Polymorphism makes it possible to clarify the relationship between emission property and crystal structure.However,based on the exact molecular conformation in tetraphenylethene polymorphisms,it is still challenging t...Polymorphism makes it possible to clarify the relationship between emission property and crystal structure.However,based on the exact molecular conformation in tetraphenylethene polymorphisms,it is still challenging to evaluate the difference of intramolecular coplanarity without the support of calculation because of the complex combination of four different torsion angles between four peripheral benzenes and the central ethylene plane.Here,by using a di-formyl-functionalized tetraphenylethene derivative,two ideal polymorphisms with a consistent trend of the corresponding torsion angles have been obtained.For the first time,we explicitly demonstrated that intramolecular coplanarity is the underlying cause of the polymorphism-dependent emission of tetraphenylethene derivatives.展开更多
Effective strategies to fabricate finite organic nanoparticles and understanding their structure-dependent cell interaction is highly important for the development of long circulating nanocarriers in cancer therapy.In...Effective strategies to fabricate finite organic nanoparticles and understanding their structure-dependent cell interaction is highly important for the development of long circulating nanocarriers in cancer therapy.In this contribution,we will capitalize on our recent development of finite supramolecular nanofibers based on the self-assembly of modularly designed cationic multidomain peptides(MDPs)and use them as a model system to investigate structure-dependent cell penetrating activity.MDPs selfassembled into nanofibers with high density of cationic charges at the fiber-solvent interface to interact with the cell membrane.However,despite the multivalent charge presentation,not all fibers led to high levels of membrane activity and cellular uptake.The flexibility of the cationic charge domains on self-assembled nanofibers plays a key role in effective membrane perturbation.Nanofibers were found to sacrifice their dimension,thermodynamic and kinetic stability for a more flexible charge domain in order to achieve effective membrane interaction.The increased membrane activity led to improved cell uptake of membrane-impermeable chemotherapeutics through membrane pore formation.In vitro cytotoxicity study showed co-administering of water-soluble doxorubicin with membrane-active peptide nanofibers dramatically reduced the IC50 by eight folds compared to drug alone.Through these detailed structure and activity studies,the acquired knowledge will provide important guidelines for the design of a variety of supramolecular cell penetrating nanomaterials not limited to peptide assembly which can be used to probe various complex biological processes.展开更多
基金the National Natural Science Foundation of China(Nos.21708039,21878286,21908216,21835001,21875085,51773080,21674041)the Program for Changbaishan Scholars of Jilin Province。
文摘Polymorphism makes it possible to clarify the relationship between emission property and crystal structure.However,based on the exact molecular conformation in tetraphenylethene polymorphisms,it is still challenging to evaluate the difference of intramolecular coplanarity without the support of calculation because of the complex combination of four different torsion angles between four peripheral benzenes and the central ethylene plane.Here,by using a di-formyl-functionalized tetraphenylethene derivative,two ideal polymorphisms with a consistent trend of the corresponding torsion angles have been obtained.For the first time,we explicitly demonstrated that intramolecular coplanarity is the underlying cause of the polymorphism-dependent emission of tetraphenylethene derivatives.
基金This study was supported by the National Science Foundation(DMR 1654426)。
文摘Effective strategies to fabricate finite organic nanoparticles and understanding their structure-dependent cell interaction is highly important for the development of long circulating nanocarriers in cancer therapy.In this contribution,we will capitalize on our recent development of finite supramolecular nanofibers based on the self-assembly of modularly designed cationic multidomain peptides(MDPs)and use them as a model system to investigate structure-dependent cell penetrating activity.MDPs selfassembled into nanofibers with high density of cationic charges at the fiber-solvent interface to interact with the cell membrane.However,despite the multivalent charge presentation,not all fibers led to high levels of membrane activity and cellular uptake.The flexibility of the cationic charge domains on self-assembled nanofibers plays a key role in effective membrane perturbation.Nanofibers were found to sacrifice their dimension,thermodynamic and kinetic stability for a more flexible charge domain in order to achieve effective membrane interaction.The increased membrane activity led to improved cell uptake of membrane-impermeable chemotherapeutics through membrane pore formation.In vitro cytotoxicity study showed co-administering of water-soluble doxorubicin with membrane-active peptide nanofibers dramatically reduced the IC50 by eight folds compared to drug alone.Through these detailed structure and activity studies,the acquired knowledge will provide important guidelines for the design of a variety of supramolecular cell penetrating nanomaterials not limited to peptide assembly which can be used to probe various complex biological processes.
