Objective:The objective of the study is to investigate the psychological status of nursing staff both working on nonfront line and on the front line during the epidemic period of COVID‑19 and to analyze the influencin...Objective:The objective of the study is to investigate the psychological status of nursing staff both working on nonfront line and on the front line during the epidemic period of COVID‑19 and to analyze the influencing factors related to mental health state,as well as to provide targeted psychological intervening measures for nursing staff in the face of this major public health event.Methods:We used data from January 28,2019,to February 08,2020,on the number of cases who worked in the 3A‑level hospital as nonfront‑line nurses(n=29,54%)and those who worked in Wuhan infectious hospital as the front‑line supporters(n=25,46%)came from the 3A‑level hospital.The participants completed the symptom checklist 90,and the researchers recorded data on demographics,psychological status,and the influencing factors.Results:In our baseline scenario,we estimated that the total symptom index was 1.676±0.654 for nurses who worked on the front line,1.260±0.304 for those who worked as the front‑line reserve nurses,and was 1.486±0.647 for those who worked as the nonfront‑line nurses.The results of correlation analysis show that the factors related to the psychological status of nurses include age,professional title,marital status,and family support;different factors have different effects on psychological status.Conclusion:In the face of major public health emergencies,both front‑line nursing staff and nonfront‑line staff are confronted with different degrees of psychological stress,so effective psychological support should be given to improve the working efficiency and enthusiasm of nurses.展开更多
Objective: The objective of the study is to explore the real psychological experience of the frontline support nurses in fight against COVID-19,so as to provide a reference basis for targeted intervention and ensure t...Objective: The objective of the study is to explore the real psychological experience of the frontline support nurses in fight against COVID-19,so as to provide a reference basis for targeted intervention and ensure the mental health of the frontline support nurses.Methods: The objective sampling method was used to conduct semi‑structured interviews with 9 frontline support nurses fighting COVID‑19,and the interview contents were analyzed using Colaizzi’s 7‑step method.Results: The psychological experience of frontline support nurses in fight against COVID-19 can be summarized into four themes: Thecoexistence of negative psychological experience and positive psychological experience (tension, anxiety, fear, and depression);psychologicalpressure;many factors that affect the negative psychological experience (the stimulation of the external environment, the care of family members,the guidance of network public opinion);and solid support system (good family support and rich social support).Conclusion: Although frontline support nurses have negative emotions and bear great psychological pressure, they all have a high sense ofprofessional responsibility. Therefore, managers should pay attention to their psychological experience and provide targeted assistance to them.展开更多
BACKGROUND Capillary leak syndrome(CLS)is characterized by the leakage of large amounts of fluid and plasma proteins into the interstitial space,resulting in hypoalbuminemia,hypovolemic shock,elevated blood concentrat...BACKGROUND Capillary leak syndrome(CLS)is characterized by the leakage of large amounts of fluid and plasma proteins into the interstitial space,resulting in hypoalbuminemia,hypovolemic shock,elevated blood concentration,systemic progressive edema,and multiple serosal cavity effusion.Clinical syndromes such as cavity effusion pose a grave threat to the life and health of the patient.CASE SUMMARY A 58-year-old female patient was admitted to the hospital after being in a coma for 6 h following accidental ingestion of a pesticide.She was treated with phencyclidine hydrochloride and pralidoxime iodide for detoxification,mechanical ventilation to maintain oxygen supply,continuous renal replacement therapy to maintain the internal environment,and hemoperfusion to promote the excretion of toxins.She also received a transfusion of red blood cells and massive fluid resuscitation.However,her blood pressure was not maintained.The patient was diagnosed with CLS due to pesticide poisoning.Oxygenation was difficult to maintain under full ventilator support;therefore,veno-venous-extracorporeal membrane oxygenation(VV-ECMO)treatment was given 13 h after admission.Her oxygenation level improved,but a large amount of ascites and pleural effusion soon became apparent.We continued drainage with an indwelling drainage tube,and the ECMO flow stabilized.The leakage gradually decreased,and ECMO was discontinued 3 d later.On the 6th day,the patient recovered from unconsciousness,but on gastroscopic evaluation,severe erosions were found in her entire stomach.With the family’s consent,treatment was stopped,and the patient was discharged from the hospital on the 7th day.CONCLUSION ECMO,liquid resuscitation and management,and improvement in plasma colloidal osmotic pressure,circulation,and tissue oxygen supply are crucial in treating CLS.展开更多
The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11)gene which resulted in the nonreceptor protein tyrosine ...The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11)gene which resulted in the nonreceptor protein tyrosine phosphatase SHP2 dysfunction has been reported in many lung cancer cases.Moreover,the Src homology region 2(SH2)-containing protein tyrosine phosphatase 2(SHP2)mutation or deletion triggers multiple signaling pathway dysfunctions including RAS/MAPK,RAS/extracellular-signal-regulated kinase(ERK),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT),Janus kinase/signal transducers and activators of transcription(JAK/STAT)and Hippo/yes-associated protein(YAP)which affect the expression of growth factors,cytokines and hormones.In recent years,the developing of the small molecule SHP2 inhibitors received a lot of attention.In this review,we summarize the recent years'progresses of the SHP2 inhibitors development for the lung cancer treatment.展开更多
基金Financial support and sponsorship This work was supported by the Lanzhou city science and technology project:Psychological Intervention Study of COVID‑19 Isolation and Protection Medical Workers by Mindfulness Behavior Delivery.
文摘Objective:The objective of the study is to investigate the psychological status of nursing staff both working on nonfront line and on the front line during the epidemic period of COVID‑19 and to analyze the influencing factors related to mental health state,as well as to provide targeted psychological intervening measures for nursing staff in the face of this major public health event.Methods:We used data from January 28,2019,to February 08,2020,on the number of cases who worked in the 3A‑level hospital as nonfront‑line nurses(n=29,54%)and those who worked in Wuhan infectious hospital as the front‑line supporters(n=25,46%)came from the 3A‑level hospital.The participants completed the symptom checklist 90,and the researchers recorded data on demographics,psychological status,and the influencing factors.Results:In our baseline scenario,we estimated that the total symptom index was 1.676±0.654 for nurses who worked on the front line,1.260±0.304 for those who worked as the front‑line reserve nurses,and was 1.486±0.647 for those who worked as the nonfront‑line nurses.The results of correlation analysis show that the factors related to the psychological status of nurses include age,professional title,marital status,and family support;different factors have different effects on psychological status.Conclusion:In the face of major public health emergencies,both front‑line nursing staff and nonfront‑line staff are confronted with different degrees of psychological stress,so effective psychological support should be given to improve the working efficiency and enthusiasm of nurses.
基金Financial support and sponsorship This work was supported the Lanzhou city science and technology development program project:Psychological intervention study of mind‑fulminant behavior delivery on COVID‑19 isolated protective medical workers.
文摘Objective: The objective of the study is to explore the real psychological experience of the frontline support nurses in fight against COVID-19,so as to provide a reference basis for targeted intervention and ensure the mental health of the frontline support nurses.Methods: The objective sampling method was used to conduct semi‑structured interviews with 9 frontline support nurses fighting COVID‑19,and the interview contents were analyzed using Colaizzi’s 7‑step method.Results: The psychological experience of frontline support nurses in fight against COVID-19 can be summarized into four themes: Thecoexistence of negative psychological experience and positive psychological experience (tension, anxiety, fear, and depression);psychologicalpressure;many factors that affect the negative psychological experience (the stimulation of the external environment, the care of family members,the guidance of network public opinion);and solid support system (good family support and rich social support).Conclusion: Although frontline support nurses have negative emotions and bear great psychological pressure, they all have a high sense ofprofessional responsibility. Therefore, managers should pay attention to their psychological experience and provide targeted assistance to them.
文摘BACKGROUND Capillary leak syndrome(CLS)is characterized by the leakage of large amounts of fluid and plasma proteins into the interstitial space,resulting in hypoalbuminemia,hypovolemic shock,elevated blood concentration,systemic progressive edema,and multiple serosal cavity effusion.Clinical syndromes such as cavity effusion pose a grave threat to the life and health of the patient.CASE SUMMARY A 58-year-old female patient was admitted to the hospital after being in a coma for 6 h following accidental ingestion of a pesticide.She was treated with phencyclidine hydrochloride and pralidoxime iodide for detoxification,mechanical ventilation to maintain oxygen supply,continuous renal replacement therapy to maintain the internal environment,and hemoperfusion to promote the excretion of toxins.She also received a transfusion of red blood cells and massive fluid resuscitation.However,her blood pressure was not maintained.The patient was diagnosed with CLS due to pesticide poisoning.Oxygenation was difficult to maintain under full ventilator support;therefore,veno-venous-extracorporeal membrane oxygenation(VV-ECMO)treatment was given 13 h after admission.Her oxygenation level improved,but a large amount of ascites and pleural effusion soon became apparent.We continued drainage with an indwelling drainage tube,and the ECMO flow stabilized.The leakage gradually decreased,and ECMO was discontinued 3 d later.On the 6th day,the patient recovered from unconsciousness,but on gastroscopic evaluation,severe erosions were found in her entire stomach.With the family’s consent,treatment was stopped,and the patient was discharged from the hospital on the 7th day.CONCLUSION ECMO,liquid resuscitation and management,and improvement in plasma colloidal osmotic pressure,circulation,and tissue oxygen supply are crucial in treating CLS.
基金This work was supported by the National Natural Science Foundation of China(Nos.81904178,82073311)"Hundred Talents Program"of the Hospital of Chengdu University of Traditional Chinese Medicine(Nos.20-Q03,20-Q08).
文摘The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11)gene which resulted in the nonreceptor protein tyrosine phosphatase SHP2 dysfunction has been reported in many lung cancer cases.Moreover,the Src homology region 2(SH2)-containing protein tyrosine phosphatase 2(SHP2)mutation or deletion triggers multiple signaling pathway dysfunctions including RAS/MAPK,RAS/extracellular-signal-regulated kinase(ERK),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT),Janus kinase/signal transducers and activators of transcription(JAK/STAT)and Hippo/yes-associated protein(YAP)which affect the expression of growth factors,cytokines and hormones.In recent years,the developing of the small molecule SHP2 inhibitors received a lot of attention.In this review,we summarize the recent years'progresses of the SHP2 inhibitors development for the lung cancer treatment.
