To investigate the effects of hypoxic exercise training on microRNA （miRNA） expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic s...To investigate the effects of hypoxic exercise training on microRNA （miRNA） expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic sedentary group （N, n=10） and a hypoxic exercise training group （H, n=10）. After four weeks, measurements were taken of body weight, body length, fat mass, serum lipid concentration, miRNAs differentially expressed in rat liver, and gene and protein expression levels of perexisome proliferator activated receptor a （PPARα）, fatty acid synthetase （FAS）, and carnitine palmitoyl transferase 1A （CPTIA） in rat liver. Body weight, Lee＇s index, fat mass, fat/weight ratio, and serum levels of total cholesterol （TC） and high density lipoprotein cholesterol （HDL-C） were all significantly lower in the H group than in the N group （P〈0.01）. Six miRNAs expressed significantly differently in the liver （P〈0.05）. Specifically, expression levels of miR-378b were significantly lower in the H group than in the N group （P〈0.05）. Compared with the normoxic sedentary group, hypoxic exercise training resulted in a lower ratio of FAS mRNA to CPTIA mRNA （P〈0.05）, as well as lower CPT1A protein levels （P〈0.01）, while a higher ratio of FAS to CPT1A protein levels （P〈0.01） was observed. In conclusion, hypoxic training may elevate the resistance of high fat diet induced obesity in rats by reducing the expression of miR-378b, and decrease the fatty acid mitochondrial oxidation in obese rat livers by decreasing the protein expression of CPTIA and increasing the protein expression ratio of FAS/CPTIA.展开更多
Background:Hormone sensitive lipase(HSL) is an enzyme that regulates adipose tissue lipolysis and plays an important role in chronic exerciseinduced changes in adipose tissue metabolism.The purpose of this study was t...Background:Hormone sensitive lipase(HSL) is an enzyme that regulates adipose tissue lipolysis and plays an important role in chronic exerciseinduced changes in adipose tissue metabolism.The purpose of this study was to determine whether aerobic exercise intensity influences abdominal adipose tissue HSL gene expression in obese women under weight loss. Methods:Thirty women(body mass index(BMI) = 33.0±0.7 kg/m^2,age = 58±1 years) completed one of three 20-week interventions: caloric restriction alone(CR only,n = 8),CR plus moderate-intensity exercise(CR + moderate-intensity,45%—50%heart rate reserve(HRR). 3 day/week,n = 9),or CR plus vigorous-intensity exercise(CR + vigorous-intensity,70%—75%HRR,3 day/week,n = 13).Each group had a similar prescribed energy deficit comprised of underfeeding alone(2800 kcal/week for CR only) or underfeeding(2400 kcal/week) plus exercise(400 kcal/week).Body composition and maximal aerobic capacity(VO_2max) were measured,and subcutaneous abdominal adipose tissue samples were collected before and after the interventions.Adipose tissue HSL gene expression was measured by real time reversetranscriptase polymerase chain reaction. Results:All three interventions reduced body weight,fat mass,percent fat.and waist to a similar degree(all p < 0.01).In addition,all interventions did not change absolute VO_2 max,but increased relative VO_2 max(p < 0.05 to P < 0.01).Compared to pre-intervention.neither CR only nor CR + moderate-intensity changed adipose tissue HSL gene expression,but CR + vigorous-intensity significantly increased adipose tissue HSL gene expression(p < 0.01).The changes of HSL gene expression levels in the CR + vigorous-intensity group were significantly different from those in the CR only(p < 0.05) and CR + moderate-intensity(p < 0.01) groups.In the whole cohort,changes in adipose tissue HSL gene expression correlated positively to changes in absolute(r = 0.55,p < 0.01) and relative(r = 0.32,p = 0.09) VO_2 max. Conclusion:These results support a potential effect of aerobic exercise training intensity on hormone sensitive lipase pathway in adipose tissue metabolism in obese women under weight loss.展开更多
Background:Evidence on the health benefits of occupational physical activity(OPA)is inconclusive.We examined the associations of baseline OPA and OPA changes with all-cause,cardiovascular disease(CVD),and cancer morta...Background:Evidence on the health benefits of occupational physical activity(OPA)is inconclusive.We examined the associations of baseline OPA and OPA changes with all-cause,cardiovascular disease(CVD),and cancer mortality and survival times.Methods:This study included prospective and longitudinal data from the MJ Cohort,comprising adults over 18 years recruited in 1998-2016,349,248 adults(177,314 women)with baseline OPA,of whom 105,715(52,503 women)had 2 OPA measures at 6.3±4.2 years(mean±SD)apart.Exposures were baseline OPA,OPA changes,and baseline leisure-time physical activity.Results:Over a mean mortality follow-up of 16.2±5.5 years for men and 16.4±5.4 years for women,11,696 deaths(2033 of CVD and 4631 of cancer causes)in men and 8980 deaths(1475 of CVD and 3689 of cancer causes)in women occurred.Combined moderately heavy/heavy baseline OPA was beneficially associated with all-cause mortality in men(multivariable-adjusted hazard ratio(HR)=0.93,95%confidence interval(95%CI):0.89-0.98 compared to light OPA)and women(HR=0.86,95%CI:0.79-0.93).Over a mean mortality follow-up of 12.5±4.6 years for men and 12.6±4.6 years for women,OPA decreases in men were detrimentally associated(HR=1.16,95%CI:1.01-1.33)with all-cause mortality,while OPA increases in women were beneficially(HR=0.83,95%CI:0.70-0.97)associated with the same outcome.Baseline or changes in OPA showed no associations with CVD or cancer mortality.Conclusion:Higher baseline OPA was beneficially associated with all-cause mortality risk in both men and women.Our longitudinal OPA analyses partly confirmed the prospective findings,with some discordance between sex groups.展开更多
Background:This study examined the joint associations of sleep patterns and physical activity(PA) with all-cause,cardiovascular disease(CVD),and cancer mortality.Methods:A total of 341,248 adults(mean age=39.7 years;m...Background:This study examined the joint associations of sleep patterns and physical activity(PA) with all-cause,cardiovascular disease(CVD),and cancer mortality.Methods:A total of 341,248 adults(mean age=39.7 years;men:48.3%) were included in the study,with a 15-year follow-up.Participants reported sleep duration and disturbances(difficulty falling asleep,easily awakened,or use of sleeping medication).PA was classified into 4 levels:<7.5,7.5-14.9,15.0-29.9,and>30.0 metabolic equivalent hours per week(MET-h/week).To understand the joint associations of sleep patterns and PA with mortality,Cox proportional hazard models were conducted,with exposure variables combining sleep duration/disturbances and PA.Results:Compared with the reference group(sleeping 6-8 h/day),individuals who slept>8 h/day had higher risk for all-cause mortality(hazard ratio(HR)=1.307,95% confidence interval(95%CI):1.248-1.369),CVD mortality(HR=1.298,95%CI:1.165-1.445),and cancer mortality(HR=1.128,95%CI:1.042-1.220).Short sleep duration was not associated with mortality risk.Increased risk of all-cause and CVD mortality was found in participants who had difficulty falling asleep(HR=1.120,95%CI:1.068-1.175;HR=1.163,95%CI:1.038-1.304,respectively),and used sleeping medication(HR=1.261,95%CI:1.159-1.372;HR=1.335,95%CI:1.102-1.618,respectively) compared with those who slept well.Long sleep duration and sleep disturbances were not associated with risk of all-cause and CVD mortality among individuals achieving a PA level of>15 MET-h/week,and in particular among those achieving> 30 MET-h/week.Conclusion:Long sleep duration,difficulty falling asleep,and use of sleeping medication were related to a higher risk of death.Being physically active at a moderate intensity for 25-65 min/day eliminated these detrimental associations.展开更多
The Coronavirus disease-2019(COVID-19)pandemic is still spreading globally.As of April 7,2020,it has reached 184 countries and territories,infecting more than 1.4 million people worldwide with more than 82,000 deaths....The Coronavirus disease-2019(COVID-19)pandemic is still spreading globally.As of April 7,2020,it has reached 184 countries and territories,infecting more than 1.4 million people worldwide with more than 82,000 deaths.1 The situation in China has improved significantly since December 31,2019.2 Owing to the unprecedented and effective quarantine measures taken across the country,Chinese health authorities reported on March 18,2020,that for the first time since the outbreak no new locally transmitted COVID-19 cases had been reported,marking a major turning point in the fight against the highly contagious coronavirus.3 Since then,the daily number of new cases in the mainland of China has dropped to double digits,with new infections primarily originating from incoming air passengers from outside China.展开更多
Introduction: Despite a growing body of research indicating that dog walking contributes to meeting physical activity (PA) guidelines, this literature is limited by the use of self-report measures of dog walking and o...Introduction: Despite a growing body of research indicating that dog walking contributes to meeting physical activity (PA) guidelines, this literature is limited by the use of self-report measures of dog walking and overall PA. The objectives of this pilot study were to objectively assess dog walking with accelerometry, characterize the frequency, duration, and intensity of dog walking, and determine the contribution of dog walking to overall moderate-vigorous physical activity (MVPA). Methods: Sixty-five dog owners wore an Actigraph GT3X accelerometer for up to 7 consecutive days and recorded start/end times for dog walks with daily log sheets. Each minute with an activity count ≥ 760 was classified as MVPA. Descriptive statistics were used to summarize all variables. Logistic regression was used to examine associations between dog walking MVPA bouts and meeting PA guidelines, controlling for age, education, income, and gender. Results: Participants walked their dog an average of 1.2 ± 1.1 times/day, averaged 28.0 ± 15.6 minutes/walk, and accumulated 22.9 ± 17.5 minutes of MVPA/day during dog walks, of which 21.7 ± 17.9 minutes were accumulated in bouts ≥10 minutes. Seventy-eight percent of dog walking was classified as moderate-intensity and 3.5% was vigorous. Dog walking MVPA had a statistically significant positive association with meeting PA guidelines (OR = 2.32;95% CI = 1.06, 5.08). Conclusions: The majority of dog walking minutes were moderate-intensity and most minutes of MVPA during dog walking occurred in bouts. These findings suggest that dog walking is consistent with current PA guidelines for adults and should receive more consideration as a PA promotion strategy.展开更多
The on-going Coronavirus disease(COVID-19)outbreak in China has become the world's leading health headline and is causing major panic and public concerns.On January 30,2020,the World Health Organization(WHO)declar...The on-going Coronavirus disease(COVID-19)outbreak in China has become the world's leading health headline and is causing major panic and public concerns.On January 30,2020,the World Health Organization(WHO)declared that the new coronavirus outbreak is a public health emergency of international concern.1 The virus has already had a direct impact on more than 10 million people in the city of Wuhan and has reached other parts of China as well,posing a health threat of unknown magnitude globally.As of February 8,2020,WHO reported 34,886 confirmed cases of COVID-19 globally,with 34,589 of them occurring in China(including 6101 severe cases and 723 deaths).A total of 288 other confirmed cases(with 1 death)have been reported in 24 countries,including Japan,Australia,Germany,and United States.2 However,these daily estimates are expected to rise even higher as reports from health authorities in China3 are gathered and near real-time updates of the Johns Hopkins virus dashboard are made 4 The outbreak has caused governments in various countries to take swift and protective measures.In China,these included putting cities on lockdown,5 implementing travel wamings/bans and cancellations,6 extending national holidays,and closing schools and postponing classes7.展开更多
This paper provides a literature review of current studies investigating the effects of meditation and mind-body exercise on peripheral concentrations of brain-derived neurotrophic factor(BDNF),an important mediator o...This paper provides a literature review of current studies investigating the effects of meditation and mind-body exercise on peripheral concentrations of brain-derived neurotrophic factor(BDNF),an important mediator of the neuroplasticity of the central nervous system and cognitive function.A literature search was conducted to collect currently published randomized controlled,non-randomized controlled and uncontrolled intervention studies.Fifteen studies were identified;and among these studies,seven were randomized controlled studies,three were non-randomized studies,and five were uncontrolled studies.Current limited evidence tends to support that mindfulness meditation and mind-body exercise(e.g.yoga and tai chi)increase circulating BDNF concentrations in healthy and diseased individuals.It is noteworthy that these findings are based on current studies with a relatively small sample size,or without a randomized controlled design.Further studies are needed to identify a definite effect of meditation or mind-body exercise on BDNF and its role in improving/maintaining brain functions in various populations.展开更多
Purpose: This 2-year follow-up study aimed to examine the associations between total volume, frequency, duration, and speed of walking with subsequent sleep difficulty in older adults.Methods: A total of 800 older adu...Purpose: This 2-year follow-up study aimed to examine the associations between total volume, frequency, duration, and speed of walking with subsequent sleep difficulty in older adults.Methods: A total of 800 older adults aged 65 years and over participated in the first survey in 2012 and 511 of them were followed 2 years later.The 5-item Athens Insomnia Scale(AIS-5) was used to measure sleep difficulty. Frequency, duration, and speed of outdoor walking were self-reported. Walking speed was assigned a metabolic equivalent value(MET) from 2.5 to 4.5. Total walking volume in MET-h/week was calculated as frequency × duration × speed. Negative binomial regressions were performed to examine the associations between volume and components of walking with subsequent sleep difficulty with covariates of age, sex, education, marital status, living arrangement, smoking, alcohol consumption, mental health, Charlson Index, exercise(excluding walking), and sleep difficulty at baseline.Results: Participants with low walking volume had a higher level of sleep difficulty 2 years later compared with those with high walking volume(incident rate ratios = 1.61, p = 0.004). When speed, frequency, and duration of walking were simultaneously entered into 1 model, only walking speed was significantly associated with subsequent sleep difficulty(after the model was adjusted for covariates and baseline sleep difficulty).Sensitivity analyses showed that walking duration emerged as a significant predictor among 3 walking parameters, with 2-year changes of sleep scores as dependent variable.Conclusion: Total amount of walking(especially faster walking and lasting for more than 20 min) is associated with less subsequent sleep difficulty after 2 years among older adults.展开更多
Previous studies have shown that Physical Activity(PA)has a positive association with emotional health and intelligence in adolescents but none have focused on the relationship of PA duration and intensity on Emotiona...Previous studies have shown that Physical Activity(PA)has a positive association with emotional health and intelligence in adolescents but none have focused on the relationship of PA duration and intensity on Emotional Intelligence(EI).The purpose of this study was to cross-sectionally assess the association of PA measures on overall EI and its domains in a cohort of 2029 adolescents aged 10-13 years of age in the National Longitudinal Survey for Children and Youth(NLSCY)from Canada.Multivariable linear regression analysis of EI was adjusted for age,sex,annual household income,and health status.One-way analysis of variance(ANOVA)was used to relate PA duration measured in minutes,frequency,and intensity categories with continuous GEI scores and also the corresponding scores for domains of GEI.The mean GEI scores were(28.3±6.6)for 0-30 minute(min)PA duration,(30.0±6.5)for 30 to<60 min,(30.8±6.7)for 60-120 min,and(30.1±6.5)for≥121 min.There was a statistically significant linear trend across PA duration categories,p?0.0004.Post-hoc pairwise comparison revealed that compared to the referent category(<30 min PA category)was statistically significantly lower GEI than each of the other two PA categories(30-59 min;and 60-120 min),both p-values<0.01.Meeting World Health Organization(WHO)guidelines for duration and vigorous intensity were positively associated with the higher overall EI and its domains except for Stress Management.展开更多
Background:The validity and reliability of the Borg 6–20 rating of perceived exertion(RPE)scale has not been tested among Chinese people from China' Mainland.The purpose of this study was to test:1)The validity o...Background:The validity and reliability of the Borg 6–20 rating of perceived exertion(RPE)scale has not been tested among Chinese people from China' Mainland.The purpose of this study was to test:1)The validity of Leung Chinese version and Wang Chinese version of the Borg 6–20 RPE scale;2)The reliability of Wang Chinese version RPE scale;and 3)The agreement of these two Chinese versions of the RPE scale among young healthy adults from China' Mainland.Methods:A total of 26 subjects(11 males,15 females;age 22.7±3.0 yrs)volunteered to participate.They performed one(n=3),two(n=14),or three trials(n=9)of the Bruce treadmill protocol test within 9.0±5.1 days(validation trials),and 30.4±27.9 days(reliability trials).Power output,heart rate,oxygen consumption,and RPE were recorded.Results:RPE was significantly correlated with power output(Leung version rs≥0.75,Wang version rs≥0.73),heart rate(HR)(Leung version rs≥0.84,Wang version rs≥0.87),and oxygen consumption(VO2)(Leung version rs≥0.80,Wang version rs≥0.81)(all p<0.01).The overall test-retest interclass correlation was 0.94(p<0.01).No significant differences in correlations(RPE against power output,HR and VO_(2))between trials existed for the reliability tests of Wang version scale.No significant differences in correlations(RPE against power output,HR and VO_(2))between the two Chinese versions of RPE scale existed.Conclusion:Both Chinese RPE scales are valid among young healthy Chinese mandarin speaking adults.The Wang scale is reliable,and the Leung and Wang scales show superior agreement with each other.展开更多
Cretaceous amber from Myanmar(～99 Ma Burmese amber) has become a valuable supplement to the traditional skeletal record of small theropod dinosaurs preserved in sedimentary rocks, particularly for coelurosaurs and en...Cretaceous amber from Myanmar(～99 Ma Burmese amber) has become a valuable supplement to the traditional skeletal record of small theropod dinosaurs preserved in sedimentary rocks, particularly for coelurosaurs and enantiornithines. The specimens recovered from this deposit preserve skeletal material and soft tissues in unmatched detail. This provides opportunities to study three-dimensional preservation of soft tissues, microstructure, and pigmentation patterns that are seldom available elsewhere in the fossil record. Ultimately, this line of research provides insights into life stages that are difficult to preserve, the ecology and appearance of the groups involved, and the evolutionarydevelopment of structures such as feathers. Here we describe the most recent discovery from Burmese amber, an articulated skeleton of an enantiornithine bird. This individual has been sectioned along the coronal plane, providing a unique view inside multiple body regions. Osteological observations and plumage patterns support placement within the Enantiornithes, and suggest that the animal may have been a juvenile at the time of death. The specimen has a complex taphonomic history that includes exposure at the surface of a resin flow prior to encapsulation, and may include scavenging by some of the insects trapped within the same amber piece. The chemical composition observed along surface exposures and shallowly buried regions of the body indicate that the specimen has not undergone significant exchange with its surroundings. High iron concentrations are present in regions that preserve soft tissues as carbon films, and calcium distribution corresponds to regions where bones breach the surface of the amber.展开更多
基金Project supported by the Science Foundation for the Youth of China Institute of Sport Science （CISS） （No. 13-19）
文摘To investigate the effects of hypoxic exercise training on microRNA （miRNA） expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic sedentary group （N, n=10） and a hypoxic exercise training group （H, n=10）. After four weeks, measurements were taken of body weight, body length, fat mass, serum lipid concentration, miRNAs differentially expressed in rat liver, and gene and protein expression levels of perexisome proliferator activated receptor a （PPARα）, fatty acid synthetase （FAS）, and carnitine palmitoyl transferase 1A （CPTIA） in rat liver. Body weight, Lee＇s index, fat mass, fat/weight ratio, and serum levels of total cholesterol （TC） and high density lipoprotein cholesterol （HDL-C） were all significantly lower in the H group than in the N group （P〈0.01）. Six miRNAs expressed significantly differently in the liver （P〈0.05）. Specifically, expression levels of miR-378b were significantly lower in the H group than in the N group （P〈0.05）. Compared with the normoxic sedentary group, hypoxic exercise training resulted in a lower ratio of FAS mRNA to CPTIA mRNA （P〈0.05）, as well as lower CPT1A protein levels （P〈0.01）, while a higher ratio of FAS to CPT1A protein levels （P〈0.01） was observed. In conclusion, hypoxic training may elevate the resistance of high fat diet induced obesity in rats by reducing the expression of miR-378b, and decrease the fatty acid mitochondrial oxidation in obese rat livers by decreasing the protein expression of CPTIA and increasing the protein expression ratio of FAS/CPTIA.
基金supported by NIH grants R01-AG/ DK20583,P30-AG21332,and M01-RR07122
文摘Background:Hormone sensitive lipase(HSL) is an enzyme that regulates adipose tissue lipolysis and plays an important role in chronic exerciseinduced changes in adipose tissue metabolism.The purpose of this study was to determine whether aerobic exercise intensity influences abdominal adipose tissue HSL gene expression in obese women under weight loss. Methods:Thirty women(body mass index(BMI) = 33.0±0.7 kg/m^2,age = 58±1 years) completed one of three 20-week interventions: caloric restriction alone(CR only,n = 8),CR plus moderate-intensity exercise(CR + moderate-intensity,45%—50%heart rate reserve(HRR). 3 day/week,n = 9),or CR plus vigorous-intensity exercise(CR + vigorous-intensity,70%—75%HRR,3 day/week,n = 13).Each group had a similar prescribed energy deficit comprised of underfeeding alone(2800 kcal/week for CR only) or underfeeding(2400 kcal/week) plus exercise(400 kcal/week).Body composition and maximal aerobic capacity(VO_2max) were measured,and subcutaneous abdominal adipose tissue samples were collected before and after the interventions.Adipose tissue HSL gene expression was measured by real time reversetranscriptase polymerase chain reaction. Results:All three interventions reduced body weight,fat mass,percent fat.and waist to a similar degree(all p < 0.01).In addition,all interventions did not change absolute VO_2 max,but increased relative VO_2 max(p < 0.05 to P < 0.01).Compared to pre-intervention.neither CR only nor CR + moderate-intensity changed adipose tissue HSL gene expression,but CR + vigorous-intensity significantly increased adipose tissue HSL gene expression(p < 0.01).The changes of HSL gene expression levels in the CR + vigorous-intensity group were significantly different from those in the CR only(p < 0.05) and CR + moderate-intensity(p < 0.01) groups.In the whole cohort,changes in adipose tissue HSL gene expression correlated positively to changes in absolute(r = 0.55,p < 0.01) and relative(r = 0.32,p = 0.09) VO_2 max. Conclusion:These results support a potential effect of aerobic exercise training intensity on hormone sensitive lipase pathway in adipose tissue metabolism in obese women under weight loss.
基金supported by a National Health and Medical Research Council (Australia) Investigator Grant (APP1194510)
文摘Background:Evidence on the health benefits of occupational physical activity(OPA)is inconclusive.We examined the associations of baseline OPA and OPA changes with all-cause,cardiovascular disease(CVD),and cancer mortality and survival times.Methods:This study included prospective and longitudinal data from the MJ Cohort,comprising adults over 18 years recruited in 1998-2016,349,248 adults(177,314 women)with baseline OPA,of whom 105,715(52,503 women)had 2 OPA measures at 6.3±4.2 years(mean±SD)apart.Exposures were baseline OPA,OPA changes,and baseline leisure-time physical activity.Results:Over a mean mortality follow-up of 16.2±5.5 years for men and 16.4±5.4 years for women,11,696 deaths(2033 of CVD and 4631 of cancer causes)in men and 8980 deaths(1475 of CVD and 3689 of cancer causes)in women occurred.Combined moderately heavy/heavy baseline OPA was beneficially associated with all-cause mortality in men(multivariable-adjusted hazard ratio(HR)=0.93,95%confidence interval(95%CI):0.89-0.98 compared to light OPA)and women(HR=0.86,95%CI:0.79-0.93).Over a mean mortality follow-up of 12.5±4.6 years for men and 12.6±4.6 years for women,OPA decreases in men were detrimentally associated(HR=1.16,95%CI:1.01-1.33)with all-cause mortality,while OPA increases in women were beneficially(HR=0.83,95%CI:0.70-0.97)associated with the same outcome.Baseline or changes in OPA showed no associations with CVD or cancer mortality.Conclusion:Higher baseline OPA was beneficially associated with all-cause mortality risk in both men and women.Our longitudinal OPA analyses partly confirmed the prospective findings,with some discordance between sex groups.
基金PWK’s work is supported in part by the Ministry of Science and Technology (MOST 108-2410-H-018-028-MY3)funded by the National Health and Medical Research Council(NHMRC) through a Senior Research Fellowship。
文摘Background:This study examined the joint associations of sleep patterns and physical activity(PA) with all-cause,cardiovascular disease(CVD),and cancer mortality.Methods:A total of 341,248 adults(mean age=39.7 years;men:48.3%) were included in the study,with a 15-year follow-up.Participants reported sleep duration and disturbances(difficulty falling asleep,easily awakened,or use of sleeping medication).PA was classified into 4 levels:<7.5,7.5-14.9,15.0-29.9,and>30.0 metabolic equivalent hours per week(MET-h/week).To understand the joint associations of sleep patterns and PA with mortality,Cox proportional hazard models were conducted,with exposure variables combining sleep duration/disturbances and PA.Results:Compared with the reference group(sleeping 6-8 h/day),individuals who slept>8 h/day had higher risk for all-cause mortality(hazard ratio(HR)=1.307,95% confidence interval(95%CI):1.248-1.369),CVD mortality(HR=1.298,95%CI:1.165-1.445),and cancer mortality(HR=1.128,95%CI:1.042-1.220).Short sleep duration was not associated with mortality risk.Increased risk of all-cause and CVD mortality was found in participants who had difficulty falling asleep(HR=1.120,95%CI:1.068-1.175;HR=1.163,95%CI:1.038-1.304,respectively),and used sleeping medication(HR=1.261,95%CI:1.159-1.372;HR=1.335,95%CI:1.102-1.618,respectively) compared with those who slept well.Long sleep duration and sleep disturbances were not associated with risk of all-cause and CVD mortality among individuals achieving a PA level of>15 MET-h/week,and in particular among those achieving> 30 MET-h/week.Conclusion:Long sleep duration,difficulty falling asleep,and use of sleeping medication were related to a higher risk of death.Being physically active at a moderate intensity for 25-65 min/day eliminated these detrimental associations.
文摘The Coronavirus disease-2019(COVID-19)pandemic is still spreading globally.As of April 7,2020,it has reached 184 countries and territories,infecting more than 1.4 million people worldwide with more than 82,000 deaths.1 The situation in China has improved significantly since December 31,2019.2 Owing to the unprecedented and effective quarantine measures taken across the country,Chinese health authorities reported on March 18,2020,that for the first time since the outbreak no new locally transmitted COVID-19 cases had been reported,marking a major turning point in the fight against the highly contagious coronavirus.3 Since then,the daily number of new cases in the mainland of China has dropped to double digits,with new infections primarily originating from incoming air passengers from outside China.
文摘Introduction: Despite a growing body of research indicating that dog walking contributes to meeting physical activity (PA) guidelines, this literature is limited by the use of self-report measures of dog walking and overall PA. The objectives of this pilot study were to objectively assess dog walking with accelerometry, characterize the frequency, duration, and intensity of dog walking, and determine the contribution of dog walking to overall moderate-vigorous physical activity (MVPA). Methods: Sixty-five dog owners wore an Actigraph GT3X accelerometer for up to 7 consecutive days and recorded start/end times for dog walks with daily log sheets. Each minute with an activity count ≥ 760 was classified as MVPA. Descriptive statistics were used to summarize all variables. Logistic regression was used to examine associations between dog walking MVPA bouts and meeting PA guidelines, controlling for age, education, income, and gender. Results: Participants walked their dog an average of 1.2 ± 1.1 times/day, averaged 28.0 ± 15.6 minutes/walk, and accumulated 22.9 ± 17.5 minutes of MVPA/day during dog walks, of which 21.7 ± 17.9 minutes were accumulated in bouts ≥10 minutes. Seventy-eight percent of dog walking was classified as moderate-intensity and 3.5% was vigorous. Dog walking MVPA had a statistically significant positive association with meeting PA guidelines (OR = 2.32;95% CI = 1.06, 5.08). Conclusions: The majority of dog walking minutes were moderate-intensity and most minutes of MVPA during dog walking occurred in bouts. These findings suggest that dog walking is consistent with current PA guidelines for adults and should receive more consideration as a PA promotion strategy.
文摘The on-going Coronavirus disease(COVID-19)outbreak in China has become the world's leading health headline and is causing major panic and public concerns.On January 30,2020,the World Health Organization(WHO)declared that the new coronavirus outbreak is a public health emergency of international concern.1 The virus has already had a direct impact on more than 10 million people in the city of Wuhan and has reached other parts of China as well,posing a health threat of unknown magnitude globally.As of February 8,2020,WHO reported 34,886 confirmed cases of COVID-19 globally,with 34,589 of them occurring in China(including 6101 severe cases and 723 deaths).A total of 288 other confirmed cases(with 1 death)have been reported in 24 countries,including Japan,Australia,Germany,and United States.2 However,these daily estimates are expected to rise even higher as reports from health authorities in China3 are gathered and near real-time updates of the Johns Hopkins virus dashboard are made 4 The outbreak has caused governments in various countries to take swift and protective measures.In China,these included putting cities on lockdown,5 implementing travel wamings/bans and cancellations,6 extending national holidays,and closing schools and postponing classes7.
文摘This paper provides a literature review of current studies investigating the effects of meditation and mind-body exercise on peripheral concentrations of brain-derived neurotrophic factor(BDNF),an important mediator of the neuroplasticity of the central nervous system and cognitive function.A literature search was conducted to collect currently published randomized controlled,non-randomized controlled and uncontrolled intervention studies.Fifteen studies were identified;and among these studies,seven were randomized controlled studies,three were non-randomized studies,and five were uncontrolled studies.Current limited evidence tends to support that mindfulness meditation and mind-body exercise(e.g.yoga and tai chi)increase circulating BDNF concentrations in healthy and diseased individuals.It is noteworthy that these findings are based on current studies with a relatively small sample size,or without a randomized controlled design.Further studies are needed to identify a definite effect of meditation or mind-body exercise on BDNF and its role in improving/maintaining brain functions in various populations.
文摘Purpose: This 2-year follow-up study aimed to examine the associations between total volume, frequency, duration, and speed of walking with subsequent sleep difficulty in older adults.Methods: A total of 800 older adults aged 65 years and over participated in the first survey in 2012 and 511 of them were followed 2 years later.The 5-item Athens Insomnia Scale(AIS-5) was used to measure sleep difficulty. Frequency, duration, and speed of outdoor walking were self-reported. Walking speed was assigned a metabolic equivalent value(MET) from 2.5 to 4.5. Total walking volume in MET-h/week was calculated as frequency × duration × speed. Negative binomial regressions were performed to examine the associations between volume and components of walking with subsequent sleep difficulty with covariates of age, sex, education, marital status, living arrangement, smoking, alcohol consumption, mental health, Charlson Index, exercise(excluding walking), and sleep difficulty at baseline.Results: Participants with low walking volume had a higher level of sleep difficulty 2 years later compared with those with high walking volume(incident rate ratios = 1.61, p = 0.004). When speed, frequency, and duration of walking were simultaneously entered into 1 model, only walking speed was significantly associated with subsequent sleep difficulty(after the model was adjusted for covariates and baseline sleep difficulty).Sensitivity analyses showed that walking duration emerged as a significant predictor among 3 walking parameters, with 2-year changes of sleep scores as dependent variable.Conclusion: Total amount of walking(especially faster walking and lasting for more than 20 min) is associated with less subsequent sleep difficulty after 2 years among older adults.
文摘Previous studies have shown that Physical Activity(PA)has a positive association with emotional health and intelligence in adolescents but none have focused on the relationship of PA duration and intensity on Emotional Intelligence(EI).The purpose of this study was to cross-sectionally assess the association of PA measures on overall EI and its domains in a cohort of 2029 adolescents aged 10-13 years of age in the National Longitudinal Survey for Children and Youth(NLSCY)from Canada.Multivariable linear regression analysis of EI was adjusted for age,sex,annual household income,and health status.One-way analysis of variance(ANOVA)was used to relate PA duration measured in minutes,frequency,and intensity categories with continuous GEI scores and also the corresponding scores for domains of GEI.The mean GEI scores were(28.3±6.6)for 0-30 minute(min)PA duration,(30.0±6.5)for 30 to<60 min,(30.8±6.7)for 60-120 min,and(30.1±6.5)for≥121 min.There was a statistically significant linear trend across PA duration categories,p?0.0004.Post-hoc pairwise comparison revealed that compared to the referent category(<30 min PA category)was statistically significantly lower GEI than each of the other two PA categories(30-59 min;and 60-120 min),both p-values<0.01.Meeting World Health Organization(WHO)guidelines for duration and vigorous intensity were positively associated with the higher overall EI and its domains except for Stress Management.
文摘Background:The validity and reliability of the Borg 6–20 rating of perceived exertion(RPE)scale has not been tested among Chinese people from China' Mainland.The purpose of this study was to test:1)The validity of Leung Chinese version and Wang Chinese version of the Borg 6–20 RPE scale;2)The reliability of Wang Chinese version RPE scale;and 3)The agreement of these two Chinese versions of the RPE scale among young healthy adults from China' Mainland.Methods:A total of 26 subjects(11 males,15 females;age 22.7±3.0 yrs)volunteered to participate.They performed one(n=3),two(n=14),or three trials(n=9)of the Bruce treadmill protocol test within 9.0±5.1 days(validation trials),and 30.4±27.9 days(reliability trials).Power output,heart rate,oxygen consumption,and RPE were recorded.Results:RPE was significantly correlated with power output(Leung version rs≥0.75,Wang version rs≥0.73),heart rate(HR)(Leung version rs≥0.84,Wang version rs≥0.87),and oxygen consumption(VO2)(Leung version rs≥0.80,Wang version rs≥0.81)(all p<0.01).The overall test-retest interclass correlation was 0.94(p<0.01).No significant differences in correlations(RPE against power output,HR and VO_(2))between trials existed for the reliability tests of Wang version scale.No significant differences in correlations(RPE against power output,HR and VO_(2))between the two Chinese versions of RPE scale existed.Conclusion:Both Chinese RPE scales are valid among young healthy Chinese mandarin speaking adults.The Wang scale is reliable,and the Leung and Wang scales show superior agreement with each other.
基金funded by the National Natural Science Foundation of China(41790455,41772008,31672345,Special Subjects in Animal Taxonomy,NSFC-J1210002)Natural Sciences and Engineering Research Council of Canada(201500681)+1 种基金Scientific Research Equipment Development Project of Chinese Academy of Sciences(YZ201509)the National Geographic Society,USA(EC0768-15)
文摘Cretaceous amber from Myanmar(～99 Ma Burmese amber) has become a valuable supplement to the traditional skeletal record of small theropod dinosaurs preserved in sedimentary rocks, particularly for coelurosaurs and enantiornithines. The specimens recovered from this deposit preserve skeletal material and soft tissues in unmatched detail. This provides opportunities to study three-dimensional preservation of soft tissues, microstructure, and pigmentation patterns that are seldom available elsewhere in the fossil record. Ultimately, this line of research provides insights into life stages that are difficult to preserve, the ecology and appearance of the groups involved, and the evolutionarydevelopment of structures such as feathers. Here we describe the most recent discovery from Burmese amber, an articulated skeleton of an enantiornithine bird. This individual has been sectioned along the coronal plane, providing a unique view inside multiple body regions. Osteological observations and plumage patterns support placement within the Enantiornithes, and suggest that the animal may have been a juvenile at the time of death. The specimen has a complex taphonomic history that includes exposure at the surface of a resin flow prior to encapsulation, and may include scavenging by some of the insects trapped within the same amber piece. The chemical composition observed along surface exposures and shallowly buried regions of the body indicate that the specimen has not undergone significant exchange with its surroundings. High iron concentrations are present in regions that preserve soft tissues as carbon films, and calcium distribution corresponds to regions where bones breach the surface of the amber.
