Restructuring of power market not only introduces competition but also brings complexity which increases overloading of Transmission Lines(TL).To obviate this complexity,this paper aims to mitigate the overloading and...Restructuring of power market not only introduces competition but also brings complexity which increases overloading of Transmission Lines(TL).To obviate this complexity,this paper aims to mitigate the overloading and estimate the optimal location of Static Synchronous Compensator(STATCOM) by reducing congestion for a deregulated power system.The proposed method is based on the use of Locational Marginal Price(LMP) difference technique and congestion cost.LMPs are obtained as a by-product of Optimal Power Flow(OPF),whereas Congestion Cost(CC) is a function of difference in LMP and power flows.The effiectiveness of this approach is demonstrated by reducing the CC and solution space which can identify the TLs more suitable for placement of STATCOM.Importantly,total real power loss,reactive power loss and total CC are the three main objective functions in this optimization process.The process is implemented by developing an IEEE-69 bus test system which verifies and validates the effectiveness of proposed optimization technique.Additionally,a comparative analysis is enumerated by implementing two optimization techniques:Flower Pollination Algorithm(FPA) and Particle Swarm Optimization(PSO).The comparative analysis is sufficient to demonstrate the superiority of FPA technique over PSO technique in estimating an optimal placement of a STATCOM.The results from the load-flow analysis illustrate the reduction in CC,total real and reactive power loss using FPA technique compared to PSO technique.Overall,satisfactory results are obtained without using complex calculations which verify the effectiveness of optimization techniques.展开更多
BACKGROUND Listening to music has been shown to reduce pain and anxiety before,during,and after invasive coronary procedures.AIM To perform a systematic review and meta-analysis to explore the effect of therapeutic us...BACKGROUND Listening to music has been shown to reduce pain and anxiety before,during,and after invasive coronary procedures.AIM To perform a systematic review and meta-analysis to explore the effect of therapeutic use of music on both,perioperative and postoperative outcomes of invasive coronary procedures.METHODS An exhaustive literature search of 3 electronic databases(MEDLINE,Scopus,Cochrane CENTRAL)was conducted from inception until 10th December 2023.The results of our analyses are presented as standard mean difference(SMD)or weighted mean difference,with 95%CI and pooled using a random effects model.A P value<0.05 was considered significant in all cases.RESULTS From 21 studies,2141 participants were included in our analysis.The pooled analysis demonstrated that music listening significantly improves post-procedural pain(SMD=-0.78,95%CI:-1.34 to-0.23;P=0.006),anxiety(SMD=-0.86,95%CI:-1.43 to-0.29;P=0.003),heart rate[mean difference(MD)=-3.38,95%CI:-5.51 to-1.25;P=0.002],and systolic blood pressure(MD=-5.89,95%CI:-9.75 to-2.02;P=0.003).There was no significant improvement in diastolic blood pressure(MD=-3.22,95%CI:-6.58 to 0.14;P=0.06)or respiratory rate(MD=-0.97,95%CI:-1.98 to 0.03;P=0.06).CONCLUSION Music listening can be used in healthcare settings for patients undergoing invasive coronary procedures to reduce anxiety levels and improve their physiological parameters.展开更多
Cancer,a leading cause of global mortality,remains a significant challenge to increasing life expectancy worldwide.Forkhead Box R2(FOXR2),identified as an oncogene within the FOX gene family,plays a crucial role in de...Cancer,a leading cause of global mortality,remains a significant challenge to increasing life expectancy worldwide.Forkhead Box R2(FOXR2),identified as an oncogene within the FOX gene family,plays a crucial role in developing various endoderm-derived organs.Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases.Dysregulation of FOXR2 has been linked to numerous malignant tumors,spanning the brain,nervous system,thyroid,osteosarcoma,Hodgkin lymphoma,colorectal,liver,pancreatic,lung,breast,ovarian,prostate,female genital tract,endometrial,and uterine cancers.Despite extensive research on FOXR2 dysregulation,its practical applications remain underexplored.This review delves into the mechanisms underlying FOXR2 dysregulation during oncogenesis and its implications for cancer diagnosis,prognosis,and treatment.展开更多
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in the presence of liver fibrosis,increases the risk of cardiovascular morbidity and mortality,but the nature of the cardio-hepat...BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in the presence of liver fibrosis,increases the risk of cardiovascular morbidity and mortality,but the nature of the cardio-hepatic interaction in the context type 2 diabetes mellitus(T2DM)is not fully understood.AIM To evaluate the changes in cardiac morphology and function in patients with T2DM and MASLD-associated liver fibrosis.METHODS T2DM patients with MASLD underwent a medical evaluation that included an assessment of lifestyle,anthropometric measurements,vital signs,an extensive laboratory panel,and a standard echocardiography.Liver fibrosis was evaluated using two scores[Fibrosis-4(FIB4)and Non-alcoholic fatty liver disease-Fibrosis Score(NFS)],and subjects were classified as having advanced fibrosis,no fibrosis,or an indeterminate risk.The correlations between structural and functional cardiac parameters and markers of liver fibrosis were evaluated through bivariate and multiple regression analyses.Statistical significance was set at P<0.05.RESULTS Data from 267 T2DM-MASLD subjects with complete assessment was analyzed.Patients with scores indicating advanced fibrosis exhibited higher interventricular septum and left ventricular(LV)posterior wall thickness,atrial diameters,LV end-systolic volume,LV mass index(LVMi),and epicardial adipose tissue thickness(EATT).Their mean ejection fraction(EF)was significantly lower(49.19%±5.62%vs 50.87%±5.14%vs 52.00%±3.25%;P=0.003),and a smaller proportion had an EF≥50%(49.40%vs 68.90%vs 84.21%;P=0.0017).Their total and mid LV wall motion score indexes were higher(P<0.05).Additionally,they had markers of diastolic dysfunction,with a higher E/e’ratio[9.64±4.10 vs 8.44(2.43-26.33)vs 7.35±2.62;P=0.026],and over 70%had lateral e’values<10 cm/second,though without significant differences between groups.In multiple regression analyses,FIB4 correlated with left atrium diameter(LAD;β=0.044;P<0.05),and NFS with both LAD(β=0.039;P<0.05)and right atrium diameter(β=0.041;P<0.01),Moreover,LVMi correlated positively with age and EATT(β=1.997;P=0.0008),and negatively with serum sex-hormone binding protein(SHBP)concentrations(β=-0.280;P=0.004).SHBP also correlated negatively with LAD(β=-0.036;P<0.05).CONCLUSION T2DM patients with markers of MASLD-related liver fibrosis exhibit lower EF and present indicators of diastolic dysfunction and cardiac hypertrophy.Additionally,LVMi and LAD correlated negatively with serum SHBP concentrations.展开更多
All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Pla...All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived microparticles (PMPs) in response to activation, injury, or apoptosis. This review introduces the origin, pathway, and biological functions of PMPs and their importance in physiological and pathological processes. In addition, we review the potential applications of PMPs in cancer, vascular homeostasis, thrombosis, inflammation, neural regeneration, biomarkers, and drug carriers to achieve targeted drug delivery. In addition, we comprehensively report on the origin, biological functions, and applications of PMPs. The clinical transformation, high heterogeneity, future development direction, and limitations of the current research on PMPs are also discussed in depth. Evidence has revealed that PMPs play an important role in cell-cell communication, providing clues for the development of PMPs as carriers for relevant cell-targeted drugs. The development history and prospects of PMPs and their cargos are explored in this guidebook.展开更多
Recent decades have seen a substantial increase in interest in research on natural fibres that is aligned with sustainable development goals(SDGs).Due to their renewable resources and biodegradability,natural fiberrei...Recent decades have seen a substantial increase in interest in research on natural fibres that is aligned with sustainable development goals(SDGs).Due to their renewable resources and biodegradability,natural fiberreinforced composites have been investigated as a sustainable alternative to synthetic materials to reduce the usage of hazardous waste and environmental pollution.Among the natural fibre,jute fibre obtained from a bast plant has an increasing trend in the application,especially as a reinforcement material.Numerous research works have been performed on jute fibre with regard to reinforced thermoset and thermoplastic composites.Nevertheless,current demands on sustainable materials have required new developments in thermoplastic composites.In this paper,the author reviews jute plants as reinforcement materials for thermoplastic matrix polymers.This review provides an overview of the sustainability of jute plants as reinforcement material for thermoplastic matrix polymers.The overview on jute based thermoplastic composites focused on the thermal behavior and mechanical properties.Apart from physical,chemical,and mechanical properties,the study also covers the current and perspectives for future research challenges faced by the researchers on jute fibre reinforced thermoplastic composites.展开更多
There are several conditions that can lead to portal vein thrombosis(PVT), including including infection, malignancies, and coagulation disorders. Anew condition of interest is protein C and S deficiencies, associated...There are several conditions that can lead to portal vein thrombosis(PVT), including including infection, malignancies, and coagulation disorders. Anew condition of interest is protein C and S deficiencies, associated with hypercoagulation and recurrent venous thromboembolism. We report the case of a non-cirrhotic 63-year-old male diagnosed with acute superior mesenteric vein thrombosis and PVT and combined deficiencies in proteins C and S, recanalized by short-term low molecular heparin plus oral warfarin therapy.展开更多
New source of light emission of high energy is found due to arising of instability in supersonic jets. These phenomena are observed in gas jets flowing from the nozzle with a central cone. It leads to high acceleratio...New source of light emission of high energy is found due to arising of instability in supersonic jets. These phenomena are observed in gas jets flowing from the nozzle with a central cone. It leads to high accelerations of the molecules, ions and elementary particles. The emission spectra of the jets are obtained. Decoding of the spectra allowed us to define inverted population of rotational and vibrational levels, electrons temperature, rotational and vibrational temperatures for molecular ions. Internal energy decreasing provides the instability and gas volume decreasing due to internal forces;super-compressibility is result of it;its produce high density of light energy emission in various continuous media.展开更多
Liver cancer is the sixth most commonly diagnosed cancer worldwide,with hepatocellular carcinoma(HCC)comprising most cases.Besides hepatitis B and C viral infections,heavy alcohol use,and nonalcoholic steatohepatitis(...Liver cancer is the sixth most commonly diagnosed cancer worldwide,with hepatocellular carcinoma(HCC)comprising most cases.Besides hepatitis B and C viral infections,heavy alcohol use,and nonalcoholic steatohepatitis(NASH)-associated advanced fibrosis/cirrhosis,several other risk factors for HCC have been identified(i.e.old age,obesity,insulin resistance,type 2 diabetes).These might in fact partially explain the occurrence of HCC in non-cirrhotic patients without viral infection.HCC surveillance through effective screening programs is still an unmet need for many nonalcoholic fatty liver disease(NAFLD)patients,and identification of pre-cirrhotic individuals who progress to HCC represents a substantial challenge in clinical practice at the moment.Patients with NASHcirrhosis should undergo systematic HCC surveillance,while this might be considered in patients with advanced fibrosis based on individual risk assessment.In this context,interventions that potentially prevent NAFLD/NASH-associated HCC are needed.This paper provided an overview of evidence related to lifestyle changes(i.e.weight loss,physical exercise,adherence to healthy dietary patterns,intake of certain dietary components,etc.)and pharmacological interventions that might play a protective role by targeting the underlying causative factors and pathogenetic mechanisms.However,well-designed prospective studies specifically dedicated to NAFLD/NASH patients are still needed to clarify the relationship with HCC risk.展开更多
Diabetic retinopathy (DR) is a well-characterized chronic ocular disorder that developed in nearly all diabetic patients in the long run. The knowledge of DR is crucial to manage this disorder when planning screening ...Diabetic retinopathy (DR) is a well-characterized chronic ocular disorder that developed in nearly all diabetic patients in the long run. The knowledge of DR is crucial to manage this disorder when planning screening and preventive programs and identifying the appropriated therapeutic strategies among. Expectant management may represent a valid therapeutic approach depending upon the clinical manifestations of the disease and, in particular, on the changes over time. If early treatment of DR reduces the probability of severe stage or slows the progression of blindness, it might sufficiently reduce treatment costs in later years to offset the costs of screening and early treatment. In addition, whether screening for DR is worthwhile is contingent on whether subjects are willing to pay the eye screening program that would decrease the risk of photocoagulation. In this review we discuss epidemiology, management, and economic evaluation of screening of DR among type 2 diabetes.展开更多
Two-dimensional(2D)nanomaterials are categorized as a new class of microwave absorption(MA)materials owing to their high specific surface area and peculiar electronic properties.In this study,2D WS2-reduced graphene o...Two-dimensional(2D)nanomaterials are categorized as a new class of microwave absorption(MA)materials owing to their high specific surface area and peculiar electronic properties.In this study,2D WS2-reduced graphene oxide(WS2-rGO)heterostructure nanosheets were synthesized via a facile hydrothermal process;moreover,their dielectric and MA properties were reported for the first time.Remarkably,the maximum reflection loss(RL)of the sample-wax composites containing 40 wt% WS2-rGO was-41.5 dB at a thickness of 2.7 mm;furthermore,the bandwidth where RL<-10 dB can reach up to 13.62 GHz(4.38-18 GHz).Synergistic mechanisms derived from the interfacial dielectric coupling and multiple-interface scattering after hybridization of WS2 with rGO were discussed to explain the drastically enhanced microwave absorption performance.The results indicate these lightweight WS2-rGO nanosheets to be potential materials for practical electromagnetic wave-absorbing applications.展开更多
The present study is concerned with the physical behavior of the combined effect of nano particle material motion and heat generation/absorption due to the effect of different parameters involved in prescribed flow mo...The present study is concerned with the physical behavior of the combined effect of nano particle material motion and heat generation/absorption due to the effect of different parameters involved in prescribed flow model.The formulation of the flow model is based on basic universal equations of conservation of momentum,energy and mass.The prescribed flow model is converted to non-dimensional form by using suitable scaling.The obtained transformed equations are solved numerically by using finite difference scheme.For the analysis of above said behavior the computed numerical data for fluid velocity,temperature profile,and mass concentration for several constraints that is mixed convection parameterλt,modified mixed convection parameterλc,Prandtl number Pr,heat generation/absorption parameterδ,Schmidt number Sc,thermophoresis parameter Nt,and thermophoretic coefficient k are sketched in graphical form.Numerical results for skin friction,heat transfer rate and the mass transfer rate are tabulated for various emerging physical parameters.It is reported that in enhancement in heat,generation boosts up the fluid temperature at some positions of the surface of the sphere.As heat absorption parameter is decreased temperature field increases at position X=π/4 on the other hand,no alteration at other considered circumferential positions is noticed.展开更多
In the paper,the results of experimental investigations on the diferences of wool structure ofhealthy mice and mice with malignant tumor(s)are represented.It is shown that destruction ofwool structure happens during p...In the paper,the results of experimental investigations on the diferences of wool structure ofhealthy mice and mice with malignant tumor(s)are represented.It is shown that destruction ofwool structure happens during pathology development.Quantity of cells of external wool layerand their thickness decrease when the tumor capsule enlarges.Difference is seen even when thetumor is small.The obtained results can be used to improve optical techniques of biomedicaldiagnostics of cancer diseases.展开更多
Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from seawater.However,the lack of active and robust electrocatalysts for the oxygen evolution reaction(...Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from seawater.However,the lack of active and robust electrocatalysts for the oxygen evolution reaction(OER)severely impedes the development of this technology.In this study,a ternary layered double hydroxide(LDH)OER electrocatalyst(NiFeCo-LDH)is developed for high-performance AEM alkaline seawater electrolyzers.The AEM alkaline seawater electrolyzer catalyzed by the NiFeCo LDH shows high seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and high hydrogen production efficiency(77.6%at 0.5 A/cm^(2)),thus outperforming an electrolyzer catalyzed by a benchmark IrO_(2)electrocatalyst.The NiFeCo-LDH electrocatalyst greatly improves the kinetics of the AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to high performance.Based on the results,this NiFeCo-LDH-catalyzed AEM alkaline seawater electrolyzer can likely surpass the energy conversion targets of the US Department of Energy.展开更多
<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:""><span style="font-family:Verdana;"> Until recently, the ex...<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:""><span style="font-family:Verdana;"> Until recently, the experience on implementing community based management of acute malnutrition (CMAM) among children has been largely based in African settings. While the government in Bangladesh is yet to scale up CMAM approach, there is still paucity of knowledge on the experience of CMAM within the complex milieu of an urban slum context. In Kamrangirchar slum, Dhaka, Bangladesh, this paper describes a CMAM programme performance and outcomes run by Médecins Sans Frontières (MSF)/Doctors without Borders, in light to performance indicators set by MSF and the Sphere minimum standards. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a descriptive retrospective study using routinely collected programme data of children admitted with severe acute malnutrition between May 2010 and November 2011. Kamrangirchar is an urban slum of a large migrant population in Dhaka, Bangladesh. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> There was a total of 640 new admissions, of whom 333 (52%) were males. The median age was 18 months (Inter-quartile range (IQR) 12 - 41). 599 children had a reported nutritional outcome at discharge from ambulatory therapeutic feeding centre (ATFC), this included: cure rate of 69% with an average length of stay of 68.8 (SD ± 46.0) days and average weight gain of 3.8 g/kg/day (SD ± 2.7). The lost-to-follow-up rate was 18% and 5% reported to the programme that they will leave the slum and go back to their villages. These performance indicators did not meet the threshold level indicators set by MSF and Sphere standards. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Our experience highlights the need for developing more adapted and contextualised indicators for assessing the performance of CMAM programmes in settings such as urban slums. Community engagement in the process of developing relevant standards is crucial. Nutrition humanitarian actors have a vital role to collaborate with local authorities to contextualize and refine these standards.展开更多
Application of optimization techniques for determining the optimal operation policy for reservoir is a major area in water resources planning and management. Linear programming, ruled by evolution techniques, has beco...Application of optimization techniques for determining the optimal operation policy for reservoir is a major area in water resources planning and management. Linear programming, ruled by evolution techniques, has become popular for solving optimization problems in diversified fields of science. An LP-based yield model (YM) has been used to reevaluate the annual yield available from the reservoirs for irrigation. This paper extends the basic yield model and presents a yield model for a multiple-reservoir system consisting of single-purpose reservoirs. Optimum yield of reservoirs system is calculated by yield model. The objective is to achieve prespecified reliability for irrigation and to incorporate an allowable deficit in the annual irrigation target. The yield model is applied to a system of two reservoirs in theManarRiverinIndia. This model can act as a better screening tool in planning by providing outputs that can be very useful in improving the efficiency and accuracy of detailed analysis methods such as simulation.展开更多
The interaction of electromagnetic and gravitational fields and gravitational super-compressibility were investigated experimentally. Dynamic emitter provides conditions for the generation of eigenfunctions with eigen...The interaction of electromagnetic and gravitational fields and gravitational super-compressibility were investigated experimentally. Dynamic emitter provides conditions for the generation of eigenfunctions with eigenvalues for the various fields, including: acoustic, gravitational and electromagnetic. We observe the gravitational waves in gas flowing from the dynamic emitter and their interaction with electromagnetic waves. The gravitational field energy was decreasing when electromagnetic field was emitted through the excitation of condensed medium. The direction of maximum change of the emitted energy of excited medium was strongly opposed to gravity vector at that point. The frequency of radiation against the gravity vector in given point of space exceeded radiation frequency of same source in opposite direction.展开更多
The main task of thyroid hormones is controlling the metabolism rate of humans,the development of neurons,and the significant growth of reproductive activities.In medical science,thyroid disorder will lead to creating ...The main task of thyroid hormones is controlling the metabolism rate of humans,the development of neurons,and the significant growth of reproductive activities.In medical science,thyroid disorder will lead to creating thyroiditis and thyroid cancer.The two main thyroid disorders are hyperthyroidism and hypothyroidism.Many research works focus on the prediction of thyroid disorder.To improve the accuracy in the classification of thyroid disorder this paper pro-poses optimization-based feature selection by using differential evolution with the Butterfly optimization algorithm(DE-BOA).For the classifier fuzzy C-means algorithm(FCM)is used.The proposed DEBOA-FCM is evaluated with para-metric metric measures of sensitivity,specificity,and accuracy.In this work,the thyroid disease dataset collected from the machine learning University of Cali-fornia Irvine(UCI)database was used.The accuracy rate for the Differential Evo-lutionary algorithm got 0.884,the Butterfly optimization algorithm got 0.906,Fuzzy C-Means algorithm got 0.899 and DEBOA+Focused Concept Miner(FCM)proposed work 0.943.展开更多
The consumption of long chain polyunsaturated fatty acids (LC-PUFA) is associated with several human health benefits. Most notable of these LC-PUFA is docosahexaenoic acid (DHA C22:6) whose inclusion is considered ess...The consumption of long chain polyunsaturated fatty acids (LC-PUFA) is associated with several human health benefits. Most notable of these LC-PUFA is docosahexaenoic acid (DHA C22:6) whose inclusion is considered essential for optimum human health. Biofortification of common foods such as eggs with DHA has emerged as a specific approach to increase the intake of DHA in human populations. This can be achieved by supplementing poultry rations with feeds like microalgae or fish oil that are rich in DHA, which results in an increased uptake in the egg. Gas chromatography with flame ionization detection (GC-FID) is the method of choice when analyzing food such as eggs for DHA and other fatty acids. For regulatory studies it is desirable to demonstrate that the method is specifically suitable for the analysis of DHA and fatty acids in eggs. The purpose of this paper is to further extend the scope of the AOAC 996.06 methodology examined in the paper by Dillon et al., and to demonstrate the fitness for purpose of the method by examining specific validation parameters. It is a further objective to investigate the stability of DHA and other fatty acids of short and long timepoints. A validation of the method for the determination of DHA and three other fatty acids in eggs is thus presented.展开更多
Research into long-chain polyunsaturated fatty acids (LC-PUFA), such as docosahexaenoic acid (DHA C22:6 n-3), has shown that their inclusion in the human diet is linked with many health benefits. This has led to an in...Research into long-chain polyunsaturated fatty acids (LC-PUFA), such as docosahexaenoic acid (DHA C22:6 n-3), has shown that their inclusion in the human diet is linked with many health benefits. This has led to an increased interest in the enrichment of certain foodstuffs with DHA by supplementing animal fed with DHA-rich ingredients which can lead to an increased uptake in the meat, milk and eggs animal by-products. The microalgae Aurantiochytrium limacinum has been found to be especially useful in this pursuit. It is subsequently desirable to availably have a simple and robust method for the routine analysis of DHA and other fatty acids in the algal biomass. The AOAC method 996.06 is often followed for the analysis of fatty acids in foods and demonstrating that its fitness for purpose in the analysis of DHA and additional fatty acids in Aurantiochytrium limacinum is therefore the objective of this paper. A validation of the method for the determination of DHA and three other fatty acids in Aurantiochytrium limacinum is presented. The method was found to be linear over the following ranges for each fatty acid methyl ester (FAME) analyte;50 to 15,000 μg/ml (C14:0), 300 to 95,000 (C16:0), 25 to 15,000 (C18:0) and 300 to 59,375 (C22:6). The accuracy, precision and LOD and LOQ of the method were confirmed and its robustness tested. The application of the method to assess the stability of Aurantiochytrium limacinum containing two alternative antioxidants was further examined. The investigation showed that DHA was stable over six months with the inclusion of either Duralox? or ethoxyquin as an antioxidant and ethoxyquin could additionally stabilize DHA in Aurantiochytrium limacinum up to 24 months.展开更多
文摘Restructuring of power market not only introduces competition but also brings complexity which increases overloading of Transmission Lines(TL).To obviate this complexity,this paper aims to mitigate the overloading and estimate the optimal location of Static Synchronous Compensator(STATCOM) by reducing congestion for a deregulated power system.The proposed method is based on the use of Locational Marginal Price(LMP) difference technique and congestion cost.LMPs are obtained as a by-product of Optimal Power Flow(OPF),whereas Congestion Cost(CC) is a function of difference in LMP and power flows.The effiectiveness of this approach is demonstrated by reducing the CC and solution space which can identify the TLs more suitable for placement of STATCOM.Importantly,total real power loss,reactive power loss and total CC are the three main objective functions in this optimization process.The process is implemented by developing an IEEE-69 bus test system which verifies and validates the effectiveness of proposed optimization technique.Additionally,a comparative analysis is enumerated by implementing two optimization techniques:Flower Pollination Algorithm(FPA) and Particle Swarm Optimization(PSO).The comparative analysis is sufficient to demonstrate the superiority of FPA technique over PSO technique in estimating an optimal placement of a STATCOM.The results from the load-flow analysis illustrate the reduction in CC,total real and reactive power loss using FPA technique compared to PSO technique.Overall,satisfactory results are obtained without using complex calculations which verify the effectiveness of optimization techniques.
文摘BACKGROUND Listening to music has been shown to reduce pain and anxiety before,during,and after invasive coronary procedures.AIM To perform a systematic review and meta-analysis to explore the effect of therapeutic use of music on both,perioperative and postoperative outcomes of invasive coronary procedures.METHODS An exhaustive literature search of 3 electronic databases(MEDLINE,Scopus,Cochrane CENTRAL)was conducted from inception until 10th December 2023.The results of our analyses are presented as standard mean difference(SMD)or weighted mean difference,with 95%CI and pooled using a random effects model.A P value<0.05 was considered significant in all cases.RESULTS From 21 studies,2141 participants were included in our analysis.The pooled analysis demonstrated that music listening significantly improves post-procedural pain(SMD=-0.78,95%CI:-1.34 to-0.23;P=0.006),anxiety(SMD=-0.86,95%CI:-1.43 to-0.29;P=0.003),heart rate[mean difference(MD)=-3.38,95%CI:-5.51 to-1.25;P=0.002],and systolic blood pressure(MD=-5.89,95%CI:-9.75 to-2.02;P=0.003).There was no significant improvement in diastolic blood pressure(MD=-3.22,95%CI:-6.58 to 0.14;P=0.06)or respiratory rate(MD=-0.97,95%CI:-1.98 to 0.03;P=0.06).CONCLUSION Music listening can be used in healthcare settings for patients undergoing invasive coronary procedures to reduce anxiety levels and improve their physiological parameters.
文摘Cancer,a leading cause of global mortality,remains a significant challenge to increasing life expectancy worldwide.Forkhead Box R2(FOXR2),identified as an oncogene within the FOX gene family,plays a crucial role in developing various endoderm-derived organs.Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases.Dysregulation of FOXR2 has been linked to numerous malignant tumors,spanning the brain,nervous system,thyroid,osteosarcoma,Hodgkin lymphoma,colorectal,liver,pancreatic,lung,breast,ovarian,prostate,female genital tract,endometrial,and uterine cancers.Despite extensive research on FOXR2 dysregulation,its practical applications remain underexplored.This review delves into the mechanisms underlying FOXR2 dysregulation during oncogenesis and its implications for cancer diagnosis,prognosis,and treatment.
基金Supported by the University of Medicine,Pharmacy,Science and Technology“George Emil Palade”of Târgu MureșResearch Grant,No.10126/5/17.12.2020.
文摘BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in the presence of liver fibrosis,increases the risk of cardiovascular morbidity and mortality,but the nature of the cardio-hepatic interaction in the context type 2 diabetes mellitus(T2DM)is not fully understood.AIM To evaluate the changes in cardiac morphology and function in patients with T2DM and MASLD-associated liver fibrosis.METHODS T2DM patients with MASLD underwent a medical evaluation that included an assessment of lifestyle,anthropometric measurements,vital signs,an extensive laboratory panel,and a standard echocardiography.Liver fibrosis was evaluated using two scores[Fibrosis-4(FIB4)and Non-alcoholic fatty liver disease-Fibrosis Score(NFS)],and subjects were classified as having advanced fibrosis,no fibrosis,or an indeterminate risk.The correlations between structural and functional cardiac parameters and markers of liver fibrosis were evaluated through bivariate and multiple regression analyses.Statistical significance was set at P<0.05.RESULTS Data from 267 T2DM-MASLD subjects with complete assessment was analyzed.Patients with scores indicating advanced fibrosis exhibited higher interventricular septum and left ventricular(LV)posterior wall thickness,atrial diameters,LV end-systolic volume,LV mass index(LVMi),and epicardial adipose tissue thickness(EATT).Their mean ejection fraction(EF)was significantly lower(49.19%±5.62%vs 50.87%±5.14%vs 52.00%±3.25%;P=0.003),and a smaller proportion had an EF≥50%(49.40%vs 68.90%vs 84.21%;P=0.0017).Their total and mid LV wall motion score indexes were higher(P<0.05).Additionally,they had markers of diastolic dysfunction,with a higher E/e’ratio[9.64±4.10 vs 8.44(2.43-26.33)vs 7.35±2.62;P=0.026],and over 70%had lateral e’values<10 cm/second,though without significant differences between groups.In multiple regression analyses,FIB4 correlated with left atrium diameter(LAD;β=0.044;P<0.05),and NFS with both LAD(β=0.039;P<0.05)and right atrium diameter(β=0.041;P<0.01),Moreover,LVMi correlated positively with age and EATT(β=1.997;P=0.0008),and negatively with serum sex-hormone binding protein(SHBP)concentrations(β=-0.280;P=0.004).SHBP also correlated negatively with LAD(β=-0.036;P<0.05).CONCLUSION T2DM patients with markers of MASLD-related liver fibrosis exhibit lower EF and present indicators of diastolic dysfunction and cardiac hypertrophy.Additionally,LVMi and LAD correlated negatively with serum SHBP concentrations.
基金supported by the National Science Fund for Distinguished Young Scholars(No:81901099 and 81703427)the 64th batch of China Postdoctoral Science Foundation(No:2018M641731).
文摘All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived microparticles (PMPs) in response to activation, injury, or apoptosis. This review introduces the origin, pathway, and biological functions of PMPs and their importance in physiological and pathological processes. In addition, we review the potential applications of PMPs in cancer, vascular homeostasis, thrombosis, inflammation, neural regeneration, biomarkers, and drug carriers to achieve targeted drug delivery. In addition, we comprehensively report on the origin, biological functions, and applications of PMPs. The clinical transformation, high heterogeneity, future development direction, and limitations of the current research on PMPs are also discussed in depth. Evidence has revealed that PMPs play an important role in cell-cell communication, providing clues for the development of PMPs as carriers for relevant cell-targeted drugs. The development history and prospects of PMPs and their cargos are explored in this guidebook.
文摘Recent decades have seen a substantial increase in interest in research on natural fibres that is aligned with sustainable development goals(SDGs).Due to their renewable resources and biodegradability,natural fiberreinforced composites have been investigated as a sustainable alternative to synthetic materials to reduce the usage of hazardous waste and environmental pollution.Among the natural fibre,jute fibre obtained from a bast plant has an increasing trend in the application,especially as a reinforcement material.Numerous research works have been performed on jute fibre with regard to reinforced thermoset and thermoplastic composites.Nevertheless,current demands on sustainable materials have required new developments in thermoplastic composites.In this paper,the author reviews jute plants as reinforcement materials for thermoplastic matrix polymers.This review provides an overview of the sustainability of jute plants as reinforcement material for thermoplastic matrix polymers.The overview on jute based thermoplastic composites focused on the thermal behavior and mechanical properties.Apart from physical,chemical,and mechanical properties,the study also covers the current and perspectives for future research challenges faced by the researchers on jute fibre reinforced thermoplastic composites.
文摘There are several conditions that can lead to portal vein thrombosis(PVT), including including infection, malignancies, and coagulation disorders. Anew condition of interest is protein C and S deficiencies, associated with hypercoagulation and recurrent venous thromboembolism. We report the case of a non-cirrhotic 63-year-old male diagnosed with acute superior mesenteric vein thrombosis and PVT and combined deficiencies in proteins C and S, recanalized by short-term low molecular heparin plus oral warfarin therapy.
文摘New source of light emission of high energy is found due to arising of instability in supersonic jets. These phenomena are observed in gas jets flowing from the nozzle with a central cone. It leads to high accelerations of the molecules, ions and elementary particles. The emission spectra of the jets are obtained. Decoding of the spectra allowed us to define inverted population of rotational and vibrational levels, electrons temperature, rotational and vibrational temperatures for molecular ions. Internal energy decreasing provides the instability and gas volume decreasing due to internal forces;super-compressibility is result of it;its produce high density of light energy emission in various continuous media.
文摘Liver cancer is the sixth most commonly diagnosed cancer worldwide,with hepatocellular carcinoma(HCC)comprising most cases.Besides hepatitis B and C viral infections,heavy alcohol use,and nonalcoholic steatohepatitis(NASH)-associated advanced fibrosis/cirrhosis,several other risk factors for HCC have been identified(i.e.old age,obesity,insulin resistance,type 2 diabetes).These might in fact partially explain the occurrence of HCC in non-cirrhotic patients without viral infection.HCC surveillance through effective screening programs is still an unmet need for many nonalcoholic fatty liver disease(NAFLD)patients,and identification of pre-cirrhotic individuals who progress to HCC represents a substantial challenge in clinical practice at the moment.Patients with NASHcirrhosis should undergo systematic HCC surveillance,while this might be considered in patients with advanced fibrosis based on individual risk assessment.In this context,interventions that potentially prevent NAFLD/NASH-associated HCC are needed.This paper provided an overview of evidence related to lifestyle changes(i.e.weight loss,physical exercise,adherence to healthy dietary patterns,intake of certain dietary components,etc.)and pharmacological interventions that might play a protective role by targeting the underlying causative factors and pathogenetic mechanisms.However,well-designed prospective studies specifically dedicated to NAFLD/NASH patients are still needed to clarify the relationship with HCC risk.
文摘Diabetic retinopathy (DR) is a well-characterized chronic ocular disorder that developed in nearly all diabetic patients in the long run. The knowledge of DR is crucial to manage this disorder when planning screening and preventive programs and identifying the appropriated therapeutic strategies among. Expectant management may represent a valid therapeutic approach depending upon the clinical manifestations of the disease and, in particular, on the changes over time. If early treatment of DR reduces the probability of severe stage or slows the progression of blindness, it might sufficiently reduce treatment costs in later years to offset the costs of screening and early treatment. In addition, whether screening for DR is worthwhile is contingent on whether subjects are willing to pay the eye screening program that would decrease the risk of photocoagulation. In this review we discuss epidemiology, management, and economic evaluation of screening of DR among type 2 diabetes.
基金financially supported by the National Natural Science Foundation of China(Nos.51272110,51772160,and 51771123)the Shenzhen Peacock Innovation Project(No.KQJSCX20170327151307811)+1 种基金the support of China Scholarship Council(No.201506100018)the START project of Japan Science and Technology Agency(JST)
文摘Two-dimensional(2D)nanomaterials are categorized as a new class of microwave absorption(MA)materials owing to their high specific surface area and peculiar electronic properties.In this study,2D WS2-reduced graphene oxide(WS2-rGO)heterostructure nanosheets were synthesized via a facile hydrothermal process;moreover,their dielectric and MA properties were reported for the first time.Remarkably,the maximum reflection loss(RL)of the sample-wax composites containing 40 wt% WS2-rGO was-41.5 dB at a thickness of 2.7 mm;furthermore,the bandwidth where RL<-10 dB can reach up to 13.62 GHz(4.38-18 GHz).Synergistic mechanisms derived from the interfacial dielectric coupling and multiple-interface scattering after hybridization of WS2 with rGO were discussed to explain the drastically enhanced microwave absorption performance.The results indicate these lightweight WS2-rGO nanosheets to be potential materials for practical electromagnetic wave-absorbing applications.
基金The authors would like to acknowledge Natural Science Foundation of China(Grant Nos.61673169,11701176,11626101,11601485).
文摘The present study is concerned with the physical behavior of the combined effect of nano particle material motion and heat generation/absorption due to the effect of different parameters involved in prescribed flow model.The formulation of the flow model is based on basic universal equations of conservation of momentum,energy and mass.The prescribed flow model is converted to non-dimensional form by using suitable scaling.The obtained transformed equations are solved numerically by using finite difference scheme.For the analysis of above said behavior the computed numerical data for fluid velocity,temperature profile,and mass concentration for several constraints that is mixed convection parameterλt,modified mixed convection parameterλc,Prandtl number Pr,heat generation/absorption parameterδ,Schmidt number Sc,thermophoresis parameter Nt,and thermophoretic coefficient k are sketched in graphical form.Numerical results for skin friction,heat transfer rate and the mass transfer rate are tabulated for various emerging physical parameters.It is reported that in enhancement in heat,generation boosts up the fluid temperature at some positions of the surface of the sphere.As heat absorption parameter is decreased temperature field increases at position X=π/4 on the other hand,no alteration at other considered circumferential positions is noticed.
基金supported by grant of Ministry of science and education of RF No.2.338.2011.
文摘In the paper,the results of experimental investigations on the diferences of wool structure ofhealthy mice and mice with malignant tumor(s)are represented.It is shown that destruction ofwool structure happens during pathology development.Quantity of cells of external wool layerand their thickness decrease when the tumor capsule enlarges.Difference is seen even when thetumor is small.The obtained results can be used to improve optical techniques of biomedicaldiagnostics of cancer diseases.
基金supported by the Fundamental Research Program of the Korean Institute of Materials Science(PNK7550)the National Research Council of Science&Technology(NST)grant by the MSIT(CAP21000-000)the New&Renewable Energy Core Technology Program of the KETEP(20213030040520)in the Republic of Korea。
文摘Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from seawater.However,the lack of active and robust electrocatalysts for the oxygen evolution reaction(OER)severely impedes the development of this technology.In this study,a ternary layered double hydroxide(LDH)OER electrocatalyst(NiFeCo-LDH)is developed for high-performance AEM alkaline seawater electrolyzers.The AEM alkaline seawater electrolyzer catalyzed by the NiFeCo LDH shows high seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and high hydrogen production efficiency(77.6%at 0.5 A/cm^(2)),thus outperforming an electrolyzer catalyzed by a benchmark IrO_(2)electrocatalyst.The NiFeCo-LDH electrocatalyst greatly improves the kinetics of the AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to high performance.Based on the results,this NiFeCo-LDH-catalyzed AEM alkaline seawater electrolyzer can likely surpass the energy conversion targets of the US Department of Energy.
文摘<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:""><span style="font-family:Verdana;"> Until recently, the experience on implementing community based management of acute malnutrition (CMAM) among children has been largely based in African settings. While the government in Bangladesh is yet to scale up CMAM approach, there is still paucity of knowledge on the experience of CMAM within the complex milieu of an urban slum context. In Kamrangirchar slum, Dhaka, Bangladesh, this paper describes a CMAM programme performance and outcomes run by Médecins Sans Frontières (MSF)/Doctors without Borders, in light to performance indicators set by MSF and the Sphere minimum standards. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a descriptive retrospective study using routinely collected programme data of children admitted with severe acute malnutrition between May 2010 and November 2011. Kamrangirchar is an urban slum of a large migrant population in Dhaka, Bangladesh. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> There was a total of 640 new admissions, of whom 333 (52%) were males. The median age was 18 months (Inter-quartile range (IQR) 12 - 41). 599 children had a reported nutritional outcome at discharge from ambulatory therapeutic feeding centre (ATFC), this included: cure rate of 69% with an average length of stay of 68.8 (SD ± 46.0) days and average weight gain of 3.8 g/kg/day (SD ± 2.7). The lost-to-follow-up rate was 18% and 5% reported to the programme that they will leave the slum and go back to their villages. These performance indicators did not meet the threshold level indicators set by MSF and Sphere standards. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Our experience highlights the need for developing more adapted and contextualised indicators for assessing the performance of CMAM programmes in settings such as urban slums. Community engagement in the process of developing relevant standards is crucial. Nutrition humanitarian actors have a vital role to collaborate with local authorities to contextualize and refine these standards.
文摘Application of optimization techniques for determining the optimal operation policy for reservoir is a major area in water resources planning and management. Linear programming, ruled by evolution techniques, has become popular for solving optimization problems in diversified fields of science. An LP-based yield model (YM) has been used to reevaluate the annual yield available from the reservoirs for irrigation. This paper extends the basic yield model and presents a yield model for a multiple-reservoir system consisting of single-purpose reservoirs. Optimum yield of reservoirs system is calculated by yield model. The objective is to achieve prespecified reliability for irrigation and to incorporate an allowable deficit in the annual irrigation target. The yield model is applied to a system of two reservoirs in theManarRiverinIndia. This model can act as a better screening tool in planning by providing outputs that can be very useful in improving the efficiency and accuracy of detailed analysis methods such as simulation.
文摘The interaction of electromagnetic and gravitational fields and gravitational super-compressibility were investigated experimentally. Dynamic emitter provides conditions for the generation of eigenfunctions with eigenvalues for the various fields, including: acoustic, gravitational and electromagnetic. We observe the gravitational waves in gas flowing from the dynamic emitter and their interaction with electromagnetic waves. The gravitational field energy was decreasing when electromagnetic field was emitted through the excitation of condensed medium. The direction of maximum change of the emitted energy of excited medium was strongly opposed to gravity vector at that point. The frequency of radiation against the gravity vector in given point of space exceeded radiation frequency of same source in opposite direction.
基金Taif University Researchers are supporting project number(TURSP-2020/211),Taif University,Taif,Saudi Arabia.
文摘The main task of thyroid hormones is controlling the metabolism rate of humans,the development of neurons,and the significant growth of reproductive activities.In medical science,thyroid disorder will lead to creating thyroiditis and thyroid cancer.The two main thyroid disorders are hyperthyroidism and hypothyroidism.Many research works focus on the prediction of thyroid disorder.To improve the accuracy in the classification of thyroid disorder this paper pro-poses optimization-based feature selection by using differential evolution with the Butterfly optimization algorithm(DE-BOA).For the classifier fuzzy C-means algorithm(FCM)is used.The proposed DEBOA-FCM is evaluated with para-metric metric measures of sensitivity,specificity,and accuracy.In this work,the thyroid disease dataset collected from the machine learning University of Cali-fornia Irvine(UCI)database was used.The accuracy rate for the Differential Evo-lutionary algorithm got 0.884,the Butterfly optimization algorithm got 0.906,Fuzzy C-Means algorithm got 0.899 and DEBOA+Focused Concept Miner(FCM)proposed work 0.943.
文摘The consumption of long chain polyunsaturated fatty acids (LC-PUFA) is associated with several human health benefits. Most notable of these LC-PUFA is docosahexaenoic acid (DHA C22:6) whose inclusion is considered essential for optimum human health. Biofortification of common foods such as eggs with DHA has emerged as a specific approach to increase the intake of DHA in human populations. This can be achieved by supplementing poultry rations with feeds like microalgae or fish oil that are rich in DHA, which results in an increased uptake in the egg. Gas chromatography with flame ionization detection (GC-FID) is the method of choice when analyzing food such as eggs for DHA and other fatty acids. For regulatory studies it is desirable to demonstrate that the method is specifically suitable for the analysis of DHA and fatty acids in eggs. The purpose of this paper is to further extend the scope of the AOAC 996.06 methodology examined in the paper by Dillon et al., and to demonstrate the fitness for purpose of the method by examining specific validation parameters. It is a further objective to investigate the stability of DHA and other fatty acids of short and long timepoints. A validation of the method for the determination of DHA and three other fatty acids in eggs is thus presented.
文摘Research into long-chain polyunsaturated fatty acids (LC-PUFA), such as docosahexaenoic acid (DHA C22:6 n-3), has shown that their inclusion in the human diet is linked with many health benefits. This has led to an increased interest in the enrichment of certain foodstuffs with DHA by supplementing animal fed with DHA-rich ingredients which can lead to an increased uptake in the meat, milk and eggs animal by-products. The microalgae Aurantiochytrium limacinum has been found to be especially useful in this pursuit. It is subsequently desirable to availably have a simple and robust method for the routine analysis of DHA and other fatty acids in the algal biomass. The AOAC method 996.06 is often followed for the analysis of fatty acids in foods and demonstrating that its fitness for purpose in the analysis of DHA and additional fatty acids in Aurantiochytrium limacinum is therefore the objective of this paper. A validation of the method for the determination of DHA and three other fatty acids in Aurantiochytrium limacinum is presented. The method was found to be linear over the following ranges for each fatty acid methyl ester (FAME) analyte;50 to 15,000 μg/ml (C14:0), 300 to 95,000 (C16:0), 25 to 15,000 (C18:0) and 300 to 59,375 (C22:6). The accuracy, precision and LOD and LOQ of the method were confirmed and its robustness tested. The application of the method to assess the stability of Aurantiochytrium limacinum containing two alternative antioxidants was further examined. The investigation showed that DHA was stable over six months with the inclusion of either Duralox? or ethoxyquin as an antioxidant and ethoxyquin could additionally stabilize DHA in Aurantiochytrium limacinum up to 24 months.
