Cloud computing has gained significant use over the last decade due to its several benefits,including cost savings associated with setup,deployments,delivery,physical resource sharing across virtual machines,and avail...Cloud computing has gained significant use over the last decade due to its several benefits,including cost savings associated with setup,deployments,delivery,physical resource sharing across virtual machines,and availability of on-demand cloud services.However,in addition to usual threats in almost every computing environment,cloud computing has also introduced a set of new threats as consumers share physical resources due to the physical co-location paradigm.Furthermore,since there are a growing number of attacks directed at cloud environments(including dictionary attacks,replay code attacks,denial of service attacks,rootkit attacks,code injection attacks,etc.),customers require additional assurances before adopting cloud services.Moreover,the continuous integration and continuous deployment of the code fragments have made cloud services more prone to security breaches.In this study,the model based on the root of trust for continuous integration and continuous deployment is proposed,instead of only relying on a single signon authentication method that typically uses only id and password.The underlying study opted hardware security module by utilizing the Trusted Platform Module(TPM),which is commonly available as a cryptoprocessor on the motherboards of the personal computers and data center servers.The preliminary proof of concept demonstrated that the TPM features can be utilized through RESTful services to establish the root of trust for continuous integration and continuous deployment pipeline and can additionally be integrated as a secure microservice feature in the cloud computing environment.展开更多
Little attention had been paid to the intracontinental strike-slip faults of the Tibetan Plateau. Since the discovery of the Longriba fault using re-measured GPS data in 2003, an increasing amount of attention has bee...Little attention had been paid to the intracontinental strike-slip faults of the Tibetan Plateau. Since the discovery of the Longriba fault using re-measured GPS data in 2003, an increasing amount of attention has been paid to this neglected fault. The local relief and transverse swath profile show that the Longriba fault is the boundary line that separates the high and flat tomography of the Tibet plateau from the high and precipitous tomography of Orogen. In addition, GPS data shows that the Longriba fault is the boundary line where the migratory direction of the Bayan Har block changed from eastward to southeastward. The GPS data shows that the Longriba fault is the boundary fault of the sub-blocks of the eastern Bayan Har block. We built three-dimensional models containing the Longriba fault and the middle segment of the Longmenshan fault, across the Bayan Har block and the Sichuan Basin. A nonlinear finite element method was used to simulate the fault behavior and the block deformation of the Eastern Tibetan Plateau. The results show that the low resistivity and low velocity layer acts as a detachment layer, which causes the overlying blocks to move southeastward. The detachment layer also controls the vertical and horizontal deformation of the rigid Bayan Har block and leads to accumulation strain on the edge of the layer where the Longmenshan thrust is located. After a sufficient amount of strain has been accumulated on the Longmenshan fault, a large earthquake occurs, such as the 2008 Wenchuan earthquake. The strike slip activity of the Longriba fault, which is above the low resistivity and low velocity layer, partitions the lateral displacements of the Bayan Har block and adjusts the direction of motion of the Bayan Har block, from the eastward moving Ahba sub-block in the west to southeastward moving Longmenshan sub-block in the east. Four models with different depths to the Longriba fault were constructed： （1） a shallow fault with a depth of only 4 km, （2） a deeper fault that is half as deep as the Longmenshan fault, （3） a deep fault that is 2 km shallower than the low resistivity and low velocity layer, and （4） a fault that is as deep as the low resistivity and low velocity layer. The activity and influence of the Longriba fault with different development stage under this tectonic system were shown： in one Earthquake recurrence period, the rupture region of the fault increases with the depth of the fault, and the lateral slip partition by the fault also changes with the fault depth. It suggests that the Longriba fault is a newly generated fault that developed after the quick uplift in Late Cenozoic along this tectonic setting and gradually extended from the northwest to southeast. The calculations provide the characteristic of block deformation and fault behaviors of intra-continental strike-slip fault and major boundary thrust faults in the eastern margin of the Tibet plateau. Although the low resistivity and low velocity layer controls the deformation of the Bayan Hat block and the uplift of the Longmenshan thrust, the partition of the Longriba fault has an important influence on the intra-plate deformation and modern geomorphic evolution.展开更多
Watermarking is a widely used solution to the problems of authentication and copyright protection of digital media especially for images,videos,and audio data.Chaos is one of the emerging techniques adopted in image w...Watermarking is a widely used solution to the problems of authentication and copyright protection of digital media especially for images,videos,and audio data.Chaos is one of the emerging techniques adopted in image watermarking schemes due to its intrinsic cryptographic properties.This paper proposes a new chaotic hybrid watermarking method combining Discrete Wavelet Transform(DWT),Z-transform(ZT)and Bidiagonal Singular Value Decomposition(BSVD).The original image is decomposed into 3-level DWT,and then,ZT is applied on the HH3 and HL3 sub-bands.The watermark image is encrypted using Arnold Cat Map.BSVD for the watermark and transformed original image were computed,and the watermark was embedded by modifying singular values of the host image with the singular values of the watermark image.Robustness of the proposed scheme was examined using standard test images and assessed against common signal processing and geometric attacks.Experiments indicated that the proposed method is transparent and highly robust.展开更多
To analyze and depict complicated fluid behaviors in fractured porous media with variably permeable matrix,an integrated discrete computational algorithm is proposed based on lattice Boltzmann method（LBM）.This paper...To analyze and depict complicated fluid behaviors in fractured porous media with variably permeable matrix,an integrated discrete computational algorithm is proposed based on lattice Boltzmann method（LBM）.This paper combines with the external force model and statistical material physics to effectively describe the feature changes while the fluid passes through the fractures within the permeable matrix.As an application example,a two dimensional rock sample is reconstructed using the digital image and characterized with different feature values at each LBM grid to distinguish pores,impermeable and permeable matrix by stating its local physical property.Compared with the conventional LBM,the results demonstrate the advantages of proposed algorithm in modeling fluid flow phenomenon in fractured porous media with variably permeable matrix.展开更多
A computational strategy is presented for the nonlinear dynamic analysis of large- scale combined finite/discrete element systems on a PC cluster.In this strategy,a dual-level domain decomposition scheme is adopted to...A computational strategy is presented for the nonlinear dynamic analysis of large- scale combined finite/discrete element systems on a PC cluster.In this strategy,a dual-level domain decomposition scheme is adopted to implement the dynamic domain decomposition.The domain decomposition approach perfectly matches the requirement of reducing the memory size per processor of the calculation.To treat the contact between boundary elements in neighbouring subdomains,the elements in a subdomain are classified into internal,interfacial and external elements.In this way,all the contact detect algorithms developed for a sequential computation could be adopted directly in the parallel computation.Numerical examples show that this implementation is suitable for simulating large-scale problems.Two typical numerical examples are given to demonstrate the parallel efficiency and scalability on a PC cluster.展开更多
Advances on bidirectional intelligence are overviewed along three threads,with extensions and new perspectives.The first thread is about bidirectional learning architecture,exploring five dualities that enable Lmser s...Advances on bidirectional intelligence are overviewed along three threads,with extensions and new perspectives.The first thread is about bidirectional learning architecture,exploring five dualities that enable Lmser six cognitive functions and provide new perspectives on which a lot of extensions and particularlly flexible Lmser are proposed.Interestingly,either or two of these dualities actually takes an important role in recent models such as U-net,ResNet,and Dense Net.The second thread is about bidirectional learning principles unified by best yIng-yAng(IA)harmony in BYY system.After getting insights on deep bidirectional learning from a bird-viewing on existing typical learning principles from one or both of the inward and outward directions,maximum likelihood,variational principle,and several other learning principles are summarised as exemplars of the BYY learning,with new perspectives on advanced topics.The third thread further proceeds to deep bidirectional intelligence,driven by long term dynamics(LTD)for parameter learning and short term dynamics(STD)for image thinking and rational thinking in harmony.Image thinking deals with information flow of continuously valued arrays and especially image sequence,as if thinking was displayed in the real world,exemplified by the flow from inward encoding/cognition to outward reconstruction/transformation performed in Lmser learning and BYY learning.In contrast,rational thinking handles symbolic strings or discretely valued vectors,performing uncertainty reasoning and problem solving.In particular,a general thesis is proposed for bidirectional intelligence,featured by BYY intelligence potential theory(BYY-IPT)and nine essential dualities in architecture,fundamentals,and implementation,respectively.Then,problems of combinatorial solving and uncertainty reasoning are investigated from this BYY IPT perspective.First,variants and extensions are suggested for AlphaGoZero like searching tasks,such as traveling salesman problem(TSP)and attributed graph matching(AGM)that are turned into Go like problems with help of a feature enrichment technique.Second,reasoning activities are summarized under guidance of BYY IPT from the aspects of constraint satisfaction,uncertainty propagation,and path or tree searching.Particularly,causal potential theory is proposed for discovering causal direction,with two roads developed for its implementation.展开更多
This paper introduces a novel application of bionic engineering： a bionic musical instrument using Physarum polycephalum. Physarum polycephalum is a huge single cell with thousands of nuclei, which behaves like a gia...This paper introduces a novel application of bionic engineering： a bionic musical instrument using Physarum polycephalum. Physarum polycephalum is a huge single cell with thousands of nuclei, which behaves like a giant amoeba. During its foraging behavior this plasmodium produces electrical activity corresponding to different physiological states. We developed a method to render sounds from such electrical activity and thus represent spatio-temporal behavior of slime mould in a form apprehended auditorily. The electrical activity is captured by various electrodes placed on a Petri dish containing the cultured slime mold. Sounds are synthesized by a bank of parallel sinusoidal oscillators connected to the electrodes. Each electrode is responsible for one partial of the spectrum of the resulting sound. The behavior of the slime mould can be controlled to produce different timbres.展开更多
Prolactin is a polypeptide hormone associated with an extensive variety of biological functions.Among the roles of prolactin in vertebrates,some were preserved throughout evolution.This is the case of its function in ...Prolactin is a polypeptide hormone associated with an extensive variety of biological functions.Among the roles of prolactin in vertebrates,some were preserved throughout evolution.This is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous system.In the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to parenthood.Prolactin is mainly produced by specialized cells in the anterior pituitary gland.However,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the brain.This review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.展开更多
Geothermal energy potential is usually discussed in the context of conventional or engineered systems and at the scale of an individual reservoir. Whereas exploration for conventional reservoirs has been relatively ea...Geothermal energy potential is usually discussed in the context of conventional or engineered systems and at the scale of an individual reservoir. Whereas exploration for conventional reservoirs has been relatively easy, with expressions of resource found close to or even at the surface, exploration for non-conventional systems relies on temperature inherently increasing with depth and searching for favourable geological environments that maximise this increase. To utilitise the information we do have, we often assimilate available exploration data with models that capture the physics of the domi- nant underlying processes. Here, we discuss computational modelling approaches to exploration at a regional or crust scale, with application to geothermal reservoirs within basins or systems of basins. Target reservoirs have （at least） appropriate temperature, permeability and are at accessible depths. We discuss the software development approach that leads to effective use of the tool Underworld. We explore its role in the process of modelling, understanding computational error, importing and exporting geological knowledge as applied to the geological system underpinning the Guangdong Province, China.展开更多
The finite element method has been considered as one of the most significant engineering advances of the twentieth century. This computational methodology has made substantial impact on many fields in science and also...The finite element method has been considered as one of the most significant engineering advances of the twentieth century. This computational methodology has made substantial impact on many fields in science and also has profoundly changed engineering design procedures and practice. This paper, mainly froln a solid mechanics perspective, and the Swansea viewpoint in particular, describes very briefly the origin of the methodology, then summaries selected milestones of the technical developments that have taken place over the last fifty years and illustrates their application to some practical engineering problems.展开更多
It is well known that soilewater characteristic curve （SWCC） plays an important role in unsaturated soil mechanics, but the measurement of SWCC is inconvenient. In laboratory it requires days of testing time. For fi...It is well known that soilewater characteristic curve （SWCC） plays an important role in unsaturated soil mechanics, but the measurement of SWCC is inconvenient. In laboratory it requires days of testing time. For fine-grained clays, it may last for a couple of months using pressure plate tests. In this study, the effects of sample dimensions and shapes on the balance time of measuring SWCCs using pressure plate tests and the shape of SWCCs are investigated. It can be found that the sample dimensions and shapes have apparent influence on the balance time. The testing durations for circular samples with smaller diameters and annular samples with larger contact area are significantly shortened. However, there is little effect of sample dimensions and shapes on the shape of SWCCs. Its mechanism is explored and discussed in details through analysing the principle of pressure plate tests and microstructure of the sample. Based on the above findings, it is found that the circular samples with smaller dimensions can accelerate the testing duration of SWCC using the pressure plate.展开更多
Traditional organic liquid electrolytes used in commercial Li-ion batteries would incur serious safety issues due to their flammability and volatility[1].The exploration and design of solid electrolytes with high room...Traditional organic liquid electrolytes used in commercial Li-ion batteries would incur serious safety issues due to their flammability and volatility[1].The exploration and design of solid electrolytes with high room-temperature Li-ion conductivities(sRT)are important to improve the safety and cycle life of Li-ion batteries[2].Although previous investigations have proven that various physical factors correlate with Li-ion diffusion in solids,there is no unified theory to explain the similarity among distinctive crystal structures of solid-state Liion conductors(SSLCs).In addition,the exploration of a vast composition-structure space of thousands of materials is extremely difficult.The current investigations mainly rely on‘trial and error’and are limited to a few kinds of candidates,such as lithium thiophosphates,garnets,sodium super ionic conductors(NASICONs),perovskites and argyrodites[3].Therefore,the discovery of novel SSLCs from wider materials on basis of available knowledge is significant.展开更多
Long Range Wide Area Network (LoRaWAN) in the Internet ofThings (IoT) domain has been the subject of interest for researchers. Thereis an increasing demand to localize these IoT devices using LoRaWAN dueto the quickly...Long Range Wide Area Network (LoRaWAN) in the Internet ofThings (IoT) domain has been the subject of interest for researchers. Thereis an increasing demand to localize these IoT devices using LoRaWAN dueto the quickly growing number of IoT devices. LoRaWAN is well suited tosupport localization applications in IoTs due to its low power consumptionand long range. Multiple approaches have been proposed to solve the localizationproblem using LoRaWAN. The Expected Signal Power (ESP) basedtrilateration algorithm has the significant potential for localization becauseESP can identify the signal’s energy below the noise floor with no additionalhardware requirements and ease of implementation. This research articleoffers the technical evaluation of the trilateration technique, its efficiency,and its limitations for the localization using LoRa ESP in a large outdoorpopulated campus environment. Additionally, experimental evaluations areconducted to determine the effects of frequency hopping, outlier removal, andincreasing the number of gateways on localization accuracy. Results obtainedfrom the experiment show the importance of calculating the path loss exponentfor every frequency to circumvent the high localization error because ofthe frequency hopping, thus improving the localization performance withoutthe need of using only a single frequency.展开更多
基金The research work was supported by UTP-Universitas Telkom,Indonesia International Collaborative Research Funding(ICRF)015ME0-153 and Center for Graduate Studies(CGS),Universiti Teknologi PETRONAS(UTP),Perak,Malaysia.
文摘Cloud computing has gained significant use over the last decade due to its several benefits,including cost savings associated with setup,deployments,delivery,physical resource sharing across virtual machines,and availability of on-demand cloud services.However,in addition to usual threats in almost every computing environment,cloud computing has also introduced a set of new threats as consumers share physical resources due to the physical co-location paradigm.Furthermore,since there are a growing number of attacks directed at cloud environments(including dictionary attacks,replay code attacks,denial of service attacks,rootkit attacks,code injection attacks,etc.),customers require additional assurances before adopting cloud services.Moreover,the continuous integration and continuous deployment of the code fragments have made cloud services more prone to security breaches.In this study,the model based on the root of trust for continuous integration and continuous deployment is proposed,instead of only relying on a single signon authentication method that typically uses only id and password.The underlying study opted hardware security module by utilizing the Trusted Platform Module(TPM),which is commonly available as a cryptoprocessor on the motherboards of the personal computers and data center servers.The preliminary proof of concept demonstrated that the TPM features can be utilized through RESTful services to establish the root of trust for continuous integration and continuous deployment pipeline and can additionally be integrated as a secure microservice feature in the cloud computing environment.
基金the project of National Natural Science Foundation of China (Grant No.41004037 and 41202235)
文摘Little attention had been paid to the intracontinental strike-slip faults of the Tibetan Plateau. Since the discovery of the Longriba fault using re-measured GPS data in 2003, an increasing amount of attention has been paid to this neglected fault. The local relief and transverse swath profile show that the Longriba fault is the boundary line that separates the high and flat tomography of the Tibet plateau from the high and precipitous tomography of Orogen. In addition, GPS data shows that the Longriba fault is the boundary line where the migratory direction of the Bayan Har block changed from eastward to southeastward. The GPS data shows that the Longriba fault is the boundary fault of the sub-blocks of the eastern Bayan Har block. We built three-dimensional models containing the Longriba fault and the middle segment of the Longmenshan fault, across the Bayan Har block and the Sichuan Basin. A nonlinear finite element method was used to simulate the fault behavior and the block deformation of the Eastern Tibetan Plateau. The results show that the low resistivity and low velocity layer acts as a detachment layer, which causes the overlying blocks to move southeastward. The detachment layer also controls the vertical and horizontal deformation of the rigid Bayan Har block and leads to accumulation strain on the edge of the layer where the Longmenshan thrust is located. After a sufficient amount of strain has been accumulated on the Longmenshan fault, a large earthquake occurs, such as the 2008 Wenchuan earthquake. The strike slip activity of the Longriba fault, which is above the low resistivity and low velocity layer, partitions the lateral displacements of the Bayan Har block and adjusts the direction of motion of the Bayan Har block, from the eastward moving Ahba sub-block in the west to southeastward moving Longmenshan sub-block in the east. Four models with different depths to the Longriba fault were constructed： （1） a shallow fault with a depth of only 4 km, （2） a deeper fault that is half as deep as the Longmenshan fault, （3） a deep fault that is 2 km shallower than the low resistivity and low velocity layer, and （4） a fault that is as deep as the low resistivity and low velocity layer. The activity and influence of the Longriba fault with different development stage under this tectonic system were shown： in one Earthquake recurrence period, the rupture region of the fault increases with the depth of the fault, and the lateral slip partition by the fault also changes with the fault depth. It suggests that the Longriba fault is a newly generated fault that developed after the quick uplift in Late Cenozoic along this tectonic setting and gradually extended from the northwest to southeast. The calculations provide the characteristic of block deformation and fault behaviors of intra-continental strike-slip fault and major boundary thrust faults in the eastern margin of the Tibet plateau. Although the low resistivity and low velocity layer controls the deformation of the Bayan Hat block and the uplift of the Longmenshan thrust, the partition of the Longriba fault has an important influence on the intra-plate deformation and modern geomorphic evolution.
文摘Watermarking is a widely used solution to the problems of authentication and copyright protection of digital media especially for images,videos,and audio data.Chaos is one of the emerging techniques adopted in image watermarking schemes due to its intrinsic cryptographic properties.This paper proposes a new chaotic hybrid watermarking method combining Discrete Wavelet Transform(DWT),Z-transform(ZT)and Bidiagonal Singular Value Decomposition(BSVD).The original image is decomposed into 3-level DWT,and then,ZT is applied on the HH3 and HL3 sub-bands.The watermark image is encrypted using Arnold Cat Map.BSVD for the watermark and transformed original image were computed,and the watermark was embedded by modifying singular values of the host image with the singular values of the watermark image.Robustness of the proposed scheme was examined using standard test images and assessed against common signal processing and geometric attacks.Experiments indicated that the proposed method is transparent and highly robust.
基金supported by the Australian Research Council(ARC DP066620,LP0560932,LX0989423 and DP110103024)
文摘To analyze and depict complicated fluid behaviors in fractured porous media with variably permeable matrix,an integrated discrete computational algorithm is proposed based on lattice Boltzmann method（LBM）.This paper combines with the external force model and statistical material physics to effectively describe the feature changes while the fluid passes through the fractures within the permeable matrix.As an application example,a two dimensional rock sample is reconstructed using the digital image and characterized with different feature values at each LBM grid to distinguish pores,impermeable and permeable matrix by stating its local physical property.Compared with the conventional LBM,the results demonstrate the advantages of proposed algorithm in modeling fluid flow phenomenon in fractured porous media with variably permeable matrix.
基金The project supported by the National Natural Science Foundation of China (10372114) and the Engineering and Physical Sciences Research Council (EPSRC) of UK (GR/R21219)
文摘A computational strategy is presented for the nonlinear dynamic analysis of large- scale combined finite/discrete element systems on a PC cluster.In this strategy,a dual-level domain decomposition scheme is adopted to implement the dynamic domain decomposition.The domain decomposition approach perfectly matches the requirement of reducing the memory size per processor of the calculation.To treat the contact between boundary elements in neighbouring subdomains,the elements in a subdomain are classified into internal,interfacial and external elements.In this way,all the contact detect algorithms developed for a sequential computation could be adopted directly in the parallel computation.Numerical examples show that this implementation is suitable for simulating large-scale problems.Two typical numerical examples are given to demonstrate the parallel efficiency and scalability on a PC cluster.
基金supported by the Zhi-Yuan Chair Professorship Start-up Grant (WF220103010) from Shanghai Jiao Tong University
文摘Advances on bidirectional intelligence are overviewed along three threads,with extensions and new perspectives.The first thread is about bidirectional learning architecture,exploring five dualities that enable Lmser six cognitive functions and provide new perspectives on which a lot of extensions and particularlly flexible Lmser are proposed.Interestingly,either or two of these dualities actually takes an important role in recent models such as U-net,ResNet,and Dense Net.The second thread is about bidirectional learning principles unified by best yIng-yAng(IA)harmony in BYY system.After getting insights on deep bidirectional learning from a bird-viewing on existing typical learning principles from one or both of the inward and outward directions,maximum likelihood,variational principle,and several other learning principles are summarised as exemplars of the BYY learning,with new perspectives on advanced topics.The third thread further proceeds to deep bidirectional intelligence,driven by long term dynamics(LTD)for parameter learning and short term dynamics(STD)for image thinking and rational thinking in harmony.Image thinking deals with information flow of continuously valued arrays and especially image sequence,as if thinking was displayed in the real world,exemplified by the flow from inward encoding/cognition to outward reconstruction/transformation performed in Lmser learning and BYY learning.In contrast,rational thinking handles symbolic strings or discretely valued vectors,performing uncertainty reasoning and problem solving.In particular,a general thesis is proposed for bidirectional intelligence,featured by BYY intelligence potential theory(BYY-IPT)and nine essential dualities in architecture,fundamentals,and implementation,respectively.Then,problems of combinatorial solving and uncertainty reasoning are investigated from this BYY IPT perspective.First,variants and extensions are suggested for AlphaGoZero like searching tasks,such as traveling salesman problem(TSP)and attributed graph matching(AGM)that are turned into Go like problems with help of a feature enrichment technique.Second,reasoning activities are summarized under guidance of BYY IPT from the aspects of constraint satisfaction,uncertainty propagation,and path or tree searching.Particularly,causal potential theory is proposed for discovering causal direction,with two roads developed for its implementation.
文摘This paper introduces a novel application of bionic engineering： a bionic musical instrument using Physarum polycephalum. Physarum polycephalum is a huge single cell with thousands of nuclei, which behaves like a giant amoeba. During its foraging behavior this plasmodium produces electrical activity corresponding to different physiological states. We developed a method to render sounds from such electrical activity and thus represent spatio-temporal behavior of slime mould in a form apprehended auditorily. The electrical activity is captured by various electrodes placed on a Petri dish containing the cultured slime mold. Sounds are synthesized by a bank of parallel sinusoidal oscillators connected to the electrodes. Each electrode is responsible for one partial of the spectrum of the resulting sound. The behavior of the slime mould can be controlled to produce different timbres.
基金supported by Fundação para a Ciência e Tecnologia(FCT,I.P.,Portugal,http://www.fct.p)project grants UID/Multi/00709/2013 and UID/Multi/00709/2019ARCB is a recipient of a PhD fellowship funded by the FCT(SFRH/BD/121890/2016)+1 种基金supported by the State Budget of the Portuguese Ministry of Science,Technology and Higher Education,by the European Commission and by the European Social Fund through the“Programa Operacional Regional Centro”funded by the grant“Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismovartis Oncology em Patologia Hipofisária 2019”and the European Regional Development Fund through the“Programa Operacional Regional do Centro(Centro 2020)-Sistema de ApoioàInvestigação Científica e Tecnológica-Programas Integrados de IC&DT”(Project Centro-01-0145-FEDER-000019-C4-Centro de Competências em Cloud Computing).
文摘Prolactin is a polypeptide hormone associated with an extensive variety of biological functions.Among the roles of prolactin in vertebrates,some were preserved throughout evolution.This is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous system.In the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to parenthood.Prolactin is mainly produced by specialized cells in the anterior pituitary gland.However,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the brain.This review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.
基金supported by the Australian Government infrastructure investment in AuScope Simulation and Modelling and the NeCTAR Geology to Geophysics eResearch toolsupported by the National Computational Infrastructure grant "p67-Energy driven understanding of deep geological resources" and the NeCTAR Research Cloud grant "Underworld_NeCTAR_ Cloud_Flow" executed at the R@CMon,the Research Cloud node at Monash University
文摘Geothermal energy potential is usually discussed in the context of conventional or engineered systems and at the scale of an individual reservoir. Whereas exploration for conventional reservoirs has been relatively easy, with expressions of resource found close to or even at the surface, exploration for non-conventional systems relies on temperature inherently increasing with depth and searching for favourable geological environments that maximise this increase. To utilitise the information we do have, we often assimilate available exploration data with models that capture the physics of the domi- nant underlying processes. Here, we discuss computational modelling approaches to exploration at a regional or crust scale, with application to geothermal reservoirs within basins or systems of basins. Target reservoirs have （at least） appropriate temperature, permeability and are at accessible depths. We discuss the software development approach that leads to effective use of the tool Underworld. We explore its role in the process of modelling, understanding computational error, importing and exporting geological knowledge as applied to the geological system underpinning the Guangdong Province, China.
文摘The finite element method has been considered as one of the most significant engineering advances of the twentieth century. This computational methodology has made substantial impact on many fields in science and also has profoundly changed engineering design procedures and practice. This paper, mainly froln a solid mechanics perspective, and the Swansea viewpoint in particular, describes very briefly the origin of the methodology, then summaries selected milestones of the technical developments that have taken place over the last fifty years and illustrates their application to some practical engineering problems.
基金supported by the National Natural Science Foundation of China (Grant No. 10872210)the State Key Laboratory of Geomechanics and Geotechnical Engineering (Grant No. Y11002)
文摘It is well known that soilewater characteristic curve （SWCC） plays an important role in unsaturated soil mechanics, but the measurement of SWCC is inconvenient. In laboratory it requires days of testing time. For fine-grained clays, it may last for a couple of months using pressure plate tests. In this study, the effects of sample dimensions and shapes on the balance time of measuring SWCCs using pressure plate tests and the shape of SWCCs are investigated. It can be found that the sample dimensions and shapes have apparent influence on the balance time. The testing durations for circular samples with smaller diameters and annular samples with larger contact area are significantly shortened. However, there is little effect of sample dimensions and shapes on the shape of SWCCs. Its mechanism is explored and discussed in details through analysing the principle of pressure plate tests and microstructure of the sample. Based on the above findings, it is found that the circular samples with smaller dimensions can accelerate the testing duration of SWCC using the pressure plate.
文摘Traditional organic liquid electrolytes used in commercial Li-ion batteries would incur serious safety issues due to their flammability and volatility[1].The exploration and design of solid electrolytes with high room-temperature Li-ion conductivities(sRT)are important to improve the safety and cycle life of Li-ion batteries[2].Although previous investigations have proven that various physical factors correlate with Li-ion diffusion in solids,there is no unified theory to explain the similarity among distinctive crystal structures of solid-state Liion conductors(SSLCs).In addition,the exploration of a vast composition-structure space of thousands of materials is extremely difficult.The current investigations mainly rely on‘trial and error’and are limited to a few kinds of candidates,such as lithium thiophosphates,garnets,sodium super ionic conductors(NASICONs),perovskites and argyrodites[3].Therefore,the discovery of novel SSLCs from wider materials on basis of available knowledge is significant.
基金the ADEK Award for Research Excellence (AARE19-245)2019.
文摘Long Range Wide Area Network (LoRaWAN) in the Internet ofThings (IoT) domain has been the subject of interest for researchers. Thereis an increasing demand to localize these IoT devices using LoRaWAN dueto the quickly growing number of IoT devices. LoRaWAN is well suited tosupport localization applications in IoTs due to its low power consumptionand long range. Multiple approaches have been proposed to solve the localizationproblem using LoRaWAN. The Expected Signal Power (ESP) basedtrilateration algorithm has the significant potential for localization becauseESP can identify the signal’s energy below the noise floor with no additionalhardware requirements and ease of implementation. This research articleoffers the technical evaluation of the trilateration technique, its efficiency,and its limitations for the localization using LoRa ESP in a large outdoorpopulated campus environment. Additionally, experimental evaluations areconducted to determine the effects of frequency hopping, outlier removal, andincreasing the number of gateways on localization accuracy. Results obtainedfrom the experiment show the importance of calculating the path loss exponentfor every frequency to circumvent the high localization error because ofthe frequency hopping, thus improving the localization performance withoutthe need of using only a single frequency.
