,50th and 95th percentiles of BMI in urban children aged 3 years and older,with a more prominent increase at the 95th percentile.The total prevalence of stunting and underweight under 7 years was 1.4%and 2.0%,respectively.The total prevalence of overweight and obesity under 7 years was 12.6%and 4.3%,respectively,with 12.7%and 4.9%for boys,12.6%and 3.6%for girls,12.1%and 4.0%in urban areas and 13.1%and 4.5%in suburban rural areas.Conclusions The average height level of Chinese urban children has reached World Health Organization child growth standards since 2005 and presented a slowing tendency in secular trend in 2005‒2015.More attention and efforts and public health interventions should be urgently made to combat overweight and obesity among preschool children.展开更多
Background In China,as the social transformation and economic development from 1985 to 2015,children's feeding pattern has undergone some changes.So we aimed to analyze the secular trend on feeding patterns of cit...Background In China,as the social transformation and economic development from 1985 to 2015,children's feeding pattern has undergone some changes.So we aimed to analyze the secular trend on feeding patterns of city children in China.Methods All data were from a series of national survey which implemented once every 10 years in China from 1985 to 2015.We use same indexes to evaluate the feeding pattern of children in these four surveys.Results From 1985 to 2005,the exclusive breastfeeding rates in infants under 6 months of age decreased,especially in suburban areas decreased by 17.7%;the continuous breastfeeding rate of 1-year-old children in suburban area decreased from 60.1 to 27.6%.However,from 2005 to 2015,the exclusive breastfeeding rates under 6 months of age increased by 16.0% in urban areas and 5.9% in suburban areas;the continuous breastfeeding rate of 1-year-old children in urban increased from 17.0 to 36.0%.The overall feeding rate of complementary food in infants under 6 months of age declined from 1985 to 2015;the average age at introduction of all complementary foods was around 6 months of age in 2015.Conclusions There is an obvious trend on feeding pattern of Chinese children.From 1985 to 2005,the breastfeeding rate decreased,the duration time of breastfeeding was shortened and the age at introduction of complementary food was advanced.From 2005 to 2015,the breastfeeding rate increased,the duration time of breastfeeding was prolonged,and the age at introduction of complementary food was postponed.展开更多
基金supported by the Ministry of Health of the People's Republic of China(No.2005‐41)
文摘Objective To describe secular trends on physical growth of children in China during the year of 1985‐2005 and to analyze the urban‐suburban‐rural difference and its change. Methods The measurements of height, weight and chest circumference obtained from two serial national cross‐sectional surveys for children aged 0 to 7 years in China were used to analyze the secular trends, and the growth differences among urban, suburban and rural children were compared. Results The average weight and height for both boys and girls from urban, suburban and rural areas have significantly increased in most age groups during the past 20 years; The average chest circumference increased slightly, ranging from 0.0 to 2.0 cm. From 1985 to 2005, the urban‐suburban difference in height had become smaller, and that in weight showed similar trend for children under 3 years old but became larger after 3 years old; the suburban‐rural difference both in height and weight became larger after 6 months old. The increment per decade in height was the greatest in the suburban group while the greatest increment in weight was the urban group. Conclusion Positive secular trends were observed among urban, suburban and rural areas in Chinese children under 7 years old during the 1980s and the 2000s, reflecting a rapid socio‐economic development in China.
文摘Growth reflects the general condition of society,and is a measure of the nutritional and hygienic status of a population[1,2].Nutrition is one of the most important components of children’s well-being[3].The Chinese government attaches great importance to children’s health and development,with a clear statement and consistent practice for“Children are the future and hope of the motherland”.
基金funding support provided by the National Institutes of Health(#R01NS134604,#R01EB034202,#R01AR078908,and#R01EB030060)the U.S.Army Medical Research Acquisition Activity(USAMRAA)through the CDMRP Peer-Reviewed Medical Research Program(Award No.W81XWH2010321,PR230581,and HT94252410137)the DoD support from BA230234(Award No.HT94252410944).
文摘Large-gap peripheral nerve injuries(PNI)are often treated with autografts,allografts,or synthetic grafts to facilitate nerve regeneration,but these options are often limited in their availability or functionality.To address these issues,we developed ionically conductive(IC)nerve guidance conduits(NGCs)of sufficient biodegrad-ability,mechanical strength,and bioactivity to support large-gap nerve regeneration.These chitosan-based NGCs release 4-aminopyridine(4-AP)from embedded halloysite nanotubes,and the NGC’s IC properties enable transcutaneous electrical stimulation(ES)without invasive electrodes.In vitro,we found scaffolds with ES+4-AP synergistically enhanced Schwann cell adhesion,proliferation,and neurotrophin secretion,significantly improving axonal growth and neurite extension.In vivo,these scaffolds in large-gap PNI boosted neurotrophin levels,myelination,nerve function,and muscle weight while promoting angiogenesis and reducing fibrosis.Upregulated Trk receptors and PI3K/Akt and MAPK pathway highlight the regenerative potential.This study advances understanding of ES-mediated regeneration and supports innovative strategies for nerve and muscu-loskeletal repair.
基金This project was supported by the National Health Commission of the People's Republic of China(No.2015-42).
文摘Background INTERGROWTH-21 st Newborn Cross-Sectional Study(NCSS)charts were established and recommended for global application.However,whether one international reference is appropriate for all populations is still unclear.We aim to compare the updated Chinese birth size charts by gestational age with INTERGROWTH-21st NCSS charts.Methods A cross-sectional survey was carried out,and the birth weight,length and head circumference of 24,375 infants born after uncomplicated pregnancies at gestational age ranging from 24+0 to 42+6 weeks were measured in 13 cities in China from 2015 to 2018.Growth charts were constructed.The measurements of all these infants were evaluated by the methods of calculating their Z scores using the INTERGROWTH-21 st standards.The prevalence of small for gestational age(SGA)and large for gestational age(LGA)based on birth weight was analyzed using Chinese charts and INTERGROWTH-21st charts.Results The mean Z scores were 0.10 for birth weight,0.35 for length and-0.02 for head circumference.Compared to the INTERGROWTH-21st charts,the Chinese birth weight percentile curves were higher except for the 90th percentile at 29-37 weeks gestational age,and the length percentile curves were higher after 33 weeks gestational age,while the 10th percentile of the head circumference was lower and the other percentiles were similar.The prevalence of SGA was 10.1%[95%confidence interval(CI)=9.7%-10.5%]using the Chinese birth weight chart and 6.5%(95%CI=6.2%-6.8%)using the INTERGROWTH-21 st birth weight chart.The prevalence of LGA was 9.9%(95%CI=9.5%-10.2%)and 8.2%(95%CI=7.9%-8.6%)using the Chinese and INTERGROWTH-21st birth weight charts,respectively.Conclusions Chinese birth size charts based on infants born after uncomplicated pregnancies were different from the INTER-GROWTH-21st charts.Differences in the classification of newborns by the two charts should receive attention,and whether the application of INTERGROWTH-21st in Chinese newborns will lead to misclassification needs to be validated in future clinical practice.
基金the Maternal and Child Health Program of the National Health Commission of the People’s Republic of China(2015–42).
文摘Background A more comprehensive assessment of growth and nutrition in children is required in China due to rapid socioeconomic processes.We aimed to investigate height and body mass index(BMI)trajectories from 1975 to 2015 and the prevalence of stunting and obesity in 2016 among children in Chinese cities.Methods A total of 904,263 children from birth to 6.9 years were collected from a series of nationally representative surveys in China.Height and BMI trajectories and prevalence of stunting,underweight,overweight and obesity were assessed.Results The average height level of Chinese urban children under 7 years presented a positive secular trend from 1975 to 2015;however,a slowing tendency occurred in 2005‒2015.An apparent increase was observed at the 5th,50th and 95th percentiles of BMI in urban children aged 3 years and older,with a more prominent increase at the 95th percentile.The total prevalence of stunting and underweight under 7 years was 1.4%and 2.0%,respectively.The total prevalence of overweight and obesity under 7 years was 12.6%and 4.3%,respectively,with 12.7%and 4.9%for boys,12.6%and 3.6%for girls,12.1%and 4.0%in urban areas and 13.1%and 4.5%in suburban rural areas.Conclusions The average height level of Chinese urban children has reached World Health Organization child growth standards since 2005 and presented a slowing tendency in secular trend in 2005‒2015.More attention and efforts and public health interventions should be urgently made to combat overweight and obesity among preschool children.
文摘Background In China,as the social transformation and economic development from 1985 to 2015,children's feeding pattern has undergone some changes.So we aimed to analyze the secular trend on feeding patterns of city children in China.Methods All data were from a series of national survey which implemented once every 10 years in China from 1985 to 2015.We use same indexes to evaluate the feeding pattern of children in these four surveys.Results From 1985 to 2005,the exclusive breastfeeding rates in infants under 6 months of age decreased,especially in suburban areas decreased by 17.7%;the continuous breastfeeding rate of 1-year-old children in suburban area decreased from 60.1 to 27.6%.However,from 2005 to 2015,the exclusive breastfeeding rates under 6 months of age increased by 16.0% in urban areas and 5.9% in suburban areas;the continuous breastfeeding rate of 1-year-old children in urban increased from 17.0 to 36.0%.The overall feeding rate of complementary food in infants under 6 months of age declined from 1985 to 2015;the average age at introduction of all complementary foods was around 6 months of age in 2015.Conclusions There is an obvious trend on feeding pattern of Chinese children.From 1985 to 2005,the breastfeeding rate decreased,the duration time of breastfeeding was shortened and the age at introduction of complementary food was advanced.From 2005 to 2015,the breastfeeding rate increased,the duration time of breastfeeding was prolonged,and the age at introduction of complementary food was postponed.
