Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss...Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.展开更多
Background:Insufficient physical activity and prolonged sedentary behavior have emerged as major global public health challenges.Short bouts(≤10 min)of accumulated exercise(SBAE)throughout the day may be a promising ...Background:Insufficient physical activity and prolonged sedentary behavior have emerged as major global public health challenges.Short bouts(≤10 min)of accumulated exercise(SBAE)throughout the day may be a promising strategy to mitigate the adverse effects of prolonged sitting and promote physical activity,ultimately promoting overall health.However,previous ambiguity in defining this concept has resulted in a fragmented and inconsistent evidence base,impeding practical applications,the development of guidelines,and policymaking.The purpose of this study is to establish an operational definition of SBAE by synthesizing systematic reviews and research trials alongside an expert consensus.Additionally,it seeks to evaluate acute and long-term efficacy and feasibility,providing evidence-based recommendations for practice and future research directions.Methods:A literature search was performed across PubMed and Web of Science,followed by systematic screening and summarization of eligible studies based on predefined inclusion criteria.Inclusion criteria encompassed various modes/types of SBAE(bouts lasting≤10 min,performed multiple times daily with≥30 min intervals);both aerobic and resistance exercise were considered.Relevant systematic reviews and research trials were included.Methodological quality,risk of bias,and evidence certainty were assessed.Expert consensus was obtained through a survey to evaluate recommendations and agreement levels on findings.Results:After analyzing 27 systematic reviews,135 research studies,and an expert consensus involving 48 researchers from 11 countries,SBAE is defined as any exercise mode of activity,regardless of intensity,that is accumulated in either continuous or intermittent bouts lasting≤10 min per session(including multiple intermittent sets)that are performed multiple times(≥2 sessions/day)per day,with intervals of≥30 min between bouts or otherwise sufficient time for recovery.When used to interrupt prolonged periods of sedentary time,SBAE mitigates the acute adverse effects of sedentary behavior on more than 10 clinical biomarkers of endocrine,cardiovascular,and brain health/function among adults of diverse ages and conditions.Moreover,SBAE was superior for improving acute glycemic control compared to a single continuous exercise session.As a long-term intervention(average of 11 weeks),SBAE can improve over 20 health outcomes,including peak oxygen uptake,resting blood pressure,and metabolic health.Additionally,SBAE might be more effective than continuous exercise for improving longer-term glycemic control and body composition.Long-term completion rates for SBAE interventions are generally high(95%),with low dropout rates(12%)and high adherence rates even without supervision(85%),and its safety has been preliminarily validated.Conclusion:An operational definition of SBAE is provided along with its classification and acute and long-term efficacy.Practical exercise prescription recommendations and evidence-based strategies for various populations and contexts are provided.Future research should focus on generating high-quality evidence for SBAE in 5 key areas:quantification and monitoring,population-specific responses,optimization of exercise prescriptions,intervention efficacy,and practical implementation.Additionally,addressing policy,environmental,and promotional barriers is crucial for transitioning from expert consensus to public consensus,and for facilitating the application of this strategy in real-world environments.展开更多
We read with great interest the recent article by Valenzuela et al.1titled“Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease”published in the Journ...We read with great interest the recent article by Valenzuela et al.1titled“Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease”published in the Journal of Sport and Health Science The study's exploration of the effects of varying carbohydrate(CHO)doses on exercise capacity in Mc Ardle disease,a condition characterized by complete muscle glycogen unavailability,is a significant contribution to the field of sports science and metabolic disorders.展开更多
To investigate the effects of hypoxic exercise training on microRNA （miRNA） expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic s...To investigate the effects of hypoxic exercise training on microRNA （miRNA） expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic sedentary group （N, n=10） and a hypoxic exercise training group （H, n=10）. After four weeks, measurements were taken of body weight, body length, fat mass, serum lipid concentration, miRNAs differentially expressed in rat liver, and gene and protein expression levels of perexisome proliferator activated receptor a （PPARα）, fatty acid synthetase （FAS）, and carnitine palmitoyl transferase 1A （CPTIA） in rat liver. Body weight, Lee＇s index, fat mass, fat/weight ratio, and serum levels of total cholesterol （TC） and high density lipoprotein cholesterol （HDL-C） were all significantly lower in the H group than in the N group （P〈0.01）. Six miRNAs expressed significantly differently in the liver （P〈0.05）. Specifically, expression levels of miR-378b were significantly lower in the H group than in the N group （P〈0.05）. Compared with the normoxic sedentary group, hypoxic exercise training resulted in a lower ratio of FAS mRNA to CPTIA mRNA （P〈0.05）, as well as lower CPT1A protein levels （P〈0.01）, while a higher ratio of FAS to CPT1A protein levels （P〈0.01） was observed. In conclusion, hypoxic training may elevate the resistance of high fat diet induced obesity in rats by reducing the expression of miR-378b, and decrease the fatty acid mitochondrial oxidation in obese rat livers by decreasing the protein expression of CPTIA and increasing the protein expression ratio of FAS/CPTIA.展开更多
Background： Poor sleep quality is associated with adverse effects on health outcomes. It is not clear whether exercise can improve sleep quality and whether intensity of exercise affects any of the effects. Methods：...Background： Poor sleep quality is associated with adverse effects on health outcomes. It is not clear whether exercise can improve sleep quality and whether intensity of exercise affects any of the effects. Methods： Fifteen healthy, non-obese （body mass index = 24.4 ± 2.1 kg/m^2, mean 4- SD）, sedentary （〈20 min of exercise on no more than 3 times/week） older women （66.1 ± 3.9 years） volunteered for the study. Peak oxygen consumption （VO2peak） was evaluated using a graded exercise test on a treadmill with a metabolic cart. Following a 7-day baseline period, each participant completed two exercise sessions （separated by 1 week） with equal caloric expenditure, but at different intensities （60% and 45% VO2peak, sequence randomized） between 9：00 and 11：00 am. A wrist ActiGraph monitor was used to assess sleep at baseline and two nights following each exercise session. Results： The average duration of the exercise was 54 and 72 rain, respectively at 60% （moderate-intensity） and 45% VO2peak （light-intensity）. Wake time after sleep onset was significantly shorter （p = 0.016）, the number of awakenings was less （p = 0.046）, and total activity counts were lower （p = 0.05） after the moderate-intensity exercise compared to baseline no-exercise condition. Conclusion： Our data showed that a single moderate-intensity aerobic exercise session improved sleep quality in older women.展开更多
Reactive oxygen species （ROS） are continuously generated during aerobic metabolism and at moderate level. They play a role in redox signaling, but in significant concentration they cause oxidative damage and neurode...Reactive oxygen species （ROS） are continuously generated during aerobic metabolism and at moderate level. They play a role in redox signaling, but in significant concentration they cause oxidative damage and neurodegeneration. Because of the enhanced sensitivity of brain to ROS, it is especially important to maintain the normal redox state in different types of neuron cells. In last decade it became clear that regular exercise beneficially affects brain function, and can play an important preventive and therapeutic role in stroke, Alzheimer, and Parkinson diseases. The effects of exercise appear to be very complex and could include neurogenesis via neurotrophic factors, increased capillariszation, decreased oxidative damage, and increased proteolyfic degradation by proteasome and neprilysin. Data from our and other laboratories indicate that exercise-induced modulation of ROS levels plays a role in the protein content and expression of brain-derived neurotrophic factor, tyrosinerelated kinase B （TrkB）, and cAMP response element binding protein, resulting in better function and increased neurogenesis. Therefore, it appears that exercise-induced modulation of the redox state is an important means, by which exercise benefits brain function, increases the resistance against oxidative stress, facilitates recovery from oxidative stress, and attenuates age-associated decline in cognition.展开更多
AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of ...AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise.展开更多
Purpose： The purpose of this study was to determine the effects of acute exercise on motor response inhibition using both behavioral and electrophysiological approaches. Methods： The P3 and N1 event-related potenti...Purpose： The purpose of this study was to determine the effects of acute exercise on motor response inhibition using both behavioral and electrophysiological approaches. Methods： The P3 and N1 event-related potential （ERP） components were recorded while performing a stop-signal task in 21 college students following a moderately intense acute exercise bout for 30 min and a sedentary control session that involved reading. Results： Acute exercise induced a shorter stop signal response time （SSRT） as compared to control; however, the go response time （Go RT） remained unchanged. In examining the ERP data, acute exercise increased both P3 amplitude and latency but did not affect the N1 component. Conclusion： Acute exercise has a selective and beneficial effect on cognitive function, specifically affecting the motor response inhibition aspect of executive function. Furthermore, acute exercise predominately impacts later stages of information processing during motor response inhibition, which may lead to an increase in attentional resource allocation and confer the ability to successfully withhold a response to achieve motor response inhibition.展开更多
Background:Hormone sensitive lipase(HSL) is an enzyme that regulates adipose tissue lipolysis and plays an important role in chronic exerciseinduced changes in adipose tissue metabolism.The purpose of this study was t...Background:Hormone sensitive lipase(HSL) is an enzyme that regulates adipose tissue lipolysis and plays an important role in chronic exerciseinduced changes in adipose tissue metabolism.The purpose of this study was to determine whether aerobic exercise intensity influences abdominal adipose tissue HSL gene expression in obese women under weight loss. Methods:Thirty women(body mass index(BMI) = 33.0±0.7 kg/m^2,age = 58±1 years) completed one of three 20-week interventions: caloric restriction alone(CR only,n = 8),CR plus moderate-intensity exercise(CR + moderate-intensity,45%—50%heart rate reserve(HRR). 3 day/week,n = 9),or CR plus vigorous-intensity exercise(CR + vigorous-intensity,70%—75%HRR,3 day/week,n = 13).Each group had a similar prescribed energy deficit comprised of underfeeding alone(2800 kcal/week for CR only) or underfeeding(2400 kcal/week) plus exercise(400 kcal/week).Body composition and maximal aerobic capacity(VO_2max) were measured,and subcutaneous abdominal adipose tissue samples were collected before and after the interventions.Adipose tissue HSL gene expression was measured by real time reversetranscriptase polymerase chain reaction. Results:All three interventions reduced body weight,fat mass,percent fat.and waist to a similar degree(all p < 0.01).In addition,all interventions did not change absolute VO_2 max,but increased relative VO_2 max(p < 0.05 to P < 0.01).Compared to pre-intervention.neither CR only nor CR + moderate-intensity changed adipose tissue HSL gene expression,but CR + vigorous-intensity significantly increased adipose tissue HSL gene expression(p < 0.01).The changes of HSL gene expression levels in the CR + vigorous-intensity group were significantly different from those in the CR only(p < 0.05) and CR + moderate-intensity(p < 0.01) groups.In the whole cohort,changes in adipose tissue HSL gene expression correlated positively to changes in absolute(r = 0.55,p < 0.01) and relative(r = 0.32,p = 0.09) VO_2 max. Conclusion:These results support a potential effect of aerobic exercise training intensity on hormone sensitive lipase pathway in adipose tissue metabolism in obese women under weight loss.展开更多
Background:Patients undergoing dialysis have high mortality rates and a unique risk factor profile. Some improvements elicited by exercise training have been shown in dialysis populations, here we aimed to further exp...Background:Patients undergoing dialysis have high mortality rates and a unique risk factor profile. Some improvements elicited by exercise training have been shown in dialysis populations, here we aimed to further explore the bene-fits of exercise. As well as changes in physical fitness we quantified cardiac function, depression, serum biochemistry, dialysis adequacy and energy intake following exercise training in people with chronic kidney disease (CKD) undertaking dialysis. Methods:A systematic literature search was completed in December 2012 identifying randomized, controlled trials of exercise training studies in haemodialysis (HD) patients. A subsequent meta-analysis was conducted.Results: Twenty four studies were included, totalling 879 patients. Exercise training produced significant improvements in physical fitness: peak VO2 5.03 mlO2·kg-1·min-1 (95% CI 3.73, 6.33, p 0.0001), Knee extensor strength 2.99 kg (95% CI 0.46, 5.52, p = 0.02) and 6 minute walk distance 60.7 metres (95% CI 18.9, 103, p = 0.004). Significant increases in energy intake MD 238 Kcal·day-1 (95% CI 94, 383, p = 0.001), serum Interleukin-6 MD-0.58 pg·ml-1 (95% CI-1.01, -0.15, p = 0.008) and Creactive protein MD 0.92 mg/L-1 (95% CI 0.29, 1.56, p = 0.004), but not Albumin or BMI, were reported. Improved Beck Depression scores were reported MD-6.9 (95% CI-9.7,-4.1, p 0.00001). Dialysis adequacy was reduced MD-0.23 (95% CI -0.29, -0.17, p 0.00001), while serum potassium was higher MD 0.14 mmol·L-1 (95% CI 0.01, 0.27, p = 0.04). Moreover exercise training appeared safe, with no direct exercise-associated deaths in over 30,000 patient-hours. Conclusions: Our pooled analyses confirmed improvements in physical fitness following exercise training and suggested additional improvements in dialysis efficiency (kt/v), serum potassium, inflammation and depression in HD patients.展开更多
Glycemic variability is a more sensitive assessment of glycemic health as opposed to traditional clinical mea-surements.It considers all blood glucose concentrations over a given period to better account for glucose o...Glycemic variability is a more sensitive assessment of glycemic health as opposed to traditional clinical mea-surements.It considers all blood glucose concentrations over a given period to better account for glucose oscil-lations that occur and provides clinicians with insight into how individuals regulate and/or maintain their glycemic health.The advancement of continuous glucose monitoring(CGM)allows for the measurement of free-living glucose concentrations while providing a more reliable assessment of treatment of dysregulated glycemic.CGM coupled with management of lifestyle behavioral factors,such as reduced sedentary behavior and increased physical activity and regular exercise,potentially offers a previously untapped method for promoting improved glycemic health through greater regulation of glucose concentrations.The aim of this review is to critically evaluate the evidence regarding the measurement of glycemic variability and summarize the current under-standing of the relationship between glycemic variability,sedentary behavior,physical activity,the influence of a single exercise session or repeated exercise sessions,and exercise training.This review considers information pertaining to the strengths and limitations for measuring glycemic variability and provides insight into future study designs aimed at evaluating the relationship between sedentary behavior and physical activity with,as well as the influence of exercise on,glycemic variability as a primary outcome.展开更多
Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing trend.Although multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play ...Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing trend.Although multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play a significant role in the genesis and progression.Most of the research supports the advantages of exercise for NAFLD.However,little is known about the molecular mechanism(s)that underpin the effectiveness of exercise training in NAFLD.This study aimed to identify how aerobic exercise affected hepatic ER stress in a mouse NAFLD model.In this study,the mice were fed either a standard diet(SD)or a high-fat diet(HFD)for 17 weeks.HFD mice were trained on a treadmill during the last eight weeks.All animals were tested for serum levels of biochemical assays,protein expression,and gene expression.The hematoxylin and eosin,Oil red O,and immunohistochemistry staining were also performed.The results indicated that a high-fat diet generated NAFLD,with serum lipid disruption and hepatic function impairment,and increased GRP78 and ATF6 expressions.However,aerobic training reversed the majority of these alterations.It is concluded that NAFLD appears to be associated with hepatic ER stress response,and aerobic exercise mitigates NAFLD via lowering ER stress proteins GRP78 and ATF6.展开更多
Endurance exercise training promotes a protective phenotype in skeletal muscle known as exercise pre-conditioning.Exercise preconditioning protects muscle fibers against a variety of threats including inactivity-induc...Endurance exercise training promotes a protective phenotype in skeletal muscle known as exercise pre-conditioning.Exercise preconditioning protects muscle fibers against a variety of threats including inactivity-induced muscle atrophy.The mechanism(s)responsible for exercise preconditioning remain unknown and are explored in these experiments.Specifically,we investigated the impact of endurance exercise training on key components of the renin-angiotensin system(RAS).The RAS was targeted because activation of the classical axis of the RAS pathway via angiotensinⅡtypeⅠreceptors(AT1Rs)promotes muscle atrophy whereas activation of the non-classical RAS axis via Mas receptors(MasRs)inhibits the atrophic signaling of the classical RAS pathway.Guided by prior studies,we hypothesized that an exercise-induced decrease in AT1Rs and/or increases in MasRs in skeletal muscle fibers is a potential mechanism responsible for exercise preconditioning.Following endurance exercise training in rats,we examined the abundance of AT1Rs and MasRs in both locomotor and respiratory muscles.Our results indicate that endurance exercise training does not alter the protein abundance of AT1Rs or MasRs in muscle fibers from the diaphragm,plantaris,and soleus muscles compared to sedentary controls(p>0.05).Furthermore,fluorescent angiotensinⅡ(AngⅡ)binding analyses confirm our results that exercise pre-conditioning does not alter the protein abundance of AT1Rs in the diaphragm,plantaris,and soleus(p>0.05).This study confirms that exercise-induced changes in RAS receptors are not a key mechanism that contributes to the beneficial effects of exercise preconditioning in skeletal muscle fibers.展开更多
This paper provides a literature review of current studies investigating the effects of meditation and mind-body exercise on peripheral concentrations of brain-derived neurotrophic factor(BDNF),an important mediator o...This paper provides a literature review of current studies investigating the effects of meditation and mind-body exercise on peripheral concentrations of brain-derived neurotrophic factor(BDNF),an important mediator of the neuroplasticity of the central nervous system and cognitive function.A literature search was conducted to collect currently published randomized controlled,non-randomized controlled and uncontrolled intervention studies.Fifteen studies were identified;and among these studies,seven were randomized controlled studies,three were non-randomized studies,and five were uncontrolled studies.Current limited evidence tends to support that mindfulness meditation and mind-body exercise(e.g.yoga and tai chi)increase circulating BDNF concentrations in healthy and diseased individuals.It is noteworthy that these findings are based on current studies with a relatively small sample size,or without a randomized controlled design.Further studies are needed to identify a definite effect of meditation or mind-body exercise on BDNF and its role in improving/maintaining brain functions in various populations.展开更多
Background:Decaffeinated green tea extract(dGTE)can increase fat oxidation during leg exercise,but dGTE is unsuitable for many people(e.g.,those with injuries/disabilities),and its effects on arm exercise and women ar...Background:Decaffeinated green tea extract(dGTE)can increase fat oxidation during leg exercise,but dGTE is unsuitable for many people(e.g.,those with injuries/disabilities),and its effects on arm exercise and women are unknown.Methods:Eight adults(23-37 years old,4 women)performed an incremental arm cycle test to measure peak oxygen uptake(VO_(2_(peak))),followed by four 1-h trials at 50%VO_(2_(peak).Subjects were randomly assigned to 650 mg of dGTE or placebo(PLA)for 4 weeks followed by a 4-week washout and crossover trial.Blood samples were obtained pre-exercise and post-exercise for glycerol and free fatty acid analysis.Respiratory gases were collected continuously.Results:VO_(2) showed no differences across trials((0.83-0.89)±(0.19-0.25)L/min,p=0.460),neither did energy expenditure((264-266)±(59-77)kcal,p=0.420)nor fat oxidation(dGTE=0.11 to 0.12 g/min vs.PLA=0.10 to 0.09 g/min,p=0.220).Fat oxidation as percentage of energy expenditure was not different for dGTE vs.PLA(23%±12%to 25%±11%vs.23%±10%to 21%±9%,p=0.532).Glycerol concentration increased post-exercise in all trials,independent of treatments(pre=(3.4-5.1)±(0.6-2.6)mg/dL vs.post=(7.9-9.8)±(2.6-3.7)mg/dL,p=0.867,η^(2)=0.005 for interaction),as did free fatty acid((3.5-4.8)±(1.4-2.2)mg/dL vs.(7.2-9.1)±(2.6-4.5)mg/dL,p=0.981,η^(2)=0.000).Conclusion:Chronic dGTE supplementation had no effect on lipolysis and fat oxidation during arm cycle exercise in men and women.展开更多
Lymphedema is an atypical accumulation of high-proteinfluid located just beneath the skin, which often occurs in the arm or leg. Exercising with lymphedema was traditionally considered to be unsafe. However, recent re...Lymphedema is an atypical accumulation of high-proteinfluid located just beneath the skin, which often occurs in the arm or leg. Exercising with lymphedema was traditionally considered to be unsafe. However, recent research indicates that exercise may be beneficial to individuals with lymphedema. Studies indicate that exercise can improve the range of motion and strength of the afflicted limb(s), as well as overall fitness and functional quality of life, and can be performed without exacerbating symptoms of lymphedema.展开更多
Background： Understanding leisure time physical inactivity is a priority in study sought to address this priority by examining whether the extraversion mediated through Elliot＇s （1999） 2 x 2 achievement goals. Wes...Background： Understanding leisure time physical inactivity is a priority in study sought to address this priority by examining whether the extraversion mediated through Elliot＇s （1999） 2 x 2 achievement goals. Westernized nations where participation rates are low. The present and emotional instability to leisure time exercise relationships were Methods： Participants were 116 female and 97 male volunteers from a Southwestern community （mean age = 37.21 years, range 24-69） who completed measures of extraversion, emotional instability, approach-avoidance achievement goals, and 7-day recall of leisure-time exercise. Multiple mediation models （Preacher and Hayes, 2008） were run to specifically examine our hypotheses. Results： The mastery-approach goal mediated the relationship from extraversion to overall exercise and strenuous intensity exercise. Results indicated emotional instability had direct effects on overall and strenuous leisure time exercise while also having significant （p 〈 0.05） indirect mediation paths through the performance-approach and avoidance goals. The extraversion and emotional instability models accounted from 15.89% to 29.82% of variance in the various self-reported exercise measures. Conclusion： The results suggest the promotion of leisure-time exercise would be improved in the studied personalities by manipulation of achievement goals. Copyright @ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.展开更多
Exercise has widely been shown to improve cognition, potentially by making individuals more receptive to sensory stimulation or inhibiting irrelevant information. Caffeine, one of the world’s most widely used stimula...Exercise has widely been shown to improve cognition, potentially by making individuals more receptive to sensory stimulation or inhibiting irrelevant information. Caffeine, one of the world’s most widely used stimulants, seems to have similar effects. It seems that both exercise and caffeine improve cognitive function separately, but little research has been done examining their combined effects. The purpose of this study was to examine the impact of caffeine and exercise, independently and combined, on cognitive function. 20 healthy college students completed the study. These participants were low caffeine consumers. Each participant came to the lab 5 times. During the first session, they completed a graded exercise test on a cycle ergometer to determine ventilatory threshold (VT). The following four sessions were test sessions involving supplementation and exercise. During these, each participant engaged in 30 minutes of cycling (at 90% VT) or 30 minutes of quiet reading after consuming either caffeine (at 4 mg/kg body weight) or a placebo. The Contingent Continuous Performance Task (CPT) and Wisconsin Card Sorting Task were used to measure cognitive function and were completed 5 minutes and 20 minutes after exercise or quiet reading. There were no significant differences found for any variables tested, for condition effect, time effect or condition*time interaction, except for a significant time effect on false alarms on the Contingent CPT (p = 0.017). This study may have been limited by multiple variables including the population, executive function measures, caffeine dosage, or exercise prescription. These findings point to the need for future research to understand the changes in cognition from exercise and caffeine in combination. Future research may include looking at exercise at different intensities, different dosages of caffeine, or looking at the long-term cognitive effects.展开更多
BACKGROUND Evidence for exercise as an efficacious strategy to improve aerobic capacity of breast cancer survivors(BCS)has come largely from intervention studies conducted in laboratory settings.There is an increasing...BACKGROUND Evidence for exercise as an efficacious strategy to improve aerobic capacity of breast cancer survivors(BCS)has come largely from intervention studies conducted in laboratory settings.There is an increasing need to translate to community-type settings,but the efficacy of those interventions using gold standard evaluation is not well-established.AIM To investigate whether similar improvement in aerobic capacity(maximal oxygen consumption[VO2])measured with gold standard testing can be achieved through a community-based setting in BCS.METHODS A peak cardiopulmonary exercise test(VO2peak),6-min walk test(6MWT),and timed up and go test(TUG)were assessed pre-and post-16 wk of progressive intensity aerobic and strength training exercise at a community center.RESULTS The sample consisted of 31 early BCS(<1 year since treatment completion)and 15 controls(CTLs).Both groups significantly improved VO2peak(+1.2 mL/kg/min;P=0.030),6MWT(+35 meters;P<0.001),and TUG(-0.44 s;P<0.01)following training.Both groups improved peak cycling power during the cardiopulmonary exercise test with BCS improving by+10 watts more than the CTLs(P=0.020).Average exercise attendance was 71%(34 of 48 possible days),but compliant days averaged only 60%of total days for aerobic,and<40%for strength in both groups.CONCLUSION Community-based exercise programs can be an effective strategy to improve aerobic capacity and physical function for early-stage BCS but potentially not to the same extent observed in laboratory-based randomized controlled trials.Further research is needed to explore barriers and facilitators of exercise engagement in community-based centers to maximize training benefits for adults with cancer.展开更多
Background: Taichi softball was voted as one of the most popular health-promoting exercises in the category of ball games, which is attributed to that Taichi softball is not only beneficial for lower extremity-related...Background: Taichi softball was voted as one of the most popular health-promoting exercises in the category of ball games, which is attributed to that Taichi softball is not only beneficial for lower extremity-related physical health (e.g., balance, leg strength, and flexibility), but can also develop manipulative skill and hand-eye coordination (eating, bathing, dressing, bathing required manipulative skills, grips movement and strength). However, the positive effects of Taichi softball on physical health have rarely been investigated. Therefore, the purpose of this systematic review was to evaluate the effect of Taichi softball on physical health. Methods: Five electronic databases were used to conduct literature searches. Two review authors independently extracted data in a standardized manner. The methodological quality of studies included was independently evaluated according to the Cochrane Collaboration’s for Assessing Risk of Bias from the Cochrane Handbook for Systematic Review Interventions. The standard mean difference (SMD) and 95% confidence interval (CI) using more conservative random effects model were calculated. Results: The sample size of 411 participants ranged from 32 to 150 in the RCTs, along with a wide age range from 18 to 75. The length of Taichi softball intervention peri-ods in the eligible studies ranged from 12 weeks to 12 months. The participants in the studies consisted of healthy college students, patients with Type 2 diabe-tes, and older adults from community centers. Six randomized controlled trials were used for the meta-analysis. The aggregated results are in favor of Taichi softball on improving physical health in participants with healthy status and Type 2 Diabetes Mellitus. The improvement on the primary components of the physical health consisted of handgrip strength (SMD, -0.6, 95% CI -0.84 to 0.36, p < 0.00001), trunk flexibility (SMD, -0.4, 95% CI -0.74 to -0.05, p = 0.03), static (SMD, -0.73, 95% CI -0.94 to -0.51, p < 0.00001) and dynamic balance (SMD, -0.68, 95% CI -1.2 to -0.17, p = 0.009). Conclusions: Taichi softball appears to be beneficial for improving physical health (hand strength, physical balance, flexibility, aerobic endurance, resting heart rate, diastolic and systolic pressures) among healthy adults and patients with Type 2 Diabetes. However, because of the low methodological quality of assessment, ill-designed experimental designs, and small study size, a definite conclusion of Taichi softball improving physical health can be confirmed along with high-quality studies with long follow-up.展开更多
基金supported by the National Institutes of Health for the Kansas Center for Metabolism and Obesity Research(award No.P20GM144269)support from the Center for Advancing Translational Sciences of the National Institutes of Health(award No.KL2TR002367)supported by the National Center for Advancing Translational Sciences of the National Institutes of Health(award No.TL1TR002368)。
文摘Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.
文摘Background:Insufficient physical activity and prolonged sedentary behavior have emerged as major global public health challenges.Short bouts(≤10 min)of accumulated exercise(SBAE)throughout the day may be a promising strategy to mitigate the adverse effects of prolonged sitting and promote physical activity,ultimately promoting overall health.However,previous ambiguity in defining this concept has resulted in a fragmented and inconsistent evidence base,impeding practical applications,the development of guidelines,and policymaking.The purpose of this study is to establish an operational definition of SBAE by synthesizing systematic reviews and research trials alongside an expert consensus.Additionally,it seeks to evaluate acute and long-term efficacy and feasibility,providing evidence-based recommendations for practice and future research directions.Methods:A literature search was performed across PubMed and Web of Science,followed by systematic screening and summarization of eligible studies based on predefined inclusion criteria.Inclusion criteria encompassed various modes/types of SBAE(bouts lasting≤10 min,performed multiple times daily with≥30 min intervals);both aerobic and resistance exercise were considered.Relevant systematic reviews and research trials were included.Methodological quality,risk of bias,and evidence certainty were assessed.Expert consensus was obtained through a survey to evaluate recommendations and agreement levels on findings.Results:After analyzing 27 systematic reviews,135 research studies,and an expert consensus involving 48 researchers from 11 countries,SBAE is defined as any exercise mode of activity,regardless of intensity,that is accumulated in either continuous or intermittent bouts lasting≤10 min per session(including multiple intermittent sets)that are performed multiple times(≥2 sessions/day)per day,with intervals of≥30 min between bouts or otherwise sufficient time for recovery.When used to interrupt prolonged periods of sedentary time,SBAE mitigates the acute adverse effects of sedentary behavior on more than 10 clinical biomarkers of endocrine,cardiovascular,and brain health/function among adults of diverse ages and conditions.Moreover,SBAE was superior for improving acute glycemic control compared to a single continuous exercise session.As a long-term intervention(average of 11 weeks),SBAE can improve over 20 health outcomes,including peak oxygen uptake,resting blood pressure,and metabolic health.Additionally,SBAE might be more effective than continuous exercise for improving longer-term glycemic control and body composition.Long-term completion rates for SBAE interventions are generally high(95%),with low dropout rates(12%)and high adherence rates even without supervision(85%),and its safety has been preliminarily validated.Conclusion:An operational definition of SBAE is provided along with its classification and acute and long-term efficacy.Practical exercise prescription recommendations and evidence-based strategies for various populations and contexts are provided.Future research should focus on generating high-quality evidence for SBAE in 5 key areas:quantification and monitoring,population-specific responses,optimization of exercise prescriptions,intervention efficacy,and practical implementation.Additionally,addressing policy,environmental,and promotional barriers is crucial for transitioning from expert consensus to public consensus,and for facilitating the application of this strategy in real-world environments.
文摘We read with great interest the recent article by Valenzuela et al.1titled“Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease”published in the Journal of Sport and Health Science The study's exploration of the effects of varying carbohydrate(CHO)doses on exercise capacity in Mc Ardle disease,a condition characterized by complete muscle glycogen unavailability,is a significant contribution to the field of sports science and metabolic disorders.
基金Project supported by the Science Foundation for the Youth of China Institute of Sport Science （CISS） （No. 13-19）
文摘To investigate the effects of hypoxic exercise training on microRNA （miRNA） expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic sedentary group （N, n=10） and a hypoxic exercise training group （H, n=10）. After four weeks, measurements were taken of body weight, body length, fat mass, serum lipid concentration, miRNAs differentially expressed in rat liver, and gene and protein expression levels of perexisome proliferator activated receptor a （PPARα）, fatty acid synthetase （FAS）, and carnitine palmitoyl transferase 1A （CPTIA） in rat liver. Body weight, Lee＇s index, fat mass, fat/weight ratio, and serum levels of total cholesterol （TC） and high density lipoprotein cholesterol （HDL-C） were all significantly lower in the H group than in the N group （P〈0.01）. Six miRNAs expressed significantly differently in the liver （P〈0.05）. Specifically, expression levels of miR-378b were significantly lower in the H group than in the N group （P〈0.05）. Compared with the normoxic sedentary group, hypoxic exercise training resulted in a lower ratio of FAS mRNA to CPTIA mRNA （P〈0.05）, as well as lower CPT1A protein levels （P〈0.01）, while a higher ratio of FAS to CPT1A protein levels （P〈0.01） was observed. In conclusion, hypoxic training may elevate the resistance of high fat diet induced obesity in rats by reducing the expression of miR-378b, and decrease the fatty acid mitochondrial oxidation in obese rat livers by decreasing the protein expression of CPTIA and increasing the protein expression ratio of FAS/CPTIA.
基金US National Institutes of Health Grants(K99AG031297 and RR024992)(Washington University School of Medicine Clinical Translational Science Award)
文摘Background： Poor sleep quality is associated with adverse effects on health outcomes. It is not clear whether exercise can improve sleep quality and whether intensity of exercise affects any of the effects. Methods： Fifteen healthy, non-obese （body mass index = 24.4 ± 2.1 kg/m^2, mean 4- SD）, sedentary （〈20 min of exercise on no more than 3 times/week） older women （66.1 ± 3.9 years） volunteered for the study. Peak oxygen consumption （VO2peak） was evaluated using a graded exercise test on a treadmill with a metabolic cart. Following a 7-day baseline period, each participant completed two exercise sessions （separated by 1 week） with equal caloric expenditure, but at different intensities （60% and 45% VO2peak, sequence randomized） between 9：00 and 11：00 am. A wrist ActiGraph monitor was used to assess sleep at baseline and two nights following each exercise session. Results： The average duration of the exercise was 54 and 72 rain, respectively at 60% （moderate-intensity） and 45% VO2peak （light-intensity）. Wake time after sleep onset was significantly shorter （p = 0.016）, the number of awakenings was less （p = 0.046）, and total activity counts were lower （p = 0.05） after the moderate-intensity exercise compared to baseline no-exercise condition. Conclusion： Our data showed that a single moderate-intensity aerobic exercise session improved sleep quality in older women.
基金supported by Hungarian grants(gsl) from ETT 38388,TeT JAP13/02,OTKA(gs2)(K75702),TAMOP-4.2.2/B-10/1-2010-0013 awarded to Z.Radak
文摘Reactive oxygen species （ROS） are continuously generated during aerobic metabolism and at moderate level. They play a role in redox signaling, but in significant concentration they cause oxidative damage and neurodegeneration. Because of the enhanced sensitivity of brain to ROS, it is especially important to maintain the normal redox state in different types of neuron cells. In last decade it became clear that regular exercise beneficially affects brain function, and can play an important preventive and therapeutic role in stroke, Alzheimer, and Parkinson diseases. The effects of exercise appear to be very complex and could include neurogenesis via neurotrophic factors, increased capillariszation, decreased oxidative damage, and increased proteolyfic degradation by proteasome and neprilysin. Data from our and other laboratories indicate that exercise-induced modulation of ROS levels plays a role in the protein content and expression of brain-derived neurotrophic factor, tyrosinerelated kinase B （TrkB）, and cAMP response element binding protein, resulting in better function and increased neurogenesis. Therefore, it appears that exercise-induced modulation of the redox state is an important means, by which exercise benefits brain function, increases the resistance against oxidative stress, facilitates recovery from oxidative stress, and attenuates age-associated decline in cognition.
文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise.
基金supported in part by grants from the Ministry of Science and Technology to Yu-Kai Chang (NSC 102-2410-H-179-014-MY3)
文摘Purpose： The purpose of this study was to determine the effects of acute exercise on motor response inhibition using both behavioral and electrophysiological approaches. Methods： The P3 and N1 event-related potential （ERP） components were recorded while performing a stop-signal task in 21 college students following a moderately intense acute exercise bout for 30 min and a sedentary control session that involved reading. Results： Acute exercise induced a shorter stop signal response time （SSRT） as compared to control; however, the go response time （Go RT） remained unchanged. In examining the ERP data, acute exercise increased both P3 amplitude and latency but did not affect the N1 component. Conclusion： Acute exercise has a selective and beneficial effect on cognitive function, specifically affecting the motor response inhibition aspect of executive function. Furthermore, acute exercise predominately impacts later stages of information processing during motor response inhibition, which may lead to an increase in attentional resource allocation and confer the ability to successfully withhold a response to achieve motor response inhibition.
基金supported by NIH grants R01-AG/ DK20583,P30-AG21332,and M01-RR07122
文摘Background:Hormone sensitive lipase(HSL) is an enzyme that regulates adipose tissue lipolysis and plays an important role in chronic exerciseinduced changes in adipose tissue metabolism.The purpose of this study was to determine whether aerobic exercise intensity influences abdominal adipose tissue HSL gene expression in obese women under weight loss. Methods:Thirty women(body mass index(BMI) = 33.0±0.7 kg/m^2,age = 58±1 years) completed one of three 20-week interventions: caloric restriction alone(CR only,n = 8),CR plus moderate-intensity exercise(CR + moderate-intensity,45%—50%heart rate reserve(HRR). 3 day/week,n = 9),or CR plus vigorous-intensity exercise(CR + vigorous-intensity,70%—75%HRR,3 day/week,n = 13).Each group had a similar prescribed energy deficit comprised of underfeeding alone(2800 kcal/week for CR only) or underfeeding(2400 kcal/week) plus exercise(400 kcal/week).Body composition and maximal aerobic capacity(VO_2max) were measured,and subcutaneous abdominal adipose tissue samples were collected before and after the interventions.Adipose tissue HSL gene expression was measured by real time reversetranscriptase polymerase chain reaction. Results:All three interventions reduced body weight,fat mass,percent fat.and waist to a similar degree(all p < 0.01).In addition,all interventions did not change absolute VO_2 max,but increased relative VO_2 max(p < 0.05 to P < 0.01).Compared to pre-intervention.neither CR only nor CR + moderate-intensity changed adipose tissue HSL gene expression,but CR + vigorous-intensity significantly increased adipose tissue HSL gene expression(p < 0.01).The changes of HSL gene expression levels in the CR + vigorous-intensity group were significantly different from those in the CR only(p < 0.05) and CR + moderate-intensity(p < 0.01) groups.In the whole cohort,changes in adipose tissue HSL gene expression correlated positively to changes in absolute(r = 0.55,p < 0.01) and relative(r = 0.32,p = 0.09) VO_2 max. Conclusion:These results support a potential effect of aerobic exercise training intensity on hormone sensitive lipase pathway in adipose tissue metabolism in obese women under weight loss.
文摘Background:Patients undergoing dialysis have high mortality rates and a unique risk factor profile. Some improvements elicited by exercise training have been shown in dialysis populations, here we aimed to further explore the bene-fits of exercise. As well as changes in physical fitness we quantified cardiac function, depression, serum biochemistry, dialysis adequacy and energy intake following exercise training in people with chronic kidney disease (CKD) undertaking dialysis. Methods:A systematic literature search was completed in December 2012 identifying randomized, controlled trials of exercise training studies in haemodialysis (HD) patients. A subsequent meta-analysis was conducted.Results: Twenty four studies were included, totalling 879 patients. Exercise training produced significant improvements in physical fitness: peak VO2 5.03 mlO2·kg-1·min-1 (95% CI 3.73, 6.33, p 0.0001), Knee extensor strength 2.99 kg (95% CI 0.46, 5.52, p = 0.02) and 6 minute walk distance 60.7 metres (95% CI 18.9, 103, p = 0.004). Significant increases in energy intake MD 238 Kcal·day-1 (95% CI 94, 383, p = 0.001), serum Interleukin-6 MD-0.58 pg·ml-1 (95% CI-1.01, -0.15, p = 0.008) and Creactive protein MD 0.92 mg/L-1 (95% CI 0.29, 1.56, p = 0.004), but not Albumin or BMI, were reported. Improved Beck Depression scores were reported MD-6.9 (95% CI-9.7,-4.1, p 0.00001). Dialysis adequacy was reduced MD-0.23 (95% CI -0.29, -0.17, p 0.00001), while serum potassium was higher MD 0.14 mmol·L-1 (95% CI 0.01, 0.27, p = 0.04). Moreover exercise training appeared safe, with no direct exercise-associated deaths in over 30,000 patient-hours. Conclusions: Our pooled analyses confirmed improvements in physical fitness following exercise training and suggested additional improvements in dialysis efficiency (kt/v), serum potassium, inflammation and depression in HD patients.
文摘Glycemic variability is a more sensitive assessment of glycemic health as opposed to traditional clinical mea-surements.It considers all blood glucose concentrations over a given period to better account for glucose oscil-lations that occur and provides clinicians with insight into how individuals regulate and/or maintain their glycemic health.The advancement of continuous glucose monitoring(CGM)allows for the measurement of free-living glucose concentrations while providing a more reliable assessment of treatment of dysregulated glycemic.CGM coupled with management of lifestyle behavioral factors,such as reduced sedentary behavior and increased physical activity and regular exercise,potentially offers a previously untapped method for promoting improved glycemic health through greater regulation of glucose concentrations.The aim of this review is to critically evaluate the evidence regarding the measurement of glycemic variability and summarize the current under-standing of the relationship between glycemic variability,sedentary behavior,physical activity,the influence of a single exercise session or repeated exercise sessions,and exercise training.This review considers information pertaining to the strengths and limitations for measuring glycemic variability and provides insight into future study designs aimed at evaluating the relationship between sedentary behavior and physical activity with,as well as the influence of exercise on,glycemic variability as a primary outcome.
基金This work was provided by the National Natural Science Foundation of China(No.31900846)the Science and Technology Program of Sichuan,China(No.2020YFS0436).We would like to thank Jiaqian Wang,Yalong Li and Changjun Jiang who assisted in performing daily training of the mice over the course of the study.
文摘Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing trend.Although multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play a significant role in the genesis and progression.Most of the research supports the advantages of exercise for NAFLD.However,little is known about the molecular mechanism(s)that underpin the effectiveness of exercise training in NAFLD.This study aimed to identify how aerobic exercise affected hepatic ER stress in a mouse NAFLD model.In this study,the mice were fed either a standard diet(SD)or a high-fat diet(HFD)for 17 weeks.HFD mice were trained on a treadmill during the last eight weeks.All animals were tested for serum levels of biochemical assays,protein expression,and gene expression.The hematoxylin and eosin,Oil red O,and immunohistochemistry staining were also performed.The results indicated that a high-fat diet generated NAFLD,with serum lipid disruption and hepatic function impairment,and increased GRP78 and ATF6 expressions.However,aerobic training reversed the majority of these alterations.It is concluded that NAFLD appears to be associated with hepatic ER stress response,and aerobic exercise mitigates NAFLD via lowering ER stress proteins GRP78 and ATF6.
基金the National Institute of Health(R21AR063956 to SKP).
文摘Endurance exercise training promotes a protective phenotype in skeletal muscle known as exercise pre-conditioning.Exercise preconditioning protects muscle fibers against a variety of threats including inactivity-induced muscle atrophy.The mechanism(s)responsible for exercise preconditioning remain unknown and are explored in these experiments.Specifically,we investigated the impact of endurance exercise training on key components of the renin-angiotensin system(RAS).The RAS was targeted because activation of the classical axis of the RAS pathway via angiotensinⅡtypeⅠreceptors(AT1Rs)promotes muscle atrophy whereas activation of the non-classical RAS axis via Mas receptors(MasRs)inhibits the atrophic signaling of the classical RAS pathway.Guided by prior studies,we hypothesized that an exercise-induced decrease in AT1Rs and/or increases in MasRs in skeletal muscle fibers is a potential mechanism responsible for exercise preconditioning.Following endurance exercise training in rats,we examined the abundance of AT1Rs and MasRs in both locomotor and respiratory muscles.Our results indicate that endurance exercise training does not alter the protein abundance of AT1Rs or MasRs in muscle fibers from the diaphragm,plantaris,and soleus muscles compared to sedentary controls(p>0.05).Furthermore,fluorescent angiotensinⅡ(AngⅡ)binding analyses confirm our results that exercise pre-conditioning does not alter the protein abundance of AT1Rs in the diaphragm,plantaris,and soleus(p>0.05).This study confirms that exercise-induced changes in RAS receptors are not a key mechanism that contributes to the beneficial effects of exercise preconditioning in skeletal muscle fibers.
文摘This paper provides a literature review of current studies investigating the effects of meditation and mind-body exercise on peripheral concentrations of brain-derived neurotrophic factor(BDNF),an important mediator of the neuroplasticity of the central nervous system and cognitive function.A literature search was conducted to collect currently published randomized controlled,non-randomized controlled and uncontrolled intervention studies.Fifteen studies were identified;and among these studies,seven were randomized controlled studies,three were non-randomized studies,and five were uncontrolled studies.Current limited evidence tends to support that mindfulness meditation and mind-body exercise(e.g.yoga and tai chi)increase circulating BDNF concentrations in healthy and diseased individuals.It is noteworthy that these findings are based on current studies with a relatively small sample size,or without a randomized controlled design.Further studies are needed to identify a definite effect of meditation or mind-body exercise on BDNF and its role in improving/maintaining brain functions in various populations.
基金University Grants Program 242545,San Diego State University。
文摘Background:Decaffeinated green tea extract(dGTE)can increase fat oxidation during leg exercise,but dGTE is unsuitable for many people(e.g.,those with injuries/disabilities),and its effects on arm exercise and women are unknown.Methods:Eight adults(23-37 years old,4 women)performed an incremental arm cycle test to measure peak oxygen uptake(VO_(2_(peak))),followed by four 1-h trials at 50%VO_(2_(peak).Subjects were randomly assigned to 650 mg of dGTE or placebo(PLA)for 4 weeks followed by a 4-week washout and crossover trial.Blood samples were obtained pre-exercise and post-exercise for glycerol and free fatty acid analysis.Respiratory gases were collected continuously.Results:VO_(2) showed no differences across trials((0.83-0.89)±(0.19-0.25)L/min,p=0.460),neither did energy expenditure((264-266)±(59-77)kcal,p=0.420)nor fat oxidation(dGTE=0.11 to 0.12 g/min vs.PLA=0.10 to 0.09 g/min,p=0.220).Fat oxidation as percentage of energy expenditure was not different for dGTE vs.PLA(23%±12%to 25%±11%vs.23%±10%to 21%±9%,p=0.532).Glycerol concentration increased post-exercise in all trials,independent of treatments(pre=(3.4-5.1)±(0.6-2.6)mg/dL vs.post=(7.9-9.8)±(2.6-3.7)mg/dL,p=0.867,η^(2)=0.005 for interaction),as did free fatty acid((3.5-4.8)±(1.4-2.2)mg/dL vs.(7.2-9.1)±(2.6-4.5)mg/dL,p=0.981,η^(2)=0.000).Conclusion:Chronic dGTE supplementation had no effect on lipolysis and fat oxidation during arm cycle exercise in men and women.
文摘Lymphedema is an atypical accumulation of high-proteinfluid located just beneath the skin, which often occurs in the arm or leg. Exercising with lymphedema was traditionally considered to be unsafe. However, recent research indicates that exercise may be beneficial to individuals with lymphedema. Studies indicate that exercise can improve the range of motion and strength of the afflicted limb(s), as well as overall fitness and functional quality of life, and can be performed without exacerbating symptoms of lymphedema.
文摘Background： Understanding leisure time physical inactivity is a priority in study sought to address this priority by examining whether the extraversion mediated through Elliot＇s （1999） 2 x 2 achievement goals. Westernized nations where participation rates are low. The present and emotional instability to leisure time exercise relationships were Methods： Participants were 116 female and 97 male volunteers from a Southwestern community （mean age = 37.21 years, range 24-69） who completed measures of extraversion, emotional instability, approach-avoidance achievement goals, and 7-day recall of leisure-time exercise. Multiple mediation models （Preacher and Hayes, 2008） were run to specifically examine our hypotheses. Results： The mastery-approach goal mediated the relationship from extraversion to overall exercise and strenuous intensity exercise. Results indicated emotional instability had direct effects on overall and strenuous leisure time exercise while also having significant （p 〈 0.05） indirect mediation paths through the performance-approach and avoidance goals. The extraversion and emotional instability models accounted from 15.89% to 29.82% of variance in the various self-reported exercise measures. Conclusion： The results suggest the promotion of leisure-time exercise would be improved in the studied personalities by manipulation of achievement goals. Copyright @ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.
文摘Exercise has widely been shown to improve cognition, potentially by making individuals more receptive to sensory stimulation or inhibiting irrelevant information. Caffeine, one of the world’s most widely used stimulants, seems to have similar effects. It seems that both exercise and caffeine improve cognitive function separately, but little research has been done examining their combined effects. The purpose of this study was to examine the impact of caffeine and exercise, independently and combined, on cognitive function. 20 healthy college students completed the study. These participants were low caffeine consumers. Each participant came to the lab 5 times. During the first session, they completed a graded exercise test on a cycle ergometer to determine ventilatory threshold (VT). The following four sessions were test sessions involving supplementation and exercise. During these, each participant engaged in 30 minutes of cycling (at 90% VT) or 30 minutes of quiet reading after consuming either caffeine (at 4 mg/kg body weight) or a placebo. The Contingent Continuous Performance Task (CPT) and Wisconsin Card Sorting Task were used to measure cognitive function and were completed 5 minutes and 20 minutes after exercise or quiet reading. There were no significant differences found for any variables tested, for condition effect, time effect or condition*time interaction, except for a significant time effect on false alarms on the Contingent CPT (p = 0.017). This study may have been limited by multiple variables including the population, executive function measures, caffeine dosage, or exercise prescription. These findings point to the need for future research to understand the changes in cognition from exercise and caffeine in combination. Future research may include looking at exercise at different intensities, different dosages of caffeine, or looking at the long-term cognitive effects.
文摘BACKGROUND Evidence for exercise as an efficacious strategy to improve aerobic capacity of breast cancer survivors(BCS)has come largely from intervention studies conducted in laboratory settings.There is an increasing need to translate to community-type settings,but the efficacy of those interventions using gold standard evaluation is not well-established.AIM To investigate whether similar improvement in aerobic capacity(maximal oxygen consumption[VO2])measured with gold standard testing can be achieved through a community-based setting in BCS.METHODS A peak cardiopulmonary exercise test(VO2peak),6-min walk test(6MWT),and timed up and go test(TUG)were assessed pre-and post-16 wk of progressive intensity aerobic and strength training exercise at a community center.RESULTS The sample consisted of 31 early BCS(<1 year since treatment completion)and 15 controls(CTLs).Both groups significantly improved VO2peak(+1.2 mL/kg/min;P=0.030),6MWT(+35 meters;P<0.001),and TUG(-0.44 s;P<0.01)following training.Both groups improved peak cycling power during the cardiopulmonary exercise test with BCS improving by+10 watts more than the CTLs(P=0.020).Average exercise attendance was 71%(34 of 48 possible days),but compliant days averaged only 60%of total days for aerobic,and<40%for strength in both groups.CONCLUSION Community-based exercise programs can be an effective strategy to improve aerobic capacity and physical function for early-stage BCS but potentially not to the same extent observed in laboratory-based randomized controlled trials.Further research is needed to explore barriers and facilitators of exercise engagement in community-based centers to maximize training benefits for adults with cancer.
文摘Background: Taichi softball was voted as one of the most popular health-promoting exercises in the category of ball games, which is attributed to that Taichi softball is not only beneficial for lower extremity-related physical health (e.g., balance, leg strength, and flexibility), but can also develop manipulative skill and hand-eye coordination (eating, bathing, dressing, bathing required manipulative skills, grips movement and strength). However, the positive effects of Taichi softball on physical health have rarely been investigated. Therefore, the purpose of this systematic review was to evaluate the effect of Taichi softball on physical health. Methods: Five electronic databases were used to conduct literature searches. Two review authors independently extracted data in a standardized manner. The methodological quality of studies included was independently evaluated according to the Cochrane Collaboration’s for Assessing Risk of Bias from the Cochrane Handbook for Systematic Review Interventions. The standard mean difference (SMD) and 95% confidence interval (CI) using more conservative random effects model were calculated. Results: The sample size of 411 participants ranged from 32 to 150 in the RCTs, along with a wide age range from 18 to 75. The length of Taichi softball intervention peri-ods in the eligible studies ranged from 12 weeks to 12 months. The participants in the studies consisted of healthy college students, patients with Type 2 diabe-tes, and older adults from community centers. Six randomized controlled trials were used for the meta-analysis. The aggregated results are in favor of Taichi softball on improving physical health in participants with healthy status and Type 2 Diabetes Mellitus. The improvement on the primary components of the physical health consisted of handgrip strength (SMD, -0.6, 95% CI -0.84 to 0.36, p < 0.00001), trunk flexibility (SMD, -0.4, 95% CI -0.74 to -0.05, p = 0.03), static (SMD, -0.73, 95% CI -0.94 to -0.51, p < 0.00001) and dynamic balance (SMD, -0.68, 95% CI -1.2 to -0.17, p = 0.009). Conclusions: Taichi softball appears to be beneficial for improving physical health (hand strength, physical balance, flexibility, aerobic endurance, resting heart rate, diastolic and systolic pressures) among healthy adults and patients with Type 2 Diabetes. However, because of the low methodological quality of assessment, ill-designed experimental designs, and small study size, a definite conclusion of Taichi softball improving physical health can be confirmed along with high-quality studies with long follow-up.
