This study investigated the effect of hydrogen-rich atomic water on eye fatigue.The experimental results show that hydrogen-rich atomic water can reduce oxidative stress and inflammatory reaction in the eye,and has a ...This study investigated the effect of hydrogen-rich atomic water on eye fatigue.The experimental results show that hydrogen-rich atomic water can reduce oxidative stress and inflammatory reaction in the eye,and has a significant improvement effect on myopia and visual fatigue,with high safety and no obvious adverse reactions.The results of myopia and visual fatigue improvement experiment showed that the prevalence of myopia in the control group was 15%,and the prevalence of myopia in the experimental group was 5%.The prevalence of myopia in the experimental group was significantly lower than that in the control group.The ocular symptoms of the experimental group were better than those of the control group in the improvement of fatigue,dry eyes,red blood stains and other symptoms.The patient satisfaction score of the experimental group was 95.5%,which was significantly higher than that of the control group.There were no adverse events such as allergic reactions or skin irritation in the experimental group and the control group during the whole experiment.展开更多
The occurrence and development of ocular surface diseases are closely related to oxidative stress.Excessive accumulation of reactive oxygen species(ROS)can lead to ocular surface cell damage and inflammatory responses...The occurrence and development of ocular surface diseases are closely related to oxidative stress.Excessive accumulation of reactive oxygen species(ROS)can lead to ocular surface cell damage and inflammatory responses.As a new type of antioxidant,hydrogen-rich water(HRW)has shown intervention potential in ocular surface diseases such as dry eye and conjunctivitis by selectively scavenging toxic ROS,inhibiting inflammatory pathways,and protecting ocular surface cells.Combining basic mechanisms and clinical evidence,this article explores the application value of hydrogen-rich water in ocular surface diseases,providing new ideas for the prevention and treatment of oxidative stress-related eye diseases.展开更多
The starting point of this study is the theory of tonal consonance by Plomp and Levelt. The major reference point is the theory of Critical Band and its use for evaluating consonance of simple tones. On the basis of s...The starting point of this study is the theory of tonal consonance by Plomp and Levelt. The major reference point is the theory of Critical Band and its use for evaluating consonance of simple tones. On the basis of such empirical criterion, our aim consists in providing a method of estimating the value of consonance of complex tones, by taking account not only of the number of harmonics, but also of the intensity of the partials which contribute to forming the tone. By introducing a specific algorithm, the level of consonance of a chord of complex tones is expressed in terms both of frequency differences and sound intensity of the partials. The results give rise to a series of considerations and applications, ranging from displaying the order of consonance of all intervals within the octave up to evaluating the hierarchy of chords in the frame of a musical scale.展开更多
目的基于脓毒症患者院内死亡预测中因机器学习样本类别不平衡导致敏感度过低的问题,构建一种新的基于平衡随机森林(Balanced Random Forest,BRF)算法的预测模型。方法从MIMIC-Ⅲ公开数据库中获取符合脓毒症(Sepsis-3.0)标准患者的17个...目的基于脓毒症患者院内死亡预测中因机器学习样本类别不平衡导致敏感度过低的问题,构建一种新的基于平衡随机森林(Balanced Random Forest,BRF)算法的预测模型。方法从MIMIC-Ⅲ公开数据库中获取符合脓毒症(Sepsis-3.0)标准患者的17个时间序列变量数据,截取入住ICU后最初48 h的数据,计算出17个变量的714个统计特征,将其用于模型构建和性能评估。利用曲线下面积(Area Under Curve,AUC)和修正的几何平均值(Adjusted Geometric-Mean,AGM)进行超参调优。除BRF算法模型外,还与传统的逻辑回归和随机森林(Random Forest,RF)算法模型性能进行比较。结果最终筛选出10270例有ICU住院经历的脓毒症患者,院内总体死亡率为18.04%。各种模型性能测试结果表明,基于样本类别不平衡的机器学习模型的预测敏感度显著提高,其中RF-AGM模型最低,为0.1826(95%CI:0.1351~0.2322),BRF-AGM模型提高到0.7110(95%CI:0.6537~0.7677),利用新的预测模型,将会发现更多面临死亡的患者并及时给予救治。BRF-AGM模型的AUC、AGM和特异性分别达到了0.7994(95%CI:0.7696~0.8288)、0.7282(95%CI:0.7046~0.7519)和0.7349(95%CI:0.7101~0.7590)。结论BRF-AGM模型在ICU脓毒症患者死亡预测方面具有巨大应用潜力,可以避免临床医生延误治疗患者,这对改善患者预后具有重要意义,但BRF-AGM模型的临床效用还需要前瞻性多中心研究来进一步评估。展开更多
A model of two oscillating pendula placed on a mobile support is studied. Once an overall scheme of equations, under general assumptions, is formulated via the Lagrangian equations of motion, the specific case of abse...A model of two oscillating pendula placed on a mobile support is studied. Once an overall scheme of equations, under general assumptions, is formulated via the Lagrangian equations of motion, the specific case of absence of escapement is examined. The mechanical model consists of two coupled pendula both oscillating on a moving board attached to a spring. The final result performs selection among the peculiar parameters of the physical process （the length, the ratio of masses, the friction and damping coefficients, and the stiffness of the spring）, providing a tendency to synchronization.展开更多
The main purpose of the paper consists in illustrating a procedure for expressing the equations of motion for a general time-dependent constrained system. Constraints are both of geometrical and differential type. The...The main purpose of the paper consists in illustrating a procedure for expressing the equations of motion for a general time-dependent constrained system. Constraints are both of geometrical and differential type. The use of quasi-velocities as variables of the mathematical problem opens the possibility of incorporating some remarkable and classic cases of equations of motion. Afterwards, the scheme of equations is implemented for a pair of substantial examples, which are presented in a double version, acting either as a scleronomic system and as a rheonomic system.展开更多
The ground plan in order to disentangle the hard problem of modelling the motion of a bicycle is to start from a very simple model and to outline the proper mathematical scheme: for this reason the first step we perfo...The ground plan in order to disentangle the hard problem of modelling the motion of a bicycle is to start from a very simple model and to outline the proper mathematical scheme: for this reason the first step we perform lies in a planar rigid body (simulating the bicylcle frame) pivoting on a horizontal segment whose extremities, subjected to nonslip conditions, oversimplify the wheels. Even in this former case, which is the topic of lots of papers in literature, we find it worthwhile to pay close attention to the formulation of the mathematical model and to focus on writing the proper equations of motion and on the possible existence of conserved quantities. In addition to the first case, being essentially an inverted pendulum on a skate, we discuss a second model, where rude handlebars are added and two rigid bodies are joined. The geometrical method of Appell is used to formulate the dynamics and to deal with the nonholonomic constraints in a correct way. At the same time the equations are explained in the context of the cardinal equations, whose use is habitual for this kind of problems. The paper aims to a threefold purpose: to formulate the mathematical scheme in the most suitable way (by means of the pseudovelocities), to achieve results about stability, to examine the legitimacy of certain assumptions and the compatibility of some conserved quantities claimed in part of the literature.展开更多
文摘This study investigated the effect of hydrogen-rich atomic water on eye fatigue.The experimental results show that hydrogen-rich atomic water can reduce oxidative stress and inflammatory reaction in the eye,and has a significant improvement effect on myopia and visual fatigue,with high safety and no obvious adverse reactions.The results of myopia and visual fatigue improvement experiment showed that the prevalence of myopia in the control group was 15%,and the prevalence of myopia in the experimental group was 5%.The prevalence of myopia in the experimental group was significantly lower than that in the control group.The ocular symptoms of the experimental group were better than those of the control group in the improvement of fatigue,dry eyes,red blood stains and other symptoms.The patient satisfaction score of the experimental group was 95.5%,which was significantly higher than that of the control group.There were no adverse events such as allergic reactions or skin irritation in the experimental group and the control group during the whole experiment.
文摘The occurrence and development of ocular surface diseases are closely related to oxidative stress.Excessive accumulation of reactive oxygen species(ROS)can lead to ocular surface cell damage and inflammatory responses.As a new type of antioxidant,hydrogen-rich water(HRW)has shown intervention potential in ocular surface diseases such as dry eye and conjunctivitis by selectively scavenging toxic ROS,inhibiting inflammatory pathways,and protecting ocular surface cells.Combining basic mechanisms and clinical evidence,this article explores the application value of hydrogen-rich water in ocular surface diseases,providing new ideas for the prevention and treatment of oxidative stress-related eye diseases.
文摘The starting point of this study is the theory of tonal consonance by Plomp and Levelt. The major reference point is the theory of Critical Band and its use for evaluating consonance of simple tones. On the basis of such empirical criterion, our aim consists in providing a method of estimating the value of consonance of complex tones, by taking account not only of the number of harmonics, but also of the intensity of the partials which contribute to forming the tone. By introducing a specific algorithm, the level of consonance of a chord of complex tones is expressed in terms both of frequency differences and sound intensity of the partials. The results give rise to a series of considerations and applications, ranging from displaying the order of consonance of all intervals within the octave up to evaluating the hierarchy of chords in the frame of a musical scale.
文摘目的基于脓毒症患者院内死亡预测中因机器学习样本类别不平衡导致敏感度过低的问题,构建一种新的基于平衡随机森林(Balanced Random Forest,BRF)算法的预测模型。方法从MIMIC-Ⅲ公开数据库中获取符合脓毒症(Sepsis-3.0)标准患者的17个时间序列变量数据,截取入住ICU后最初48 h的数据,计算出17个变量的714个统计特征,将其用于模型构建和性能评估。利用曲线下面积(Area Under Curve,AUC)和修正的几何平均值(Adjusted Geometric-Mean,AGM)进行超参调优。除BRF算法模型外,还与传统的逻辑回归和随机森林(Random Forest,RF)算法模型性能进行比较。结果最终筛选出10270例有ICU住院经历的脓毒症患者,院内总体死亡率为18.04%。各种模型性能测试结果表明,基于样本类别不平衡的机器学习模型的预测敏感度显著提高,其中RF-AGM模型最低,为0.1826(95%CI:0.1351~0.2322),BRF-AGM模型提高到0.7110(95%CI:0.6537~0.7677),利用新的预测模型,将会发现更多面临死亡的患者并及时给予救治。BRF-AGM模型的AUC、AGM和特异性分别达到了0.7994(95%CI:0.7696~0.8288)、0.7282(95%CI:0.7046~0.7519)和0.7349(95%CI:0.7101~0.7590)。结论BRF-AGM模型在ICU脓毒症患者死亡预测方面具有巨大应用潜力,可以避免临床医生延误治疗患者,这对改善患者预后具有重要意义,但BRF-AGM模型的临床效用还需要前瞻性多中心研究来进一步评估。
文摘A model of two oscillating pendula placed on a mobile support is studied. Once an overall scheme of equations, under general assumptions, is formulated via the Lagrangian equations of motion, the specific case of absence of escapement is examined. The mechanical model consists of two coupled pendula both oscillating on a moving board attached to a spring. The final result performs selection among the peculiar parameters of the physical process （the length, the ratio of masses, the friction and damping coefficients, and the stiffness of the spring）, providing a tendency to synchronization.
文摘The main purpose of the paper consists in illustrating a procedure for expressing the equations of motion for a general time-dependent constrained system. Constraints are both of geometrical and differential type. The use of quasi-velocities as variables of the mathematical problem opens the possibility of incorporating some remarkable and classic cases of equations of motion. Afterwards, the scheme of equations is implemented for a pair of substantial examples, which are presented in a double version, acting either as a scleronomic system and as a rheonomic system.
文摘The ground plan in order to disentangle the hard problem of modelling the motion of a bicycle is to start from a very simple model and to outline the proper mathematical scheme: for this reason the first step we perform lies in a planar rigid body (simulating the bicylcle frame) pivoting on a horizontal segment whose extremities, subjected to nonslip conditions, oversimplify the wheels. Even in this former case, which is the topic of lots of papers in literature, we find it worthwhile to pay close attention to the formulation of the mathematical model and to focus on writing the proper equations of motion and on the possible existence of conserved quantities. In addition to the first case, being essentially an inverted pendulum on a skate, we discuss a second model, where rude handlebars are added and two rigid bodies are joined. The geometrical method of Appell is used to formulate the dynamics and to deal with the nonholonomic constraints in a correct way. At the same time the equations are explained in the context of the cardinal equations, whose use is habitual for this kind of problems. The paper aims to a threefold purpose: to formulate the mathematical scheme in the most suitable way (by means of the pseudovelocities), to achieve results about stability, to examine the legitimacy of certain assumptions and the compatibility of some conserved quantities claimed in part of the literature.
