Background and Objectives:Although excess white sugar intake imposes various health burdens,brown sugar is high in minerals,polyphenols,and polycosanol.However,few epidemiological studies have assessed brown sugar int...Background and Objectives:Although excess white sugar intake imposes various health burdens,brown sugar is high in minerals,polyphenols,and polycosanol.However,few epidemiological studies have assessed brown sugar intake for health benefit.People in the Amami islands region,with a relatively high proportion of individuals with longevity,consume brown sugar as a type of refreshment.This cohort study was conducted in Amami to clarify the association of brown sugar intake with mortality risk and cancer incidence.Methods and Study Design:Participants were recruited from the general population of Amami as part of the Japan Multi-Institutional Collaborative Cohort Study.The number of eligible participants was 5004(2057 men and 2947 women).During the median follow-up period of 13.4 years,274 deaths and 338 cases of cancer were observed.HRs and 95%CIs were estimated using the Cox proportional hazard model,after adjusting for sugar-related and other variables.Results:After adjusting for their related confounding factors,brown sugar intake was associated with decreased HRs and a decreasing trend for all-site and stomach cancer incidence(p=0.001 and 0.017,respectively)in women and men,and for breast cancer incidence(p=0.034)in women.Additionally,a decreasing trend in the HRs for lung cancer incidence was observed among never and ex-smokers(p=0.039).Decreased HRs for overall death,cancer,and cardiovascular disease were not apparent.Conclusions:Brown sugar intake was associated with decreased risk of all-site,stomach,and breast cancer incidences in the Amami population.展开更多
基金supported by Grants-in-Aid for Scientific Research on Priority Areas of Cancer(No.17015018)Innovative Areas(No.221S0001)by JSPS KAKENHI Grant Number JP16H06277(CoBiA)from the Japanese Ministry of Education,Culture,Sports,Science,and Technology。
文摘Background and Objectives:Although excess white sugar intake imposes various health burdens,brown sugar is high in minerals,polyphenols,and polycosanol.However,few epidemiological studies have assessed brown sugar intake for health benefit.People in the Amami islands region,with a relatively high proportion of individuals with longevity,consume brown sugar as a type of refreshment.This cohort study was conducted in Amami to clarify the association of brown sugar intake with mortality risk and cancer incidence.Methods and Study Design:Participants were recruited from the general population of Amami as part of the Japan Multi-Institutional Collaborative Cohort Study.The number of eligible participants was 5004(2057 men and 2947 women).During the median follow-up period of 13.4 years,274 deaths and 338 cases of cancer were observed.HRs and 95%CIs were estimated using the Cox proportional hazard model,after adjusting for sugar-related and other variables.Results:After adjusting for their related confounding factors,brown sugar intake was associated with decreased HRs and a decreasing trend for all-site and stomach cancer incidence(p=0.001 and 0.017,respectively)in women and men,and for breast cancer incidence(p=0.034)in women.Additionally,a decreasing trend in the HRs for lung cancer incidence was observed among never and ex-smokers(p=0.039).Decreased HRs for overall death,cancer,and cardiovascular disease were not apparent.Conclusions:Brown sugar intake was associated with decreased risk of all-site,stomach,and breast cancer incidences in the Amami population.
