目的利用两样本孟德尔随机化(MR)分析阿尔茨海默病(AD)与年龄相关性黄斑变性(AMD)之间存在的潜在因果关联。方法使用IEU Open GWAS数据库AD和干性AMD、湿性AMD全基因组关联研究的汇总统计数据,使用单核苷酸多态性(SNP)作为因果推断的工...目的利用两样本孟德尔随机化(MR)分析阿尔茨海默病(AD)与年龄相关性黄斑变性(AMD)之间存在的潜在因果关联。方法使用IEU Open GWAS数据库AD和干性AMD、湿性AMD全基因组关联研究的汇总统计数据,使用单核苷酸多态性(SNP)作为因果推断的工具变量,进行两样本MR分析。采用逆方差加权法(IVW)评估AD与湿性AMD、干性AMD的是否存在因果关联,同时采用MR-Egger回归法、加权中位数法(WME)、异质性检验及敏感性分析对结果进行补充分析。结果(1)筛选结果:暴露因素中,AD、湿性AMD、干性AMD均筛选出13个SNP。(2)AD与湿性AMD:AD与湿性AMD发生的强相关因素,有统计学意义[OR=0.883,95%CI(0.784,0.885),F=34.848,P=0.000],MR-Egger回归法显示不存在水平多效性(P>0.05),且AD与湿性AMD散点图斜率为负,表明二者存在因果关系。(3)AD与干性AMD:AD与干性AMD发生的强相关因素,有统计学意义[OR=0.875,95%CI(0.828,0.925),F=22.563,P=0.000],MR-Egger回归法显示不存在水平多效性(P>0.05),且AD与干性AMD散点图斜率为负,表明二者存在因果关系。结论AD与AMD存在潜在联系。由于AMD具有高致盲性,认识和控制AMD危险因素,阐明这两种疾病的共同致病途径将有助于其预防、治疗的研究。展开更多
Research on neutron-induced fission product yields of^(232)Th is crucial for understanding the competition between symmetric and asymmetric fission in actinide nuclei.However,obtaining complete isotopic yield distribu...Research on neutron-induced fission product yields of^(232)Th is crucial for understanding the competition between symmetric and asymmetric fission in actinide nuclei.However,obtaining complete isotopic yield distributions over a wide range of neutron energies remains a challenge.In this study,a Bayesian neural network model was developed to predict the independent(IND)and cumulative fission yields of^(232)Th under neutron irradiation at various incident energies.To address the limited availability of experimental data for the analysis of IND mass distributions,we substituted mass-number-based yields with the yields of specific isotopes.Furthermore,physical phenomena or quantities,such as the odd-even effect and isospin,were introduced as constraints to enhance the physical consistency of the predictions.The impact of these constraints was evaluated using mass-chain yield distributions and their dependence on energy.Incorporating physical constraints significantly improves the prediction accuracy,yielding more reliable and physically meaningful fission yield data for nuclear physics and reactor design applications.展开更多
Integral experiments on tungsten slab samples were carried out on the D-T neutron source facility at China Institute of Atomic Energy. Leakage neutron spectra from the irradiated tungsten target were measured by the t...Integral experiments on tungsten slab samples were carried out on the D-T neutron source facility at China Institute of Atomic Energy. Leakage neutron spectra from the irradiated tungsten target were measured by the time-of-flight technique. Accuracy of the nuclear data for tungsten was examined by comparing the measured neutron spectra with the leakage neutron spectra simulated using the MCNP-4C code with evaluated nuclear data of the JEFF-3.2, FENDL-3.0 and TENDL-2014 libraries. The results show that the calculations with JEFF-3.2 agree well with the measurements in the whole energy range and all angles, whereas the spectra calculated with FENDL-3.0 and TENDL-2014 have some discrepancies with the experimental data.展开更多
By introducing a general equilibrium framework to China's dual economic structure, this paper studies the microscopic mechanism of education input to narrow the urban-rural income gap and how to improve the alloca...By introducing a general equilibrium framework to China's dual economic structure, this paper studies the microscopic mechanism of education input to narrow the urban-rural income gap and how to improve the allocation efficiency of education funds in China's "new normal" economy. The empirical analysis results show that education input is effective in narrowing the urban-rural income gap and achieving a Pareto improvement state in both direct and indirect ways. However, the effect of education input at different stages varies. In particular, the impact of compulsory education on improving inequality is more significant than the other education levels. With adjustment for the macroeconomic slowdown, raising fiscal expenditures on education can improve potential economic growth by promoting human capital accumulation and labor productivity in the long run. In all, education input can promote labor migration and narrow the urban-rural income gap, which is conducive to alleviating the contradiction of the structural transformation lag in employment and achieving inclusive growth targets.展开更多
To satisfy the requirements of nuclear reaction cross sections in nuclear engineering applications and nuclear physics studies,the Neutron Activation Cross Section Data Library has been established.818 target nuclei i...To satisfy the requirements of nuclear reaction cross sections in nuclear engineering applications and nuclear physics studies,the Neutron Activation Cross Section Data Library has been established.818 target nuclei including unstable target or isomeric target nuclei are considered in this library.The induced neutron energy range region is between 10^(-5)eV and 20 MeV.The standard ENDF-6 format is adopted,including general information,reaction cross sections,multiplicities,and so on.The recommended reaction cross sections were obtained using UNF code system and FDRR nuclear model codes or systematic analysis based on available experimental data.展开更多
213Bi disintegrates (97.91±0.03) % by β-emission to the levels in 213Po, and (2.09±0.03) % through α decay to 209Tl. The evaluation of the complete decay scheme and data of 213Bi including the recent new m...213Bi disintegrates (97.91±0.03) % by β-emission to the levels in 213Po, and (2.09±0.03) % through α decay to 209Tl. The evaluation of the complete decay scheme and data of 213Bi including the recent new measurements are presented in this report. The Limitation of Relative Statistical Weight Method (LWM) was applied to average numbers throughout the evaluation. The uncertainty assigned to the average value was always greater than or equal to the smallest uncertainty of the values used to calculate the average. The half-life is determined to be 45.59±0.06 minutes. All known measured gamma-ray relative emission probabilities have been examined. And the gamma-ray emission probability of the reference γ line of 440.44keV is recommended to be (26.1±0.3) %. The calculated internal conversion coefficients and their uncertainties have been used to obtain the complete decay intensity balance. The other decay characteristics are calculated using the ENSDF analysis program. Finally the new 213Bi decay scheme was re-built.展开更多
The principal contradiction facing the Chinese society has evolved to be that between imbalanced and inadequate development and the people’s ever-growing needs for a better life.Given China’s vision for achieving mo...The principal contradiction facing the Chinese society has evolved to be that between imbalanced and inadequate development and the people’s ever-growing needs for a better life.Given China’s vision for achieving moderate prosperity,it is relevant to conduct theoretical and empirical studies on the nation’s development imbalances.As a quantitative index,the Tsinghua China Balanced Development Index measures the extent to which development is uneven and insuf ficient across regions,re flecting the progress and shortfalls in China’s efforts to promote balanced development.Our findings provide implications for how policymakers may help people’s expectations for a better life materialize by spurring balanced economic,social,environmental and livelihood development across regions.展开更多
Based on the mass distribution data up to 200 MeV measured by Zoller with kinetic energy method (corrected), the systematics on dependence of chain yield on incident neutron energy for each mass number A with a linear...Based on the mass distribution data up to 200 MeV measured by Zoller with kinetic energy method (corrected), the systematics on dependence of chain yield on incident neutron energy for each mass number A with a linear and quadric function was studied. And also the systematics of mass distribution on mass A and incident neutron energy was investigated by using 5 (or 3 ) Gaussian model. A code of nonlinear squared least method was developed and the parameters were deduced by fitting the experimental data. The calculated results with the parameters obtained could reproduce the experimental data used well. But comparisons with the data measured by radiochemistry method show some systematical difference. It is shown that there is some systematical difference between the measured data with kinetic and radioactive nuclide methods, the reasons of which need to be investigate further.展开更多
文摘目的利用两样本孟德尔随机化(MR)分析阿尔茨海默病(AD)与年龄相关性黄斑变性(AMD)之间存在的潜在因果关联。方法使用IEU Open GWAS数据库AD和干性AMD、湿性AMD全基因组关联研究的汇总统计数据,使用单核苷酸多态性(SNP)作为因果推断的工具变量,进行两样本MR分析。采用逆方差加权法(IVW)评估AD与湿性AMD、干性AMD的是否存在因果关联,同时采用MR-Egger回归法、加权中位数法(WME)、异质性检验及敏感性分析对结果进行补充分析。结果(1)筛选结果:暴露因素中,AD、湿性AMD、干性AMD均筛选出13个SNP。(2)AD与湿性AMD:AD与湿性AMD发生的强相关因素,有统计学意义[OR=0.883,95%CI(0.784,0.885),F=34.848,P=0.000],MR-Egger回归法显示不存在水平多效性(P>0.05),且AD与湿性AMD散点图斜率为负,表明二者存在因果关系。(3)AD与干性AMD:AD与干性AMD发生的强相关因素,有统计学意义[OR=0.875,95%CI(0.828,0.925),F=22.563,P=0.000],MR-Egger回归法显示不存在水平多效性(P>0.05),且AD与干性AMD散点图斜率为负,表明二者存在因果关系。结论AD与AMD存在潜在联系。由于AMD具有高致盲性,认识和控制AMD危险因素,阐明这两种疾病的共同致病途径将有助于其预防、治疗的研究。
基金supported by the National Natural Science Foundation of China(Nos.12247126 and 12375123)Henan Postdoctoral Foundation(No.HN2024013)the Natural Science Foundation of Henan Province(No.242300421048)。
文摘Research on neutron-induced fission product yields of^(232)Th is crucial for understanding the competition between symmetric and asymmetric fission in actinide nuclei.However,obtaining complete isotopic yield distributions over a wide range of neutron energies remains a challenge.In this study,a Bayesian neural network model was developed to predict the independent(IND)and cumulative fission yields of^(232)Th under neutron irradiation at various incident energies.To address the limited availability of experimental data for the analysis of IND mass distributions,we substituted mass-number-based yields with the yields of specific isotopes.Furthermore,physical phenomena or quantities,such as the odd-even effect and isospin,were introduced as constraints to enhance the physical consistency of the predictions.The impact of these constraints was evaluated using mass-chain yield distributions and their dependence on energy.Incorporating physical constraints significantly improves the prediction accuracy,yielding more reliable and physically meaningful fission yield data for nuclear physics and reactor design applications.
基金supported by the National Natural Science Foundation of China(No.11605097,91426301,and 11605257)Doctoral Scientific Research Foundation of Inner Mongolia University for the Nationalities(No.BS365)the‘‘ADS project 302’’of the Chinese Academy of Sciences(No.XDA03030200)
文摘Integral experiments on tungsten slab samples were carried out on the D-T neutron source facility at China Institute of Atomic Energy. Leakage neutron spectra from the irradiated tungsten target were measured by the time-of-flight technique. Accuracy of the nuclear data for tungsten was examined by comparing the measured neutron spectra with the leakage neutron spectra simulated using the MCNP-4C code with evaluated nuclear data of the JEFF-3.2, FENDL-3.0 and TENDL-2014 libraries. The results show that the calculations with JEFF-3.2 agree well with the measurements in the whole energy range and all angles, whereas the spectra calculated with FENDL-3.0 and TENDL-2014 have some discrepancies with the experimental data.
文摘By introducing a general equilibrium framework to China's dual economic structure, this paper studies the microscopic mechanism of education input to narrow the urban-rural income gap and how to improve the allocation efficiency of education funds in China's "new normal" economy. The empirical analysis results show that education input is effective in narrowing the urban-rural income gap and achieving a Pareto improvement state in both direct and indirect ways. However, the effect of education input at different stages varies. In particular, the impact of compulsory education on improving inequality is more significant than the other education levels. With adjustment for the macroeconomic slowdown, raising fiscal expenditures on education can improve potential economic growth by promoting human capital accumulation and labor productivity in the long run. In all, education input can promote labor migration and narrow the urban-rural income gap, which is conducive to alleviating the contradiction of the structural transformation lag in employment and achieving inclusive growth targets.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11934004 and U1832201)the Science Challenge Project (Grant No. TZ2016005)the CAEP Foundation (Grant No. CX2019022)
文摘To satisfy the requirements of nuclear reaction cross sections in nuclear engineering applications and nuclear physics studies,the Neutron Activation Cross Section Data Library has been established.818 target nuclei including unstable target or isomeric target nuclei are considered in this library.The induced neutron energy range region is between 10^(-5)eV and 20 MeV.The standard ENDF-6 format is adopted,including general information,reaction cross sections,multiplicities,and so on.The recommended reaction cross sections were obtained using UNF code system and FDRR nuclear model codes or systematic analysis based on available experimental data.
基金IAEA under IAEA Research Contract No. 13339/R0/RBF
文摘213Bi disintegrates (97.91±0.03) % by β-emission to the levels in 213Po, and (2.09±0.03) % through α decay to 209Tl. The evaluation of the complete decay scheme and data of 213Bi including the recent new measurements are presented in this report. The Limitation of Relative Statistical Weight Method (LWM) was applied to average numbers throughout the evaluation. The uncertainty assigned to the average value was always greater than or equal to the smallest uncertainty of the values used to calculate the average. The half-life is determined to be 45.59±0.06 minutes. All known measured gamma-ray relative emission probabilities have been examined. And the gamma-ray emission probability of the reference γ line of 440.44keV is recommended to be (26.1±0.3) %. The calculated internal conversion coefficients and their uncertainties have been used to obtain the complete decay intensity balance. The other decay characteristics are calculated using the ENSDF analysis program. Finally the new 213Bi decay scheme was re-built.
基金the final result of the “Tsinghua China Balanced Development Index” Project of the China Data CenterTsinghua University+1 种基金Sponsored by the Minshan Public-Interest Fund of the China Siyuan Foundation for Poverty Alleviation (CSFPA) with special sponsorship from the China Post-Doctoral Science Foundation (2018T110079)general sponsorship from the China Post-Doctoral Science Foundation (2017M620719)。
文摘The principal contradiction facing the Chinese society has evolved to be that between imbalanced and inadequate development and the people’s ever-growing needs for a better life.Given China’s vision for achieving moderate prosperity,it is relevant to conduct theoretical and empirical studies on the nation’s development imbalances.As a quantitative index,the Tsinghua China Balanced Development Index measures the extent to which development is uneven and insuf ficient across regions,re flecting the progress and shortfalls in China’s efforts to promote balanced development.Our findings provide implications for how policymakers may help people’s expectations for a better life materialize by spurring balanced economic,social,environmental and livelihood development across regions.
文摘Based on the mass distribution data up to 200 MeV measured by Zoller with kinetic energy method (corrected), the systematics on dependence of chain yield on incident neutron energy for each mass number A with a linear and quadric function was studied. And also the systematics of mass distribution on mass A and incident neutron energy was investigated by using 5 (or 3 ) Gaussian model. A code of nonlinear squared least method was developed and the parameters were deduced by fitting the experimental data. The calculated results with the parameters obtained could reproduce the experimental data used well. But comparisons with the data measured by radiochemistry method show some systematical difference. It is shown that there is some systematical difference between the measured data with kinetic and radioactive nuclide methods, the reasons of which need to be investigate further.
