BACKGROUND Functional constipation(FC)is a common functional gastrointestinal disease with various clinical manifestations.It is a physical and mental disease,which seriously affects patient physical and mental health...BACKGROUND Functional constipation(FC)is a common functional gastrointestinal disease with various clinical manifestations.It is a physical and mental disease,which seriously affects patient physical and mental health and quality of life.Biofeedback therapy is the treatment of choice for FC,especially outlet obstructive constipation caused by pelvic floor dysfunction.High-quality nursing is a new nursing model in modern clinical work and a new concept of modern nursing service.AIM To explore the effect of biofeedback combined with high-quality nursing in the treatment of FC.METHODS A total of 100 patients with FC admitted to our hospital from March 2015 to July 2019 were selected for clinical observation.These patients were randomly divided into two groups of 50:Experimental group(biofeedback combined with highquality nursing treatment group)and control group(biofeedback group).RESULTS The constipation symptom score of the experimental group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The anal canal resting pressure and initial defecation threshold of the experimental group were significantly lower than those of the control group,and the maximum squeeze systolic pressure of the anal canal of the experimental group was significantly higher than that of the control group(P<0.05).The Self-Rating Anxiety Scale and Zung’s Self-Rating Depression Scale scores of the two groups were significantly lower than before treatment.The Self-Rating Anxiety Scale and Self-Rating Depression Scale scores of the experimental group were significantly lower than those of the control group(P<0.05).The patient satisfaction score of the experimental group was significantly higher than that of the control group(P<0.05).CONCLUSION The application of biofeedback combined with high-quality nursing in the treatment of FC has significant advantages over pure biofeedback treatment,and it is worthy of promotion in clinical work.展开更多
AIM: To evaluate the efficacy of botulinum toxin type A injection to the puborectalis and external sphincter muscle in the treatment of patients with anismus unresponsive to simple biofeedback training.
Introduction:Stool DNA testing based on methylated syndecan-2(mSDC2)is a potential novel non-invasive screening test for colorectal cancer(CRC).This study aimed to assess its positive predictive value(PPV)in real-worl...Introduction:Stool DNA testing based on methylated syndecan-2(mSDC2)is a potential novel non-invasive screening test for colorectal cancer(CRC).This study aimed to assess its positive predictive value(PPV)in real-world practice.Methods:This study retrospectively recruited consecutive patients with positive stool DNA-based SDC2 methylation tests from 18 hospitals between November 2016 and July 2021.Included patients were classified into the average-risk equivalent or increased-risk population and the previous-negative-colonoscopy or no-previous-colonoscopy groups.Multivariate logistic regression was conducted to investigate the risk factors that affect the detection of advanced colorectal neoplasia(ACN)in patients with a positive mSDC2 test.The primary outcome was the PPV for ACN.Results:The overall PPVs for ACN,CRC,and colorectal neoplasia were 28.5%,12.8%,and 44.6%,respectively.The PPV for ACN was higher in the no-previous-colonoscopy group than in the previous-negative-colonoscopy group(30.1%vs 18.5%,P=0.008)and higher in the increased-risk population than in the average-risk equivalent population(41.1%vs 21.6%,P<0.001).However,the PPV(18.5%)was still high for patients with a previous negative colonoscopy.For ACN detection in patients with a positive mSDC2 test,old age,increased risk,and smoking history were identified as independent risk factors;previous negative colonoscopy was identified as a protective factor.Conclusions:The mSDC2 test,which has a high PPV for both ACN and CRC,is expected to be an alternative CRC screening strategy.Patients with a positive mSDC2 test might require a colonoscopy as soon as possible,even if the previous colonoscopy was negative.展开更多
文摘BACKGROUND Functional constipation(FC)is a common functional gastrointestinal disease with various clinical manifestations.It is a physical and mental disease,which seriously affects patient physical and mental health and quality of life.Biofeedback therapy is the treatment of choice for FC,especially outlet obstructive constipation caused by pelvic floor dysfunction.High-quality nursing is a new nursing model in modern clinical work and a new concept of modern nursing service.AIM To explore the effect of biofeedback combined with high-quality nursing in the treatment of FC.METHODS A total of 100 patients with FC admitted to our hospital from March 2015 to July 2019 were selected for clinical observation.These patients were randomly divided into two groups of 50:Experimental group(biofeedback combined with highquality nursing treatment group)and control group(biofeedback group).RESULTS The constipation symptom score of the experimental group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The anal canal resting pressure and initial defecation threshold of the experimental group were significantly lower than those of the control group,and the maximum squeeze systolic pressure of the anal canal of the experimental group was significantly higher than that of the control group(P<0.05).The Self-Rating Anxiety Scale and Zung’s Self-Rating Depression Scale scores of the two groups were significantly lower than before treatment.The Self-Rating Anxiety Scale and Self-Rating Depression Scale scores of the experimental group were significantly lower than those of the control group(P<0.05).The patient satisfaction score of the experimental group was significantly higher than that of the control group(P<0.05).CONCLUSION The application of biofeedback combined with high-quality nursing in the treatment of FC has significant advantages over pure biofeedback treatment,and it is worthy of promotion in clinical work.
基金Supported by Foundation of Science and Technology Plan Projects of Shenyang,No.P112238
文摘AIM: To evaluate the efficacy of botulinum toxin type A injection to the puborectalis and external sphincter muscle in the treatment of patients with anismus unresponsive to simple biofeedback training.
基金Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2023ZD0501600)Changhai Hospital Special Foundation for Clinical Research Program(No.2024LYB05)+5 种基金the China National Postdoctoral Program for Innovative Talents(No.BX20230482)Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(Grant No.22CGA42)Natural Science Foundation of Shanghai(No.23ZR1478700)Shanghai Sailing Program(No.23YF1458600)Shanghai Eastern Talent Youth Program(QNWS2024108)Changfeng Guhai Project of Changying Youth Seedling Plan of Changhai Hospital.
文摘Introduction:Stool DNA testing based on methylated syndecan-2(mSDC2)is a potential novel non-invasive screening test for colorectal cancer(CRC).This study aimed to assess its positive predictive value(PPV)in real-world practice.Methods:This study retrospectively recruited consecutive patients with positive stool DNA-based SDC2 methylation tests from 18 hospitals between November 2016 and July 2021.Included patients were classified into the average-risk equivalent or increased-risk population and the previous-negative-colonoscopy or no-previous-colonoscopy groups.Multivariate logistic regression was conducted to investigate the risk factors that affect the detection of advanced colorectal neoplasia(ACN)in patients with a positive mSDC2 test.The primary outcome was the PPV for ACN.Results:The overall PPVs for ACN,CRC,and colorectal neoplasia were 28.5%,12.8%,and 44.6%,respectively.The PPV for ACN was higher in the no-previous-colonoscopy group than in the previous-negative-colonoscopy group(30.1%vs 18.5%,P=0.008)and higher in the increased-risk population than in the average-risk equivalent population(41.1%vs 21.6%,P<0.001).However,the PPV(18.5%)was still high for patients with a previous negative colonoscopy.For ACN detection in patients with a positive mSDC2 test,old age,increased risk,and smoking history were identified as independent risk factors;previous negative colonoscopy was identified as a protective factor.Conclusions:The mSDC2 test,which has a high PPV for both ACN and CRC,is expected to be an alternative CRC screening strategy.Patients with a positive mSDC2 test might require a colonoscopy as soon as possible,even if the previous colonoscopy was negative.
