Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understandi...Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.展开更多
Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogen...Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogenesis owing to their multi-component and multi-target properties.This review focuses on the mechanisms of action of TCM monomers(e.g.,curcumin,tanshinone IIA,and ginsenoside)through the modulation of key pathways,such as HIF-1α,VEGF/VEGFRs,and Notch signaling,and explores their modulatory effects on the tumor microenvironment(e.g.,tumor-associated macrophage polarization).Despite the low toxicity and multi-targeting advantages of TCM,their clinical translation is still limited by low bioavailability and standardization difficulties.In this review,we further analyze the role of modern approaches,such as nanocarriers(liposomes,polymer nanoparticles,metal-coordinated nanomaterials,and plant exosome-like vesicles),in overcoming these bottlenecks and propose a strategy of combining TCM with chemotherapy,radiotherapy,and immunotherapy to overcome drug resistance and enhance therapeutic efficacy.By integrating traditional wisdom with cutting-edge technologies,anti-angiogenesis research in TCM is expected to contribute to the development of safer and more effective individualised cancer treatment.展开更多
Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal ...Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.展开更多
Objective:To evaluate the nursing effects of auricular seed therapy combined with Chinese herbal poultice treatment for patients with lumbar disc herniation(LDH).Method:A total of 80 patients with LDH were randomly di...Objective:To evaluate the nursing effects of auricular seed therapy combined with Chinese herbal poultice treatment for patients with lumbar disc herniation(LDH).Method:A total of 80 patients with LDH were randomly divided into two groups.The combined group received auricular acupuncture with seed application combined with Chinese herbal poultice therapy,while the reference group received auricular acupuncture with seed application alone.The therapeutic outcomes of both groups were compared.Results:The combined intervention group demonstrated decreased sleep quality scores,reduced pain neurotransmitter levels,and improved lumbar spine function scores post-intervention,with significant intergroup differences(p<0.05).Conclusion:Auricular seed therapy combined with Chinese herbal poultice care effectively improves sleep quality and lumbar spine function while alleviating pain perception in patients with lumbar disc herniation,indicating superior therapeutic efficacy.展开更多
Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentia...Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentiation 4(CD4)^(+)T lymphocyte(CD4 cell)counts—a condition known as immunological non-response(INRs).INRs are associated with elevated health risks,including increased susceptibility to AIDS-related and non-AIDS-related complications.The pathogenesis of INRs remains incompletely understood,and no established therapeutic interventions exist,posing a major challenge in contemporary HIV/AIDS management.Emerging evidence indicates that INRs exhibit significant alterations in gut microbiota composition.Dysbiosis of the gut microbiota may contribute to persistent immune activation,cytokine imbalance,and cellular pyroptosis,all of which could impair immune reconstitution in people living with HIV/AIDS.Traditional Chinese medicine(TCM)has demonstrated potential immunomodulatory effects and is increasingly utilized in the management of INRs.Targeting the gut microbiota and elucidating the mechanisms by which TCM modulates this microbial ecosystem may offer new avenues for preventing and treating INRs.This review explores the interplay between gut microbiota and TCM,examines the association between gut dysbiosis and INRs,discusses the mechanistic pathways through which microbiota imbalance contributes to INRs development,and highlights how TCM interventions regulate gut microbiota to promote immune recovery.By focusing on the gut microbiota as a therapeutic interface,this article provides novel insights into TCM-based strategies for improving outcomes in INRs and supports the development of innovative treatment approaches.展开更多
Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by mosquito vectors[1].Its clinical manifestations include high fever,headache,muscle and joint pain,and rash.It holds a significa...Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by mosquito vectors[1].Its clinical manifestations include high fever,headache,muscle and joint pain,and rash.It holds a significant position in global public health.In recent years,its incidence has continued to rise worldwide[2],making it one of the major diseases threatening human health.The disease course of dengue fever is divided into three typical phases:the acute febrile phase,the critical phase,and the recovery phase.While most patients experience mild symptoms,some may progress to severe dengue and potentially fatal outcomes if not promptly and effectively treated during the critical phase.展开更多
Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
Background: The human gut microbiome is an important target for disease treatment and prevention. Various microbial species within the complex ecosystem of the microbiome have been shown to play important roles in dis...Background: The human gut microbiome is an important target for disease treatment and prevention. Various microbial species within the complex ecosystem of the microbiome have been shown to play important roles in disease. Identification of bioactive materials capable of altering the abundances of these species both safely and effectively is a major goal in microbiome research. Many traditional Chinese medicines (TCMs) have been reported to affect the composition of the gut microbiome. Here, we summarize studies that have used TCMs to alter the gut microbiome and discuss the response relationship between TCMs and gut microbial species. Methods: We searched the PubMed, Web of Science, and Knowledge Network databases using the terms “traditional Chinese medicine,” “gut microbiome,” and specific system disease names (endocrine, immune, nervous, cardiovascular, and digestive). Studies were excluded if irrelevant or if the experimental procedures were unclear. Results: TCMs have been reported to affect a wide range of gut microbial taxa spanning major phyla, including Firmicutes, Bacteroidetes, Proteobacteria, Verrucomicrobiota, Actinobacteria, and Fusobacteria. In all, 54 TCMs including compounds and extracts have been tested in rodents and 30 have been examined in human trials. Almost all studies have reported positive results in regulating the gut microbiome as well as modulating corresponding phenotypes, spanning diseases of the endocrine, immune, nervous, cardiovascular, and digestive systems. Gut species, including Akkermansia, Bacteroides, Fusobacterium, Faecalibacterium, and E. coli, were found to be regulated by 19 TCMs. A network was constructed to visualize the interactions between TCMs and these taxa. Conclusion: There exists a complex and close relationship between intestinal microflora and diseases. Sufficient experimental data and studies have proved that the imbalance of intestinal microflora affects health by mediating metabolism, immune regulation, inflammation and signal transduction. Many characteristic alterations of intestinal microflora are positively correlated with diseases, so intestinal microflora has become a potential risk index and treatment target for many diseases. Many TCMs affect the relative abundances of microbial species in the gut, and therefore may be useful for modulating the gut microbiome. This review provides a reference for prioritizing candidate TCMs from the enormous repertoire of such medicines to test which specific gut microbes are targeted.展开更多
Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cel...Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cell therapy and tissue regeneration.However,cellular senescence induced by replication or external stimuli can impair MSC proliferation and differentiation,making it crucial to develop interventions that delay or reverse the senescence process.From a traditional Chinese medicine perspective,senescence stems from spleen and stomach deficiency,kidney deficiency,and related factors;thus,medicines that tonify the kidney and promote Qi and blood circulation play vital roles in anti-senescence therapy.Chinese medicine,characterized by low toxicity and multi-target,multi-functional properties,has become prominent in anti-senescence research.This paper examines the MSC senescence process by discussing its causes,characteristics,and mechanisms,then summarizes how active ingredients in herbal medicines and natural compounds reverse MSC senescence,facilitating the discovery of additional anti-senescence Chinese medicines and their effective components.展开更多
Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal ...Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.展开更多
The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuli...The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuling Mountain Area from various perspectives, including geographical indication products, geographical indication trademarks, China s geographical indication products mutually recognized and protected with the EU, geographical indication standards, and the exclusive geographical indication logo. It studies the regional public brand characteristics of Chinese authentic medicinal herbs, based on hometown of authentic Chinese medicinal herbs, advantageous regions of characteristic agricultural products, important agricultural cultural heritage, national famous and excellent new agricultural products, national characteristic agricultural products, geographical indication Chinese well-known trademarks, advantageous regions of characteristic agricultural products, and regional public brands of agricultural products. It analyzes the main problems in the protection of geographical indications and the creation of regional public brands, and proposes suggestions for building high-quality authentic medicinal herb bases, developing new quality productivity in the authentic medicinal herb industry, implementing regional brand strategies for authentic medicinal herbs, constructing a new development pattern of dual circulation authentic medicinal herbs, etc.展开更多
This paper explores the historical development and modern transformation of traditional Chinese medicine(TCM)to dispel the misconception that it is merely“traditional,ancient,backward and unscientific”.TCM,with root...This paper explores the historical development and modern transformation of traditional Chinese medicine(TCM)to dispel the misconception that it is merely“traditional,ancient,backward and unscientific”.TCM,with roots in ancient times,has evolved into a comprehensive medical system through the integration of empirical knowledge and theoretical frameworks.This review summarizes TCM’s development from three aspects:(1)Ancient Medical Development:From the Spring and Autumn to Han-Tang periods(770 B.C.E.-907 C.E.),the focus was on summarizing experience.A clear disciplinary classification emerged during the Song and Ming Dynasties(960 C.E.-1644 C.E.),and a complete medical system was established in the Qing Dynasty(1636 C.E.-1912 C.E.).(2)Modern Medical Development:Influenced by the European Industrial Revolution,new natural sciences-based technologies enhanced Western medicine’s diagnostic and treatment efficiency.The promotion of Western medicine in China and its metrological concepts,which underpin metrology-based medicine(MBM),in turn propelled the development of TCM.(3)The integration of modern TCM with metrology science has significantly changed TCM’s treatment and pharmaceutical fields.In recent decades,the introduction of western medicine has advanced TCM,creating a combined approach that leverages the advantages of both traditions.Supported by metrology and modern sciences,this integration has provided new tools for TCM quantification,standardization,and quality control.The paper emphasizes key milestones in TCM history,the impact of Western medicine and metrology on its modernization,and the potential of integrated approaches for complex medical challenges.It highlights the importance of preserving traditional knowledge while innovating to enhance TCM’s efficacy and safety.Future prospects suggest that TCM,combined with Metrology-based medicine,may play a crucial role in treating complex diseases,as modern Chinese medicine(MCM)has evolved with scientific advancements and integration of contemporary techniques.展开更多
Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A p...Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.展开更多
Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low b...Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low bio-availability,and potential toxicity.Nanocarriers,such as liposomes,polymeric nanoparticles,inorganic nanoparticles,and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations.This article summarizes the recent progress in nanocarrier-based delivery systems.Nanotechnology can broaden the scope of applications of traditional Chinese medicine.The concept of nano-traditional Chinese medicine(nano-TCM)is introduced,and the progress of nanomedicine,the advantages,and the development direction of nano-TCM are reviewed,providing new ideas for the development of nano-TCM.展开更多
Objective The rising prevalence of childhood obesity is closely associated with suboptimal dietary patterns.To address this public health concern,we conducted a comprehensive study to examine the association between c...Objective The rising prevalence of childhood obesity is closely associated with suboptimal dietary patterns.To address this public health concern,we conducted a comprehensive study to examine the association between coarse cereals consumption and body fat percentage(BFP)in Chinese children and adolescents.Methods The study included 48,305 children aged 6–17 years from 28 districts/counties in 14 provinces across seven regions of China(24,152 girls and 24,153 boys).BFP was examined using bioelectrical impedance analysis in the early morning.Coarse cereals consumption was assessed using a Food Frequency Questionnaire and categorized into three groups:0 g/1,000 kcal per day,0–10 g/1,000kcal per day,and>10 g/1,000 kcal per day(daily consumption of coarse cereals×1,000/total energy consumption).Quantile regression model was used to analyze the association between coarse cereals and BFP,adjusting for potential confounders such as age,pubertal development stage,urban/rural and regional factors,total daily dietary energy consumption,sedentary time,moderate-to-high physical activity,household income,parental education,and consumption of other foods.Results Boys aged 6–10,11–14,and 15–17 years had median daily coarse cereals consumptions of6.6 g,7.1 g,and 5.7 g,with BFP of 19.6%,19.5%,and 17.5%(all P<0.05).Girls in the same age groups showed consumption of 7.1 g,8.4 g,and 6.7 g,with BFP of 20.3%,26.4%,and 31.0%(all P<0.05).The quantile regression results for boys showed that daily consumption of coarse cereals was significantly correlated with their BFP in the 0.15,0.25,and 0.50 quartiles,with regression coefficients of-0.257,-0.221,and-0.330,respectively,after adjusting for potential confounders(P<0.05).For girls,there was a significant correlation with PBF at the 0.05,0.15,0.25,0.50,0.75,and 0.85 quartiles,with regression coefficients of-0.258,-0.366,-0.372,-0.431,-0.472,and-0.503(P<0.05 for all).Conclusions Coarse cereals consumption among Chinese children and adolescents remains relatively low.Higher consumption was inversely associated with BFP in children aged 6–17 years.Future interventional studies should assess how increased coarse cereals consumption prevents childhood obesity.展开更多
Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medi...Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).展开更多
Objective:To observe the clinical efficacy of acupuncture and moxibustion plus traditional Chinese herbs in treating depression after ischemic stroke and its effects on monoamine neurotransmitter levels.Methods:A tota...Objective:To observe the clinical efficacy of acupuncture and moxibustion plus traditional Chinese herbs in treating depression after ischemic stroke and its effects on monoamine neurotransmitter levels.Methods:A total of 80 patients with depression after ischemic stroke were divided into a control group and an observation group using the random number table method,with 40 cases in each group.The two groups were treated with Wen Yang Jie Yu Tang(decoction for warming Yang and relieving depression).The observation group was treated with additional acupuncture and moxibustion therapy.The therapeutic effect was evaluated after 4 weeks of treatment.The traditional Chinese medicine(TCM)main symptoms and depression symptoms were scored before and after 4 weeks of treatment.Neurological function was assessed using the National Institutes of Health stroke scale(NIHSS),depressive symptoms were evaluated by the 17-item Hamilton depression scale(HAMD-17),and sleep quality was assessed using the Pittsburgh sleep quality index(PSQI).Meanwhile,the serum levels of monoamine neurotransmitters,including 5-hydroxytryptamine(5-HT),noradrenaline(NE),and dopamine(DA),were measured.The incidence of adverse reactions during treatment was compared between the two groups.Results:The total effective rates in improving depression symptoms and TCM main symptoms in the observation group were both higher than those in the control group(P<0.05).After treatment,the scores of each TCM main symptom,NIHSS,HAMD-17,and PSQI in both groups were all lower than those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).After 4 weeks of treatment,the serum levels of 5-HT,NE,and DA in both groups were all higher than those before treatment(P<0.05),and the serum levels in the observation group were higher than those in the control group(P<0.05).During the treatment period,there was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of acupuncture and moxibustion plus traditional Chinese herbs has significant efficacy in treating depression after ischemic stroke;it can effectively relieve the symptoms,improve neurological function and sleep quality,increase monoamine neurotransmitter levels,and has high safety.展开更多
Component-based Chinese Medicine(CCM)stands as a pivotal endeavor in modernizing traditional Chinese medicine(TCM).By integrating classical TCM theories with modern scientific methodologies,CCM aims to achieve herbal ...Component-based Chinese Medicine(CCM)stands as a pivotal endeavor in modernizing traditional Chinese medicine(TCM).By integrating classical TCM theories with modern scientific methodologies,CCM aims to achieve herbal formulas with“defined components,clarified mechanisms,and controllable quality.”This approach not only transitions TCM development from empirical tradition to evidence-based science but also positions it for global recognition.Drawing on recent advancements in CCM,this editorial explores key insights and challenges shaping its trajectory.展开更多
Objective:To observe the efficacy of acupuncture combined with traditional Chinese herbs in the treatment of poststroke vascular dementia(VD)and the effects on serum interleukin(IL)-6 and superoxide dismutase(SOD).Met...Objective:To observe the efficacy of acupuncture combined with traditional Chinese herbs in the treatment of poststroke vascular dementia(VD)and the effects on serum interleukin(IL)-6 and superoxide dismutase(SOD).Methods:A total of 240 patients with poststroke VD were selected and randomly divided into two groups according to the random number table method,with 120 cases in each group.Both groups received Hua Tan Tong Luo(phlegmresolving and collateral-activating)formula,once daily;the observation group was additionally treated with Yi Shen Tiao Du(kidney-tonifying and Governor Vessel-regulating)acupuncture once daily for 6 consecutive days,followed by 1 d of rest.Both groups were treated for 15 d as one course,for a total of 2 courses.After treatment,the total effective rate was compared.Changes in scores of traditional Chinese medicine(TCM)symptoms,clinical dementia rating(CDR),National Institutes of Health stroke scale(NIHSS),and Chinese version of mini-mental state examination(MMSE),and serum levels of IL-6 and SOD were observed in both groups.Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels in both groups were lower than those before treatment(P<0.05),while MMSE scores and serum SOD levels were higher than those before treatment(P<0.05).After treatment,the observation group showed lower TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels than the control group(P<0.05),and higher MMSE scores and serum SOD levels than the control group(P<0.05).Conclusion:Compared to Hua Tan Tong Luo formula alone,Yi Shen Tiao Du acupuncture combined with Hua Tan Tong Luo formula demonstrates better efficacy in reducing dementia severity,improving cognitive and neurological function,and inhibiting inflammation in patients with poststroke VD.展开更多
[Objectives]To analyze the clinical characteristics,distribution of traditional Chinese medicine(TCM)syndrome types,spectrum of comorbidities,and complications among inpatients with gout.[Methods]Data from 592 gout pa...[Objectives]To analyze the clinical characteristics,distribution of traditional Chinese medicine(TCM)syndrome types,spectrum of comorbidities,and complications among inpatients with gout.[Methods]Data from 592 gout patients admitted in the Department of Rheumatology at Wuxi Traditional Chinese Medicine Hospital between January 2018 and December 2024 were retrospectively collected.The data collected encompassed patient gender,age,TCM syndrome types,underlying comorbidities,infection status,and major complications,including renal insufficiency,interstitial lung disease,and osteoporosis.Descriptive statistical analyses were subsequently performed.[Results]Among the 592 inpatients,80.75%were male and 19.25%were female.A total of 94.76%patients had at least one underlying condition,with hypertension(80.74%),cerebral infarction(29.59%),heart disease(24.24%),and diabetes(21.56%)being the most prevalent.The primary TCM syndrome types identified were damp-heat obstruction syndrome(63.51%)and phlegm-stasis obstruction syndrome(21.11%).During hospitalization,20.94%of patients experienced concurrent infections,predominantly pulmonary infections(38.10%).The principal complications observed included renal insufficiency(32.09%),interstitial lung disease(18.75%),and osteoporosis(9.29%).[Conclusions]Inpatients diagnosed with gout often present with complex conditions and a high burden of comorbidities,predominantly cardiovascular and cerebrovascular diseases,as well as metabolic disorders.Additionally,there is a high incidence of infections and renal insufficiency within this population.TCM syndrome types in these patients are primarily characterized by damp-heat obstruction.In clinical practice,a comprehensive management approach that incorporates multidisciplinary collaboration is recommended.Alongside the control of uric acid levels and joint inflammation,proactive screening and management of comorbidities and related complications are essential.展开更多
基金supported by the National Social Science Fund of China(NSSFC):NSSFC Major Project“Exploration and Practice in the Development of Chinese Economics Since the Modern Era”(Grant No.17ZDA034)NSSFC Key Project“The Status and Value of Traditional Chinese Economic Thought”(Grant No.17AJL006)NSSFC General Project“The Transformation and Evolution of Chinese Economic Thought During the Republican Era”(Grant No.22BJL130).
文摘Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.
基金supported by the Xinglin Scholars Nursery Program Talent Fund of Chengdu University of Traditional Chinese Medicine(MPRC2023005).
文摘Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogenesis owing to their multi-component and multi-target properties.This review focuses on the mechanisms of action of TCM monomers(e.g.,curcumin,tanshinone IIA,and ginsenoside)through the modulation of key pathways,such as HIF-1α,VEGF/VEGFRs,and Notch signaling,and explores their modulatory effects on the tumor microenvironment(e.g.,tumor-associated macrophage polarization).Despite the low toxicity and multi-targeting advantages of TCM,their clinical translation is still limited by low bioavailability and standardization difficulties.In this review,we further analyze the role of modern approaches,such as nanocarriers(liposomes,polymer nanoparticles,metal-coordinated nanomaterials,and plant exosome-like vesicles),in overcoming these bottlenecks and propose a strategy of combining TCM with chemotherapy,radiotherapy,and immunotherapy to overcome drug resistance and enhance therapeutic efficacy.By integrating traditional wisdom with cutting-edge technologies,anti-angiogenesis research in TCM is expected to contribute to the development of safer and more effective individualised cancer treatment.
基金supported by the Innovative Team Project of Ordinary Universities in Guangdong Province(No.2022KCXTD016).
文摘Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.
文摘Objective:To evaluate the nursing effects of auricular seed therapy combined with Chinese herbal poultice treatment for patients with lumbar disc herniation(LDH).Method:A total of 80 patients with LDH were randomly divided into two groups.The combined group received auricular acupuncture with seed application combined with Chinese herbal poultice therapy,while the reference group received auricular acupuncture with seed application alone.The therapeutic outcomes of both groups were compared.Results:The combined intervention group demonstrated decreased sleep quality scores,reduced pain neurotransmitter levels,and improved lumbar spine function scores post-intervention,with significant intergroup differences(p<0.05).Conclusion:Auricular seed therapy combined with Chinese herbal poultice care effectively improves sleep quality and lumbar spine function while alleviating pain perception in patients with lumbar disc herniation,indicating superior therapeutic efficacy.
基金supported by the National Natural Science Foundation of China(No.82274474)。
文摘Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentiation 4(CD4)^(+)T lymphocyte(CD4 cell)counts—a condition known as immunological non-response(INRs).INRs are associated with elevated health risks,including increased susceptibility to AIDS-related and non-AIDS-related complications.The pathogenesis of INRs remains incompletely understood,and no established therapeutic interventions exist,posing a major challenge in contemporary HIV/AIDS management.Emerging evidence indicates that INRs exhibit significant alterations in gut microbiota composition.Dysbiosis of the gut microbiota may contribute to persistent immune activation,cytokine imbalance,and cellular pyroptosis,all of which could impair immune reconstitution in people living with HIV/AIDS.Traditional Chinese medicine(TCM)has demonstrated potential immunomodulatory effects and is increasingly utilized in the management of INRs.Targeting the gut microbiota and elucidating the mechanisms by which TCM modulates this microbial ecosystem may offer new avenues for preventing and treating INRs.This review explores the interplay between gut microbiota and TCM,examines the association between gut dysbiosis and INRs,discusses the mechanistic pathways through which microbiota imbalance contributes to INRs development,and highlights how TCM interventions regulate gut microbiota to promote immune recovery.By focusing on the gut microbiota as a therapeutic interface,this article provides novel insights into TCM-based strategies for improving outcomes in INRs and supports the development of innovative treatment approaches.
文摘Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by mosquito vectors[1].Its clinical manifestations include high fever,headache,muscle and joint pain,and rash.It holds a significant position in global public health.In recent years,its incidence has continued to rise worldwide[2],making it one of the major diseases threatening human health.The disease course of dengue fever is divided into three typical phases:the acute febrile phase,the critical phase,and the recovery phase.While most patients experience mild symptoms,some may progress to severe dengue and potentially fatal outcomes if not promptly and effectively treated during the critical phase.
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
基金funding by National Natural Science Foundation of China(No.82174492)National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Project(N o.ZJJBGS2024002-1).
文摘Background: The human gut microbiome is an important target for disease treatment and prevention. Various microbial species within the complex ecosystem of the microbiome have been shown to play important roles in disease. Identification of bioactive materials capable of altering the abundances of these species both safely and effectively is a major goal in microbiome research. Many traditional Chinese medicines (TCMs) have been reported to affect the composition of the gut microbiome. Here, we summarize studies that have used TCMs to alter the gut microbiome and discuss the response relationship between TCMs and gut microbial species. Methods: We searched the PubMed, Web of Science, and Knowledge Network databases using the terms “traditional Chinese medicine,” “gut microbiome,” and specific system disease names (endocrine, immune, nervous, cardiovascular, and digestive). Studies were excluded if irrelevant or if the experimental procedures were unclear. Results: TCMs have been reported to affect a wide range of gut microbial taxa spanning major phyla, including Firmicutes, Bacteroidetes, Proteobacteria, Verrucomicrobiota, Actinobacteria, and Fusobacteria. In all, 54 TCMs including compounds and extracts have been tested in rodents and 30 have been examined in human trials. Almost all studies have reported positive results in regulating the gut microbiome as well as modulating corresponding phenotypes, spanning diseases of the endocrine, immune, nervous, cardiovascular, and digestive systems. Gut species, including Akkermansia, Bacteroides, Fusobacterium, Faecalibacterium, and E. coli, were found to be regulated by 19 TCMs. A network was constructed to visualize the interactions between TCMs and these taxa. Conclusion: There exists a complex and close relationship between intestinal microflora and diseases. Sufficient experimental data and studies have proved that the imbalance of intestinal microflora affects health by mediating metabolism, immune regulation, inflammation and signal transduction. Many characteristic alterations of intestinal microflora are positively correlated with diseases, so intestinal microflora has become a potential risk index and treatment target for many diseases. Many TCMs affect the relative abundances of microbial species in the gut, and therefore may be useful for modulating the gut microbiome. This review provides a reference for prioritizing candidate TCMs from the enormous repertoire of such medicines to test which specific gut microbes are targeted.
基金supported by Zhejiang Provincial Natural Science Foundation of China(No.LQ23H290006)the National Natural Science Foundation of China(No.82204781)+2 种基金the Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province(No.2020E10021)Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents(No.ZWB-2020-18)Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project(No.2023ZR119).
文摘Mesenchymal stem cells(MSCs)are pluripotent stem cells isolated from human tissues.Due to their strong self-renewal capacity,pluripotency,and immunomodulatory properties,MSCs have garnered significant attention in cell therapy and tissue regeneration.However,cellular senescence induced by replication or external stimuli can impair MSC proliferation and differentiation,making it crucial to develop interventions that delay or reverse the senescence process.From a traditional Chinese medicine perspective,senescence stems from spleen and stomach deficiency,kidney deficiency,and related factors;thus,medicines that tonify the kidney and promote Qi and blood circulation play vital roles in anti-senescence therapy.Chinese medicine,characterized by low toxicity and multi-target,multi-functional properties,has become prominent in anti-senescence research.This paper examines the MSC senescence process by discussing its causes,characteristics,and mechanisms,then summarizes how active ingredients in herbal medicines and natural compounds reverse MSC senescence,facilitating the discovery of additional anti-senescence Chinese medicines and their effective components.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
文摘Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.
基金Supported by the Project of National Social Science Fund of China (22CMZ015).
文摘The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuling Mountain Area from various perspectives, including geographical indication products, geographical indication trademarks, China s geographical indication products mutually recognized and protected with the EU, geographical indication standards, and the exclusive geographical indication logo. It studies the regional public brand characteristics of Chinese authentic medicinal herbs, based on hometown of authentic Chinese medicinal herbs, advantageous regions of characteristic agricultural products, important agricultural cultural heritage, national famous and excellent new agricultural products, national characteristic agricultural products, geographical indication Chinese well-known trademarks, advantageous regions of characteristic agricultural products, and regional public brands of agricultural products. It analyzes the main problems in the protection of geographical indications and the creation of regional public brands, and proposes suggestions for building high-quality authentic medicinal herb bases, developing new quality productivity in the authentic medicinal herb industry, implementing regional brand strategies for authentic medicinal herbs, constructing a new development pattern of dual circulation authentic medicinal herbs, etc.
文摘This paper explores the historical development and modern transformation of traditional Chinese medicine(TCM)to dispel the misconception that it is merely“traditional,ancient,backward and unscientific”.TCM,with roots in ancient times,has evolved into a comprehensive medical system through the integration of empirical knowledge and theoretical frameworks.This review summarizes TCM’s development from three aspects:(1)Ancient Medical Development:From the Spring and Autumn to Han-Tang periods(770 B.C.E.-907 C.E.),the focus was on summarizing experience.A clear disciplinary classification emerged during the Song and Ming Dynasties(960 C.E.-1644 C.E.),and a complete medical system was established in the Qing Dynasty(1636 C.E.-1912 C.E.).(2)Modern Medical Development:Influenced by the European Industrial Revolution,new natural sciences-based technologies enhanced Western medicine’s diagnostic and treatment efficiency.The promotion of Western medicine in China and its metrological concepts,which underpin metrology-based medicine(MBM),in turn propelled the development of TCM.(3)The integration of modern TCM with metrology science has significantly changed TCM’s treatment and pharmaceutical fields.In recent decades,the introduction of western medicine has advanced TCM,creating a combined approach that leverages the advantages of both traditions.Supported by metrology and modern sciences,this integration has provided new tools for TCM quantification,standardization,and quality control.The paper emphasizes key milestones in TCM history,the impact of Western medicine and metrology on its modernization,and the potential of integrated approaches for complex medical challenges.It highlights the importance of preserving traditional knowledge while innovating to enhance TCM’s efficacy and safety.Future prospects suggest that TCM,combined with Metrology-based medicine,may play a crucial role in treating complex diseases,as modern Chinese medicine(MCM)has evolved with scientific advancements and integration of contemporary techniques.
基金National Multidisciplinary Innovation Team of Traditional Chinese Medicine (ZYYCXTD-D-202204)Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00013)。
文摘Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.
基金supported by Young Talent Program of The Affiliated Hospital of Xuzhou Medical University,Advanced Program of The Affiliated Hospital of Xuzhou Medical University(PYJH2024210)Medical Research Project of Jiangsu Provincial Health Commission(H2023050)National Natural Science Foundation of China(No.32301278).
文摘Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low bio-availability,and potential toxicity.Nanocarriers,such as liposomes,polymeric nanoparticles,inorganic nanoparticles,and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations.This article summarizes the recent progress in nanocarrier-based delivery systems.Nanotechnology can broaden the scope of applications of traditional Chinese medicine.The concept of nano-traditional Chinese medicine(nano-TCM)is introduced,and the progress of nanomedicine,the advantages,and the development direction of nano-TCM are reviewed,providing new ideas for the development of nano-TCM.
基金supported by the Special Project of National Science and Technology Basic Resources Survey(Grant No.2017FY101100)。
文摘Objective The rising prevalence of childhood obesity is closely associated with suboptimal dietary patterns.To address this public health concern,we conducted a comprehensive study to examine the association between coarse cereals consumption and body fat percentage(BFP)in Chinese children and adolescents.Methods The study included 48,305 children aged 6–17 years from 28 districts/counties in 14 provinces across seven regions of China(24,152 girls and 24,153 boys).BFP was examined using bioelectrical impedance analysis in the early morning.Coarse cereals consumption was assessed using a Food Frequency Questionnaire and categorized into three groups:0 g/1,000 kcal per day,0–10 g/1,000kcal per day,and>10 g/1,000 kcal per day(daily consumption of coarse cereals×1,000/total energy consumption).Quantile regression model was used to analyze the association between coarse cereals and BFP,adjusting for potential confounders such as age,pubertal development stage,urban/rural and regional factors,total daily dietary energy consumption,sedentary time,moderate-to-high physical activity,household income,parental education,and consumption of other foods.Results Boys aged 6–10,11–14,and 15–17 years had median daily coarse cereals consumptions of6.6 g,7.1 g,and 5.7 g,with BFP of 19.6%,19.5%,and 17.5%(all P<0.05).Girls in the same age groups showed consumption of 7.1 g,8.4 g,and 6.7 g,with BFP of 20.3%,26.4%,and 31.0%(all P<0.05).The quantile regression results for boys showed that daily consumption of coarse cereals was significantly correlated with their BFP in the 0.15,0.25,and 0.50 quartiles,with regression coefficients of-0.257,-0.221,and-0.330,respectively,after adjusting for potential confounders(P<0.05).For girls,there was a significant correlation with PBF at the 0.05,0.15,0.25,0.50,0.75,and 0.85 quartiles,with regression coefficients of-0.258,-0.366,-0.372,-0.431,-0.472,and-0.503(P<0.05 for all).Conclusions Coarse cereals consumption among Chinese children and adolescents remains relatively low.Higher consumption was inversely associated with BFP in children aged 6–17 years.Future interventional studies should assess how increased coarse cereals consumption prevents childhood obesity.
基金funded by the National Natural Science Foundation of China(Grant Nos.:82222068,82070423,82270348,and 82173779)the Innovation Team and Talents Cultivation Pro-gram of National Administration of Traditional Chinese Medicine,China(Grant No:ZYYCXTD-D-202206)+1 种基金Fujian Province Science and Technology Project,China(Grant Nos.:2021J01420479,2021J02058,2022J011374,and 2022J02057)Fundamental Research Funds for the Chinese Central Universities,China(Grant No.:20720230070).
文摘Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).
基金supported by the Science and Technology Research and Development Program Project of Qinhuangdao(秦皇岛市科学技术研究与发展计划项目,No.202301A067).
文摘Objective:To observe the clinical efficacy of acupuncture and moxibustion plus traditional Chinese herbs in treating depression after ischemic stroke and its effects on monoamine neurotransmitter levels.Methods:A total of 80 patients with depression after ischemic stroke were divided into a control group and an observation group using the random number table method,with 40 cases in each group.The two groups were treated with Wen Yang Jie Yu Tang(decoction for warming Yang and relieving depression).The observation group was treated with additional acupuncture and moxibustion therapy.The therapeutic effect was evaluated after 4 weeks of treatment.The traditional Chinese medicine(TCM)main symptoms and depression symptoms were scored before and after 4 weeks of treatment.Neurological function was assessed using the National Institutes of Health stroke scale(NIHSS),depressive symptoms were evaluated by the 17-item Hamilton depression scale(HAMD-17),and sleep quality was assessed using the Pittsburgh sleep quality index(PSQI).Meanwhile,the serum levels of monoamine neurotransmitters,including 5-hydroxytryptamine(5-HT),noradrenaline(NE),and dopamine(DA),were measured.The incidence of adverse reactions during treatment was compared between the two groups.Results:The total effective rates in improving depression symptoms and TCM main symptoms in the observation group were both higher than those in the control group(P<0.05).After treatment,the scores of each TCM main symptom,NIHSS,HAMD-17,and PSQI in both groups were all lower than those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).After 4 weeks of treatment,the serum levels of 5-HT,NE,and DA in both groups were all higher than those before treatment(P<0.05),and the serum levels in the observation group were higher than those in the control group(P<0.05).During the treatment period,there was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of acupuncture and moxibustion plus traditional Chinese herbs has significant efficacy in treating depression after ischemic stroke;it can effectively relieve the symptoms,improve neurological function and sleep quality,increase monoamine neurotransmitter levels,and has high safety.
文摘Component-based Chinese Medicine(CCM)stands as a pivotal endeavor in modernizing traditional Chinese medicine(TCM).By integrating classical TCM theories with modern scientific methodologies,CCM aims to achieve herbal formulas with“defined components,clarified mechanisms,and controllable quality.”This approach not only transitions TCM development from empirical tradition to evidence-based science but also positions it for global recognition.Drawing on recent advancements in CCM,this editorial explores key insights and challenges shaping its trajectory.
基金supported by the Research Cultivation Project of Beijing Municipal Hospital(北京市属医院科研培育课题,No.PZ2022015).
文摘Objective:To observe the efficacy of acupuncture combined with traditional Chinese herbs in the treatment of poststroke vascular dementia(VD)and the effects on serum interleukin(IL)-6 and superoxide dismutase(SOD).Methods:A total of 240 patients with poststroke VD were selected and randomly divided into two groups according to the random number table method,with 120 cases in each group.Both groups received Hua Tan Tong Luo(phlegmresolving and collateral-activating)formula,once daily;the observation group was additionally treated with Yi Shen Tiao Du(kidney-tonifying and Governor Vessel-regulating)acupuncture once daily for 6 consecutive days,followed by 1 d of rest.Both groups were treated for 15 d as one course,for a total of 2 courses.After treatment,the total effective rate was compared.Changes in scores of traditional Chinese medicine(TCM)symptoms,clinical dementia rating(CDR),National Institutes of Health stroke scale(NIHSS),and Chinese version of mini-mental state examination(MMSE),and serum levels of IL-6 and SOD were observed in both groups.Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels in both groups were lower than those before treatment(P<0.05),while MMSE scores and serum SOD levels were higher than those before treatment(P<0.05).After treatment,the observation group showed lower TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels than the control group(P<0.05),and higher MMSE scores and serum SOD levels than the control group(P<0.05).Conclusion:Compared to Hua Tan Tong Luo formula alone,Yi Shen Tiao Du acupuncture combined with Hua Tan Tong Luo formula demonstrates better efficacy in reducing dementia severity,improving cognitive and neurological function,and inhibiting inflammation in patients with poststroke VD.
基金Supported by Wuxi Taihu Talent Program(202101)Project of Wu Jieping Medical Foundation(320.6750.2023-03-33).
文摘[Objectives]To analyze the clinical characteristics,distribution of traditional Chinese medicine(TCM)syndrome types,spectrum of comorbidities,and complications among inpatients with gout.[Methods]Data from 592 gout patients admitted in the Department of Rheumatology at Wuxi Traditional Chinese Medicine Hospital between January 2018 and December 2024 were retrospectively collected.The data collected encompassed patient gender,age,TCM syndrome types,underlying comorbidities,infection status,and major complications,including renal insufficiency,interstitial lung disease,and osteoporosis.Descriptive statistical analyses were subsequently performed.[Results]Among the 592 inpatients,80.75%were male and 19.25%were female.A total of 94.76%patients had at least one underlying condition,with hypertension(80.74%),cerebral infarction(29.59%),heart disease(24.24%),and diabetes(21.56%)being the most prevalent.The primary TCM syndrome types identified were damp-heat obstruction syndrome(63.51%)and phlegm-stasis obstruction syndrome(21.11%).During hospitalization,20.94%of patients experienced concurrent infections,predominantly pulmonary infections(38.10%).The principal complications observed included renal insufficiency(32.09%),interstitial lung disease(18.75%),and osteoporosis(9.29%).[Conclusions]Inpatients diagnosed with gout often present with complex conditions and a high burden of comorbidities,predominantly cardiovascular and cerebrovascular diseases,as well as metabolic disorders.Additionally,there is a high incidence of infections and renal insufficiency within this population.TCM syndrome types in these patients are primarily characterized by damp-heat obstruction.In clinical practice,a comprehensive management approach that incorporates multidisciplinary collaboration is recommended.Alongside the control of uric acid levels and joint inflammation,proactive screening and management of comorbidities and related complications are essential.
