BACKGROUND： Chinese and contemporary Western medical practices evolved on different cultures and historical contexts and, therefore, their medical knowledge represents this cultural divergence. Computerization of tra...BACKGROUND： Chinese and contemporary Western medical practices evolved on different cultures and historical contexts and, therefore, their medical knowledge represents this cultural divergence. Computerization of traditional Chinese medicine （TCM） is being used to promote the integrative medicine to manage, process and integrate the knowledge related to TCM anatomy, physiology, semiology, pathophysiology, and therapy. METHODS： We proposed the development of the SuiteTCM software, a collection of integrated computational models mainly derived from epidemiology and statistical sciences for computerization of Chinese medicine scientific research and clinical practice in all levels of prevention. The software includes components for data management （DataTCM）, simulation of cases （SimTCM）, analyses and validation of datasets （SciTCM）, clinical examination and pattern differentiation （DiagTCM, TongueTCM, and PulseTCM）, intervention selection （AcuTCM, HerbsTCM, and DietTCM）, management of medical records （ProntTCM）, epidemiologic investigation of sampled data （ResearchTCM）, and medical education, training, and assessment （StudentTCM）. DISCUSSION： The SuiteTCM project is expected to contribute to the ongoing development of integrative medicine and the applicability of TCM in worldwide scientific research and health care. The SuiteTCM 1.0 runs on Windows XP or later and is freely available for download as an executable application.展开更多
High blood pressure is among the most prevalent chronic disease in adults that impacts on the quality of life of patients, which are often subjected to physical rehabilitation. Chinese medicine intervention in patient...High blood pressure is among the most prevalent chronic disease in adults that impacts on the quality of life of patients, which are often subjected to physical rehabilitation. Chinese medicine intervention in patients with hypertension presents promising albeit inconclu-sive results, mostly due to methodological issues. This paper discusses asserted and neglected issues linking evidence-based and Chinese medicines as related to systemic arterial hypertension, as well as their impact on the physical rehabilitation of those patients. On the one hand, natural history of hypertension, pulse palpa-tion, and herbal therapy are among the asserted issues because of the scientific evidence collected about them, either in favor or against its integration to the current medical practice. On the other hand, anatomical varia-tions of vessels and comparative physiology are among the most commonly neglected issues because previous researches on integrative medicine ignored the pos-sible effects of these issues as related to the study's outcome. The asserted issues highlighted in this paperstimulate the increasing use of Chinese medicine for health care and the continuity of research on integra-tive medicine in the cardiovascular field for rehabilita-tion. The neglected issues poses additional challenges that must not be overlooked in future research on this topic so that the integration of both traditional and cur-rent knowledge may be of benefit to the population with cardiovascular disease.展开更多
The aggregation behavior of the mixture of cetyltrimethylammonium chloride(CTAC), a cationic surfactant, and moxifloxacin hydrochloride(MFH), a fourth-generation fluoroquinolone antibiotic drug, has been studied using...The aggregation behavior of the mixture of cetyltrimethylammonium chloride(CTAC), a cationic surfactant, and moxifloxacin hydrochloride(MFH), a fourth-generation fluoroquinolone antibiotic drug, has been studied using the conductivity technique in aqueous and alcoholic(EtOH, 1-PrOH, and 2-BuOH)media. The study was performed at several temperatures between 298.15 and 323.15 K at 5 K intervals.The assembly has been characterized by evaluating the micellar parameters, such as the critical micelle concentration(CMC) and the counter ion binding(β), of the CTAC + MFH mixture. The values of the CMC for the assembly of the CTAC + MFH mixture were reliant on the composition of alcohols in the mixed solvents and the temperature. The CMC values of the CTAC + MFH mixture increased with increasing temperature;that is, assembly was delayed by increased temperature. The micellization of the CTAC + MFH mixed system was delayed in alcoholic media. The observed-ΔG0mvalues for the association of the CTAC + MFH mixed system demonstrated a spontaneous aggregation process under all study conditions.Based on the-ΔH^(0)_(m) and +ΔS^(0)_(m) values, the association of the CTAC + MFH mixture is exothermic and the interaction forces acting between the CTAC and MFH species are hydrophobic, ion–dipole, and electrostatic interactions. The transfer properties and enthalpy–entropy compensation were also assessed and described comprehensively.展开更多
Modeling ferroelectric materials from first principles is one of the successes of density-functional theory and the driver of much development effort,requiring an accurate description of the electronic processes and t...Modeling ferroelectric materials from first principles is one of the successes of density-functional theory and the driver of much development effort,requiring an accurate description of the electronic processes and the thermodynamic equilibrium that drive the spontaneous symmetry breaking and the emergence of macroscopic polarization.We demonstrate the development and application of an integrated machine learning model that describes on the same footing structural,energetic,and functional properties of barium titanate(BaTiO_(3)),a prototypical ferroelectric.The model uses ab initio calculations as a reference and achieves accurate yet inexpensive predictions of energy and polarization on time and length scales that are not accessible to direct ab initio modeling.These predictions allow us to assess the microscopic mechanism of the ferroelectric transition.The presence of an order-disorder transition for the Ti off-centered states is the main driver of the ferroelectric transition,even though the coupling between symmetry breaking and cell distortions determines the presence of intermediate,partly-ordered phases.Moreover,we thoroughly probe the static and dynamical behavior of BaTiO_(3)across its phase diagram without the need to introduce a coarse-grained description of the ferroelectric transition.Finally,we apply the polarization model to calculate the dielectric response properties of the material in a full ab initio manner,again reproducing the correct qualitative experimental behavior.展开更多
Gout is a form of inflammatory arthritis characterized by sharp pain and severe swelling that often causes severe physical disability. Gout is caused by the chronic elevation of uric acid levels in the blood and is kn...Gout is a form of inflammatory arthritis characterized by sharp pain and severe swelling that often causes severe physical disability. Gout is caused by the chronic elevation of uric acid levels in the blood and is known as the disease of kings due to its strong association with a diet rich in fructose and beer. Recent studies suggest that a high uric acid concentration is the result of a dynamical process that highlights the interactions between leptin production, insulin resistance, low muscle mass and a diet rich in fructose. Once individuals develop hyperuricemia, reach a high uric acid concentration in excess of 7 mg/dL for men and 6 mg/dL for women, they become susceptible to developing gout. We propose a novel dynamic system to analyze and determine the connections between a diet involving different levels of fructose (in both adult men and women in the U.S.) and the concentration of uric acid in the blood. Our model simulations suggest that adult males under a diet containing levels of fructose stimulating a 0.5 uric acid growth rate, could develop hyperuricemia after around 10,000 days, while it only takes women about 5000 days with a diet stimulating a 0.4 growth rate.展开更多
An investigation on the possible dynamical models of the core galaxy NGC 1399 is performed.Because early-type galaxies are likely to be formed through merging events, remnant rings are considered in the modeling proce...An investigation on the possible dynamical models of the core galaxy NGC 1399 is performed.Because early-type galaxies are likely to be formed through merging events, remnant rings are considered in the modeling process.A numerical survey over three parameters is employed to obtain the best-fit models that are completely consistent with observations.It is found that the inner slope of the dark matter profile is cuspy for this core galaxy.The existence of remnant rings in best-fit models indicates a merging history.The remnant ring explains the flattened surface brightness and thus could be the physical counterpart of the core structure of NGC 1399.展开更多
Finite difference type preconditioners for spectral element discretizations based on Legendre-Gauss-Lobatto points are analyzed. The latter is employed for the approximation of uniformly elliptic partial differential ...Finite difference type preconditioners for spectral element discretizations based on Legendre-Gauss-Lobatto points are analyzed. The latter is employed for the approximation of uniformly elliptic partial differential problems. In this work, it is shown that the condition number of the resulting preconditioned system is bounded independently of both of the polynomial degrees used in the spectral element method and the element sizes. Several numerical tests verify the h-p independence of the proposed preconditioning.展开更多
Considering the importance of investigating the transit timing variations(TTVs)of transiting exoplanets,we present a follow-up study of HAT-P-12 b.We include six new light curves observed between2011 and 2015 from thr...Considering the importance of investigating the transit timing variations(TTVs)of transiting exoplanets,we present a follow-up study of HAT-P-12 b.We include six new light curves observed between2011 and 2015 from three different observatories,in association with 25 light curves taken from the published literature.The sample of the data used thus covers a time span of~10.2 years with a large coverage of epochs(1160)for the transiting events of the exoplanet HAT-P-12 b.The light curves are utilized to determine the orbital parameters and conduct an investigation of possible TTVs.The new linear ephemeris shows a large value of reducedχ^(2),i.e.X_(red)^(2)(23)=7.93,and the sinusoidal fitting using the prominent frequency coming from a periodogram shows a reducedχ^(2) around 4.Based on these values and the corresponding O-C diagrams,we suspect the presence of a possible non-sinusoidal TTV in this planetary system.Finally,we find that a scenario with an additional non-transiting exoplanet could explain this TTV with an even smaller reducedχ^(2) value of around 2.展开更多
Changsha was one of the most affected areas during the 2009 A(H1N1)influenza pandemic in China.Here,we analyze the spatial–temporal dynamics of the 2009 pandemic across Changsha municipal districts,evaluate the relat...Changsha was one of the most affected areas during the 2009 A(H1N1)influenza pandemic in China.Here,we analyze the spatial–temporal dynamics of the 2009 pandemic across Changsha municipal districts,evaluate the relationship between case incidence and the local urban spatial structure and predict high-risk areas of influenza A(H1N1).We obtained epidemiological data on all cases of influenza A(H1N1)reported across municipal districts in Changsha during period May 2009–December 2010 and data on population density and basic geographic characteristics for 239 primary schools,97 middle schools,347 universities,96 malls and markets,674 business districts and 121 hospitals.Spatial–temporal K functions,proximity models and logistic regression were used to analyze the spatial distribution pattern of influenza A(H1N1)incidence and the association between influenza A(H1N1)cases and spatial risk factors and predict the infection risks.We found that the 2009 influenza A(H1N1)was driven by a transmission wave from the center of the study area to surrounding areas and reported cases increased significantly after September 2009.We also found that the distribution of influenza A(H1N1)cases was associated with population density and the presence of nearest public places,especially universities(OR=10.166).The final predictive risk map based on the multivariate logistic analysis showed high-risk areas concentrated in the center areas of the study area associated with high population density.Our findings support the identification of spatial risk factors and highrisk areas to guide the prioritization of preventive and mitigation efforts against future influenza pandemics.展开更多
Chinese medicine is among other traditional medical systems practiced either as a coadjutant intervention to Greek medicine or as the unique therapeutic intervention for illness prevention, treatment or rehabilitation...Chinese medicine is among other traditional medical systems practiced either as a coadjutant intervention to Greek medicine or as the unique therapeutic intervention for illness prevention, treatment or rehabilitation. The complete spectrum from that traditional system includes acupuncture and moxibustion, herbal and food therapy, massage therapy （tuina）, physical exercises （taijiquan）, and breathing exercises （qigong）. In this article, it is presented several randomized controlled trials and systematic reviews on the application of all therapeutic modalities from Chinese medicine in the physical rehabilitation scenario. The discussed studies encompasses both ＂positive＂ and ＂negative＂ results of Chinese medicine intervention for disabilities due to illnesses of the nervous, musculoskeletal or cardiovascular systems. Additionally, the importance of the personalized approach for Chinese medicineand rehabilitation is emphasized together with the need for reproducible methods for pattern differentiation and intervention selection. Chinese medicine resources are recognized as promising methods for therapeutic rehabilitation and can be incorporated into the rehabilitation science. The wide variety of therapeutic resources explains why Chinese medicine is currently a multidisciplinary practice for health protection and promotion, early diagnosis and treatment as well as rehabilitation with roles in the public health care system.展开更多
In November 2015,El Salvador reported their first case of Zika virus(ZIKV)infection,an event followed by an explosive outbreak that generated over 6000 suspected cases in a period of two months.National agencies began...In November 2015,El Salvador reported their first case of Zika virus(ZIKV)infection,an event followed by an explosive outbreak that generated over 6000 suspected cases in a period of two months.National agencies began implementing control measures that included vector control and recommending an increased use of repellents.Further,in response to the alarming and growing number of microcephaly cases in Brazil,the importance of avoiding pregnancies for two years was stressed.In this paper,we explore the role of mobility within communities characterized by extreme poverty,crime and violence.Specifically,the role of short term mobility between two idealized interconnected highly distinct communities is explored in the context of ZIKV outbreaks.We make use of a Lagrangian modeling approach within a two-patch setting in order to highlight the possible effects that short-term mobility,within highly distinct environments,may have on the dynamics of ZIKV outbreak when the overall goal is to reduce the number of cases not just in the most affluent areas but everywhere.Outcomes depend on existing mobility patterns,levels of disease risk,and the ability of federal or state public health services to invest in resource limited areas,particularly in those where violence is systemic.The results of simulations in highly polarized and simplified scenarios are used to assess the role of mobility.It quickly became evident that matching observed patterns of ZIKV outbreaks could not be captured without incorporating increasing levels of heterogeneity.The number of distinct patches and variations on patch connectivity structure required to match ZIKV patterns could not be met within the highly aggregated model that is used in the simulations.展开更多
In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin America.In the non-endemic city of San Ramòn de la Nueva Orán,located in Nor...In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin America.In the non-endemic city of San Ramòn de la Nueva Orán,located in Northwest Argentina,large dengue outbreaks alternate with several years of smaller ones.This pattern,as well as the understanding of the underlying mechanisms,could be essential to design proper strategies to reduce epidemic size.We develop a stochastic model that includes climate variables,social structure,and mobility between a non-endemic city and an endemic area.Climatic variables were input of a mosquito population ecological model,which in turn was coupled to a meta-population,spatially explicit,epidemiological model.Human mobility was included into the model given the high border crossing to the northern country of Bolivia,where dengue transmission is sustained during the whole year.We tested different hypotheses regarding people mobility as well as climate variability by fitting numerical simulations to weekly clinical data reported from 2009 to 2016.After assessing the number of imported cases that triggered the observed outbreaks,our model allows to explain the observed epidemic pattern.We found that the number of vectors per host and the effective reproductive number are proxies for large epidemics.Both proxies are related with climate variability such as rainfall and temperature,opening the possibility to test these meteorological variables for forecast purposes.展开更多
基金supported by a grant (n°E-26/103.066/2012)from the Fundao Carlos Chagas Filho de Amparo à Pesquisa no Estado do Rio de Janeiro (FAPERJ)
文摘BACKGROUND： Chinese and contemporary Western medical practices evolved on different cultures and historical contexts and, therefore, their medical knowledge represents this cultural divergence. Computerization of traditional Chinese medicine （TCM） is being used to promote the integrative medicine to manage, process and integrate the knowledge related to TCM anatomy, physiology, semiology, pathophysiology, and therapy. METHODS： We proposed the development of the SuiteTCM software, a collection of integrated computational models mainly derived from epidemiology and statistical sciences for computerization of Chinese medicine scientific research and clinical practice in all levels of prevention. The software includes components for data management （DataTCM）, simulation of cases （SimTCM）, analyses and validation of datasets （SciTCM）, clinical examination and pattern differentiation （DiagTCM, TongueTCM, and PulseTCM）, intervention selection （AcuTCM, HerbsTCM, and DietTCM）, management of medical records （ProntTCM）, epidemiologic investigation of sampled data （ResearchTCM）, and medical education, training, and assessment （StudentTCM）. DISCUSSION： The SuiteTCM project is expected to contribute to the ongoing development of integrative medicine and the applicability of TCM in worldwide scientific research and health care. The SuiteTCM 1.0 runs on Windows XP or later and is freely available for download as an executable application.
文摘High blood pressure is among the most prevalent chronic disease in adults that impacts on the quality of life of patients, which are often subjected to physical rehabilitation. Chinese medicine intervention in patients with hypertension presents promising albeit inconclu-sive results, mostly due to methodological issues. This paper discusses asserted and neglected issues linking evidence-based and Chinese medicines as related to systemic arterial hypertension, as well as their impact on the physical rehabilitation of those patients. On the one hand, natural history of hypertension, pulse palpa-tion, and herbal therapy are among the asserted issues because of the scientific evidence collected about them, either in favor or against its integration to the current medical practice. On the other hand, anatomical varia-tions of vessels and comparative physiology are among the most commonly neglected issues because previous researches on integrative medicine ignored the pos-sible effects of these issues as related to the study's outcome. The asserted issues highlighted in this paperstimulate the increasing use of Chinese medicine for health care and the continuity of research on integra-tive medicine in the cardiovascular field for rehabilita-tion. The neglected issues poses additional challenges that must not be overlooked in future research on this topic so that the integration of both traditional and cur-rent knowledge may be of benefit to the population with cardiovascular disease.
基金funded by Institutional Fund Projects (IFPIP:515-961-1443)technical and financial support provided by the Ministry of Education and King Abdulaziz University, DSR, Jeddah, Saudi Arabia。
文摘The aggregation behavior of the mixture of cetyltrimethylammonium chloride(CTAC), a cationic surfactant, and moxifloxacin hydrochloride(MFH), a fourth-generation fluoroquinolone antibiotic drug, has been studied using the conductivity technique in aqueous and alcoholic(EtOH, 1-PrOH, and 2-BuOH)media. The study was performed at several temperatures between 298.15 and 323.15 K at 5 K intervals.The assembly has been characterized by evaluating the micellar parameters, such as the critical micelle concentration(CMC) and the counter ion binding(β), of the CTAC + MFH mixture. The values of the CMC for the assembly of the CTAC + MFH mixture were reliant on the composition of alcohols in the mixed solvents and the temperature. The CMC values of the CTAC + MFH mixture increased with increasing temperature;that is, assembly was delayed by increased temperature. The micellization of the CTAC + MFH mixed system was delayed in alcoholic media. The observed-ΔG0mvalues for the association of the CTAC + MFH mixed system demonstrated a spontaneous aggregation process under all study conditions.Based on the-ΔH^(0)_(m) and +ΔS^(0)_(m) values, the association of the CTAC + MFH mixture is exothermic and the interaction forces acting between the CTAC and MFH species are hydrophobic, ion–dipole, and electrostatic interactions. The transfer properties and enthalpy–entropy compensation were also assessed and described comprehensively.
基金L.G.,M.K.and M.C.were supported by the Samsung Advanced Institute of Technology(SAIT)M.V.,G.P.,N.M.and M.C.acknowledge support from the MARVEL National Centre of Competence in Research(NCCR),funded by the Swiss National Science Foundation(grant agreement ID 51NF40-182892)+2 种基金G.P.acknowledges the swissuniversities“Materials Cloud”project(number 201-003)G.P.and N.M.acknowledge support from the European Centre of Excellence MaX“Materials design at the Exascale”(824143)This work was supported by a grant from the Swiss National Supercomputing Centre(CSCS)under project IDs mr0 and s1073.
文摘Modeling ferroelectric materials from first principles is one of the successes of density-functional theory and the driver of much development effort,requiring an accurate description of the electronic processes and the thermodynamic equilibrium that drive the spontaneous symmetry breaking and the emergence of macroscopic polarization.We demonstrate the development and application of an integrated machine learning model that describes on the same footing structural,energetic,and functional properties of barium titanate(BaTiO_(3)),a prototypical ferroelectric.The model uses ab initio calculations as a reference and achieves accurate yet inexpensive predictions of energy and polarization on time and length scales that are not accessible to direct ab initio modeling.These predictions allow us to assess the microscopic mechanism of the ferroelectric transition.The presence of an order-disorder transition for the Ti off-centered states is the main driver of the ferroelectric transition,even though the coupling between symmetry breaking and cell distortions determines the presence of intermediate,partly-ordered phases.Moreover,we thoroughly probe the static and dynamical behavior of BaTiO_(3)across its phase diagram without the need to introduce a coarse-grained description of the ferroelectric transition.Finally,we apply the polarization model to calculate the dielectric response properties of the material in a full ab initio manner,again reproducing the correct qualitative experimental behavior.
文摘Gout is a form of inflammatory arthritis characterized by sharp pain and severe swelling that often causes severe physical disability. Gout is caused by the chronic elevation of uric acid levels in the blood and is known as the disease of kings due to its strong association with a diet rich in fructose and beer. Recent studies suggest that a high uric acid concentration is the result of a dynamical process that highlights the interactions between leptin production, insulin resistance, low muscle mass and a diet rich in fructose. Once individuals develop hyperuricemia, reach a high uric acid concentration in excess of 7 mg/dL for men and 6 mg/dL for women, they become susceptible to developing gout. We propose a novel dynamic system to analyze and determine the connections between a diet involving different levels of fructose (in both adult men and women in the U.S.) and the concentration of uric acid in the blood. Our model simulations suggest that adult males under a diet containing levels of fructose stimulating a 0.5 uric acid growth rate, could develop hyperuricemia after around 10,000 days, while it only takes women about 5000 days with a diet stimulating a 0.4 growth rate.
基金supported in part by the Ministry of Science and Technology, Taiwan, under Li-Chin Yeh’s Grant MOST 106-2115-M-007-014Ing-Guey Jiang’s Grant MOST 106-2112-M-007-006-MY3
文摘An investigation on the possible dynamical models of the core galaxy NGC 1399 is performed.Because early-type galaxies are likely to be formed through merging events, remnant rings are considered in the modeling process.A numerical survey over three parameters is employed to obtain the best-fit models that are completely consistent with observations.It is found that the inner slope of the dark matter profile is cuspy for this core galaxy.The existence of remnant rings in best-fit models indicates a merging history.The remnant ring explains the flattened surface brightness and thus could be the physical counterpart of the core structure of NGC 1399.
文摘Finite difference type preconditioners for spectral element discretizations based on Legendre-Gauss-Lobatto points are analyzed. The latter is employed for the approximation of uniformly elliptic partial differential problems. In this work, it is shown that the condition number of the resulting preconditioned system is bounded independently of both of the polynomial degrees used in the spectral element method and the element sizes. Several numerical tests verify the h-p independence of the proposed preconditioning.
基金supported by grants from the Ministry of Science and Technology(MOST),Taiwan,China.The grant numbers are MOST 105-2119-M-007-029-MY3,MOST 1062112-M-007-006-MY3the University Grants Commission(UGC)+6 种基金financial support through Major Research Project no.UGC-MRP 43-521/2014(SR)IUCCA,Pune,India for providing supports through the IUCCA Associateship Programmefinancially supported by the National Natural Science Foundation of China(Grant Nos.11590782 and 11421303)supported by the B-type Strategic Priority Program of the Chinese Academy of Sciences(Grant No.XDB41000000)the National Natural Science Foundation of China(Grant No.11773081)CAS Interdisciplinary Innovation TeamFoundation of Minor Planets of the Purple Mountain Observatory。
文摘Considering the importance of investigating the transit timing variations(TTVs)of transiting exoplanets,we present a follow-up study of HAT-P-12 b.We include six new light curves observed between2011 and 2015 from three different observatories,in association with 25 light curves taken from the published literature.The sample of the data used thus covers a time span of~10.2 years with a large coverage of epochs(1160)for the transiting events of the exoplanet HAT-P-12 b.The light curves are utilized to determine the orbital parameters and conduct an investigation of possible TTVs.The new linear ephemeris shows a large value of reducedχ^(2),i.e.X_(red)^(2)(23)=7.93,and the sinusoidal fitting using the prominent frequency coming from a periodogram shows a reducedχ^(2) around 4.Based on these values and the corresponding O-C diagrams,we suspect the presence of a possible non-sinusoidal TTV in this planetary system.Finally,we find that a scenario with an additional non-transiting exoplanet could explain this TTV with an even smaller reducedχ^(2) value of around 2.
基金supported by the Key Discipline Construction Project in Hunan Province(2008001)the National Natural Science Foundation of China and the Scientific Research Fund of Hunan Provincial Education Department(13A051)
文摘Changsha was one of the most affected areas during the 2009 A(H1N1)influenza pandemic in China.Here,we analyze the spatial–temporal dynamics of the 2009 pandemic across Changsha municipal districts,evaluate the relationship between case incidence and the local urban spatial structure and predict high-risk areas of influenza A(H1N1).We obtained epidemiological data on all cases of influenza A(H1N1)reported across municipal districts in Changsha during period May 2009–December 2010 and data on population density and basic geographic characteristics for 239 primary schools,97 middle schools,347 universities,96 malls and markets,674 business districts and 121 hospitals.Spatial–temporal K functions,proximity models and logistic regression were used to analyze the spatial distribution pattern of influenza A(H1N1)incidence and the association between influenza A(H1N1)cases and spatial risk factors and predict the infection risks.We found that the 2009 influenza A(H1N1)was driven by a transmission wave from the center of the study area to surrounding areas and reported cases increased significantly after September 2009.We also found that the distribution of influenza A(H1N1)cases was associated with population density and the presence of nearest public places,especially universities(OR=10.166).The final predictive risk map based on the multivariate logistic analysis showed high-risk areas concentrated in the center areas of the study area associated with high population density.Our findings support the identification of spatial risk factors and highrisk areas to guide the prioritization of preventive and mitigation efforts against future influenza pandemics.
文摘Chinese medicine is among other traditional medical systems practiced either as a coadjutant intervention to Greek medicine or as the unique therapeutic intervention for illness prevention, treatment or rehabilitation. The complete spectrum from that traditional system includes acupuncture and moxibustion, herbal and food therapy, massage therapy （tuina）, physical exercises （taijiquan）, and breathing exercises （qigong）. In this article, it is presented several randomized controlled trials and systematic reviews on the application of all therapeutic modalities from Chinese medicine in the physical rehabilitation scenario. The discussed studies encompasses both ＂positive＂ and ＂negative＂ results of Chinese medicine intervention for disabilities due to illnesses of the nervous, musculoskeletal or cardiovascular systems. Additionally, the importance of the personalized approach for Chinese medicineand rehabilitation is emphasized together with the need for reproducible methods for pattern differentiation and intervention selection. Chinese medicine resources are recognized as promising methods for therapeutic rehabilitation and can be incorporated into the rehabilitation science. The wide variety of therapeutic resources explains why Chinese medicine is currently a multidisciplinary practice for health protection and promotion, early diagnosis and treatment as well as rehabilitation with roles in the public health care system.
基金This paper is dedicated to the inauguration of the Centro de Modelamiento Matematico Carlos Castillo-Chavez at Universidad Francisco Gavidia in San Salvador,El SalvadorThis project has been partially supported by grants from the National Science Foundation(DMS-1263374 and DUE-1101782),the National Security Agency(H98230-14-1-0157)the Office of the President of ASU,and the Office of the Provost of ASU.The views expressed are sole responsibility of the authors and not the funding agencies.
文摘In November 2015,El Salvador reported their first case of Zika virus(ZIKV)infection,an event followed by an explosive outbreak that generated over 6000 suspected cases in a period of two months.National agencies began implementing control measures that included vector control and recommending an increased use of repellents.Further,in response to the alarming and growing number of microcephaly cases in Brazil,the importance of avoiding pregnancies for two years was stressed.In this paper,we explore the role of mobility within communities characterized by extreme poverty,crime and violence.Specifically,the role of short term mobility between two idealized interconnected highly distinct communities is explored in the context of ZIKV outbreaks.We make use of a Lagrangian modeling approach within a two-patch setting in order to highlight the possible effects that short-term mobility,within highly distinct environments,may have on the dynamics of ZIKV outbreak when the overall goal is to reduce the number of cases not just in the most affluent areas but everywhere.Outcomes depend on existing mobility patterns,levels of disease risk,and the ability of federal or state public health services to invest in resource limited areas,particularly in those where violence is systemic.The results of simulations in highly polarized and simplified scenarios are used to assess the role of mobility.It quickly became evident that matching observed patterns of ZIKV outbreaks could not be captured without incorporating increasing levels of heterogeneity.The number of distinct patches and variations on patch connectivity structure required to match ZIKV patterns could not be met within the highly aggregated model that is used in the simulations.
基金supported by grants PICT 2017-3117,PIP 112e201501-00644CO,SeCYT-UNC 05/B457,CIUNSa 2467,CIUNSa B-2572,PICT-2019-2019-03558.
文摘In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin America.In the non-endemic city of San Ramòn de la Nueva Orán,located in Northwest Argentina,large dengue outbreaks alternate with several years of smaller ones.This pattern,as well as the understanding of the underlying mechanisms,could be essential to design proper strategies to reduce epidemic size.We develop a stochastic model that includes climate variables,social structure,and mobility between a non-endemic city and an endemic area.Climatic variables were input of a mosquito population ecological model,which in turn was coupled to a meta-population,spatially explicit,epidemiological model.Human mobility was included into the model given the high border crossing to the northern country of Bolivia,where dengue transmission is sustained during the whole year.We tested different hypotheses regarding people mobility as well as climate variability by fitting numerical simulations to weekly clinical data reported from 2009 to 2016.After assessing the number of imported cases that triggered the observed outbreaks,our model allows to explain the observed epidemic pattern.We found that the number of vectors per host and the effective reproductive number are proxies for large epidemics.Both proxies are related with climate variability such as rainfall and temperature,opening the possibility to test these meteorological variables for forecast purposes.
