AIM To determine the predictive role of body mass index(BMI) and waist circumference(WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS In a population base...AIM To determine the predictive role of body mass index(BMI) and waist circumference(WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS In a population based cohort study, 1765 with mean ± SD age: 42.32 ± 6.18 healthy participants were followed up from 2003 till 2013(n = 960). Anthropometric and biochemical measures of participants were evaluated regularly during the follow up period. BMI and WC measures at baseline and diabetes and prediabetes status of participants at 2013 were determined. Multivariable logistic regression analysis was used for determining the risk of diabetes and prediabetes considering important potential confounding variables. Receiver operatingcharacteristic curve analysis was conducted to determine the best cut of values of BMI and WC for diabetes and prediabetes. RESULTS At 2013, among participants who had complete data, 45 and 307 people were diabetic and prediabetic, respectively. In final fully adjusted model, BMI value was a significant predictor of diabetes(RR = 1.39, 95%CI: 1.06-1.82 and AUC = 0.68, 95%CI: 0.59-0.75; P < 0.001) however not a significant risk factor for prediabetes. Also, WC was a significant predictor for diabetes(RR = 1.2, 95%CI: 1.05-1.38 and AUC = 0.67, 95%CI: 0.6-0.75) but not significant risk factor for prediabetes. Similar results were observed in both genders.CONCLUSION General and abdominal obesity are significant risk factors for diabetes in future.展开更多
AIM:To explore the association between consumption of spicy foods and prevalence of irritable bowel syndrome(IBS)among Iranian adults.METHODS:In this cross-sectional study,data from4763 Iranian adult participants were...AIM:To explore the association between consumption of spicy foods and prevalence of irritable bowel syndrome(IBS)among Iranian adults.METHODS:In this cross-sectional study,data from4763 Iranian adult participants were used.Consumption of spicy foods was estimated using a dietary habits questionnaire that included a question on spicy foods consumption:"how frequently do you use spicy foods(pepper,curry,ginger,cinnamon and turmeric)during a week?"Participants could respond to the question by choosing one of these choices:never,1-3 times,4-6times,7-9 times,or more than 10 times per week.A modified Persian version of the RomeⅢquestionnaire was used to determine the prevalence of IBS.RESULTS:IBS was prevalent in 21.7%(18.6%of men and 24.1%of women)of the study population.After controlling for potential confounders including dietary behaviors,those consuming spicy foods≥10 times per week were 92%more likely to have IBS compared with those who never consumed spicy foods(OR=1.92;95%CI:1.23-3.01,Ptrend<0.01).The association remained significant even after taking lactose intolerance into account(OR=1.85;95%CI:1.18-2.90,Ptrend<0.01).Stratified analysis by gender revealed that the association between consumption of spicy foods and IBS was not significant in men;however,a significant association was found among women after taking potential cofounders,including meal regularity and lactose intolerance,into account.Women who consumed spicy foods≥10 times per week were two times more likely to have IBS compared with those who never consumed spicy foods(OR=2.03;95%CI:1.09-3.77,Ptrend=0.02).CONCLUSION:Consumption of spicy foods is directly associated with IBS,particularly in women.Further,prospective studies are warranted to(1)examine this association in other populations;and(2)evaluate whether dietary interventions,for example a reduction in spice consumption,would improve IBS symptoms.展开更多
BACKGROUND The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM To examine the association of baseline metabolic/obesity phenotypes and their changes over time...BACKGROUND The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM To examine the association of baseline metabolic/obesity phenotypes and their changes over time with the risk of prediabetes development. METHODS In a population-based cohort study, 1741 adults (aged > 19 years) with normal blood glucose were followed for 14 years. Anthropometric and biochemical measures were evaluated regularly during the follow-up period. According to body mass index and metabolic health status, participants were categorized into four groups: Metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW) and metabolically unhealthy obese (MUO). Multivariable Cox regression analysis was used to measure the risk of prediabetes according to the baseline metabolic/obesity phenotype and their changes during the follow-up. RESULTS In the whole population with a mean (95CCI for mean) follow up duration of 12.7 years (12.6-12.9), all three MUNW, MHO, MUO groups were at higher risk for developing prediabetes compared to the MHNW group (P = 0.022). The MUNW group had the highest risk for developing prediabetes (hazard ratio (HR): 3.84, 95%CI: 1.20, 12.27). In stratified analysis by sex, no significant association was found in men, while women in the MUNW group were at the greatest risk for prediabetes (HR: 6.74, 95%CI: 1.53, 29.66). Transforming from each phenotype to MHNW or MHO was not related to the risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with an increased risk of prediabetes (HR > 1;P < 0.05). CONCLUSION Our findings indicate that MHO is not a high risk, unless it transforms into MUO over time. However, people in the MUNW group have the greatest risk for developing prediabetes, and therefore, they should be screened and treated.展开更多
Objective To compare the blood antioxidant levels and dietary antioxidant intakes between pilots and non-flight staff of the Army Force in The Islamic Republic of Iran. Methods Thirty-seven helicopter pilots and 40 no...Objective To compare the blood antioxidant levels and dietary antioxidant intakes between pilots and non-flight staff of the Army Force in The Islamic Republic of Iran. Methods Thirty-seven helicopter pilots and 40 non-flight staff were included in this study. Their general characteristics were recorded and their weight, height, and waist circumference were measured. Their daily intake of energy and nutrients including antioxidants was assessed using a semi-quantitative food frequency questionnaire. Serum levels of total antioxidant capacity （TAC）, malondialdehyde （MDA）, and glutathione reductase （GR）, glutathione peroxidase （GPx）, superoxide dismutase （SOD）, and catalase （CAT） in red blood cells were also measured. Results The median erythrocytes SOD, serum MDA level and the mean serum level of TAC and erythrocytes GPx were significantly higher in pilots than in non-flight staff. The median vitamin C intake was significantly lower in pilots than in non-flight staff. The serum MDA levels were similar in non-flight staff and pilots when their vitamin C intake was 〈168 mg and significantly lower in non-flight staff than in pilots when their vitamin C intake was 〉168 mg. Conclusion The serum MDA level is lower in non-flight staff than in pilots when their vitamin C intake level is high, indicating that pilots need more vitamin C than non-flight staff.展开更多
AIM：To assess the relation between nutrient patterns and cataract risk.METHODS：This is a hospital-based case-control study with 97 cataract patients and 198 matched controls.Dietary consumption was collected through...AIM：To assess the relation between nutrient patterns and cataract risk.METHODS：This is a hospital-based case-control study with 97 cataract patients and 198 matched controls.Dietary consumption was collected through a valid food frequency questionnaire（FFQ）.Nutrient patterns were detected by applying factor analysis.Unconditional logistic regression models were used to estimate odds ratio（ORs） and 95%CIs.RESULTS：We extracted 5 main nutrient patterns.Factor 1 included niacin,thiamin,carbohydrates,protein,zinc,vitamin B6 and sodium（sodium pattern）.Factor 2 was characterized by oleic acid,monounsaturated fats,polyunsaturated fats,linoleic acid,trans fatty acid,linolenic acid,vitamin E and saturated fats（fatty acid pattern）.The third factor represented high intake of vitamin B12,vitamin D,cholesterol and calcium（mixed pattern）.The 4^（th） pattern was high in intake of beta and alpha carotene,vitamin A and vitamin C（antioxidant pattern）.Finally,the 5^（th） pattern loaded heavily on docosahexaenoic acid（DHA） and eicosapentaenoic acid（EPA）（omega-3 pattern）.In crude and multivariate analysis,the sodium pattern was associated with increased risk of cataract（OR=1.97,95%CI：1.09-3.96）.The fatty acid pattern elevated the risk of cataract（OR=1.94,95%CI：1.1-3.86）.Antioxidant pattern was associated with a significant 79% reduced risk（2^（nd） category compared with the 1st）.Omega-3 pattern was significantly negatively associated with risk of cataract（P=0.04）.CONCLUSION：These findings imply that nutrient patterns reflecting a combined consumption of nutrients might be important in the etiology of cataract.Additional studies with more efficient designs are warranted to confirm our findings.展开更多
The aim of this study was to formulate and develop a low calorie and low glycemic index (GI) of soft ice cream by using mixture of sucrose and Stevia. Five different formulations of ice cream were produced by using di...The aim of this study was to formulate and develop a low calorie and low glycemic index (GI) of soft ice cream by using mixture of sucrose and Stevia. Five different formulations of ice cream were produced by using different proportions of sucrose and Stevia. Physicochemical characteristics, hedonic sensory evaluations and glycemic index determination of products were carried out by following conventional methods. Replacement of sucrose with Stevia resulted in a significantly lower viscosity and brix with a higher overrun and melting rate in a dose dependent manner. Total replacing of sucrose with Stevia resulted in significant reduction in caloric value from 143.03 to 105.25 Kcal and GI from 79.06 ± 4.0 to 72.18 ± 5.27 as compared to those of sucrose based formulation (p 0.05) indicating a 37.78% and 6.88% reduction, respectively. TB had the best sensory acceptance among all the treatments. We concluded that substitution of sucrose with Stevia may be a choice to produce low caloric and GI ice creams. However, using mixture of the two sweeteners improves sensory acceptance of the formulations.展开更多
Background: No published information is available on the status of childhood obesity in Bangladeshi primary school children of urban middle and upper-middle income group. The aim of the study was to explore the propor...Background: No published information is available on the status of childhood obesity in Bangladeshi primary school children of urban middle and upper-middle income group. The aim of the study was to explore the proportion of childhood obesity in the primary school children of middle and upper-middle income group in capital city and to gather information on their dietary pattern and physical activity. Methods: One hundred and fifty children (age 9 ± 1 years, height (ht) 118 ± 20 cm, weight (wt) 36 ± 8 kg, wt/ht% 126 ± 24, mean ± SD) were selected purposively from the primary schools of Dhaka city. On the basis of predefined scoring, subjects were classified as underweight, normal, overweight and obese if their weight-for-height values were 120% of median values for Bangladeshi children respectively. Dietary intake and energy expenditure of the study subjects were calculated by standard techniques. Results: The proportion of childhood overweight and obesity was 52% and 20%. The proportion of overweight and obesity was higher (78%) among girls compared to boys (54%). Similarly, height, weight and other anthropometrics indices were significantly (p < 0.05) higher in girls compared to boys. The daily intake of carbohydrate and protein was significantly (p < 0.05) higher among obese group. Total energy balance was significantly correlated with weight-for-height% (r = 0.541, p = 0.0001). Conclusions: A higher proportion of overweight and obesity had been found in girls’ children than their counter parts in this study. Positive energy balance with higher energy intake from carbohydrate and fast/processed food culture habit were found among primary school children of middle and upper-middle income group in the capital city of Bangladesh.展开更多
AIM To investigate the relation between plain water drinking and risk of depression and anxiety among a large sample of Iranian adults.METHODS A total of 3327 Iranian general adults were included in this cross-section...AIM To investigate the relation between plain water drinking and risk of depression and anxiety among a large sample of Iranian adults.METHODS A total of 3327 Iranian general adults were included in this cross-sectional study.Validated Iranian version of the Hospital Anxiety and Depression Scale was used to assess anxiety and depression.Water consumption was assessed by asking about the number of glasses of water that consumed daily.Water consumption was categorized into<2,2-5,and≥5 glasses of water/d.RESULTS In the crude model,the lowest level of water drinking(<2 glasses/d)compared with reference group(≥5 glasses/d)doubled the risk of depression and anxiety(P<0.0001).After adjusting potential confounders,this inverse link remained significant for depression(OR:1.79;95%CI:1.32,2.42;P<0.0001),but not for anxiety(OR:1.49;95%CI:0.98,2.25;P=0.109).In stratified analyses by sex,after controlling for potential confounders,water drinking<2 glasses/d was associated with 73%and 54%increment in the risk of depression in men and women,respectively(P<0.05),whilst no significant association was observed for anxiety either in men or in women.CONCLUSION We found inverse associations between plain water consumption and depression.Also,these findings showed a tended risky association,but not statistically significant,between lower levels of water consumption and anxiety.These findings warrant evaluation in prospective and clinical trials studies to establish the plausible role of water in mental health status.展开更多
Dear Editor：Fortification programs are not established for nutrients like vitamin D among other nutrients in Iran.It is reported that approximately 80%of Iranians do not meet the estimated average requirement for cal...Dear Editor：Fortification programs are not established for nutrients like vitamin D among other nutrients in Iran.It is reported that approximately 80%of Iranians do not meet the estimated average requirement for calcium and vitamin D.The Iranian Multicenter Osteoporosis Study（IMOS）has shown that more than 80%of Iranians have vitamin D deficiency.However,currently,there is no data on vitamin D supplementation in elderly adults in Iran.We carried out a secondary analysis of a bigger population-based cross-sectional study,which was conducted among elderly men and women in the 6^th district of Tehran to determine the frequency of sarcopenia.展开更多
To investigate the Infant and Young Child Feeding Practice and Nutrition status among 6-23 months age group children in nutrition intervention （national nutrition program） and non-intervention areas. Nutrition inter...To investigate the Infant and Young Child Feeding Practice and Nutrition status among 6-23 months age group children in nutrition intervention （national nutrition program） and non-intervention areas. Nutrition intervention has been proposed to reduce the risk of malnutrition. It was a comparative cross-sectional study. A total of 360 households, of which 180 were from the nutrition intervention area each with at least a child aged between 6-23 months were randomly selected. Statistical package for Social Scientists （SPSS/PC^＋） was used for data entry and analysis. Nutritional status that is weight-for-age, height-for-age and weight-for-height were computed using anthro software. T-test, chi-square and Pearson＇s correlation （p 〈 0.05） were administered to compare the two groups. There was a significant difference between the intervention and non intervention groups in relation to the incidence of initiation of breast feeding, prelacteal and exclusive breast feeding and complementary feeding （p 〈 0.05）. The prevalence of wasting （p = 0.004）, stunting （p = 0.015） and underweight （p = 0.003） was observed to be greater for non NNP area compared with the group of NNP area and association was found between those areas. In the study showed that the Infant and Young Child Feeding Practice and Nutritional status are better in nutrition intervention area.展开更多
Spasticity is a stiff muscle condition because the muscles receive impulses continuously. Calcium ions play a role in the ability of nerves to stimulate muscle contraction. This study aimed to analyze the effect of ca...Spasticity is a stiff muscle condition because the muscles receive impulses continuously. Calcium ions play a role in the ability of nerves to stimulate muscle contraction. This study aimed to analyze the effect of calcium consumption on the changes of spasticity and the relation of calcium levels in the blood and muscle to the spasticity. The experimental study was conducted on 42 male Sprague-Dawley rats aged 12 - 14 weeks. The 15-d intervention was conducted on six groups of spastic rats by administering 20 g of feed containing 50 mg, 100 mg, and 200 mg of calcium, it also received 100 mg, 200 mg, and 300 mg of calcium lactate supplementation. The experimental rats were induced with 80 mg/kg BW of Erythrocin B through the tail vein to make them spastic. This study showed a tendency of increased spasticity along with the increased dose of calcium given to the subjects. There were significant differences (p = 0.007) in changes in spasticity between groups. The significant differences (p = 0.02) in changes in blood calcium levels. The Spearman’s correlations test on the changes in blood calcium levels and changes in spasticity showed a positive coefficient correlation (r = 0.097) with a p-value of 0.54. An increase in blood calcium levels and a large decrease in spasticity were found in the group receiving 100 mg calcium intake in 20 g of feed. The calcium levels in muscles had a significant correlation with spasticity (p = 0.038, r = 0.810). The calcium levels in the muscle had a strong correlation with blood calcium levels (p = 0.041, r = 0.748). The biggest decrease in spasticity occurred after 100 mg of calcium were given to the rats for 15 days, and it was considered as an optimal dose. The calcium levels in the muscles had a strong correlation with blood calcium levels and the spasticity of the spastic rats.展开更多
Climate extreme events have threatened food security and the second Sustainable development goals (SDGs) “zero hunger” both directly via agricultural food loss and indirectly through rising food prices. We systemati...Climate extreme events have threatened food security and the second Sustainable development goals (SDGs) “zero hunger” both directly via agricultural food loss and indirectly through rising food prices. We systematically searched and used a combination of results from various models, which play a crucial role in predicting the potential impact of climate change on agricultural production and food price. Therefore, we searched online databases including EMBASE, Web of Science, Scopus, Google Scholar, and grey literature. Then observational studies were included from January 1990 to August 2021, which reported food price proportion under climate disturbances. Results showed that 22 out of 26 studies from 615 articles, identified in the meta-analysis predicted the food price ratio would be fluctuated up to 28% before 2020, while the ratio will be marked up at 31% from 2020 to 2049 and then will scale down during 2050-2100. The compiled ratio was estimated at 26% in the long period between 2000 until 2100 under climatic weather events. Drought was a significant weather disturbance with a 32% increase in food prices. Consequently, the Food price increase will significantly affect food accessibility in lower-income countries, primarily until 2050. Policymakers should prioritize and act through redesigning food security policies according to climatic extremes in their settings.展开更多
Background and Objectives:Type 2 diabetes mellitus(T2DM)has emerged as a significant global public health concern.Multiple studies have shown that traditional nutraceuticals are potential to treat T2DM and its complic...Background and Objectives:Type 2 diabetes mellitus(T2DM)has emerged as a significant global public health concern.Multiple studies have shown that traditional nutraceuticals are potential to treat T2DM and its complications.This review will explore traditional nutraceuticals with antidiabetic properties with a focus on traditional Asian nutraceuticals and their antioxidant effects on gene expression associated to T2DM.Methods and Study Design:Literature searching was conducted in Pubmed,Scopus,and Science Direct using the keywords“nutraceutical”,“antidiabetic”,“insulin resistance”,“Diabetes Mellitus”,“herbal medicine”,“mechanism”,“pathway”,“traditional food”,“functional food”,“antioxidant”,“clinical”,“preclinical”,“animal studies”,and“Asian”combined with Boolean operators“OR”.Results:Nutraceuticals sourced from traditional Indonesian herbal beverages,including Galohgor,Bir Pletok,and Wedang Uwuh,have shown potential efficacy in reducing hyperglycemia,oxidative stress,and obesity in T2DM.展开更多
Objective:To investigate the effect and safety of phytosomal curcumin supplementation on patients with migraine.Methods:In this randomized,double-blind and placebo-controlled trial,70 patients suffered from migraine w...Objective:To investigate the effect and safety of phytosomal curcumin supplementation on patients with migraine.Methods:In this randomized,double-blind and placebo-controlled trial,70 patients suffered from migraine without aura were randomized into 2 groups to receive 250 mg/d of phytosomal curcumin(intervention group)or maltodextrin(placebo group)for 8 weeks,35 cases per group.All patients in both groups received their standard treatment and common medications.The severity,duration,frequency of headaches,quality of life(QoL),mental status,headache impact,and sleep quality of patients were assessed before and after treatment.Adverse effects were also assessed.Results:Sixty-five patients completed the trial(33 in the intervention group and 32 in the placebo group).Phytosomal curcumin supplementation significantly reduced severity,duration and frequency of migraine attacks,stress score,and headache impact,and improved QoL and sleep quality of patients in the intervention group,compared with the placebo group(P<0.05 or P<0.01).However,it had no significant effect on depression and anxiety scores in the intervention group,compared with the placebo group(P>0.05).No adverse effects had been reported in response to the intervention.Conclusion:Phytosomal curcumin as a safe supplement had a beneficial effect on migraine symptoms,stress level,as well as the sleep quality and QoL in patients with migraine.(Trial registration No.IRCT20201129049534N2)展开更多
Background and Objectives:Intestinal permeability(IP)is known to contribute to the immune system activation and inflammation;thus,it is proposed to have a role in the pathogenesis and exacerbation of many chronic dise...Background and Objectives:Intestinal permeability(IP)is known to contribute to the immune system activation and inflammation;thus,it is proposed to have a role in the pathogenesis and exacerbation of many chronic diseases.Several studies have indicated that diet and nutritional status are risk factors for increased IP.In this mini review,we discussed the recent evidence on the association of diet,nutritional status,and intestinal permeability assessed by zonulin concentrations in serum and feces.Methods and Study Design:Literature searching was conducted in Pubmed,ProQuest and Google Scholar using the keywords“diet quality”,“intestinal permeability”,“nutritional status”,and“zonulin”combined with Boolean operators“AND”and“OR”.Results:Some studies indicated that intake of proper nutrition and good diet such as low total calorie intake,high intakes of omega-3 polyunsaturated fatty acids,fiber,vitamins,minerals,probiotics,and polyphenol-rich diet have significant impact on improvement of intestinal permeability marked by lower zonulin concentrations.Higher zonulin concentrations are found in those with overweight and obesity indicating that these population have increased IP.Most studies were conducted in adults and there are limited studies in children and adolescents.In addition,no studies have assessed diet quality to obtain a comprehensive picture on the complexities of diet in the population in relation to intestinal permeability.Conclusions:Diet and nutritional status are linked to zonulin concentrations,indicating a role in intestinal permeability.Further research should be conducted to investigate the relationship between diet quality,as measured by appropriate diet quality indices,and intestinal permeability in children,adolescents,and adults.展开更多
文摘AIM To determine the predictive role of body mass index(BMI) and waist circumference(WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS In a population based cohort study, 1765 with mean ± SD age: 42.32 ± 6.18 healthy participants were followed up from 2003 till 2013(n = 960). Anthropometric and biochemical measures of participants were evaluated regularly during the follow up period. BMI and WC measures at baseline and diabetes and prediabetes status of participants at 2013 were determined. Multivariable logistic regression analysis was used for determining the risk of diabetes and prediabetes considering important potential confounding variables. Receiver operatingcharacteristic curve analysis was conducted to determine the best cut of values of BMI and WC for diabetes and prediabetes. RESULTS At 2013, among participants who had complete data, 45 and 307 people were diabetic and prediabetic, respectively. In final fully adjusted model, BMI value was a significant predictor of diabetes(RR = 1.39, 95%CI: 1.06-1.82 and AUC = 0.68, 95%CI: 0.59-0.75; P < 0.001) however not a significant risk factor for prediabetes. Also, WC was a significant predictor for diabetes(RR = 1.2, 95%CI: 1.05-1.38 and AUC = 0.67, 95%CI: 0.6-0.75) but not significant risk factor for prediabetes. Similar results were observed in both genders.CONCLUSION General and abdominal obesity are significant risk factors for diabetes in future.
基金Supported by A grant from Isfahan University of Medical Sciences,Isfahan,IranA Senior Research Fellowship from the National Health and Medical Research Council of Australia(NHMRC Grant No.627002,2010-2014)to Feinle-Bisset C
文摘AIM:To explore the association between consumption of spicy foods and prevalence of irritable bowel syndrome(IBS)among Iranian adults.METHODS:In this cross-sectional study,data from4763 Iranian adult participants were used.Consumption of spicy foods was estimated using a dietary habits questionnaire that included a question on spicy foods consumption:"how frequently do you use spicy foods(pepper,curry,ginger,cinnamon and turmeric)during a week?"Participants could respond to the question by choosing one of these choices:never,1-3 times,4-6times,7-9 times,or more than 10 times per week.A modified Persian version of the RomeⅢquestionnaire was used to determine the prevalence of IBS.RESULTS:IBS was prevalent in 21.7%(18.6%of men and 24.1%of women)of the study population.After controlling for potential confounders including dietary behaviors,those consuming spicy foods≥10 times per week were 92%more likely to have IBS compared with those who never consumed spicy foods(OR=1.92;95%CI:1.23-3.01,Ptrend<0.01).The association remained significant even after taking lactose intolerance into account(OR=1.85;95%CI:1.18-2.90,Ptrend<0.01).Stratified analysis by gender revealed that the association between consumption of spicy foods and IBS was not significant in men;however,a significant association was found among women after taking potential cofounders,including meal regularity and lactose intolerance,into account.Women who consumed spicy foods≥10 times per week were two times more likely to have IBS compared with those who never consumed spicy foods(OR=2.03;95%CI:1.09-3.77,Ptrend=0.02).CONCLUSION:Consumption of spicy foods is directly associated with IBS,particularly in women.Further,prospective studies are warranted to(1)examine this association in other populations;and(2)evaluate whether dietary interventions,for example a reduction in spice consumption,would improve IBS symptoms.
文摘BACKGROUND The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM To examine the association of baseline metabolic/obesity phenotypes and their changes over time with the risk of prediabetes development. METHODS In a population-based cohort study, 1741 adults (aged > 19 years) with normal blood glucose were followed for 14 years. Anthropometric and biochemical measures were evaluated regularly during the follow-up period. According to body mass index and metabolic health status, participants were categorized into four groups: Metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW) and metabolically unhealthy obese (MUO). Multivariable Cox regression analysis was used to measure the risk of prediabetes according to the baseline metabolic/obesity phenotype and their changes during the follow-up. RESULTS In the whole population with a mean (95CCI for mean) follow up duration of 12.7 years (12.6-12.9), all three MUNW, MHO, MUO groups were at higher risk for developing prediabetes compared to the MHNW group (P = 0.022). The MUNW group had the highest risk for developing prediabetes (hazard ratio (HR): 3.84, 95%CI: 1.20, 12.27). In stratified analysis by sex, no significant association was found in men, while women in the MUNW group were at the greatest risk for prediabetes (HR: 6.74, 95%CI: 1.53, 29.66). Transforming from each phenotype to MHNW or MHO was not related to the risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with an increased risk of prediabetes (HR > 1;P < 0.05). CONCLUSION Our findings indicate that MHO is not a high risk, unless it transforms into MUO over time. However, people in the MUNW group have the greatest risk for developing prediabetes, and therefore, they should be screened and treated.
基金funded by the Medical University of Armed Forces
文摘Objective To compare the blood antioxidant levels and dietary antioxidant intakes between pilots and non-flight staff of the Army Force in The Islamic Republic of Iran. Methods Thirty-seven helicopter pilots and 40 non-flight staff were included in this study. Their general characteristics were recorded and their weight, height, and waist circumference were measured. Their daily intake of energy and nutrients including antioxidants was assessed using a semi-quantitative food frequency questionnaire. Serum levels of total antioxidant capacity （TAC）, malondialdehyde （MDA）, and glutathione reductase （GR）, glutathione peroxidase （GPx）, superoxide dismutase （SOD）, and catalase （CAT） in red blood cells were also measured. Results The median erythrocytes SOD, serum MDA level and the mean serum level of TAC and erythrocytes GPx were significantly higher in pilots than in non-flight staff. The median vitamin C intake was significantly lower in pilots than in non-flight staff. The serum MDA levels were similar in non-flight staff and pilots when their vitamin C intake was 〈168 mg and significantly lower in non-flight staff than in pilots when their vitamin C intake was 〉168 mg. Conclusion The serum MDA level is lower in non-flight staff than in pilots when their vitamin C intake level is high, indicating that pilots need more vitamin C than non-flight staff.
基金Supported by the National Nutrition and Food Technology Research Institute(NNFTRI)of Shahid Beheshti University of Medical Sciences,Tehran,Iran
文摘AIM：To assess the relation between nutrient patterns and cataract risk.METHODS：This is a hospital-based case-control study with 97 cataract patients and 198 matched controls.Dietary consumption was collected through a valid food frequency questionnaire（FFQ）.Nutrient patterns were detected by applying factor analysis.Unconditional logistic regression models were used to estimate odds ratio（ORs） and 95%CIs.RESULTS：We extracted 5 main nutrient patterns.Factor 1 included niacin,thiamin,carbohydrates,protein,zinc,vitamin B6 and sodium（sodium pattern）.Factor 2 was characterized by oleic acid,monounsaturated fats,polyunsaturated fats,linoleic acid,trans fatty acid,linolenic acid,vitamin E and saturated fats（fatty acid pattern）.The third factor represented high intake of vitamin B12,vitamin D,cholesterol and calcium（mixed pattern）.The 4^（th） pattern was high in intake of beta and alpha carotene,vitamin A and vitamin C（antioxidant pattern）.Finally,the 5^（th） pattern loaded heavily on docosahexaenoic acid（DHA） and eicosapentaenoic acid（EPA）（omega-3 pattern）.In crude and multivariate analysis,the sodium pattern was associated with increased risk of cataract（OR=1.97,95%CI：1.09-3.96）.The fatty acid pattern elevated the risk of cataract（OR=1.94,95%CI：1.1-3.86）.Antioxidant pattern was associated with a significant 79% reduced risk（2^（nd） category compared with the 1st）.Omega-3 pattern was significantly negatively associated with risk of cataract（P=0.04）.CONCLUSION：These findings imply that nutrient patterns reflecting a combined consumption of nutrients might be important in the etiology of cataract.Additional studies with more efficient designs are warranted to confirm our findings.
文摘The aim of this study was to formulate and develop a low calorie and low glycemic index (GI) of soft ice cream by using mixture of sucrose and Stevia. Five different formulations of ice cream were produced by using different proportions of sucrose and Stevia. Physicochemical characteristics, hedonic sensory evaluations and glycemic index determination of products were carried out by following conventional methods. Replacement of sucrose with Stevia resulted in a significantly lower viscosity and brix with a higher overrun and melting rate in a dose dependent manner. Total replacing of sucrose with Stevia resulted in significant reduction in caloric value from 143.03 to 105.25 Kcal and GI from 79.06 ± 4.0 to 72.18 ± 5.27 as compared to those of sucrose based formulation (p 0.05) indicating a 37.78% and 6.88% reduction, respectively. TB had the best sensory acceptance among all the treatments. We concluded that substitution of sucrose with Stevia may be a choice to produce low caloric and GI ice creams. However, using mixture of the two sweeteners improves sensory acceptance of the formulations.
文摘Background: No published information is available on the status of childhood obesity in Bangladeshi primary school children of urban middle and upper-middle income group. The aim of the study was to explore the proportion of childhood obesity in the primary school children of middle and upper-middle income group in capital city and to gather information on their dietary pattern and physical activity. Methods: One hundred and fifty children (age 9 ± 1 years, height (ht) 118 ± 20 cm, weight (wt) 36 ± 8 kg, wt/ht% 126 ± 24, mean ± SD) were selected purposively from the primary schools of Dhaka city. On the basis of predefined scoring, subjects were classified as underweight, normal, overweight and obese if their weight-for-height values were 120% of median values for Bangladeshi children respectively. Dietary intake and energy expenditure of the study subjects were calculated by standard techniques. Results: The proportion of childhood overweight and obesity was 52% and 20%. The proportion of overweight and obesity was higher (78%) among girls compared to boys (54%). Similarly, height, weight and other anthropometrics indices were significantly (p < 0.05) higher in girls compared to boys. The daily intake of carbohydrate and protein was significantly (p < 0.05) higher among obese group. Total energy balance was significantly correlated with weight-for-height% (r = 0.541, p = 0.0001). Conclusions: A higher proportion of overweight and obesity had been found in girls’ children than their counter parts in this study. Positive energy balance with higher energy intake from carbohydrate and fast/processed food culture habit were found among primary school children of middle and upper-middle income group in the capital city of Bangladesh.
文摘AIM To investigate the relation between plain water drinking and risk of depression and anxiety among a large sample of Iranian adults.METHODS A total of 3327 Iranian general adults were included in this cross-sectional study.Validated Iranian version of the Hospital Anxiety and Depression Scale was used to assess anxiety and depression.Water consumption was assessed by asking about the number of glasses of water that consumed daily.Water consumption was categorized into<2,2-5,and≥5 glasses of water/d.RESULTS In the crude model,the lowest level of water drinking(<2 glasses/d)compared with reference group(≥5 glasses/d)doubled the risk of depression and anxiety(P<0.0001).After adjusting potential confounders,this inverse link remained significant for depression(OR:1.79;95%CI:1.32,2.42;P<0.0001),but not for anxiety(OR:1.49;95%CI:0.98,2.25;P=0.109).In stratified analyses by sex,after controlling for potential confounders,water drinking<2 glasses/d was associated with 73%and 54%increment in the risk of depression in men and women,respectively(P<0.05),whilst no significant association was observed for anxiety either in men or in women.CONCLUSION We found inverse associations between plain water consumption and depression.Also,these findings showed a tended risky association,but not statistically significant,between lower levels of water consumption and anxiety.These findings warrant evaluation in prospective and clinical trials studies to establish the plausible role of water in mental health status.
基金funded by TUMS and EMRS in order of their financial contributions
文摘Dear Editor：Fortification programs are not established for nutrients like vitamin D among other nutrients in Iran.It is reported that approximately 80%of Iranians do not meet the estimated average requirement for calcium and vitamin D.The Iranian Multicenter Osteoporosis Study（IMOS）has shown that more than 80%of Iranians have vitamin D deficiency.However,currently,there is no data on vitamin D supplementation in elderly adults in Iran.We carried out a secondary analysis of a bigger population-based cross-sectional study,which was conducted among elderly men and women in the 6^th district of Tehran to determine the frequency of sarcopenia.
文摘To investigate the Infant and Young Child Feeding Practice and Nutrition status among 6-23 months age group children in nutrition intervention （national nutrition program） and non-intervention areas. Nutrition intervention has been proposed to reduce the risk of malnutrition. It was a comparative cross-sectional study. A total of 360 households, of which 180 were from the nutrition intervention area each with at least a child aged between 6-23 months were randomly selected. Statistical package for Social Scientists （SPSS/PC^＋） was used for data entry and analysis. Nutritional status that is weight-for-age, height-for-age and weight-for-height were computed using anthro software. T-test, chi-square and Pearson＇s correlation （p 〈 0.05） were administered to compare the two groups. There was a significant difference between the intervention and non intervention groups in relation to the incidence of initiation of breast feeding, prelacteal and exclusive breast feeding and complementary feeding （p 〈 0.05）. The prevalence of wasting （p = 0.004）, stunting （p = 0.015） and underweight （p = 0.003） was observed to be greater for non NNP area compared with the group of NNP area and association was found between those areas. In the study showed that the Infant and Young Child Feeding Practice and Nutritional status are better in nutrition intervention area.
文摘Spasticity is a stiff muscle condition because the muscles receive impulses continuously. Calcium ions play a role in the ability of nerves to stimulate muscle contraction. This study aimed to analyze the effect of calcium consumption on the changes of spasticity and the relation of calcium levels in the blood and muscle to the spasticity. The experimental study was conducted on 42 male Sprague-Dawley rats aged 12 - 14 weeks. The 15-d intervention was conducted on six groups of spastic rats by administering 20 g of feed containing 50 mg, 100 mg, and 200 mg of calcium, it also received 100 mg, 200 mg, and 300 mg of calcium lactate supplementation. The experimental rats were induced with 80 mg/kg BW of Erythrocin B through the tail vein to make them spastic. This study showed a tendency of increased spasticity along with the increased dose of calcium given to the subjects. There were significant differences (p = 0.007) in changes in spasticity between groups. The significant differences (p = 0.02) in changes in blood calcium levels. The Spearman’s correlations test on the changes in blood calcium levels and changes in spasticity showed a positive coefficient correlation (r = 0.097) with a p-value of 0.54. An increase in blood calcium levels and a large decrease in spasticity were found in the group receiving 100 mg calcium intake in 20 g of feed. The calcium levels in muscles had a significant correlation with spasticity (p = 0.038, r = 0.810). The calcium levels in the muscle had a strong correlation with blood calcium levels (p = 0.041, r = 0.748). The biggest decrease in spasticity occurred after 100 mg of calcium were given to the rats for 15 days, and it was considered as an optimal dose. The calcium levels in the muscles had a strong correlation with blood calcium levels and the spasticity of the spastic rats.
文摘Climate extreme events have threatened food security and the second Sustainable development goals (SDGs) “zero hunger” both directly via agricultural food loss and indirectly through rising food prices. We systematically searched and used a combination of results from various models, which play a crucial role in predicting the potential impact of climate change on agricultural production and food price. Therefore, we searched online databases including EMBASE, Web of Science, Scopus, Google Scholar, and grey literature. Then observational studies were included from January 1990 to August 2021, which reported food price proportion under climate disturbances. Results showed that 22 out of 26 studies from 615 articles, identified in the meta-analysis predicted the food price ratio would be fluctuated up to 28% before 2020, while the ratio will be marked up at 31% from 2020 to 2049 and then will scale down during 2050-2100. The compiled ratio was estimated at 26% in the long period between 2000 until 2100 under climatic weather events. Drought was a significant weather disturbance with a 32% increase in food prices. Consequently, the Food price increase will significantly affect food accessibility in lower-income countries, primarily until 2050. Policymakers should prioritize and act through redesigning food security policies according to climatic extremes in their settings.
基金supported by Ministry of Education,Culture,Research,and Technology,Republic of Indonesia under the Regular Fundamental Research Grant[Grant No.22049/IT3.D10/PT.01.03/P/B/2024]。
文摘Background and Objectives:Type 2 diabetes mellitus(T2DM)has emerged as a significant global public health concern.Multiple studies have shown that traditional nutraceuticals are potential to treat T2DM and its complications.This review will explore traditional nutraceuticals with antidiabetic properties with a focus on traditional Asian nutraceuticals and their antioxidant effects on gene expression associated to T2DM.Methods and Study Design:Literature searching was conducted in Pubmed,Scopus,and Science Direct using the keywords“nutraceutical”,“antidiabetic”,“insulin resistance”,“Diabetes Mellitus”,“herbal medicine”,“mechanism”,“pathway”,“traditional food”,“functional food”,“antioxidant”,“clinical”,“preclinical”,“animal studies”,and“Asian”combined with Boolean operators“OR”.Results:Nutraceuticals sourced from traditional Indonesian herbal beverages,including Galohgor,Bir Pletok,and Wedang Uwuh,have shown potential efficacy in reducing hyperglycemia,oxidative stress,and obesity in T2DM.
基金Supported by Isfahan University of Medical Sciences(No.340081)。
文摘Objective:To investigate the effect and safety of phytosomal curcumin supplementation on patients with migraine.Methods:In this randomized,double-blind and placebo-controlled trial,70 patients suffered from migraine without aura were randomized into 2 groups to receive 250 mg/d of phytosomal curcumin(intervention group)or maltodextrin(placebo group)for 8 weeks,35 cases per group.All patients in both groups received their standard treatment and common medications.The severity,duration,frequency of headaches,quality of life(QoL),mental status,headache impact,and sleep quality of patients were assessed before and after treatment.Adverse effects were also assessed.Results:Sixty-five patients completed the trial(33 in the intervention group and 32 in the placebo group).Phytosomal curcumin supplementation significantly reduced severity,duration and frequency of migraine attacks,stress score,and headache impact,and improved QoL and sleep quality of patients in the intervention group,compared with the placebo group(P<0.05 or P<0.01).However,it had no significant effect on depression and anxiety scores in the intervention group,compared with the placebo group(P>0.05).No adverse effects had been reported in response to the intervention.Conclusion:Phytosomal curcumin as a safe supplement had a beneficial effect on migraine symptoms,stress level,as well as the sleep quality and QoL in patients with migraine.(Trial registration No.IRCT20201129049534N2)
基金supported by Ministry of Education,Culture,Research,and Technology,Republic of Indonesia under the Doctoral Dissertation Research Grant[Grant No.NKB-306/UN2.RST/HKP.05.00/2021].
文摘Background and Objectives:Intestinal permeability(IP)is known to contribute to the immune system activation and inflammation;thus,it is proposed to have a role in the pathogenesis and exacerbation of many chronic diseases.Several studies have indicated that diet and nutritional status are risk factors for increased IP.In this mini review,we discussed the recent evidence on the association of diet,nutritional status,and intestinal permeability assessed by zonulin concentrations in serum and feces.Methods and Study Design:Literature searching was conducted in Pubmed,ProQuest and Google Scholar using the keywords“diet quality”,“intestinal permeability”,“nutritional status”,and“zonulin”combined with Boolean operators“AND”and“OR”.Results:Some studies indicated that intake of proper nutrition and good diet such as low total calorie intake,high intakes of omega-3 polyunsaturated fatty acids,fiber,vitamins,minerals,probiotics,and polyphenol-rich diet have significant impact on improvement of intestinal permeability marked by lower zonulin concentrations.Higher zonulin concentrations are found in those with overweight and obesity indicating that these population have increased IP.Most studies were conducted in adults and there are limited studies in children and adolescents.In addition,no studies have assessed diet quality to obtain a comprehensive picture on the complexities of diet in the population in relation to intestinal permeability.Conclusions:Diet and nutritional status are linked to zonulin concentrations,indicating a role in intestinal permeability.Further research should be conducted to investigate the relationship between diet quality,as measured by appropriate diet quality indices,and intestinal permeability in children,adolescents,and adults.
