BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive di...BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive disorders.Accurate assessment and precise treatment are essential in initial intensive therapy.AIM To investigate the efficacy and safety of a vonoprazan(VPZ)-based triple regimen for first-line eradication of H.pylori in China.METHODS This multicenter noninferior randomized controlled trial(June 2022 to November 2023)involved 524 H.pyloripositive patients across 19 centers in Shandong,China.Participants were randomized to 14-day esomeprazole/bismuth/amoxicillin/clarithromycin(EBAC),14-day VPZ/amoxicillin/clarithromycin(VACa),or 10-day VPZ/amoxicillin/clarithromycin(VACb)-all administered twice daily.Primary outcomes(eradication rates)were assessed via intention-to-treat(ITT)and per-protocol(PP)analyses.Secondary endpoints included adverse events and adherence.Noninferiority testing andχ^(2)tests were used for statistical comparisons.RESULTS A total of 524 patients participated in this study.In ITT analysis,the eradication rates of the EBAC,VACa,and VACb groups were 72.6%(127/175),88.0%(154/175),and 83.3%(145/174),respectively(P=0.001).The difference in the eradication rate between the EBAC and VPCa groups was 15.4%[95%confidence interval(CI):7.3-23.6,P<0.001],and that between the EBAC and VACb groups was 10.8%(95%CI:2.1-19.4,P=0.018).In PP analysis,the eradication rates of the EBAC,VACa,and VACb groups were 81.4%(127/156),93.9%(154/164),and 90.6%(145/160),respectively(P=0.001).There was no significant difference in the incidence of adverse reactions among the three groups,which were 36.6%,33.8%and 29.6%,respectively(P=0.50).CONCLUSION VPZ-based triple therapies demonstrate noninferiority to 14-day bismuth-containing regimens,with the 10-day regimen showing comparable efficacy and similar adverse event rates.展开更多
BACKGROUND Acute variceal bleeding(AVB)in patients with cirrhosis remains life-threatening;moreover,the current risk stratification methods have certain limitations.Rebleeding and mortality after AVB remain major chal...BACKGROUND Acute variceal bleeding(AVB)in patients with cirrhosis remains life-threatening;moreover,the current risk stratification methods have certain limitations.Rebleeding and mortality after AVB remain major challenges.Although preemptive transjugular intrahepatic portosystemic shunt(p-TIPS)can improve outcomes,not all patients benefit equally.Accurate risk stratification is needed to guide treatment decisions and identify those most likely to benefit from p-TIPS.AIM To develop an artificial intelligence(AI)-driven model to guide AVB treatment decisions,and identify candidates eligible for p-TIPS.METHODS Patients with cirrhosis and AVB,from two multicenter retrospective cohorts in China,who received endoscopic variceal ligation plus pharmacotherapy(n=1227)or p-TIPS(n=1863)were included.Baseline data within 24 hours of hospital admission were obtained.The AI-AVB model,based on the six-week failure and one-year mortality rates,was developed to predict treatment efficacy and compared with standard risk scores.Outcomes and adverse events of the treatments were compared across the high-and low-risk subgroups stratified using the AI-AVB model.RESULTS The AI-AVB model demonstrated superior predictive performance compared to traditional risk stratification methods.In the internal validation cohort,the model achieved an area under the curve(AUC)of 0.842 for predicting six-week treatment failure and 0.954 for one-year mortality.In the external validation cohort,the AUCs were 0.814 and 0.889,respectively.The model effectively identified patients at high risk of first-line treatment failure who may benefit from aggressive interventions such as p-TIPS.In contrast,advancing the treatment strategy for low-risk patients did not notably improve the short-term prognosis.CONCLUSION The AI-AVB model can predict treatment outcomes,stratify the failure risk in cirrhotic patients with AVB,aid in clinical decisions,identify p-TIPS beneficiaries,and optimize personalized treatment strategies.展开更多
Increasing the allowable gas pressure of underground gas storage(UGS) is one of the most effective methods to increase its working gas capacity. In this context, hydraulic fracturing tests are implemented on the targe...Increasing the allowable gas pressure of underground gas storage(UGS) is one of the most effective methods to increase its working gas capacity. In this context, hydraulic fracturing tests are implemented on the target formation for the UGS construction of Jintan salt caverns, China, in order to obtain the minimum principal in situ stress and the fracture breakdown pressure. Based on the test results, the maximum allowable gas pressure of the Jintan UGS salt cavern is calibrated. To determine the maximum allowable gas pressure, KING-1 and KING-2 caverns are used as examples. A three-dimensional(3D)geomechanical model is established based on the sonar data of the two caverns with respect to the features of the target formation. New criteria for evaluating gas penetration failure and gas seepage are proposed. Results show that the maximum allowable gas pressure of the Jintan UGS salt cavern can be increased from 17 MPa to 18 MPa(i.e. a gradient of about 18 k Pa/m at the casing shoe depth). Based on numerical results, a field test with increasing maximum gas pressure to 18 MPa has been carried out in KING-1 cavern. Microseismic monitoring has been conducted during the test to evaluate the safety of the rock mass around the cavern. Field monitoring data show that KING-1 cavern is safe globally when the maximum gas pressure is increased from 17 MPa to 18 MPa. This shows that the geomechanical model and criteria proposed in this context for evaluating the maximum allowable gas pressure are reliable.展开更多
This work addresses the alloying of titanium aluminides used in aircraft engine applications and automobiles. The oxidation resistance behavior of two titanium aluminides of α2 ＋ γ （Ti3Al ＋ TiAl） and orthorhombi...This work addresses the alloying of titanium aluminides used in aircraft engine applications and automobiles. The oxidation resistance behavior of two titanium aluminides of α2 ＋ γ （Ti3Al ＋ TiAl） and orthorhombic Ti2NbAl, recognized as candidates for high-temperature applications, was investigated by exposure of the alloys for 100 h in air. Thus, oxidation resistance was expressed as the mass gain rate, whereas surface aspects were analyzed using scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy, and the type of oxidation products was analyzed by X-ray diffraction and Raman spectroscopy. The orthorhombic Ti2NbAl alloy was embrittled, and pores and microcracks were formed as a result of oxygen diffusion through the external oxide layer formed during thermal oxidation for 100 h.展开更多
Fischer-Tropsch synthesis under supercritical phase condition was examined in a continuous and a high-pressure fixed bed reactor by employing a cobalt catalyst （Co-Ru/γ-Al2O3）. An integral reactor model involving F...Fischer-Tropsch synthesis under supercritical phase condition was examined in a continuous and a high-pressure fixed bed reactor by employing a cobalt catalyst （Co-Ru/γ-Al2O3）. An integral reactor model involving Fischer-Tropsch reaction kinetics in the supercritical fluid n-hexane was used to describe the overall performance. On the basis of Langmuir-Hinshelwood-Hougen-Watson （LHHW） model, the reaction rate constants were obtained for the rate equations of CO conversion to CH4 formation under supercritical conditions.展开更多
AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals ...AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico.展开更多
BACKGROUND Recurrent hepatitis C virus(HCV)infection of transplanted liver allografts is universal in patients with detectable HCV viremia at the time of transplantation.Direct-acting antiviral(DAA)therapy has been ad...BACKGROUND Recurrent hepatitis C virus(HCV)infection of transplanted liver allografts is universal in patients with detectable HCV viremia at the time of transplantation.Direct-acting antiviral(DAA)therapy has been adopted as the standard of care for recurrent HCV infection in the post-transplant setting.However,there are insufficient data regarding its efficacy in liver transplant(LT)recipients with a history of hepatocellular carcinoma(HCC),and the risk of HCC recurrence after DAA therapy is unknown.predictors of DAA treatment failure and HCC recurrence in LT recipients.METHODS A total of 106 LT recipients given DAAs for recurrent HCV infection from 2015 to 2019 were identified(68 with and 38 without HCC).Descriptive statistics and logistic regression models were used to estimate the multivariate odds ratios and respective 95%confidence intervals for predictors of treatment failure and HCC recurrence.RESULTS Six patients(6%)experienced DAA therapy failure post-LT and 100(94%)had a sustained virologic response at follow-up week 12.A high alanine transaminase level>35 U/L at treatment week 4 was a significant predictor of treatment failure.Relapse to pre-LT DAA therapy is a predictor of post-LT HCC recurrence,P=0.04.DAA relapse post-LT was also associated with post-transplantation HCC recurrence,P=0.05.CONCLUSION DAAs are effective and safe in the treatment of recurrent HCV infection in LT recipients with history of HCC.Relapse to pre-and post-LT DAA therapy is associated with post-transplantation HCC recurrence.展开更多
BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy an...BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome.展开更多
BACKGROUND Understanding the treatment landscape of inflammatory bowel diseases(IBD)is essential for improving disease management and patient outcomes.Brazil is the largest Latin American country,and it presents socio...BACKGROUND Understanding the treatment landscape of inflammatory bowel diseases(IBD)is essential for improving disease management and patient outcomes.Brazil is the largest Latin American country,and it presents socioeconomic and health care differences across its geographical regions.This country has the highest increase in IBD incidence and prevalence in Latin America,but information about the clinical and treatment characteristics of IBD is scarce.AIM To describe the sociodemographic,clinical,and treatment characteristics of IBD outpatients in Brazil overall and in the Southeast,South and Northeast/Midwest regions.METHODS Multicenter,cross-sectional study with a 3-year retrospective chart review component.Patients with moderate-to-severe Crohn’s disease(CD)or ulcerative colitis(UC)were consecutively enrolled between October 2016 and February 2017.Active CD at enrollment was defined as a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or a calprotectin level>200μg/g or an active result based on colonoscopy suggestive of inadequate control during the previous year;active UC was defined as a partial Mayo score≥5.Descriptive statistics were used to analyze all variables.RESULTS In a total of 407 included patients,CD was more frequent than UC,both overall(264 CD/143 UC patients)and by region(CD:UC ratios of 2.1 in the Southeast,1.6 in the South and 1.2 in the Northeast/Midwest).The majority of patients were female(54.2%of CD;56.6%of UC),and the mean ages were 45.9±13.8 years(CD)and 42.9±13.0 years(UC).The median disease duration was 10.0(range:0.5-45)years for both IBD types.At enrollment,44.7%[95%confidence interval(CI):38.7-50.7]of CD patients and 25.2%(95%CI:18.1-32.3)of UC patients presented with active disease.More than 95%of IBD patients were receiving treatment at enrollment;CD patients were commonly treated with biologics(71.6%)and immunosuppressors(67.4%),and UC patients were commonly treated with mesalazine[5-Aminosalicylic acid(5-ASA)]derivates(69.9%)and immunosuppressors(44.1%).More than 50%of the CD patients had ileocolonic disease,and 41.7%presented with stricturing disease.One-quarter of CD patients had undergone CD-related surgery in the past 3 years,and this proportion was lower in the Northeast/Midwest region(2.9%).CONCLUSION In Brazil,there are regional variations in IBD management.CD outweighs UC in both frequency and disease activity.However,one-quarter of UC patients have active disease,and most are receiving 5-ASA treatment.展开更多
Many scientists used the power spectrum of the gravity anomaly to obtain the average depth of the disturbing surface or equivalently the average depth to the top of the disturbing body. The spectrum of gravity anomaly...Many scientists used the power spectrum of the gravity anomaly to obtain the average depth of the disturbing surface or equivalently the average depth to the top of the disturbing body. The spectrum of gravity anomaly due to layered source is separated into multiple segments in frequency domain that can be interpreted in terms of mean depth of the interface. The half of the slope of the segments gives the mean depth of the interfaces. This study aims to estimate the average residual depth anomalies of various regions of the northern Logone Birni sedimentary basin of Cameroon using polynomial separation of gravity anomalies, and spectral analysis along different profiles (segments). The profiles were derived from residual anomaly maps obtained by fitting the Bouguer anomalies, the interpretation used polynomial separation and depth average was done using spectral analysis. Positive and negative residual gravity anomalies were highlighted and their interpretation revealed the structural directions of the sedimentary basin (NW-SE and NE-SW), as well as an intimate relationship between the negative anomalies and the northern Logone Birni sedimentary basin. Three distinct residual anomalies were identified over the Goulfey, Tom Merifine and Tourba basin with an average depth varying between 0.24 km and 4.55 km.展开更多
Gravity and magnetic data were analyzed in conjunction with available geological data to determine the origin of observed positive gravity anomaly at Waza and its possible relationship to mafic intrusions. The data an...Gravity and magnetic data were analyzed in conjunction with available geological data to determine the origin of observed positive gravity anomaly at Waza and its possible relationship to mafic intrusions. The data analysis includes the construction of a Bouguer gravity anomaly, isostatic residual gravity anomaly, total magnetic gradient and Euler solutions maps, and two and one-half dimensional gravity models. A positive gravity anomaly that occurs in Waza has amplitude of 35 mGal and can be separated into two parts. The top of the disturbing body causing the anomaly cannot be deeper than 4 km. We believe the anomaly is probably caused by a body of basaltic rocks lying at the upper surface of the Precambrian basement and originate from a self-propagating disturbance of magmatic loads on a pre-existing zone of lithospheric weakness. Melt migration might have been aided by tectonic and flexural stresses, such that the intrusion is limited in extent to the melting region of the plume and did not reach the surface. The model calculated to satisfy the observed anomaly consists of a 2.5 Km-thick slab underlain by a 10.5 km deep column. This model is interpreted to represent a sheet or saucer-like mafic intrusion that has a thick deep feeder. Detailed geophysical studies would be necessary to locate any possible economic occurrences.展开更多
The paper is devoted to new, experimentally registered thermo physical problems of high temperature applied external and internal aerodynamics which is defined first of all by intensive interaction of the gaseous medi...The paper is devoted to new, experimentally registered thermo physical problems of high temperature applied external and internal aerodynamics which is defined first of all by intensive interaction of the gaseous media and thermal radiation. The first report section analyses basic complexities of designing high temperature air breathing engines related to origin of so-called ＂unexpected＂ heat of working process. The next parts of the report consider physical, chemical and plasma features of aerodynamics of reentry space blunt bodies and meteors with specified account of thermal radiation influence. Our solutions are based on the classical Dark Matter-Energy simulation. We present special experimental data for Dark Matter pressure registration on the earth conditions.展开更多
Tin sulfide nanoparticles(SnS -NPs) were prepared in aqueous solution at room temperature on the surface of activated carbon(AC) and were investigated using field-emission scanning electron mi-croscopy(FE-SEM), transm...Tin sulfide nanoparticles(SnS -NPs) were prepared in aqueous solution at room temperature on the surface of activated carbon(AC) and were investigated using field-emission scanning electron mi-croscopy(FE-SEM), transmission electron microscopy(TEM), X-ray diffraction, reflective ultravio-let-visible spectrophotometry, and spectrofluorimetry. Calculations based on the SEM and TEM images showed that the sizes of the SnS -NPs immobilized on the AC were 30–70 nm. The prepared nanocomposite was used as a heterogeneous Lewis acid catalyst for the three-components one-pot synthesis of 4H-pyrano[2,3-c]pyrazole derivatives in ethanol at 80 ℃. The reactions were efficiently performed in the presence of the prepared catalyst in short reaction times, and gave the desired products in high yields. This catalyst can be easily recovered by simple filtration and recycled up to eight consecutive times without significant loss of its efficiency.展开更多
AIM: To assess the distribution of human leukocyte antigen (HLA)-DQ2 and -DQ8 in Iranian celiac disease (CD) patients and compare them to healthy Iranian controls.
57Fe Mossbauer spectroscopy was used to investigate the evolution of Fe-Zn binary metal oxide sorbent in the process of high-temperature fuel gas desulfurization. The results of phase analyses show that Fe-Zn binary m...57Fe Mossbauer spectroscopy was used to investigate the evolution of Fe-Zn binary metal oxide sorbent in the process of high-temperature fuel gas desulfurization. The results of phase analyses show that Fe-Zn binary metal oxide sorbent is rapidly reduced in hot fuel gas and decomposed to new phases of highly dispersed microcrystalline elemental iron and zinc oxide, both of which become the active desulfurization constituents. A complementary and synergistic effect between active iron acting as a high sulfur capacity constituent and active zinc oxide acting as a deep refining desulfurization constituent exists in this type of sorbent for hot fuel gas desulfurization.展开更多
Precipitation of heavy hydrocarbon components such as Wax and Asphaltenes are one of the most challenging issues in oil production processes.The associated complications extend from the reservoir to refineries and pet...Precipitation of heavy hydrocarbon components such as Wax and Asphaltenes are one of the most challenging issues in oil production processes.The associated complications extend from the reservoir to refineries and petrochemical plants.Precipitation is most destructive when the affected areas are hard to reach,for example the wellbore of producing wells.This work demonstrates the effect of adjusting choke valve sizes on thermodynamic parameters of fluid flowing in a vertical well.Our simulation results revealed optimum choke valve sizes that could keep producing vertical wells away from Asphaltene precipitation.The results of this study were implemented on a well in Darquin Reservoir that had been experiencing asphaltene precipitation.Experimental analysis of reservoir fluid,Asphaltene tests and thermodynamic simulations of well column were carried out and the most appropriate size of choke valve was determined.After replacing the well's original choke valve with the suggested choke valve,the Asphaltene precipitation problem diminished.展开更多
Stick-slip vibration presents one of the major causes of drilling problems,such as premature tool failures,low drilling efficiency and poor wellbore quality.The objective of this work is to investigate the influences ...Stick-slip vibration presents one of the major causes of drilling problems,such as premature tool failures,low drilling efficiency and poor wellbore quality.The objective of this work is to investigate the influences of rotary table speed(RTS)on stick-slip phenomenon of the drilling system.In this study,the drilling system is treated as a lumped torsional pendulum model of which the bit/rock interaction is regarded as Coulomb friction.By analyzing cases with different RTS,two types of vibrations on the bit are found:stick-slip vibration and uniform motion.With an increase in the RTS,the stick-slip vibration on the drill bit disappears once the RTS arrives at its critical value.For the cases that stick-slip vibrations occur,the phase trajectories converge toward a limit cycle.For the cases that stick-slip vibration does not appear,the drill bit tends to stabilize at a uniform motion and the phase trajectories correspond to contracting spirals observed in the phase plane.展开更多
In this study,an immiscible oil-water two phase flow in a typical porous media was modeled using the well-known Lattice Boltzmann method.A set of flow tests for modeling an oil-water two phase flow in the porous media...In this study,an immiscible oil-water two phase flow in a typical porous media was modeled using the well-known Lattice Boltzmann method.A set of flow tests for modeling an oil-water two phase flow in the porous media were conducted to generate the capillary pressure curves for two distinctive initial conditions,namely,water and oil dispersed conditions in two domains of different resolutions.Based on the obtained results,the general trend of these curves has an acceptable agreement with the usual trend of these curves in hydrocarbon reservoirs and the capillary data are independent of the initial conditions.Also,the results showed the effect of grid resolution on capillary data which are validated quantitatively by proposing a new approach using Purcell's equation.One can see that they are compatible with the geometrical characteristics of the porous media as well as the conditions governing the tests.Finally,another set of tests for oil water pairs of higher viscosity ratio up to 4.4 was performed in a low porosity heterogeneous porous media and the viscous coupling effect on capillary data,due to viscosity ratio,was studied to strengthen the model validation.展开更多
With the continuous growth of the population and the improvement of production, the shortage of freshwater has plagued many countries. The use of novel technologies such as desalination to produce fresh water on a lar...With the continuous growth of the population and the improvement of production, the shortage of freshwater has plagued many countries. The use of novel technologies such as desalination to produce fresh water on a large scale has become inevitable in the world. Hydrate-based desalination (HBD) technology has drawn an increasing amount of attention due to its mild operation condition and environmental friendliness. In this paper, literature on hydrate-based desalination is comprehensively analyzed and critically evaluated, focuses on experimental progress in different hydrate formers that have an impact on thermodynamics and dynamics in hydrate formation. Besides, various porous media promotion is investigated. Besides, the hydrate formation morphology and hydrate crystal structure with different hydrate formers are analyzed and compared. Moreover, molecular dynamic simulation is discussed to further understand microscopic information of hydrate formation. Furthermore, simulations of the HBD process by considering the energy consumption are also investigated. In conclusion, the hydrated based desalination is a potential technology to get fresh water in a sustainable way.展开更多
In this study,alkali/acid treatment and ion exchange post-synthesis modification methods to modify the pore diameter and structure of molecular sieve 13X(MS13X)were applied to obtain products,which could then be imple...In this study,alkali/acid treatment and ion exchange post-synthesis modification methods to modify the pore diameter and structure of molecular sieve 13X(MS13X)were applied to obtain products,which could then be implemented to improve the enrichment recovery of hopanoids in petroleum.The modification products were analyzed by SEM with EDS,XRD and nitrogen physisorption.The results indicated that the product which had been prepared in the oxalic acid ethanol solution formed some mesopores,and also retained the initial framework of crystal.It was revealed that this product was able to remarkably increase the recovery rate of hopanoids in petroleum without leading to a significant isotope fractionation phenomenon.It is thus shown that this modification method of non-aqueous oxalic acid solution for MS13X can be used as an effective pretreatment tool in the application of compoundspecific isotope analysis of hopanes with low concentration.展开更多
基金Supported by Qilu Health Outstanding Young Talent Cultivation Project,No.QDFY-3839。
文摘BACKGROUND Helicobacter pylori(H.pylori)is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach,damaging the gastric mucosa through various mechanisms and leading to various digestive disorders.Accurate assessment and precise treatment are essential in initial intensive therapy.AIM To investigate the efficacy and safety of a vonoprazan(VPZ)-based triple regimen for first-line eradication of H.pylori in China.METHODS This multicenter noninferior randomized controlled trial(June 2022 to November 2023)involved 524 H.pyloripositive patients across 19 centers in Shandong,China.Participants were randomized to 14-day esomeprazole/bismuth/amoxicillin/clarithromycin(EBAC),14-day VPZ/amoxicillin/clarithromycin(VACa),or 10-day VPZ/amoxicillin/clarithromycin(VACb)-all administered twice daily.Primary outcomes(eradication rates)were assessed via intention-to-treat(ITT)and per-protocol(PP)analyses.Secondary endpoints included adverse events and adherence.Noninferiority testing andχ^(2)tests were used for statistical comparisons.RESULTS A total of 524 patients participated in this study.In ITT analysis,the eradication rates of the EBAC,VACa,and VACb groups were 72.6%(127/175),88.0%(154/175),and 83.3%(145/174),respectively(P=0.001).The difference in the eradication rate between the EBAC and VPCa groups was 15.4%[95%confidence interval(CI):7.3-23.6,P<0.001],and that between the EBAC and VACb groups was 10.8%(95%CI:2.1-19.4,P=0.018).In PP analysis,the eradication rates of the EBAC,VACa,and VACb groups were 81.4%(127/156),93.9%(154/164),and 90.6%(145/160),respectively(P=0.001).There was no significant difference in the incidence of adverse reactions among the three groups,which were 36.6%,33.8%and 29.6%,respectively(P=0.50).CONCLUSION VPZ-based triple therapies demonstrate noninferiority to 14-day bismuth-containing regimens,with the 10-day regimen showing comparable efficacy and similar adverse event rates.
基金Supported by Key Research and Development Program of Jiangsu Province,No.BE2023767Xuzhou Key Research and Development Program under Grant,No.KC23273+1 种基金Affiliated Hospital of Xuzhou Medical University,No.2022ZL26Construction Project of High-Level Hospital of Jiangsu Province,No.GSPSJ20240802.
文摘BACKGROUND Acute variceal bleeding(AVB)in patients with cirrhosis remains life-threatening;moreover,the current risk stratification methods have certain limitations.Rebleeding and mortality after AVB remain major challenges.Although preemptive transjugular intrahepatic portosystemic shunt(p-TIPS)can improve outcomes,not all patients benefit equally.Accurate risk stratification is needed to guide treatment decisions and identify those most likely to benefit from p-TIPS.AIM To develop an artificial intelligence(AI)-driven model to guide AVB treatment decisions,and identify candidates eligible for p-TIPS.METHODS Patients with cirrhosis and AVB,from two multicenter retrospective cohorts in China,who received endoscopic variceal ligation plus pharmacotherapy(n=1227)or p-TIPS(n=1863)were included.Baseline data within 24 hours of hospital admission were obtained.The AI-AVB model,based on the six-week failure and one-year mortality rates,was developed to predict treatment efficacy and compared with standard risk scores.Outcomes and adverse events of the treatments were compared across the high-and low-risk subgroups stratified using the AI-AVB model.RESULTS The AI-AVB model demonstrated superior predictive performance compared to traditional risk stratification methods.In the internal validation cohort,the model achieved an area under the curve(AUC)of 0.842 for predicting six-week treatment failure and 0.954 for one-year mortality.In the external validation cohort,the AUCs were 0.814 and 0.889,respectively.The model effectively identified patients at high risk of first-line treatment failure who may benefit from aggressive interventions such as p-TIPS.In contrast,advancing the treatment strategy for low-risk patients did not notably improve the short-term prognosis.CONCLUSION The AI-AVB model can predict treatment outcomes,stratify the failure risk in cirrhotic patients with AVB,aid in clinical decisions,identify p-TIPS beneficiaries,and optimize personalized treatment strategies.
基金financial supports of National Natural Science Foundation of China (Grant No. 41502296)Youth Innovation Promotion Association, Chinese Academy of Sciences (CAS) (Grant No. 2016296)+1 种基金National Natural Science Foundation of China Innovative Research Team (Grant No. 51621006)Natural Science Foundation for Innovation Group of Hubei Province, China (Grant No. 2016CFA014)
文摘Increasing the allowable gas pressure of underground gas storage(UGS) is one of the most effective methods to increase its working gas capacity. In this context, hydraulic fracturing tests are implemented on the target formation for the UGS construction of Jintan salt caverns, China, in order to obtain the minimum principal in situ stress and the fracture breakdown pressure. Based on the test results, the maximum allowable gas pressure of the Jintan UGS salt cavern is calibrated. To determine the maximum allowable gas pressure, KING-1 and KING-2 caverns are used as examples. A three-dimensional(3D)geomechanical model is established based on the sonar data of the two caverns with respect to the features of the target formation. New criteria for evaluating gas penetration failure and gas seepage are proposed. Results show that the maximum allowable gas pressure of the Jintan UGS salt cavern can be increased from 17 MPa to 18 MPa(i.e. a gradient of about 18 k Pa/m at the casing shoe depth). Based on numerical results, a field test with increasing maximum gas pressure to 18 MPa has been carried out in KING-1 cavern. Microseismic monitoring has been conducted during the test to evaluate the safety of the rock mass around the cavern. Field monitoring data show that KING-1 cavern is safe globally when the maximum gas pressure is increased from 17 MPa to 18 MPa. This shows that the geomechanical model and criteria proposed in this context for evaluating the maximum allowable gas pressure are reliable.
基金funded by National Project PCCA contract No.65/2012POS-CCE O 2.2.1 project INFRANANOCHEM-No 19/January 3,2009 of the EU(ERDF)and Romanian Government
文摘This work addresses the alloying of titanium aluminides used in aircraft engine applications and automobiles. The oxidation resistance behavior of two titanium aluminides of α2 ＋ γ （Ti3Al ＋ TiAl） and orthorhombic Ti2NbAl, recognized as candidates for high-temperature applications, was investigated by exposure of the alloys for 100 h in air. Thus, oxidation resistance was expressed as the mass gain rate, whereas surface aspects were analyzed using scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy, and the type of oxidation products was analyzed by X-ray diffraction and Raman spectroscopy. The orthorhombic Ti2NbAl alloy was embrittled, and pores and microcracks were formed as a result of oxygen diffusion through the external oxide layer formed during thermal oxidation for 100 h.
文摘Fischer-Tropsch synthesis under supercritical phase condition was examined in a continuous and a high-pressure fixed bed reactor by employing a cobalt catalyst （Co-Ru/γ-Al2O3）. An integral reactor model involving Fischer-Tropsch reaction kinetics in the supercritical fluid n-hexane was used to describe the overall performance. On the basis of Langmuir-Hinshelwood-Hougen-Watson （LHHW） model, the reaction rate constants were obtained for the rate equations of CO conversion to CH4 formation under supercritical conditions.
基金Supported by Medica Sur Clinic and Foundation(in part)
文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico.
基金Supported by Ministry of Higher Education,Egypt,No.JS-3787.
文摘BACKGROUND Recurrent hepatitis C virus(HCV)infection of transplanted liver allografts is universal in patients with detectable HCV viremia at the time of transplantation.Direct-acting antiviral(DAA)therapy has been adopted as the standard of care for recurrent HCV infection in the post-transplant setting.However,there are insufficient data regarding its efficacy in liver transplant(LT)recipients with a history of hepatocellular carcinoma(HCC),and the risk of HCC recurrence after DAA therapy is unknown.predictors of DAA treatment failure and HCC recurrence in LT recipients.METHODS A total of 106 LT recipients given DAAs for recurrent HCV infection from 2015 to 2019 were identified(68 with and 38 without HCC).Descriptive statistics and logistic regression models were used to estimate the multivariate odds ratios and respective 95%confidence intervals for predictors of treatment failure and HCC recurrence.RESULTS Six patients(6%)experienced DAA therapy failure post-LT and 100(94%)had a sustained virologic response at follow-up week 12.A high alanine transaminase level>35 U/L at treatment week 4 was a significant predictor of treatment failure.Relapse to pre-LT DAA therapy is a predictor of post-LT HCC recurrence,P=0.04.DAA relapse post-LT was also associated with post-transplantation HCC recurrence,P=0.05.CONCLUSION DAAs are effective and safe in the treatment of recurrent HCV infection in LT recipients with history of HCC.Relapse to pre-and post-LT DAA therapy is associated with post-transplantation HCC recurrence.
文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome.
文摘BACKGROUND Understanding the treatment landscape of inflammatory bowel diseases(IBD)is essential for improving disease management and patient outcomes.Brazil is the largest Latin American country,and it presents socioeconomic and health care differences across its geographical regions.This country has the highest increase in IBD incidence and prevalence in Latin America,but information about the clinical and treatment characteristics of IBD is scarce.AIM To describe the sociodemographic,clinical,and treatment characteristics of IBD outpatients in Brazil overall and in the Southeast,South and Northeast/Midwest regions.METHODS Multicenter,cross-sectional study with a 3-year retrospective chart review component.Patients with moderate-to-severe Crohn’s disease(CD)or ulcerative colitis(UC)were consecutively enrolled between October 2016 and February 2017.Active CD at enrollment was defined as a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or a calprotectin level>200μg/g or an active result based on colonoscopy suggestive of inadequate control during the previous year;active UC was defined as a partial Mayo score≥5.Descriptive statistics were used to analyze all variables.RESULTS In a total of 407 included patients,CD was more frequent than UC,both overall(264 CD/143 UC patients)and by region(CD:UC ratios of 2.1 in the Southeast,1.6 in the South and 1.2 in the Northeast/Midwest).The majority of patients were female(54.2%of CD;56.6%of UC),and the mean ages were 45.9±13.8 years(CD)and 42.9±13.0 years(UC).The median disease duration was 10.0(range:0.5-45)years for both IBD types.At enrollment,44.7%[95%confidence interval(CI):38.7-50.7]of CD patients and 25.2%(95%CI:18.1-32.3)of UC patients presented with active disease.More than 95%of IBD patients were receiving treatment at enrollment;CD patients were commonly treated with biologics(71.6%)and immunosuppressors(67.4%),and UC patients were commonly treated with mesalazine[5-Aminosalicylic acid(5-ASA)]derivates(69.9%)and immunosuppressors(44.1%).More than 50%of the CD patients had ileocolonic disease,and 41.7%presented with stricturing disease.One-quarter of CD patients had undergone CD-related surgery in the past 3 years,and this proportion was lower in the Northeast/Midwest region(2.9%).CONCLUSION In Brazil,there are regional variations in IBD management.CD outweighs UC in both frequency and disease activity.However,one-quarter of UC patients have active disease,and most are receiving 5-ASA treatment.
文摘Many scientists used the power spectrum of the gravity anomaly to obtain the average depth of the disturbing surface or equivalently the average depth to the top of the disturbing body. The spectrum of gravity anomaly due to layered source is separated into multiple segments in frequency domain that can be interpreted in terms of mean depth of the interface. The half of the slope of the segments gives the mean depth of the interfaces. This study aims to estimate the average residual depth anomalies of various regions of the northern Logone Birni sedimentary basin of Cameroon using polynomial separation of gravity anomalies, and spectral analysis along different profiles (segments). The profiles were derived from residual anomaly maps obtained by fitting the Bouguer anomalies, the interpretation used polynomial separation and depth average was done using spectral analysis. Positive and negative residual gravity anomalies were highlighted and their interpretation revealed the structural directions of the sedimentary basin (NW-SE and NE-SW), as well as an intimate relationship between the negative anomalies and the northern Logone Birni sedimentary basin. Three distinct residual anomalies were identified over the Goulfey, Tom Merifine and Tourba basin with an average depth varying between 0.24 km and 4.55 km.
文摘Gravity and magnetic data were analyzed in conjunction with available geological data to determine the origin of observed positive gravity anomaly at Waza and its possible relationship to mafic intrusions. The data analysis includes the construction of a Bouguer gravity anomaly, isostatic residual gravity anomaly, total magnetic gradient and Euler solutions maps, and two and one-half dimensional gravity models. A positive gravity anomaly that occurs in Waza has amplitude of 35 mGal and can be separated into two parts. The top of the disturbing body causing the anomaly cannot be deeper than 4 km. We believe the anomaly is probably caused by a body of basaltic rocks lying at the upper surface of the Precambrian basement and originate from a self-propagating disturbance of magmatic loads on a pre-existing zone of lithospheric weakness. Melt migration might have been aided by tectonic and flexural stresses, such that the intrusion is limited in extent to the melting region of the plume and did not reach the surface. The model calculated to satisfy the observed anomaly consists of a 2.5 Km-thick slab underlain by a 10.5 km deep column. This model is interpreted to represent a sheet or saucer-like mafic intrusion that has a thick deep feeder. Detailed geophysical studies would be necessary to locate any possible economic occurrences.
文摘The paper is devoted to new, experimentally registered thermo physical problems of high temperature applied external and internal aerodynamics which is defined first of all by intensive interaction of the gaseous media and thermal radiation. The first report section analyses basic complexities of designing high temperature air breathing engines related to origin of so-called ＂unexpected＂ heat of working process. The next parts of the report consider physical, chemical and plasma features of aerodynamics of reentry space blunt bodies and meteors with specified account of thermal radiation influence. Our solutions are based on the classical Dark Matter-Energy simulation. We present special experimental data for Dark Matter pressure registration on the earth conditions.
基金Islamic Azad University, Gachsaran Branchthe Research Council of Yasouj University for financial support
文摘Tin sulfide nanoparticles(SnS -NPs) were prepared in aqueous solution at room temperature on the surface of activated carbon(AC) and were investigated using field-emission scanning electron mi-croscopy(FE-SEM), transmission electron microscopy(TEM), X-ray diffraction, reflective ultravio-let-visible spectrophotometry, and spectrofluorimetry. Calculations based on the SEM and TEM images showed that the sizes of the SnS -NPs immobilized on the AC were 30–70 nm. The prepared nanocomposite was used as a heterogeneous Lewis acid catalyst for the three-components one-pot synthesis of 4H-pyrano[2,3-c]pyrazole derivatives in ethanol at 80 ℃. The reactions were efficiently performed in the presence of the prepared catalyst in short reaction times, and gave the desired products in high yields. This catalyst can be easily recovered by simple filtration and recycled up to eight consecutive times without significant loss of its efficiency.
文摘AIM: To assess the distribution of human leukocyte antigen (HLA)-DQ2 and -DQ8 in Iranian celiac disease (CD) patients and compare them to healthy Iranian controls.
文摘57Fe Mossbauer spectroscopy was used to investigate the evolution of Fe-Zn binary metal oxide sorbent in the process of high-temperature fuel gas desulfurization. The results of phase analyses show that Fe-Zn binary metal oxide sorbent is rapidly reduced in hot fuel gas and decomposed to new phases of highly dispersed microcrystalline elemental iron and zinc oxide, both of which become the active desulfurization constituents. A complementary and synergistic effect between active iron acting as a high sulfur capacity constituent and active zinc oxide acting as a deep refining desulfurization constituent exists in this type of sorbent for hot fuel gas desulfurization.
文摘Precipitation of heavy hydrocarbon components such as Wax and Asphaltenes are one of the most challenging issues in oil production processes.The associated complications extend from the reservoir to refineries and petrochemical plants.Precipitation is most destructive when the affected areas are hard to reach,for example the wellbore of producing wells.This work demonstrates the effect of adjusting choke valve sizes on thermodynamic parameters of fluid flowing in a vertical well.Our simulation results revealed optimum choke valve sizes that could keep producing vertical wells away from Asphaltene precipitation.The results of this study were implemented on a well in Darquin Reservoir that had been experiencing asphaltene precipitation.Experimental analysis of reservoir fluid,Asphaltene tests and thermodynamic simulations of well column were carried out and the most appropriate size of choke valve was determined.After replacing the well's original choke valve with the suggested choke valve,the Asphaltene precipitation problem diminished.
基金This research is supported by the National Natural Science Foundation of China(Grant No.51222406)New Century Excellent Talents in University of China(NCET-12-1061)+2 种基金Scientific Research Innovation Team Project of Sichuan Colleges and Universities(12TD007)Youth Scientific Research Innovation Team Project of Sichuan Province(2014TD0025)the key projects of academic and technical leaders cultivate fund in Sichuan Province,China(2011-441-zxh).
文摘Stick-slip vibration presents one of the major causes of drilling problems,such as premature tool failures,low drilling efficiency and poor wellbore quality.The objective of this work is to investigate the influences of rotary table speed(RTS)on stick-slip phenomenon of the drilling system.In this study,the drilling system is treated as a lumped torsional pendulum model of which the bit/rock interaction is regarded as Coulomb friction.By analyzing cases with different RTS,two types of vibrations on the bit are found:stick-slip vibration and uniform motion.With an increase in the RTS,the stick-slip vibration on the drill bit disappears once the RTS arrives at its critical value.For the cases that stick-slip vibrations occur,the phase trajectories converge toward a limit cycle.For the cases that stick-slip vibration does not appear,the drill bit tends to stabilize at a uniform motion and the phase trajectories correspond to contracting spirals observed in the phase plane.
文摘In this study,an immiscible oil-water two phase flow in a typical porous media was modeled using the well-known Lattice Boltzmann method.A set of flow tests for modeling an oil-water two phase flow in the porous media were conducted to generate the capillary pressure curves for two distinctive initial conditions,namely,water and oil dispersed conditions in two domains of different resolutions.Based on the obtained results,the general trend of these curves has an acceptable agreement with the usual trend of these curves in hydrocarbon reservoirs and the capillary data are independent of the initial conditions.Also,the results showed the effect of grid resolution on capillary data which are validated quantitatively by proposing a new approach using Purcell's equation.One can see that they are compatible with the geometrical characteristics of the porous media as well as the conditions governing the tests.Finally,another set of tests for oil water pairs of higher viscosity ratio up to 4.4 was performed in a low porosity heterogeneous porous media and the viscous coupling effect on capillary data,due to viscosity ratio,was studied to strengthen the model validation.
文摘With the continuous growth of the population and the improvement of production, the shortage of freshwater has plagued many countries. The use of novel technologies such as desalination to produce fresh water on a large scale has become inevitable in the world. Hydrate-based desalination (HBD) technology has drawn an increasing amount of attention due to its mild operation condition and environmental friendliness. In this paper, literature on hydrate-based desalination is comprehensively analyzed and critically evaluated, focuses on experimental progress in different hydrate formers that have an impact on thermodynamics and dynamics in hydrate formation. Besides, various porous media promotion is investigated. Besides, the hydrate formation morphology and hydrate crystal structure with different hydrate formers are analyzed and compared. Moreover, molecular dynamic simulation is discussed to further understand microscopic information of hydrate formation. Furthermore, simulations of the HBD process by considering the energy consumption are also investigated. In conclusion, the hydrated based desalination is a potential technology to get fresh water in a sustainable way.
基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA14010101)the National Natural Science Foundation of China(NNSFC,Project No.41473020)PetroChina Science and Technology Projects(Grants 2019A-0208)for supporting this research project.
文摘In this study,alkali/acid treatment and ion exchange post-synthesis modification methods to modify the pore diameter and structure of molecular sieve 13X(MS13X)were applied to obtain products,which could then be implemented to improve the enrichment recovery of hopanoids in petroleum.The modification products were analyzed by SEM with EDS,XRD and nitrogen physisorption.The results indicated that the product which had been prepared in the oxalic acid ethanol solution formed some mesopores,and also retained the initial framework of crystal.It was revealed that this product was able to remarkably increase the recovery rate of hopanoids in petroleum without leading to a significant isotope fractionation phenomenon.It is thus shown that this modification method of non-aqueous oxalic acid solution for MS13X can be used as an effective pretreatment tool in the application of compoundspecific isotope analysis of hopanes with low concentration.
