Background: Adherence to medications is dependent upon a variety of factors, including individual characteristics of the patient, interactions with health care providers, and medication complexity. Even though several...Background: Adherence to medications is dependent upon a variety of factors, including individual characteristics of the patient, interactions with health care providers, and medication complexity. Even though several studies were conducted to test intervention strategies, results are uncertain. Aim: The aim of the study is to assess if a tailored combined intervention strategy improves medication adherence in a large population of post-menopausal women affected by hypertension or metabolic syndrome. Methods: We enrolled 6833 patients aged 50 to 69 years, 85.7% with hypertension, and 14.3% with metabolic syndrome. A network between patients, general practitioners, and cardiologists was established. Interventions included education, adequate information to patients, a simplified scheme of treatment, and periodic adherence assessment. These were either delivered as healthcare provider supports or using modern technology. Medication adherence was estimated by the proportion of days covered for all classes of drugs after the index date. Results: Non-adherent hypertensive women were 297 (5%), and those with metabolic syndrome were 73 (7.4%) (p Conclusions: The rate of non-adherence in both settings of postmenopausal women was 7.7%, much lower than that described in the literature. This rate was increased in patients with metabolic syndrome;probably it is related to the complexity of the therapeutic scheme or to a poor consciousness of the disease. Therefore, implementing a tailored combined intervention can improve significantly patients’ adherence to medical therapy.展开更多
Acute intestinal ischemia is an abdominal emergency occurring in nearly 1% of patients presenting with acute abdomen. The causes can be occlusive or non occlusive. Early diagnosis is important to improve survival rate...Acute intestinal ischemia is an abdominal emergency occurring in nearly 1% of patients presenting with acute abdomen. The causes can be occlusive or non occlusive. Early diagnosis is important to improve survival rates. In most cases of late or missed diagnosis, the mortality rate from intestinal infarction is very high, with a reported value ranging from 60% to 90%. Multidetector computed tomography(MDCT) is a fundamental imaging technique that must be promptly performed in all patients with suspected bowel ischemia. Thanks to the new dedicated reconstruction program, its diagnostic potential is much improved compared to the past and currently it is superior to that of any other noninvasive technique. The increased spatial and temporal resolution, high-quality multi-planar reconstructions, maximum intensity projections, vessel probe, surface-shaded volume rending and tissue transition projections make MDCT the gold standard for the diagnosis of intestinal ischemia, with reported sensitivity, specificity, positive and negative predictive values of 64%-93%, 92%-100%, 90%-100% and 94%-98%, respectively. MDCT contributes to appropriate treatment planning and provides important prognostic informationthanks to its ability to define the nature and extent of the disease. The purpose of this review is to examine the diagnostic and prognostic role of MDCT in bowel ischemia with special regard to the state of art new reconstruction software.展开更多
The present study deals with the determination of Mount Olympus summit(Mytikas),exploiting modern observations such as Global Navigation Satellite Systems(GNSS)and existing geodetic information.The last official Olymp...The present study deals with the determination of Mount Olympus summit(Mytikas),exploiting modern observations such as Global Navigation Satellite Systems(GNSS)and existing geodetic information.The last official Olympus height determination goes back 102 years by the Swiss surveyor M.Kurz.Since then,only unofficial measurement campaigns have taken place.There is a variety of released heights,which range from 2917 to 2919 meters.In September and October of 2022,we conducted a GNSS campaign,focusing on the area of highest Olympus peaks.Employing precise GNSS measurements(accuracy of 1-3 cm),in conjunction with height information from Greece’s National Triangulation Network(5-10 cm accuracy)and an appropriate,recent geoid model(5-6 cm accuracy),we estimate through the so-called GNSS-levelling,the height of Olympus to 2917.727 m with respect to Greece’s officially accepted mean sea level and 2918.390 m with respect to the global vertical datum.Our estimation of Olympus highest peak shows remarkable consistency at the level of 12.8 cm to that of M.Kurz in 1921.展开更多
It has long been assumed that the owl has high scotopic sensitivity. Investigators have long since been interested in the research of the visual function of owls in dim illumination. It was considered that owls were a...It has long been assumed that the owl has high scotopic sensitivity. Investigators have long since been interested in the research of the visual function of owls in dim illumination. It was considered that owls were able to detect infrared rays. However Hecht et al. denied this idea. By means of behavioral experiment, Dice also demonstrated that owls were capable of catching prey on the basis of ordinary vision instead of the sensitivity to infrared rays in dim illumination. Fire observed that there was high展开更多
Geometric continuity between parametric surfaces is an important issue in CAGD.So far rest-arches have been concentrated on it for N-dimensional surfaces whose common boundary is of N-1 dimensions.No results have ever...Geometric continuity between parametric surfaces is an important issue in CAGD.So far rest-arches have been concentrated on it for N-dimensional surfaces whose common boundary is of N-1 dimensions.No results have ever been obtained for the case where the common boundary of the two surfaces is of L dimensions,0≤L≤N,or the two adjacent surfaces are of unequal dimensions.In this paper,the conditions of high-order geometric continuity between parametric surfaces are studied for these general cases By analysing the structure of Gn transformations,general solutions as well as an iterative method for determining adjustable functions are proposed.Some equivalent conditions of Gn continuity (nth order geometric continuity) are derived with an emphasis on conditions for triangular and rectangular Bezier surfaces.Since the Gn conditions for polynomial parametric surfaces are expressed in the form of explicit relationship of control points of Bezier surfaces,they are very useful both in theory and application for CAD/CAM and CAGD.Finally,Gn conditions between q-dimensional submanifolds of N-dimensional and M-dimensional surfaces are studied,thus a complete theoretical basis is laid for the problem of geometric continuity展开更多
文摘Background: Adherence to medications is dependent upon a variety of factors, including individual characteristics of the patient, interactions with health care providers, and medication complexity. Even though several studies were conducted to test intervention strategies, results are uncertain. Aim: The aim of the study is to assess if a tailored combined intervention strategy improves medication adherence in a large population of post-menopausal women affected by hypertension or metabolic syndrome. Methods: We enrolled 6833 patients aged 50 to 69 years, 85.7% with hypertension, and 14.3% with metabolic syndrome. A network between patients, general practitioners, and cardiologists was established. Interventions included education, adequate information to patients, a simplified scheme of treatment, and periodic adherence assessment. These were either delivered as healthcare provider supports or using modern technology. Medication adherence was estimated by the proportion of days covered for all classes of drugs after the index date. Results: Non-adherent hypertensive women were 297 (5%), and those with metabolic syndrome were 73 (7.4%) (p Conclusions: The rate of non-adherence in both settings of postmenopausal women was 7.7%, much lower than that described in the literature. This rate was increased in patients with metabolic syndrome;probably it is related to the complexity of the therapeutic scheme or to a poor consciousness of the disease. Therefore, implementing a tailored combined intervention can improve significantly patients’ adherence to medical therapy.
文摘Acute intestinal ischemia is an abdominal emergency occurring in nearly 1% of patients presenting with acute abdomen. The causes can be occlusive or non occlusive. Early diagnosis is important to improve survival rates. In most cases of late or missed diagnosis, the mortality rate from intestinal infarction is very high, with a reported value ranging from 60% to 90%. Multidetector computed tomography(MDCT) is a fundamental imaging technique that must be promptly performed in all patients with suspected bowel ischemia. Thanks to the new dedicated reconstruction program, its diagnostic potential is much improved compared to the past and currently it is superior to that of any other noninvasive technique. The increased spatial and temporal resolution, high-quality multi-planar reconstructions, maximum intensity projections, vessel probe, surface-shaded volume rending and tissue transition projections make MDCT the gold standard for the diagnosis of intestinal ischemia, with reported sensitivity, specificity, positive and negative predictive values of 64%-93%, 92%-100%, 90%-100% and 94%-98%, respectively. MDCT contributes to appropriate treatment planning and provides important prognostic informationthanks to its ability to define the nature and extent of the disease. The purpose of this review is to examine the diagnostic and prognostic role of MDCT in bowel ischemia with special regard to the state of art new reconstruction software.
文摘The present study deals with the determination of Mount Olympus summit(Mytikas),exploiting modern observations such as Global Navigation Satellite Systems(GNSS)and existing geodetic information.The last official Olympus height determination goes back 102 years by the Swiss surveyor M.Kurz.Since then,only unofficial measurement campaigns have taken place.There is a variety of released heights,which range from 2917 to 2919 meters.In September and October of 2022,we conducted a GNSS campaign,focusing on the area of highest Olympus peaks.Employing precise GNSS measurements(accuracy of 1-3 cm),in conjunction with height information from Greece’s National Triangulation Network(5-10 cm accuracy)and an appropriate,recent geoid model(5-6 cm accuracy),we estimate through the so-called GNSS-levelling,the height of Olympus to 2917.727 m with respect to Greece’s officially accepted mean sea level and 2918.390 m with respect to the global vertical datum.Our estimation of Olympus highest peak shows remarkable consistency at the level of 12.8 cm to that of M.Kurz in 1921.
文摘It has long been assumed that the owl has high scotopic sensitivity. Investigators have long since been interested in the research of the visual function of owls in dim illumination. It was considered that owls were able to detect infrared rays. However Hecht et al. denied this idea. By means of behavioral experiment, Dice also demonstrated that owls were capable of catching prey on the basis of ordinary vision instead of the sensitivity to infrared rays in dim illumination. Fire observed that there was high
基金Project supported by the National Natural Science Foundation of ChinaPost Doctoral Foundation of China
文摘Geometric continuity between parametric surfaces is an important issue in CAGD.So far rest-arches have been concentrated on it for N-dimensional surfaces whose common boundary is of N-1 dimensions.No results have ever been obtained for the case where the common boundary of the two surfaces is of L dimensions,0≤L≤N,or the two adjacent surfaces are of unequal dimensions.In this paper,the conditions of high-order geometric continuity between parametric surfaces are studied for these general cases By analysing the structure of Gn transformations,general solutions as well as an iterative method for determining adjustable functions are proposed.Some equivalent conditions of Gn continuity (nth order geometric continuity) are derived with an emphasis on conditions for triangular and rectangular Bezier surfaces.Since the Gn conditions for polynomial parametric surfaces are expressed in the form of explicit relationship of control points of Bezier surfaces,they are very useful both in theory and application for CAD/CAM and CAGD.Finally,Gn conditions between q-dimensional submanifolds of N-dimensional and M-dimensional surfaces are studied,thus a complete theoretical basis is laid for the problem of geometric continuity
