Objective:To explore the clinical application effect of autologous fat granule transplantation in facial depression plastic surgery.Methods:A total of 98 patients with facial depression admitted to the plastic surgery...Objective:To explore the clinical application effect of autologous fat granule transplantation in facial depression plastic surgery.Methods:A total of 98 patients with facial depression admitted to the plastic surgery department of our hospital from January 2021 to December 2023 were selected and divided into observation group(49 cases)and control group(49 cases)according to the random number table method.The observation group was treated with autologous fat granule transplantation,while the control group was treated with hyaluronic acid filling.The total effective rate of treatment,incidence of postoperative complications,improvement indicators of facial morphology(depth of depression,symmetry),and effect maintenance rate after 6 months of follow-up were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.88%(46/49),which was significantly higher than that in the control group(79.59%,39/49)(P<0.05).The incidence of postoperative complications in the observation group was 6.12%(3/49),which was lower than that in the control group(20.41%,10/49)(P<0.05).One month after surgery,the depth of depression(1.23±0.31 mm)and symmetry(1.02±0.15 points)in the observation group were better than those in the control group(P<0.05).After 6 months of follow-up,the effect maintenance rate in the observation group was 89.80%(44/49),which was significantly higher than that in the control group(67.35%,33/49)(P<0.05).Conclusion:Autologous fat granule transplantation for the treatment of facial depression can significantly improve facial morphology,enhance treatment effect and patient satisfaction,reduce the incidence of complications,and maintain a more durable effect.It is a clinically preferred facial depression plastic surgery solution.展开更多
BACKGROUND Post-operative massive hemorrhage is a critical concern in oral cancer surgery,associated with severe complications and heightened morbidity and mortality rates.CASE SUMMARY A 46-year-old male with advanced...BACKGROUND Post-operative massive hemorrhage is a critical concern in oral cancer surgery,associated with severe complications and heightened morbidity and mortality rates.CASE SUMMARY A 46-year-old male with advanced poorly differentiated squamous cell carcinoma(ypT4aN3bN0M0)of the oral floor underwent extensive surgery,including total glossectomy,partial mandibulectomy,and free flap reconstruction.Postoperatively,he developed life-threatening hemorrhage on day 3 due to wound dehiscence.Rapid nursing interventions-prompt suture removal,pressure hemostasis,and multidisciplinary collaboration-controlled bleeding.Postoperative care emphasized hemodynamic monitoring,infection prevention,and rehabilitation.Despite comorbidities(hypertension,diabetes,prior stroke),the patient achieved functional recovery:Oral flap epithelialization,restored swallowing(water swallow test:Grade 1),70% tongue mobility,and 80% preoperative chewing efficiency at 6-month follow-up.This case underscores the critical role of structured nursing protocols in managing postoperative hemorrhage and optimizing outcomes in high-risk oral cancer surgery.CONCLUSION This case report highlights the pivotal role of structured nursing interventions in managing life-threatening postoperative hemorrhage following complex oral cancer surgery.By integrating meticulous preoperative risk stratification,intraoperative hemostatic collaboration,and vigilant postoperative monitoring(e.g.,timely suture management,pressure hemostasis,blood product administration),the interdisciplinary team achieved rapid hemorrhage control.Comprehensive psychological care and rehabilitation protocols further facilitated functional recovery,enabling the patient to regain swallowing,speech,and mobility despite advanced disease and comorbidities.The findings underscore that standardized nursing workflows,balancing procedural rigor with holistic patient support,are essential for mitigating complications and enhancing outcomes in high-risk head and neck surgical populations.展开更多
The treatment of a 40-year-old woman with a giant fibroadenoma in her left breast is presented. The fibroadenoma measured 14 × 5 × 3 cm and weighed 170 g. We demonstrate that the surgical strategy and the re...The treatment of a 40-year-old woman with a giant fibroadenoma in her left breast is presented. The fibroadenoma measured 14 × 5 × 3 cm and weighed 170 g. We demonstrate that the surgical strategy and the reconstructive techniques in oncoplastic breast cancer surgery successfully can be applied to the treatment of these rare benign tumours improving the cosmetic and functional outcome.展开更多
BACKGROUND Endometrial cancer(EC)is a common gynecological malignancy,but metastasis to the abdominal wall is extremely rare.Therefore,an appropriate treatment approach for large metastatic lesions with infection rema...BACKGROUND Endometrial cancer(EC)is a common gynecological malignancy,but metastasis to the abdominal wall is extremely rare.Therefore,an appropriate treatment approach for large metastatic lesions with infection remains a great challenge.CASE SUMMARY We report the case of a 65-year-old woman who developed abdominal metastasis of endometrioid adenocarcinoma,as defined by International Obstetrics and Gynecology stage II,in which the lesion was complicated by infection.A right hemicolectomy was performed for colon metastasis in relation to her initial gynecological cancer 3 years ago.When admitted to our department,a complete resection of the giant abdominal wall lesion was performed,and a Bard composite mesh was used to reconstruct the abdominal wall.A local flap was used to close the resultant large defect in the external covering of the abdomen.The patient underwent chemotherapy following cytoreductive surgery.Pathology revealed metastasis of EC,and molecular subtyping showed copy number high of TP53 mutation,implying a poor prognosis.CONCLUSION When EC patients develop giant abdominal wall metastasis,a plastic surgeon should be included before contemplating resection of tumors.展开更多
This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived MSCs.Ophthalmic and oculoplastic surgery,encompassing diverse procedures for ocular ...This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived MSCs.Ophthalmic and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and aging.Investigating immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.展开更多
An increasing number of researchers have demonstrated that poloxamer 188(P188)can be used as a pharmaceutical excipient for clinical applications.Its membrane-sealing effects and inherent biological activities make it...An increasing number of researchers have demonstrated that poloxamer 188(P188)can be used as a pharmaceutical excipient for clinical applications.Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery.In this review,we summarize the positive roles of P188 in autologous fat grafting,wound healing,and cartilage transplantation.These roles include improving the survival rate of fat grafts and chondrocytes,stimulating the metabolic activity of adipocytes,promoting wound healing,and contributing to cartilage formation.Although further research is still needed,it is clear that P188 has great potential and application value in the field of plastic surgery.展开更多
The aging of the periocular region has always aroused great interest.A fresh,young,and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this result.In particular,...The aging of the periocular region has always aroused great interest.A fresh,young,and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this result.In particular,the change in the concept of a young look,considered then“full”,led to the increasing use of surgical(fat grafting)or medical(hyaluronic acid)filling techniques.Eyelid rejuvenation became increasingly popular in the field of cosmetic treatments,with a focus on achieving a youthful and refreshed appearance.Among the various techniques available,the choice between using fat grafting or fillers presented a clinical dilemma.In particular,what surgery considered of fundamental importance was a long-lasting result over time.On the other hand,aesthetic medicine considered it fundamental not to have to resort to invasive treatments.But what was the reality?Was there one path better than the other,and above all,was there a better path for patients?The minireview aims to explore the physiopathology,diagnosis,treatment options,prognosis,and future studies regarding this dilemma.We analyzed the literature produced in the last 20 years comparing the two techniques.Current literature reveals advancements in biomaterials,stem cell research and tissue engineering held promise for further enhancing the field of eyelid rejuvenation.The choice between fat grafting and fillers in eyelid cosmetic treatments presented a clinical dilemma.Understanding physiopathology,accurately diagnosing eyelid aging,exploring treatment options,assessing prognosis,and conducting future studies were essential for providing optimal care to patients seeking eyelid rejuvenation.展开更多
Autologous fat grafting is an increasingly popular technique in plastic surgery for volume augmentation and rejuvenation.However,the unpredictability of long-term volume retention limits its clinical application.Vario...Autologous fat grafting is an increasingly popular technique in plastic surgery for volume augmentation and rejuvenation.However,the unpredictability of long-term volume retention limits its clinical application.Various animal studies have documented the positive effects of adipose tissue-derived stem cells(ADSCs)on the acceleration of lipofilling.However,the results have been inconsistent,and there is an insufficient number of high-quality clinical studies to formulate evidence-based recommendations for ADSC-enriched fat grafts.Moreover,related technical standards,such as the final count of harvested ADSCs and the enrichment ratio,have not yet been established.This systematic review included all clinical trials on ADSC-enriched fat grafts in plastic surgery from PubMed in the past 10 years,as well as all registered clinical trials on ClinicalTrials.Gov.To examine the current landscape of ADSCs harvest,we summarize the current applications of ADSCs in the field of plastic surgery and discuss the current barriers to universal clinical use.展开更多
Objective: to analyze the application and clinical significance of early burn plastic surgery. Methods: Methods: 156 cases of burn and plastic surgery patients in my hospital who received early plastic surgery after 1...Objective: to analyze the application and clinical significance of early burn plastic surgery. Methods: Methods: 156 cases of burn and plastic surgery patients in my hospital who received early plastic surgery after 10 days were compared. The cases of two groups of patients who received early plastic surgery after 10 days were compared, and 102 cases of two groups of patients who received early plastic surgery after 10 days were compared. Results: The excellent and good rates of the short-term therapeutic effects in the experimental group after the operation reached 93.99% respectively;However, in the control group, the excellent and good rate of the recent treatment after the recent treatment reached 79.29% respectively, and the comparative difference between the two was statistically significant (P<0.05). During the long-term follow-up of the patients, no case in the experimental group may have significant scar and scar hyperplasia in the operation area, so it is required to complete the secondary operation, which is equivalent to the control group. Only 19 hands may have significant scar and scar, and need to undergo the secondary operation again. The occurrence rate has reached 13.57%. The difference between the two groups has certain data and statistical significance (P<0.05). Conclusion: For patients with severe hand burn and inflammation, early reconstructive surgery should be adopted. In principle, the necessary surgical treatment should be completed. Effective surgical treatment or ideal recovery of body function should be given accordingly, which can be popularized and applied in clinical practice.展开更多
Objective: to analyze the clinical effect of orthopedic surgery combined with 90Si-90Y radionuclide in the treatment of keloid. Methods: 76 keloid patients admitted from June 2018 to June 2019 were randomly divided in...Objective: to analyze the clinical effect of orthopedic surgery combined with 90Si-90Y radionuclide in the treatment of keloid. Methods: 76 keloid patients admitted from June 2018 to June 2019 were randomly divided into control group and observation group, with 38 patients in each group. The control group was treated with resection suture combined with 90Si-90Y radionuclide. Patients in the observation group underwent plastic surgery in addition to those in the control group, and scar scale scores related to treatment outcomes were statistically compared between the two groups. The scores of observation group were significantly lower than control group. The overall clinical effective rate was significantly higher than that of the control group, both of which had statistical significance (P < 0.05). Conclusion: the application of orthopedic surgery and 90Si-90Y radionuclide in keloid patients can effectively improve the clinical efficacy and has obvious application value.展开更多
Objective: to study the factors influencing the effect of plastic surgery and its preventive measures. Methods: during the period from January 2020 to January 2021, 200 cases of patients receiving plastic surgery in o...Objective: to study the factors influencing the effect of plastic surgery and its preventive measures. Methods: during the period from January 2020 to January 2021, 200 cases of patients receiving plastic surgery in our hospital were taken as the main objects of analysis. Retrospective analysis was conducted to find out the factors influencing the therapeutic effect of plastic surgery through the relevant data of surgery, and relevant preventive measures were put forward. Results: according to the analysis of satisfaction questionnaire, the probability of dissatisfaction among 200 patients was 28.57%. The main factors included high preoperative expectation of surgical effect, defects in preoperative design, improper intraoperative and post-operative operation, which led to some complications, and inappropriate material, model and specification of prosthesis during operation. After communication with the patients, the patients were given secondary repair surgery or follow-up treatment, and the results were basically satisfactory. Conclusion: through the analysis of the factors affecting the effect of plastic surgery, find out the relevant factors, through the relevant preventive measures, strengthen the professional skills of medical workers, and improve the correct cognitive awareness of patients and other measures, so that the operation effect is more significant.展开更多
BACKGROUND In rhinoplasty,calcification around silicone implants is frequently observed in the tip dorsum(TD)area.Additionally,based on a review of various literature,it is presumed that calcification in silicone impl...BACKGROUND In rhinoplasty,calcification around silicone implants is frequently observed in the tip dorsum(TD)area.Additionally,based on a review of various literature,it is presumed that calcification in silicone implants occurs due to both inflammatory chemical reactions and physical friction against the tissue.The calcification of nasal silicone implants not only results in the functional loss of the implants,but also leads to material deformation.However,there is a lack of research on calcification of nasal silicone implants in the current literature.AIM To elucidate various clinical characteristics of calcification around nasal silicone implants,using histological and radiological analysis.METHODS This study analyzed data from 16 patients of calcified nasal implants,who underwent revision rhinoplasty for various reasons after undergoing augmentation rhinoplasty with silicone implants.The collected data included information on implant duration,implant types,location of calcification,presence of inflammatory reactions,and computed tomography(CT)scans.RESULTS The most common location of calcification,as visually analyzed,was in the TD area,accounting for 56%.Additionally,the analysis of CT scans revealed a trend of increasing Hounsfield Unit values for calcification with the duration of implantation,although this trend was not statistically significant(P=0.139).CONCLUSION Our study shows that reducing the frequency of calcification may be achievable by using softer silicone implants and by minimizing the damage to perioperative tissues.展开更多
Apart from listening to the cry of a healthy newborn,it is the declaration by the attending paediatrician in the labour room that the child is normal which brings utmost joy to parents.The global incidence of children...Apart from listening to the cry of a healthy newborn,it is the declaration by the attending paediatrician in the labour room that the child is normal which brings utmost joy to parents.The global incidence of children born with congenital anomalies has been reported to be 3%-6%with more than 90%of these occurring in low-and middle-income group countries.The exact percentages/total numbers of children requiring surgical treatment cannot be estimated for several reasons.These children are operated under several surgical disciplines,viz,paediatric-,plastic reconstructive,neuro-,cardiothoracic-,orthopaedic surgery etc.These conditions may be life-threatening,e.g.,trachea-oesophageal fistula,critical pulmonary stenosis,etc.and require immediate surgical intervention.Some,e.g.,hydrocephalus,may need intervention as soon as the patient is fit for surgery.Some,e.g.,patent ductus arteriosus need‘wait and watch’policy up to a certain age in the hope of spontaneous recovery.Another extremely important category is that of patients where the operative intervention is done based on their age.Almost all the congenital anomalies coming under care of a plastic surgeon are operated as elective surgery(many as multiple stages of correction)at appropriate ages.There are advantages and disadvantages of intervention at different ages.In this article,we present a review of optimal timings,along with reasoning,for surgery of many of the common congenital anomalies which are treated by plastic surgeons.Obstetricians,paediatricians and general practitioners/family physicians,who most often are the first ones to come across such children,must know to guide the parents appropriately and convincingly impress upon the them as to why their child should not be operated immediately and also the consequences of too soon or too late.展开更多
BACKGROUND Ischemic heart disease(IHD)impacts the quality of life and has the highest mortality rate of cardiovascular diseases globally.AIM To compare variations in the parameters of the single-lead electrocardiogram...BACKGROUND Ischemic heart disease(IHD)impacts the quality of life and has the highest mortality rate of cardiovascular diseases globally.AIM To compare variations in the parameters of the single-lead electrocardiogram(ECG)during resting conditions and physical exertion in individuals diagnosed with IHD and those without the condition using vasodilator-induced stress computed tomography(CT)myocardial perfusion imaging as the diagnostic reference standard.METHODS This single center observational study included 80 participants.The participants were aged≥40 years and given an informed written consent to participate in the study.Both groups,G1(n=31)with and G2(n=49)without post stress induced myocardial perfusion defect,passed cardiologist consultation,anthropometric measurements,blood pressure and pulse rate measurement,echocardiography,cardio-ankle vascular index,bicycle ergometry,recording 3-min single-lead ECG(Cardio-Qvark)before and just after bicycle ergometry followed by performing CT myocardial perfusion.The LASSO regression with nested cross-validation was used to find the association between Cardio-Qvark parameters and the existence of the perfusion defect.Statistical processing was performed with the R programming language v4.2,Python v.3.10[^R],and Statistica 12 program.RESULTS Bicycle ergometry yielded an area under the receiver operating characteristic curve of 50.7%[95%confidence interval(CI):0.388-0.625],specificity of 53.1%(95%CI:0.392-0.673),and sensitivity of 48.4%(95%CI:0.306-0.657).In contrast,the Cardio-Qvark test performed notably better with an area under the receiver operating characteristic curve of 67%(95%CI:0.530-0.801),specificity of 75.5%(95%CI:0.628-0.88),and sensitivity of 51.6%(95%CI:0.333-0.695).CONCLUSION The single-lead ECG has a relatively higher diagnostic accuracy compared with bicycle ergometry by using machine learning models,but the difference was not statistically significant.However,further investigations are required to uncover the hidden capabilities of single-lead ECG in IHD diagnosis.展开更多
Increased matrix stiffness of nucleus pulposus(NP)tissue is a main feature of intervertebral disc degeneration(IVDD)and affects various functions of nucleus pulposus cells(NPCs).Glycolysis is the main energy source fo...Increased matrix stiffness of nucleus pulposus(NP)tissue is a main feature of intervertebral disc degeneration(IVDD)and affects various functions of nucleus pulposus cells(NPCs).Glycolysis is the main energy source for NPC survival,but the effects and underlying mechanisms of increased extracellular matrix(ECM)stiffness on NPC glycolysis remain unknown.In this study,hydrogels with different stiffness were established to mimic the mechanical environment of NPCs.Notably,increased matrix stiffness in degenerated NP tissues from IVDD patients was accompanied with impaired glycolysis,and NPCs cultured on rigid substrates exhibited a reduction in glycolysis.展开更多
Magnesium-based materials,including magnesium alloys,have emerged as a promising class of biodegradable materials with potential applications in cancer therapy due to their unique properties,including biocompatibility...Magnesium-based materials,including magnesium alloys,have emerged as a promising class of biodegradable materials with potential applications in cancer therapy due to their unique properties,including biocompatibility,biodegradability,and the ability to modulate the tumor microenvironment.The main degradation products of magnesium alloys are magnesium ions(Mg^(2+)),hydrogen(H_(2)),and magnesium hydroxide(Mg(OH)_(2)).Magnesium ions can regulate tumor growth and metastasis by mediating the inflammatory response and oxidative stress,maintaining genomic stability,and affecting the tumor microenvironment.Similarly,hydrogen can inhibit tumorigenesis through antioxidant and anti-inflammatory properties.Moreover,Mg(OH)_(2) can alter the pH of the microenvironment,impacting tumorigenesis.Biodegradable magnesium alloys serve various functions in clinical applications,including,but not limited to,bonefixation,coronary stents,and drug carriers.Nonetheless,the anti-tumor mechanism associated with magnesium-based materials has not been thoroughly investigated.This review provides a comprehensive overview of the current state of magnesium-based therapies for cancer.It highlights the mechanisms of action,identifies the challenges that must be addressed,and discusses prospects for oncological applications.展开更多
BACKGROUND Pain often predisposes patients with diabetic foot ulcers(DFUs)to negative emotional states,such as anxiety and depression,which can significantly impair treatment outcomes and recovery.However,very few stu...BACKGROUND Pain often predisposes patients with diabetic foot ulcers(DFUs)to negative emotional states,such as anxiety and depression,which can significantly impair treatment outcomes and recovery.However,very few studies have explored the relationship between anxiety,depression,and pain in DFUs,as well as the associated risk factors.AIM To analyze the correlation between anxiety,depression,and pain in patients with DFUs and to identify the associated risk factors.METHODS This study included 106 patients diagnosed with DFUs who were admitted to Tiantai County People’s Hospital between March 2022 and March 2024.The patients’anxiety levels were evaluated using Zung’s self-rating anxiety scale(SAS),depression status was assessed using Zung’s self-rating depression scale(SDS),and pain intensity was assessed using the visual analog scale(VAS).Subsequently,correlations between SAS,SDS,and VAS scores were analyzed.Univariate and multivariate analyses were conducted to explore the risk factors that contributed to anxiety and depression in patients with DFUs.RESULTS Among the 106 patients,39.62%exhibited anxiety and 43.40%presented with depression.Most patients experiencing anxiety or depression exhibited mild symptoms,with no severe cases observed.Compared with asymptomatic patients,those with anxiety or depression had significantly higher VAS scores.Correlation analysis indicated a significant positive relationship between both SAS and SDS scores and the VAS score.Univariate analysis identified sex,age,Wagner’s grade,presence of other complications,and smoking history as factors significantly associated with anxiety and depression.Multivariate analysis further confirmed that younger age,higher Wagner’s grade,and higher VAS scores were independent predictors of anxiety and depression.CONCLUSION This study reveals a significant positive correlation between anxiety,depression,and pain in patients with DFUs.This finding suggests that timely and effective pain intervention may be beneficial in alleviating negative emotions such as anxiety and depression.In addition,younger age(<50 years),higher Wagner’s grade,and higher VAS scores increase the risk of developing anxiety and depression in this patient population.展开更多
BACKGROUND The Turkish Delight technique,initially described by Erol in 2000,involves the use of diced cartilage wrapped in oxidized cellulose(Surgicel^(TM))for nasal grafting in secondary rhinoplasty.CASE SUMMARY Thi...BACKGROUND The Turkish Delight technique,initially described by Erol in 2000,involves the use of diced cartilage wrapped in oxidized cellulose(Surgicel^(TM))for nasal grafting in secondary rhinoplasty.CASE SUMMARY This paper presents a novel adaptation called Diced Cartilage in Capsula,where diced cartilage is wrapped in the periprosthetic capsule material formed from a previous breast augmentation procedure instead of fascia,a technique based on the Diced Cartilage in Fascia method.Utilizing autologous,biocompatible material minimizes foreign body reactions and enhances graft integration.This innovative approach demonstrates the potential for specific practices in cosmetic surgery by optimizing patient-specific resources and improving surgical outcomes.CONCLUSION The report compares traditional Turkish Delight applications with this new method,discussing biocompatibility,technique efficacy,and benefits in rhinoplasty.展开更多
Poland syndrome(PS)is a rare congenital condition characterized by unilateral absence or underdevelopment of the pectoralis major muscle,frequently accompanied by breast and chest wall anomalies.We report the case of ...Poland syndrome(PS)is a rare congenital condition characterized by unilateral absence or underdevelopment of the pectoralis major muscle,frequently accompanied by breast and chest wall anomalies.We report the case of an 18-year-old Chinese female diagnosed with PS complicated by contralateral macromastia who presented with significant breast asymmetry.Magnetic resonance imaging revealed a left breast volume of 618.90 mL and a right breast volume of 1137.04 mL.The patient underwent a staged reconstruction that included a right breast reduction mammaplasty and three sessions of autologous fat grafting to the left breast.Postoperative imaging 3 months after the final procedure confirmed near symmetry,with volumes measuring 831.37 mL(left)and 841.07 mL(right).The clinical follow-up demonstrated stable results and no complications.This case underscores the importance of individualized surgical planning,precise volumetric assessment,and the role of fat grafting in achieving satisfactory aesthetic outcomes in patients with PS and complex breast deformities.展开更多
This editorial underscores the importance of Maranhão et al’s study,which investigates pleural adenosine deaminase(P-ADA)as a biomarker for inflammatory pleural effusions.Despite advances in imaging,distinguishi...This editorial underscores the importance of Maranhão et al’s study,which investigates pleural adenosine deaminase(P-ADA)as a biomarker for inflammatory pleural effusions.Despite advances in imaging,distinguishing between inflammatory and non-inflammatory causes of pleural effusion remains a diagnostic challenge.The authors conducted a rigorous retrospective cohort analysis of 157 patients(124 with inflammatory exudates and 33 with non-inflammatory transudates),establishing a robust cutoff value of P-ADA≥9.00 U/L for diagnosing inflammatory diseases using receiver operating characteristic curve analysis and internal statistical calibration.This is the first study to define a standardized PADA threshold in a Brazilian cohort,addressing previous inconsistencies in cutoff values.Furthermore,the authors delved into the pathophysiological mechanisms underlying elevated P-ADA,linking it to purinergic signaling pathways and immune cell activation,particularly emphasizing the role of ADA2 isoforms in macrophages and lymphocytes.Their findings support P-ADA as a non-invasive,cost-effective biomarker for early diagnosis,treatment stratification,and minimizing the need for invasive procedures such as thoracentesis.This has particular relevance in resource-limited settings,where streamlined diagnostics can reduce healthcare costs and improve patient outcomes.Future studies must prioritize global validation,explore the integration of adenosine deaminase with additional biomarkers(e.g.,interleukin 6,C-reactive protein),and support the development of point-of-care technologies.展开更多
文摘Objective:To explore the clinical application effect of autologous fat granule transplantation in facial depression plastic surgery.Methods:A total of 98 patients with facial depression admitted to the plastic surgery department of our hospital from January 2021 to December 2023 were selected and divided into observation group(49 cases)and control group(49 cases)according to the random number table method.The observation group was treated with autologous fat granule transplantation,while the control group was treated with hyaluronic acid filling.The total effective rate of treatment,incidence of postoperative complications,improvement indicators of facial morphology(depth of depression,symmetry),and effect maintenance rate after 6 months of follow-up were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.88%(46/49),which was significantly higher than that in the control group(79.59%,39/49)(P<0.05).The incidence of postoperative complications in the observation group was 6.12%(3/49),which was lower than that in the control group(20.41%,10/49)(P<0.05).One month after surgery,the depth of depression(1.23±0.31 mm)and symmetry(1.02±0.15 points)in the observation group were better than those in the control group(P<0.05).After 6 months of follow-up,the effect maintenance rate in the observation group was 89.80%(44/49),which was significantly higher than that in the control group(67.35%,33/49)(P<0.05).Conclusion:Autologous fat granule transplantation for the treatment of facial depression can significantly improve facial morphology,enhance treatment effect and patient satisfaction,reduce the incidence of complications,and maintain a more durable effect.It is a clinically preferred facial depression plastic surgery solution.
基金Supported by the First Batch of 2024 Social Welfare and Basic Research Projects in Zhongshan City(General Projects in the Field of Healthcare),No.2024B1100Guangdong Provincial Administration of Traditional Chinese Medicine,No.20241357.
文摘BACKGROUND Post-operative massive hemorrhage is a critical concern in oral cancer surgery,associated with severe complications and heightened morbidity and mortality rates.CASE SUMMARY A 46-year-old male with advanced poorly differentiated squamous cell carcinoma(ypT4aN3bN0M0)of the oral floor underwent extensive surgery,including total glossectomy,partial mandibulectomy,and free flap reconstruction.Postoperatively,he developed life-threatening hemorrhage on day 3 due to wound dehiscence.Rapid nursing interventions-prompt suture removal,pressure hemostasis,and multidisciplinary collaboration-controlled bleeding.Postoperative care emphasized hemodynamic monitoring,infection prevention,and rehabilitation.Despite comorbidities(hypertension,diabetes,prior stroke),the patient achieved functional recovery:Oral flap epithelialization,restored swallowing(water swallow test:Grade 1),70% tongue mobility,and 80% preoperative chewing efficiency at 6-month follow-up.This case underscores the critical role of structured nursing protocols in managing postoperative hemorrhage and optimizing outcomes in high-risk oral cancer surgery.CONCLUSION This case report highlights the pivotal role of structured nursing interventions in managing life-threatening postoperative hemorrhage following complex oral cancer surgery.By integrating meticulous preoperative risk stratification,intraoperative hemostatic collaboration,and vigilant postoperative monitoring(e.g.,timely suture management,pressure hemostasis,blood product administration),the interdisciplinary team achieved rapid hemorrhage control.Comprehensive psychological care and rehabilitation protocols further facilitated functional recovery,enabling the patient to regain swallowing,speech,and mobility despite advanced disease and comorbidities.The findings underscore that standardized nursing workflows,balancing procedural rigor with holistic patient support,are essential for mitigating complications and enhancing outcomes in high-risk head and neck surgical populations.
文摘The treatment of a 40-year-old woman with a giant fibroadenoma in her left breast is presented. The fibroadenoma measured 14 × 5 × 3 cm and weighed 170 g. We demonstrate that the surgical strategy and the reconstructive techniques in oncoplastic breast cancer surgery successfully can be applied to the treatment of these rare benign tumours improving the cosmetic and functional outcome.
基金the National Key Technology R&D Program of China,No.2019YFC1005200,and No.2019YFC1005201the Natural Science Foundation of Beijing,No.7202213+1 种基金the National Natural Science Foundation of ChinaNo. 82072861, 81672571, and 81874108.
文摘BACKGROUND Endometrial cancer(EC)is a common gynecological malignancy,but metastasis to the abdominal wall is extremely rare.Therefore,an appropriate treatment approach for large metastatic lesions with infection remains a great challenge.CASE SUMMARY We report the case of a 65-year-old woman who developed abdominal metastasis of endometrioid adenocarcinoma,as defined by International Obstetrics and Gynecology stage II,in which the lesion was complicated by infection.A right hemicolectomy was performed for colon metastasis in relation to her initial gynecological cancer 3 years ago.When admitted to our department,a complete resection of the giant abdominal wall lesion was performed,and a Bard composite mesh was used to reconstruct the abdominal wall.A local flap was used to close the resultant large defect in the external covering of the abdomen.The patient underwent chemotherapy following cytoreductive surgery.Pathology revealed metastasis of EC,and molecular subtyping showed copy number high of TP53 mutation,implying a poor prognosis.CONCLUSION When EC patients develop giant abdominal wall metastasis,a plastic surgeon should be included before contemplating resection of tumors.
文摘This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived MSCs.Ophthalmic and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and aging.Investigating immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.
基金The study was supported by the Scientific Research Staring Foundation for the Returned Overseas Chinese Scholars of the Peking University Third Hospital(grant no.BYSYLXHG2019001).
文摘An increasing number of researchers have demonstrated that poloxamer 188(P188)can be used as a pharmaceutical excipient for clinical applications.Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery.In this review,we summarize the positive roles of P188 in autologous fat grafting,wound healing,and cartilage transplantation.These roles include improving the survival rate of fat grafts and chondrocytes,stimulating the metabolic activity of adipocytes,promoting wound healing,and contributing to cartilage formation.Although further research is still needed,it is clear that P188 has great potential and application value in the field of plastic surgery.
文摘The aging of the periocular region has always aroused great interest.A fresh,young,and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this result.In particular,the change in the concept of a young look,considered then“full”,led to the increasing use of surgical(fat grafting)or medical(hyaluronic acid)filling techniques.Eyelid rejuvenation became increasingly popular in the field of cosmetic treatments,with a focus on achieving a youthful and refreshed appearance.Among the various techniques available,the choice between using fat grafting or fillers presented a clinical dilemma.In particular,what surgery considered of fundamental importance was a long-lasting result over time.On the other hand,aesthetic medicine considered it fundamental not to have to resort to invasive treatments.But what was the reality?Was there one path better than the other,and above all,was there a better path for patients?The minireview aims to explore the physiopathology,diagnosis,treatment options,prognosis,and future studies regarding this dilemma.We analyzed the literature produced in the last 20 years comparing the two techniques.Current literature reveals advancements in biomaterials,stem cell research and tissue engineering held promise for further enhancing the field of eyelid rejuvenation.The choice between fat grafting and fillers in eyelid cosmetic treatments presented a clinical dilemma.Understanding physiopathology,accurately diagnosing eyelid aging,exploring treatment options,assessing prognosis,and conducting future studies were essential for providing optimal care to patients seeking eyelid rejuvenation.
文摘Autologous fat grafting is an increasingly popular technique in plastic surgery for volume augmentation and rejuvenation.However,the unpredictability of long-term volume retention limits its clinical application.Various animal studies have documented the positive effects of adipose tissue-derived stem cells(ADSCs)on the acceleration of lipofilling.However,the results have been inconsistent,and there is an insufficient number of high-quality clinical studies to formulate evidence-based recommendations for ADSC-enriched fat grafts.Moreover,related technical standards,such as the final count of harvested ADSCs and the enrichment ratio,have not yet been established.This systematic review included all clinical trials on ADSC-enriched fat grafts in plastic surgery from PubMed in the past 10 years,as well as all registered clinical trials on ClinicalTrials.Gov.To examine the current landscape of ADSCs harvest,we summarize the current applications of ADSCs in the field of plastic surgery and discuss the current barriers to universal clinical use.
文摘Objective: to analyze the application and clinical significance of early burn plastic surgery. Methods: Methods: 156 cases of burn and plastic surgery patients in my hospital who received early plastic surgery after 10 days were compared. The cases of two groups of patients who received early plastic surgery after 10 days were compared, and 102 cases of two groups of patients who received early plastic surgery after 10 days were compared. Results: The excellent and good rates of the short-term therapeutic effects in the experimental group after the operation reached 93.99% respectively;However, in the control group, the excellent and good rate of the recent treatment after the recent treatment reached 79.29% respectively, and the comparative difference between the two was statistically significant (P<0.05). During the long-term follow-up of the patients, no case in the experimental group may have significant scar and scar hyperplasia in the operation area, so it is required to complete the secondary operation, which is equivalent to the control group. Only 19 hands may have significant scar and scar, and need to undergo the secondary operation again. The occurrence rate has reached 13.57%. The difference between the two groups has certain data and statistical significance (P<0.05). Conclusion: For patients with severe hand burn and inflammation, early reconstructive surgery should be adopted. In principle, the necessary surgical treatment should be completed. Effective surgical treatment or ideal recovery of body function should be given accordingly, which can be popularized and applied in clinical practice.
文摘Objective: to analyze the clinical effect of orthopedic surgery combined with 90Si-90Y radionuclide in the treatment of keloid. Methods: 76 keloid patients admitted from June 2018 to June 2019 were randomly divided into control group and observation group, with 38 patients in each group. The control group was treated with resection suture combined with 90Si-90Y radionuclide. Patients in the observation group underwent plastic surgery in addition to those in the control group, and scar scale scores related to treatment outcomes were statistically compared between the two groups. The scores of observation group were significantly lower than control group. The overall clinical effective rate was significantly higher than that of the control group, both of which had statistical significance (P < 0.05). Conclusion: the application of orthopedic surgery and 90Si-90Y radionuclide in keloid patients can effectively improve the clinical efficacy and has obvious application value.
文摘Objective: to study the factors influencing the effect of plastic surgery and its preventive measures. Methods: during the period from January 2020 to January 2021, 200 cases of patients receiving plastic surgery in our hospital were taken as the main objects of analysis. Retrospective analysis was conducted to find out the factors influencing the therapeutic effect of plastic surgery through the relevant data of surgery, and relevant preventive measures were put forward. Results: according to the analysis of satisfaction questionnaire, the probability of dissatisfaction among 200 patients was 28.57%. The main factors included high preoperative expectation of surgical effect, defects in preoperative design, improper intraoperative and post-operative operation, which led to some complications, and inappropriate material, model and specification of prosthesis during operation. After communication with the patients, the patients were given secondary repair surgery or follow-up treatment, and the results were basically satisfactory. Conclusion: through the analysis of the factors affecting the effect of plastic surgery, find out the relevant factors, through the relevant preventive measures, strengthen the professional skills of medical workers, and improve the correct cognitive awareness of patients and other measures, so that the operation effect is more significant.
基金Supported by The Soonchunhyang University Research Fund,No.2024-0022.
文摘BACKGROUND In rhinoplasty,calcification around silicone implants is frequently observed in the tip dorsum(TD)area.Additionally,based on a review of various literature,it is presumed that calcification in silicone implants occurs due to both inflammatory chemical reactions and physical friction against the tissue.The calcification of nasal silicone implants not only results in the functional loss of the implants,but also leads to material deformation.However,there is a lack of research on calcification of nasal silicone implants in the current literature.AIM To elucidate various clinical characteristics of calcification around nasal silicone implants,using histological and radiological analysis.METHODS This study analyzed data from 16 patients of calcified nasal implants,who underwent revision rhinoplasty for various reasons after undergoing augmentation rhinoplasty with silicone implants.The collected data included information on implant duration,implant types,location of calcification,presence of inflammatory reactions,and computed tomography(CT)scans.RESULTS The most common location of calcification,as visually analyzed,was in the TD area,accounting for 56%.Additionally,the analysis of CT scans revealed a trend of increasing Hounsfield Unit values for calcification with the duration of implantation,although this trend was not statistically significant(P=0.139).CONCLUSION Our study shows that reducing the frequency of calcification may be achievable by using softer silicone implants and by minimizing the damage to perioperative tissues.
文摘Apart from listening to the cry of a healthy newborn,it is the declaration by the attending paediatrician in the labour room that the child is normal which brings utmost joy to parents.The global incidence of children born with congenital anomalies has been reported to be 3%-6%with more than 90%of these occurring in low-and middle-income group countries.The exact percentages/total numbers of children requiring surgical treatment cannot be estimated for several reasons.These children are operated under several surgical disciplines,viz,paediatric-,plastic reconstructive,neuro-,cardiothoracic-,orthopaedic surgery etc.These conditions may be life-threatening,e.g.,trachea-oesophageal fistula,critical pulmonary stenosis,etc.and require immediate surgical intervention.Some,e.g.,hydrocephalus,may need intervention as soon as the patient is fit for surgery.Some,e.g.,patent ductus arteriosus need‘wait and watch’policy up to a certain age in the hope of spontaneous recovery.Another extremely important category is that of patients where the operative intervention is done based on their age.Almost all the congenital anomalies coming under care of a plastic surgeon are operated as elective surgery(many as multiple stages of correction)at appropriate ages.There are advantages and disadvantages of intervention at different ages.In this article,we present a review of optimal timings,along with reasoning,for surgery of many of the common congenital anomalies which are treated by plastic surgeons.Obstetricians,paediatricians and general practitioners/family physicians,who most often are the first ones to come across such children,must know to guide the parents appropriately and convincingly impress upon the them as to why their child should not be operated immediately and also the consequences of too soon or too late.
基金Supported by Government Assignment,No.1023022600020-6RSF Grant,No.24-15-00549Ministry of Science and Higher Education of the Russian Federation within the Framework of State Support for the Creation and Development of World-Class Research Center,No.075-15-2022-304.
文摘BACKGROUND Ischemic heart disease(IHD)impacts the quality of life and has the highest mortality rate of cardiovascular diseases globally.AIM To compare variations in the parameters of the single-lead electrocardiogram(ECG)during resting conditions and physical exertion in individuals diagnosed with IHD and those without the condition using vasodilator-induced stress computed tomography(CT)myocardial perfusion imaging as the diagnostic reference standard.METHODS This single center observational study included 80 participants.The participants were aged≥40 years and given an informed written consent to participate in the study.Both groups,G1(n=31)with and G2(n=49)without post stress induced myocardial perfusion defect,passed cardiologist consultation,anthropometric measurements,blood pressure and pulse rate measurement,echocardiography,cardio-ankle vascular index,bicycle ergometry,recording 3-min single-lead ECG(Cardio-Qvark)before and just after bicycle ergometry followed by performing CT myocardial perfusion.The LASSO regression with nested cross-validation was used to find the association between Cardio-Qvark parameters and the existence of the perfusion defect.Statistical processing was performed with the R programming language v4.2,Python v.3.10[^R],and Statistica 12 program.RESULTS Bicycle ergometry yielded an area under the receiver operating characteristic curve of 50.7%[95%confidence interval(CI):0.388-0.625],specificity of 53.1%(95%CI:0.392-0.673),and sensitivity of 48.4%(95%CI:0.306-0.657).In contrast,the Cardio-Qvark test performed notably better with an area under the receiver operating characteristic curve of 67%(95%CI:0.530-0.801),specificity of 75.5%(95%CI:0.628-0.88),and sensitivity of 51.6%(95%CI:0.333-0.695).CONCLUSION The single-lead ECG has a relatively higher diagnostic accuracy compared with bicycle ergometry by using machine learning models,but the difference was not statistically significant.However,further investigations are required to uncover the hidden capabilities of single-lead ECG in IHD diagnosis.
基金supported by the National Nature Science Foundation of China(No.82002345 to J.D and 81902179 to L.S)the Gusu Talent Program(No.Qngg2022008 and GSWS2021027 to J.D)the Preliminary Research Project of the Second Affiliated Hospital of Soochow University(No.SDFEYBS1905 to J.D).
文摘Increased matrix stiffness of nucleus pulposus(NP)tissue is a main feature of intervertebral disc degeneration(IVDD)and affects various functions of nucleus pulposus cells(NPCs).Glycolysis is the main energy source for NPC survival,but the effects and underlying mechanisms of increased extracellular matrix(ECM)stiffness on NPC glycolysis remain unknown.In this study,hydrogels with different stiffness were established to mimic the mechanical environment of NPCs.Notably,increased matrix stiffness in degenerated NP tissues from IVDD patients was accompanied with impaired glycolysis,and NPCs cultured on rigid substrates exhibited a reduction in glycolysis.
文摘Magnesium-based materials,including magnesium alloys,have emerged as a promising class of biodegradable materials with potential applications in cancer therapy due to their unique properties,including biocompatibility,biodegradability,and the ability to modulate the tumor microenvironment.The main degradation products of magnesium alloys are magnesium ions(Mg^(2+)),hydrogen(H_(2)),and magnesium hydroxide(Mg(OH)_(2)).Magnesium ions can regulate tumor growth and metastasis by mediating the inflammatory response and oxidative stress,maintaining genomic stability,and affecting the tumor microenvironment.Similarly,hydrogen can inhibit tumorigenesis through antioxidant and anti-inflammatory properties.Moreover,Mg(OH)_(2) can alter the pH of the microenvironment,impacting tumorigenesis.Biodegradable magnesium alloys serve various functions in clinical applications,including,but not limited to,bonefixation,coronary stents,and drug carriers.Nonetheless,the anti-tumor mechanism associated with magnesium-based materials has not been thoroughly investigated.This review provides a comprehensive overview of the current state of magnesium-based therapies for cancer.It highlights the mechanisms of action,identifies the challenges that must be addressed,and discusses prospects for oncological applications.
文摘BACKGROUND Pain often predisposes patients with diabetic foot ulcers(DFUs)to negative emotional states,such as anxiety and depression,which can significantly impair treatment outcomes and recovery.However,very few studies have explored the relationship between anxiety,depression,and pain in DFUs,as well as the associated risk factors.AIM To analyze the correlation between anxiety,depression,and pain in patients with DFUs and to identify the associated risk factors.METHODS This study included 106 patients diagnosed with DFUs who were admitted to Tiantai County People’s Hospital between March 2022 and March 2024.The patients’anxiety levels were evaluated using Zung’s self-rating anxiety scale(SAS),depression status was assessed using Zung’s self-rating depression scale(SDS),and pain intensity was assessed using the visual analog scale(VAS).Subsequently,correlations between SAS,SDS,and VAS scores were analyzed.Univariate and multivariate analyses were conducted to explore the risk factors that contributed to anxiety and depression in patients with DFUs.RESULTS Among the 106 patients,39.62%exhibited anxiety and 43.40%presented with depression.Most patients experiencing anxiety or depression exhibited mild symptoms,with no severe cases observed.Compared with asymptomatic patients,those with anxiety or depression had significantly higher VAS scores.Correlation analysis indicated a significant positive relationship between both SAS and SDS scores and the VAS score.Univariate analysis identified sex,age,Wagner’s grade,presence of other complications,and smoking history as factors significantly associated with anxiety and depression.Multivariate analysis further confirmed that younger age,higher Wagner’s grade,and higher VAS scores were independent predictors of anxiety and depression.CONCLUSION This study reveals a significant positive correlation between anxiety,depression,and pain in patients with DFUs.This finding suggests that timely and effective pain intervention may be beneficial in alleviating negative emotions such as anxiety and depression.In addition,younger age(<50 years),higher Wagner’s grade,and higher VAS scores increase the risk of developing anxiety and depression in this patient population.
文摘BACKGROUND The Turkish Delight technique,initially described by Erol in 2000,involves the use of diced cartilage wrapped in oxidized cellulose(Surgicel^(TM))for nasal grafting in secondary rhinoplasty.CASE SUMMARY This paper presents a novel adaptation called Diced Cartilage in Capsula,where diced cartilage is wrapped in the periprosthetic capsule material formed from a previous breast augmentation procedure instead of fascia,a technique based on the Diced Cartilage in Fascia method.Utilizing autologous,biocompatible material minimizes foreign body reactions and enhances graft integration.This innovative approach demonstrates the potential for specific practices in cosmetic surgery by optimizing patient-specific resources and improving surgical outcomes.CONCLUSION The report compares traditional Turkish Delight applications with this new method,discussing biocompatibility,technique efficacy,and benefits in rhinoplasty.
文摘Poland syndrome(PS)is a rare congenital condition characterized by unilateral absence or underdevelopment of the pectoralis major muscle,frequently accompanied by breast and chest wall anomalies.We report the case of an 18-year-old Chinese female diagnosed with PS complicated by contralateral macromastia who presented with significant breast asymmetry.Magnetic resonance imaging revealed a left breast volume of 618.90 mL and a right breast volume of 1137.04 mL.The patient underwent a staged reconstruction that included a right breast reduction mammaplasty and three sessions of autologous fat grafting to the left breast.Postoperative imaging 3 months after the final procedure confirmed near symmetry,with volumes measuring 831.37 mL(left)and 841.07 mL(right).The clinical follow-up demonstrated stable results and no complications.This case underscores the importance of individualized surgical planning,precise volumetric assessment,and the role of fat grafting in achieving satisfactory aesthetic outcomes in patients with PS and complex breast deformities.
文摘This editorial underscores the importance of Maranhão et al’s study,which investigates pleural adenosine deaminase(P-ADA)as a biomarker for inflammatory pleural effusions.Despite advances in imaging,distinguishing between inflammatory and non-inflammatory causes of pleural effusion remains a diagnostic challenge.The authors conducted a rigorous retrospective cohort analysis of 157 patients(124 with inflammatory exudates and 33 with non-inflammatory transudates),establishing a robust cutoff value of P-ADA≥9.00 U/L for diagnosing inflammatory diseases using receiver operating characteristic curve analysis and internal statistical calibration.This is the first study to define a standardized PADA threshold in a Brazilian cohort,addressing previous inconsistencies in cutoff values.Furthermore,the authors delved into the pathophysiological mechanisms underlying elevated P-ADA,linking it to purinergic signaling pathways and immune cell activation,particularly emphasizing the role of ADA2 isoforms in macrophages and lymphocytes.Their findings support P-ADA as a non-invasive,cost-effective biomarker for early diagnosis,treatment stratification,and minimizing the need for invasive procedures such as thoracentesis.This has particular relevance in resource-limited settings,where streamlined diagnostics can reduce healthcare costs and improve patient outcomes.Future studies must prioritize global validation,explore the integration of adenosine deaminase with additional biomarkers(e.g.,interleukin 6,C-reactive protein),and support the development of point-of-care technologies.
