BACKGROUND Gastric cancer is a malignant tumor with high morbidity and mortality worldwide.Neoadjuvant chemotherapy(NAC),defined as chemotherapy administered before the primary treatment(usually surgery)to reduce tumo...BACKGROUND Gastric cancer is a malignant tumor with high morbidity and mortality worldwide.Neoadjuvant chemotherapy(NAC),defined as chemotherapy administered before the primary treatment(usually surgery)to reduce tumor size and control micrometastases,has emerged as a crucial therapeutic strategy for locally advanced gastric cancer.Pathological complete response(pCR),characterized by the absence of viable tumor cells in the resected specimen after neoadjuvant treatment,is recognized as a strong predictor of favorable prognosis.However,the factors influencing the achievement of pCR remain incompletely understood.AIM To identify and analyze the predictive factors associated with achieving pCR after NAC in gastric cancer patients,thereby providing evidence-based guidance for clinical decision-making.METHODS A retrospective analysis was performed on 215 patients from Shandong Cancer Hospital and Tai’an Central Hospital with locally advanced gastric cancer who underwent NAC followed by radical surgery at our hospital between January 2015 and December 2023.Comprehensive clinical and pathological data were collected,including age,gender,tumor location,Lauren classification,clinical staging,chemotherapy regimens,number of chemotherapy cycles,and baseline hematological indicators.The baseline hematological indicators included neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio,albumin level,carcinoembryonic antigen(CEA),and carbohydrate antigen 19-9.Univariate and multivariate logistic regression analyses were employed to determine the independent predictive factors for pCR.RESULTS Among 215 gastric cancer patients,41(19.1%)achieved pCR after NAC.Multivariate analysis identified five independent predictive factors for pCR:Lauren intestinal type[odds ratio(OR)=3.28],lower clinical T stage(OR=2.75),CEA decrease≥70%after NAC(OR=3.42),pre-treatment NLR<2.5(OR=2.13),and≥4 chemotherapy cycles(OR=2.87).The fluorouracil,leucovorin,oxaliplatin,docetaxel regimen achieved the highest pCR rate(27.5%),and oxaliplatin-containing regimens were superior to cisplatin-containing regimens(22.3%vs 12.7%,P=0.034).Patients with both low NLR and platelet-to-lymphocyte ratio had the highest pCR rate(33.8%),while those with both high inflammatory markers had the lowest rate(10.7%).Earlier clinical stage disease(cT3N+vs cT4N+:28.6%vs 13.0%)and lower lymph node burden were associated with higher pCR rates.CONCLUSION The achievement of pCR after NAC in gastric cancer patients is closely associated with Lauren intestinal type,lower clinical T stage,a significant decrease in CEA after chemotherapy,low pre-treatment NLR,and an adequate number of chemotherapy cycles.展开更多
Endothelial dysfunction is a key factor linking obstructive sleep apnea hypopnea syndrome(OSAHS)with cardiovascular diseases.In this study,we used advanced proteomics and metabolomics approaches to investigate the imp...Endothelial dysfunction is a key factor linking obstructive sleep apnea hypopnea syndrome(OSAHS)with cardiovascular diseases.In this study,we used advanced proteomics and metabolomics approaches to investigate the impact of extracellular vesicles(EVs)derived from the serum of OSAHS patients on endothelial function.Our multi-omics analysis identified dysregulated pathways related to fatty acid metabolism,apoptosis regulation,and inflammatory responses,highlighting fatty acid synthase(FASN)as a crucial player in OSAHS-induced endothelial dysfunction.Both in vitro and in vivo experiments demonstrated that FASN-enriched EVs impair endothelial cell viability and disrupt metabolic homeostasis,offering new insights for the development of targeted therapies for cardiovascular complications associated with OSAHS.展开更多
Objective:To investigate the current psychological well-being of older people in the community and analyze its influencing factors.Methods:A total of 265 community-dwelling older adults aged 60 and above in Baoding Ci...Objective:To investigate the current psychological well-being of older people in the community and analyze its influencing factors.Methods:A total of 265 community-dwelling older adults aged 60 and above in Baoding City,Hebei Province,were selected through convenience sampling from November 2023 to March 2024.They were surveyed using a general information questionnaire and a comprehensive well-being questionnaire,with results analyzed statistically using SPSS 27.0.Results:Six dimensions of the psychological well-being scale for community older adults were identified:life vitality(P50=4.83),health concern(P50=4.6),self-worth(P50=5.6),friendly relationships(P50=5.33),altruistic behavior(P50=5.2),personality growth(P50=4.67),and comprehensive well-being(P50=161).Multivariate regression analysis showed that social isolation(β=-0.021,P<0.001),type of work(β=-0.142,P<0.001),chronic disease history(β=0.004,P<0.001),need for mobility aid(β=0.192,P<0.001),and monthly income(β=0.381,P<0.001)were factors influencing psychological well-being.Conclusion:The psychological well-being of the elderly is slightly above moderate and requires improvement.Enhancing factors such as reducing social isolation,addressing chronic disease history,and improving financial support could improve psychological well-being in older adults.展开更多
Objective:To investigate the psychological well-being of the elderly in Baoding City,Hebei Province,and analyze its influencing factors,with a focus on exploring the relationship between social isolation and psycholog...Objective:To investigate the psychological well-being of the elderly in Baoding City,Hebei Province,and analyze its influencing factors,with a focus on exploring the relationship between social isolation and psychological well-being.This study aims to provide a reference for effective interventions that promote the physical and mental health of elderly individuals in the community.Methods:A total of 265 elderly individuals from six communities in Baoding City,Hebei Province were surveyed between November 2023 and March 2024 using the general information questionnaire,the Social Isolation Scale for the Elderly,and the Comprehensive Happiness Questionnaire.Results:The total score of the Social Isolation Scale for the elderly in the community was(14.15±3.73)points,indicating a moderate level of social isolation.The average score of P50 on the Psychological Well-being Scale was 4.88,suggesting that the psychological well-being of the elderly in the community was moderate to high.Multivariate regression analysis showed that the level of social isolation significantly influenced the psychological well-being of the elderly(P<0.05),with social isolation negatively correlated with psychological well-being.Conclusion:Healthcare professionals should pay attention to the social isolation of elderly individuals in the community and develop targeted interventions to improve their psychological well-being and quality of life.展开更多
Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic ...Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood.In this study,we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.To help determine the mechanism of action,we measured levels of seve ral impo rtant brain activity-related proteins and their mRNA.On the injured side of the brain,we found that rTMS increased the protein levels and mRNA expression of brain-derived neurotrophic factor,tropomyosin receptor kinase B,N-methyl-D-aspartic acid receptor 1,and phosphorylated cAMP response element binding protein,which are closely associated with the occurrence of long-term potentiation.rTMS also partially reve rsed the loss of synaptophysin after injury and promoted the remodeling of synaptic ultrastructure.These findings suggest that upregulation of synaptic plasticity-related protein expression is the mechanism through which rTMS promotes neurological function recovery after moderate traumatic brain injury.展开更多
文摘BACKGROUND Gastric cancer is a malignant tumor with high morbidity and mortality worldwide.Neoadjuvant chemotherapy(NAC),defined as chemotherapy administered before the primary treatment(usually surgery)to reduce tumor size and control micrometastases,has emerged as a crucial therapeutic strategy for locally advanced gastric cancer.Pathological complete response(pCR),characterized by the absence of viable tumor cells in the resected specimen after neoadjuvant treatment,is recognized as a strong predictor of favorable prognosis.However,the factors influencing the achievement of pCR remain incompletely understood.AIM To identify and analyze the predictive factors associated with achieving pCR after NAC in gastric cancer patients,thereby providing evidence-based guidance for clinical decision-making.METHODS A retrospective analysis was performed on 215 patients from Shandong Cancer Hospital and Tai’an Central Hospital with locally advanced gastric cancer who underwent NAC followed by radical surgery at our hospital between January 2015 and December 2023.Comprehensive clinical and pathological data were collected,including age,gender,tumor location,Lauren classification,clinical staging,chemotherapy regimens,number of chemotherapy cycles,and baseline hematological indicators.The baseline hematological indicators included neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio,albumin level,carcinoembryonic antigen(CEA),and carbohydrate antigen 19-9.Univariate and multivariate logistic regression analyses were employed to determine the independent predictive factors for pCR.RESULTS Among 215 gastric cancer patients,41(19.1%)achieved pCR after NAC.Multivariate analysis identified five independent predictive factors for pCR:Lauren intestinal type[odds ratio(OR)=3.28],lower clinical T stage(OR=2.75),CEA decrease≥70%after NAC(OR=3.42),pre-treatment NLR<2.5(OR=2.13),and≥4 chemotherapy cycles(OR=2.87).The fluorouracil,leucovorin,oxaliplatin,docetaxel regimen achieved the highest pCR rate(27.5%),and oxaliplatin-containing regimens were superior to cisplatin-containing regimens(22.3%vs 12.7%,P=0.034).Patients with both low NLR and platelet-to-lymphocyte ratio had the highest pCR rate(33.8%),while those with both high inflammatory markers had the lowest rate(10.7%).Earlier clinical stage disease(cT3N+vs cT4N+:28.6%vs 13.0%)and lower lymph node burden were associated with higher pCR rates.CONCLUSION The achievement of pCR after NAC in gastric cancer patients is closely associated with Lauren intestinal type,lower clinical T stage,a significant decrease in CEA after chemotherapy,low pre-treatment NLR,and an adequate number of chemotherapy cycles.
文摘Endothelial dysfunction is a key factor linking obstructive sleep apnea hypopnea syndrome(OSAHS)with cardiovascular diseases.In this study,we used advanced proteomics and metabolomics approaches to investigate the impact of extracellular vesicles(EVs)derived from the serum of OSAHS patients on endothelial function.Our multi-omics analysis identified dysregulated pathways related to fatty acid metabolism,apoptosis regulation,and inflammatory responses,highlighting fatty acid synthase(FASN)as a crucial player in OSAHS-induced endothelial dysfunction.Both in vitro and in vivo experiments demonstrated that FASN-enriched EVs impair endothelial cell viability and disrupt metabolic homeostasis,offering new insights for the development of targeted therapies for cardiovascular complications associated with OSAHS.
基金Medical Science Foundation of Hebei University(2022X01)。
文摘Objective:To investigate the current psychological well-being of older people in the community and analyze its influencing factors.Methods:A total of 265 community-dwelling older adults aged 60 and above in Baoding City,Hebei Province,were selected through convenience sampling from November 2023 to March 2024.They were surveyed using a general information questionnaire and a comprehensive well-being questionnaire,with results analyzed statistically using SPSS 27.0.Results:Six dimensions of the psychological well-being scale for community older adults were identified:life vitality(P50=4.83),health concern(P50=4.6),self-worth(P50=5.6),friendly relationships(P50=5.33),altruistic behavior(P50=5.2),personality growth(P50=4.67),and comprehensive well-being(P50=161).Multivariate regression analysis showed that social isolation(β=-0.021,P<0.001),type of work(β=-0.142,P<0.001),chronic disease history(β=0.004,P<0.001),need for mobility aid(β=0.192,P<0.001),and monthly income(β=0.381,P<0.001)were factors influencing psychological well-being.Conclusion:The psychological well-being of the elderly is slightly above moderate and requires improvement.Enhancing factors such as reducing social isolation,addressing chronic disease history,and improving financial support could improve psychological well-being in older adults.
基金Medical Science Foundation of Hebei University(2022X01)。
文摘Objective:To investigate the psychological well-being of the elderly in Baoding City,Hebei Province,and analyze its influencing factors,with a focus on exploring the relationship between social isolation and psychological well-being.This study aims to provide a reference for effective interventions that promote the physical and mental health of elderly individuals in the community.Methods:A total of 265 elderly individuals from six communities in Baoding City,Hebei Province were surveyed between November 2023 and March 2024 using the general information questionnaire,the Social Isolation Scale for the Elderly,and the Comprehensive Happiness Questionnaire.Results:The total score of the Social Isolation Scale for the elderly in the community was(14.15±3.73)points,indicating a moderate level of social isolation.The average score of P50 on the Psychological Well-being Scale was 4.88,suggesting that the psychological well-being of the elderly in the community was moderate to high.Multivariate regression analysis showed that the level of social isolation significantly influenced the psychological well-being of the elderly(P<0.05),with social isolation negatively correlated with psychological well-being.Conclusion:Healthcare professionals should pay attention to the social isolation of elderly individuals in the community and develop targeted interventions to improve their psychological well-being and quality of life.
基金supported by the President Foundation of Nanfang Hospital,Southern Medical University,No.2016Z003(50107021)(to JZF).
文摘Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood.In this study,we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.To help determine the mechanism of action,we measured levels of seve ral impo rtant brain activity-related proteins and their mRNA.On the injured side of the brain,we found that rTMS increased the protein levels and mRNA expression of brain-derived neurotrophic factor,tropomyosin receptor kinase B,N-methyl-D-aspartic acid receptor 1,and phosphorylated cAMP response element binding protein,which are closely associated with the occurrence of long-term potentiation.rTMS also partially reve rsed the loss of synaptophysin after injury and promoted the remodeling of synaptic ultrastructure.These findings suggest that upregulation of synaptic plasticity-related protein expression is the mechanism through which rTMS promotes neurological function recovery after moderate traumatic brain injury.
