Hydrogen-powered electric aircraft have attracted significant interests aiming to achieve decarbonization targets.Onboard DC electric networks are facing great challenges in DC fault protection requirements.Vacuum int...Hydrogen-powered electric aircraft have attracted significant interests aiming to achieve decarbonization targets.Onboard DC electric networks are facing great challenges in DC fault protection requirements.Vacuum interrupters are widely used in low voltage and medium voltage power systems due to being environmentally friendly with low maintenance.In this paper a moving coil actuator with compensation coils for a vacuum interrupter,as part of a hybrid direct current circuit breaker,is designed and experimentally tested.Compensation coils are used to improve operating speed compared with original moving coil actuator.Comparisons between four possible connections of compensation coils and original moving coil actuator are carried out.Experimental results show comparisons between different connections of actuator coils in terms of opening time and coil current with a range of pre-charged capacitor voltages.Dynamic performance of each actuator connection is also compared.The actuator with compensation coils is shown to have a higher current rising rate and achieve faster opening speed,which is a critical requirement for electric aircraft network protection.The parallel connection actuator achieves the highest opening speed within 3.5 ms with capacitor voltage of 50 V.展开更多
CD82 is a transmembrane protein that is involved in cancer suppression and activates immune cells;however, information on the NLRP3 inflammasome is limited. Herein, we show that although CD82 suppressed the activation...CD82 is a transmembrane protein that is involved in cancer suppression and activates immune cells;however, information on the NLRP3 inflammasome is limited. Herein, we show that although CD82 suppressed the activation of the NLRP3 inflammasome in vivo and in vitro, CD82 deficiency decreased the severity of colitis in mice. Furthermore, two binding partners of CD82, NLRP3 and BRCC3, were identified. CD82 binding to these partners increased the degradation of NLRP3 by blocking BRCC3-dependent K63-specific deubiquitination. Previous studies have shown that CD82-specific bacteria in the colon microbiota called Bacteroides vulgatus (B. vulgatus) regulated the expression of CD82 and promoted the activation of the NLRP3 inflammasome. Accordingly, we observed that B. vulgatus administration increased mouse survival by mediating CD82 expression and activating NLRP3 in mice with colitis. Overall, this study showed that CD82 suppression reduced the pathogenesis of colitis by elevating the activation of the NLRP3 inflammasome through BRCC3-dependent K63 deubiquitination. Based on our findings, we propose that B. vulgatus is a novel therapeutic candidate for colitis.展开更多
Metal oxide resistive gas sensors suffer from poor selectivity that restricts their practical applicability.Conventional sensor arrays are used to improve selectivity which increased the system complexity.Here,we have...Metal oxide resistive gas sensors suffer from poor selectivity that restricts their practical applicability.Conventional sensor arrays are used to improve selectivity which increased the system complexity.Here,we have proposed a novel NiO/ZnO-based p–n junction single-diode device for selective sensing of several volatile organic compounds(VOCs)simultaneously by tuning bias voltage.The operating voltage was varied between 3 and 5 volts to achieve selective sensing of 2-propanol(19.1 times for 95ppm with response and recovery times of 70 s and 55s respectively‚at 3 volts),toluene(20.1 times for 95 ppm with response and recovery times of 100 s and 60 s respectively,at 4 volts),and formaldehyde(11.2 times for 95 ppm with response and recovery times of 88 s and 54s respectively,at 5 volts).A probable mechanism of the tunable selectivity with operating bias voltage due to increase in surface carriers with increasing voltage was hence put forth.Thus,this device may play an important role to develop future selective multiple VOC sensor thereby replacing standard sensor arrays.展开更多
基金supported in part by the UK Aerospace Technology Institute under contract 103136-Zero Emissions for Sustainable Transport 1(ZEST 1).
文摘Hydrogen-powered electric aircraft have attracted significant interests aiming to achieve decarbonization targets.Onboard DC electric networks are facing great challenges in DC fault protection requirements.Vacuum interrupters are widely used in low voltage and medium voltage power systems due to being environmentally friendly with low maintenance.In this paper a moving coil actuator with compensation coils for a vacuum interrupter,as part of a hybrid direct current circuit breaker,is designed and experimentally tested.Compensation coils are used to improve operating speed compared with original moving coil actuator.Comparisons between four possible connections of compensation coils and original moving coil actuator are carried out.Experimental results show comparisons between different connections of actuator coils in terms of opening time and coil current with a range of pre-charged capacitor voltages.Dynamic performance of each actuator connection is also compared.The actuator with compensation coils is shown to have a higher current rising rate and achieve faster opening speed,which is a critical requirement for electric aircraft network protection.The parallel connection actuator achieves the highest opening speed within 3.5 ms with capacitor voltage of 50 V.
基金supported by the NRF grant funded by the Korean government(MSIP)(2021R1A4A5032463)the research fund of Hanyang University(HY-2021)We thank all members of the Infection Biology Laboratory for critical reading and discussion of the manuscript.
文摘CD82 is a transmembrane protein that is involved in cancer suppression and activates immune cells;however, information on the NLRP3 inflammasome is limited. Herein, we show that although CD82 suppressed the activation of the NLRP3 inflammasome in vivo and in vitro, CD82 deficiency decreased the severity of colitis in mice. Furthermore, two binding partners of CD82, NLRP3 and BRCC3, were identified. CD82 binding to these partners increased the degradation of NLRP3 by blocking BRCC3-dependent K63-specific deubiquitination. Previous studies have shown that CD82-specific bacteria in the colon microbiota called Bacteroides vulgatus (B. vulgatus) regulated the expression of CD82 and promoted the activation of the NLRP3 inflammasome. Accordingly, we observed that B. vulgatus administration increased mouse survival by mediating CD82 expression and activating NLRP3 in mice with colitis. Overall, this study showed that CD82 suppression reduced the pathogenesis of colitis by elevating the activation of the NLRP3 inflammasome through BRCC3-dependent K63 deubiquitination. Based on our findings, we propose that B. vulgatus is a novel therapeutic candidate for colitis.
基金The authors would like to acknowledge Central Research Facility(CRF)of IIT Kharagpur for various characterization support of nanomaterial.S.S would like to acknowledge Department of Science and Technology(DST)for DST Women Scientist Scheme A(WOS-A)for the partial support of this work(project no.-SR/WOS-A/PM-100/2017(G))。
文摘Metal oxide resistive gas sensors suffer from poor selectivity that restricts their practical applicability.Conventional sensor arrays are used to improve selectivity which increased the system complexity.Here,we have proposed a novel NiO/ZnO-based p–n junction single-diode device for selective sensing of several volatile organic compounds(VOCs)simultaneously by tuning bias voltage.The operating voltage was varied between 3 and 5 volts to achieve selective sensing of 2-propanol(19.1 times for 95ppm with response and recovery times of 70 s and 55s respectively‚at 3 volts),toluene(20.1 times for 95 ppm with response and recovery times of 100 s and 60 s respectively,at 4 volts),and formaldehyde(11.2 times for 95 ppm with response and recovery times of 88 s and 54s respectively,at 5 volts).A probable mechanism of the tunable selectivity with operating bias voltage due to increase in surface carriers with increasing voltage was hence put forth.Thus,this device may play an important role to develop future selective multiple VOC sensor thereby replacing standard sensor arrays.
