The Chinese government has always attached great importance to disease control and prevention efforts.Recently,the general office of China’s State Council issued the“Guidelines for High-Quality Development of Diseas...The Chinese government has always attached great importance to disease control and prevention efforts.Recently,the general office of China’s State Council issued the“Guidelines for High-Quality Development of Disease Prevention and Control”(hereinafter referred to as the“Guidelines”)(1).The Guidelines focus on promoting high-quality development of disease control and prevention and the strategic goal of“Healthy China,”providing specific implementation pathways for the development of national disease control and prevention in the new era,including overall planning,restructuring of governance,enhancing core capabilities,strengthening talent development,and improving organizational support.展开更多
BACKGROUND President Xi Jinping emphasized the paramount importance of bolstering early surveillance and early warning capacities within a robust public health system(1).These elements constitute one of the five major...BACKGROUND President Xi Jinping emphasized the paramount importance of bolstering early surveillance and early warning capacities within a robust public health system(1).These elements constitute one of the five major functionalities of the National Bureau of Disease Control and Prevention(2).As an integral division of the National Bureau of Disease Control and Prevention,the Center for Disease Control and Prevention(CDC)is responsible for executing early surveillance and warning procedures in the realm of public health.Nonetheless,a deficiency persists concerning the early warning of public health risk factors.展开更多
China is still a high tuberculosis(TB)burden country,and the number of new cases of TB was 833,000 in 2019(1).School campuses are highlycrowded places with potential for close contact,which suggests that a few cases o...China is still a high tuberculosis(TB)burden country,and the number of new cases of TB was 833,000 in 2019(1).School campuses are highlycrowded places with potential for close contact,which suggests that a few cases of TB may lead to a large outbreak.Thus,TB prevention and control in schools is an important disease control challenge for educational and health departments at all levels.展开更多
Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the preven...Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.展开更多
INTRODUCTION Contemporary human living environments present complex and pervasive health risks,and environmental health challenges are becoming increasingly prominent.These risks encompass diverse domains,such as chem...INTRODUCTION Contemporary human living environments present complex and pervasive health risks,and environmental health challenges are becoming increasingly prominent.These risks encompass diverse domains,such as chemical factors(e.g.,heavy metals,nanomaterials,per-and polyfluoroalkyl substances),physical factors(e.g.,noise,radiation,and extreme weather)biological factors(e.g.,pathogenic microorganisms and parasites),natural disasters(e.g.,earthquakes and floods),and anthropogenic incidents(e.g.,chemical spills,fires,and explosions).展开更多
Personal care products(PCPs)are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the environment.Biomonitoring data is valuable for insight the levels of P...Personal care products(PCPs)are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the environment.Biomonitoring data is valuable for insight the levels of PCPs in the human body and can be crucial for identifying potential health hazards.To gain a better understanding of timely exposure profiles and health risk of reproductive-age population to PCPs,we determined six parabens,six benzophenone-type ultraviolet filters,and three disinfectants in 256 urine samples collected from young adults aged 18-44 years in Beijing,China.The urinary levels of benzophenone-3(BP-3)and 4-hydroxybenzophenone(4-OHBP)were significantly higher in summer compared to winter,suggesting these compounds have different seasonal usage patterns.Moreover,the total concentration of 15 PCPs in female was 430 ng/mL,approximately two times higher than that in male.P-chloro-m-xylenol(PCMX),as a new type of antibacterial agent,has the greatest level among all target analytes,indicating the increasingly use of this antibacterial alternative recently.Five potential influencing factors that lead to the elevated exposure level of PCPs were identified.Over 19%of the target population had a high hazard index value(greater than 1)which was attributed to exposure to propyl paraben(PrP),benzophenone-1(BP-1),BP-3 and PCMX,indicating that PCPs may pose a relatively high exposure risk at environmental levels that should be a cause for concern.展开更多
Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involve...Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involved 4,033 Chinese older adults aged≥65 years from the Healthy Ageing and Biomarkers Cohort Study.Muscle mass and total skeletal muscle mass index(TSMI)were measured by bioelectric impedance analysis.WBC,PLT,and PWR were measured using standard methods.Multivariate linear regression was used to examine the associations of WBC count,PLT count,and PWR with TSMI.Results High WBC count,PLT count,and PWR were associated with low TSMI,with coefficients of-0.0091(95%confidence interval[CI]:-0.0142 to-0.0041),-0.0119(95%CI:-0.0170 to-0.0068),and-0.0051(95%CI:-0.0102 to-0.0001).The associations between the three inflammatory indices and TSMI were linear.Stratified analyses indicated that the relationship between inflammatory markers and TSMI was more evident in male participants and in individuals aged<80 years than in their counterparts.Conclusion Elevated WBC count,PLT count,and PWR correlated with muscle mass loss.This study highlights the importance of regular monitoring of inflammatory markers as a potential strategy for the screening and management of sarcopenia in older adults.展开更多
Background:Cervical and breast cancers are among the top 4 leading causes of cancer-related mortality in women.This study aimed to examine age-specific temporal trends in mortality for cervical and breast cancers in u...Background:Cervical and breast cancers are among the top 4 leading causes of cancer-related mortality in women.This study aimed to examine age-specific temporal trends in mortality for cervical and breast cancers in urban and rural areas of China from 2009 to 2021.Methods:Age-specific mortality data for cervical and breast cancers among Chinese women aged 20-84 years were obtained from China’s National Disease Surveillance Points system spanning the years 2009 to 2021.Negative binomial regression models were utilized to assess urban-rural differences in mortality rate ratios,while Joinpoint models with estimated average annual percent changes(AAPC)and slopes were employed to compare temporal trends and the acceleration of mortality rates within different age groups.Results:From 2009 to 2021,there was a relative increase in age-specific mortality associated with the two cancers observed in rural areas compared with urban areas.A rising trend in the screening age of 35-64[AAPC:4.0%,95%confidence interval(CI)0.5-7.6,P=0.026]for cervical cancer was noted in rural areas,while a stable trend(AAPC:-0.7%,95%CI-5.8 to 4.6,P=0.780)was observed in urban areas.As for breast cancer,a stable trend(AAPC:0.3%,95%CI-0.3 to 0.9,P=0.280)was observed in rural areas compared to a decreasing trend(AAPC:-2.7%,95%CI-4.6 to-0.7,P=0.007)in urban areas.Urban-rural differences in mortality rates increased over time for cervical cancer but decreased for breast cancer.Mortality trends for both cervical and breast cancers showed an increase with age across 4 segments,with the most significant surge in mortality observed among the 35-54 age group across urban and rural areas,periods,and regions in China.Conclusions:Special attention should be given to women aged 35-54 years due to mortality trends and rural-urban disparities.Focusing on vulnerable age groups and addressing rural-urban differences in the delivery of cancer control programs can enhance resource efficiency and promote health equity.展开更多
To explore the multicenter characteristics of endocrine-like phthalate esters(PAEs)in household dust and propose effective control strategies for global indoor public health.An on-site observational investigation was ...To explore the multicenter characteristics of endocrine-like phthalate esters(PAEs)in household dust and propose effective control strategies for global indoor public health.An on-site observational investigation was conducted in nine Chinese cities from 2018 to 2019.A total of 246 household dust sampleswere collected and analyzed for ten PAE congeners using Gas Chromatography-Mass Spectrometry(GC-MS).Questionnaires were used to gather information on building conditions,indoor behaviors,and ventilation habits.In residential dust from the nine cities,the total concentrations of the ten PAE congeners(PAEs)ranged from 0.921 to 29097.297μg/g.Dicyclohexyl phthalate(DCHP)and di(2-ethylhexyl)phthalate(DEHP)were the dominant congeners inPAEs.Childhood exposure to PAEs through dust ingestion was four orders of magnitude higher than through inhalation,with a carcinogenic risk of 5.47×10^(−6) for DEHP exposure in household dust.HigherPAEs concentrations were associated with higher temperature,double glazing,wall paint usage,television and computer use,and indoor plant growth.This multicenter on-site investigation confirmed PAE pollution characteristics and uncovered the inacceptable risk of daily DEHP exposure in household dust under real living conditions.Effective mitigation measures based on household-related information,residential characteristics,decoration materials,and lifestyle should be taken to build a healthy household environment.展开更多
Objective To estimate the burden of cirrhosis and other chronic liver diseases caused by specific etiologies in China.Methods Data from the Global Burden of Disease Study 2016(GBD 2016)were used.We evaluated the burde...Objective To estimate the burden of cirrhosis and other chronic liver diseases caused by specific etiologies in China.Methods Data from the Global Burden of Disease Study 2016(GBD 2016)were used.We evaluated the burden by analyzing age-sex-province-specific prevalence,mortality,and disability-adjusted lifeyears(DALYs)of 33 provinces in China.Results From 1990 to 2016,prevalence cases in thousands increased by 73.7%from 6833.3(95%UI:6498.0–7180.6)to 11869.6(95%UI:11274.6–12504.7).Age-standardized mortality and DALY rates per100,000 decreased by 51.2%and 53.3%,respectively.Male and elderly people(aged≥60 years)preponderance were found for prevalence,mortality,and DALYs.The number of prevalence cases,deaths,and DALYs due to hepatitis C virus(HCV)increased by 86.6%,8.7%,and 0.9%,respectively.Also,age-standardized prevalence rates decreased in 31 provinces,but increased in Yunnan and Shandong.The Socio-demographic Index(SDI)values were negatively correlated with age-standardized mortality and DALY rates by provinces in 2016;the correlation coefficients were-0.817 and-0.828,respectively.Conclusion Cirrhosis and other chronic liver diseases remain a huge health burden in China,with the increase of population and the aging of population.Hepatitis B virus(HBV)remains the leading cause of the health burden in China.展开更多
Objective:To investigate the situation of anaplasmosis in Yiyuan county.Shandong Province. Methods:A total of 26 blood samples from febrile patients suspected of anaplasmosis,48 blood samples from healthy farmers,8 fr...Objective:To investigate the situation of anaplasmosis in Yiyuan county.Shandong Province. Methods:A total of 26 blood samples from febrile patients suspected of anaplasmosis,48 blood samples from healthy farmers,8 from dogs,and 10 from goats and 170 ticks were collected in the same area during 2005-2007,and detected by serological and molecular methods.Results: Eight confirmed cases and 6 probable cases were determined using serologic and molecular methods.The seroprevalence of Anaplasma phagocytophilum(A.phagocytophilum) was 26.7% in healthy cases.Nine out of 10 sheep samples and 7 out of 8 dog samples reacted positively to the A.phagocytophilum antigen.PCR amplification and sequencing of the 16SrRNA of,4. phagocytophilum gene showed that some samples from patients,goats and ticks were 100% identical.The seroprevalence of Rickettsia typhi was 22.9%,Orientia tsutsugamushi 6.3%, Rickettsia sibirica 27.1%,Coxiella burnetii 18.8%,Bartonella henselae 31.3%,and Borrelia burgdorferi 41.6%.Conclusions:It is important to make differential diagnosis of febrile patients and to apply treatment with specific antibiotics.It is needed to enforce essential prevention and control measures including tick control and to improve sanitation conditions.展开更多
To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug naive AIDS patients, 118 AIDS patients who rec...To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug naive AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug naive patients. The prevalence rate of drug resistant HIV strains were 13.9%, 45.4% and 62.7% in drug naive patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT＋DDI＋NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continuation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible.展开更多
Results of the Global Burden of Disease, Injury and Risk Factor Study 2010 （GBD 2010） were released on December 13, 2012 in London, a series of papers concerning the project have been published in the Lancet[1]. Res...Results of the Global Burden of Disease, Injury and Risk Factor Study 2010 （GBD 2010） were released on December 13, 2012 in London, a series of papers concerning the project have been published in the Lancet[1]. Research findings of the project have been reported in the United States, the United Kingdom, Indonesia, China[2] and Australia, and widely applied across the world. In addition, the GBD 2010 will see more countries report their project research findings and implement these findings in the near future. The GBD 2010 provides researchers, administrators and policymakers with new and critical sources for their research, teaching and policymaking.展开更多
Objective:To report a training course on the laboratory diagnoses of rickettsioses that 10 provincial/city CDCs participated in laboratory external quality assurance(EQA) based on the serological specific antibodies d...Objective:To report a training course on the laboratory diagnoses of rickettsioses that 10 provincial/city CDCs participated in laboratory external quality assurance(EQA) based on the serological specific antibodies detection and rapid PCR amplifying targeted genes of rickettsiae. Methods:An EQA program to evaluate the following laboratory procedures was developed to detect rickettsiae:(1) immunofluorescent assay(IFA) to detect specific antibodies of A. phagocytophilum,R.heilongjiangensis and 0.tsutsugamshi respectively.(2) Two sets of nested PCR were used amplifying groEL genes for most members of the family Rickettsiaceae and amplifying 16SrRNA genes for the most members of family anaplasmae,respectively.A scoring scheme based on the distribution of the median antibody titer values of the serologic assays was designed and a ranking list of the scores of the PCR results based on the detected minimal copy numbers of reference DNA was created.Results:Among nine laboratories who reported the results on time,eight laboratories gave acceptable serologic results,the other one provided an unacceptable antibody titer(1:2 vs median 1:64) results for 0.tsutsugamshi.The limits of detection(LOD) for the PCR amplifying for five references DNA ranged from 1copy/μL to 10~6 copy/μL.Conclusions:We successfully trained and popularized modern diagnostic methods of rickettsiae in 10 provincial CDCs in China and first conducted the EQA projects and evaluated the results.展开更多
We assessed the incidence of adverse drug reactions （ADRs） with anti-TB medications and evaluated the risk factors for developing ADRs in previously treated tuberculosis patients in China. All patients received the ...We assessed the incidence of adverse drug reactions （ADRs） with anti-TB medications and evaluated the risk factors for developing ADRs in previously treated tuberculosis patients in China. All patients received the first-line anti-TB regimen （2HREZS/6HRE） as recommended by the national guidelines.展开更多
This study projected dengue distribution risk map using representative concentration pathways(RCP2.6,RCP4.5,RCP6.0,RCP8.5)in China in 2020s,2030s,2050s and 2100s.Based on the biological characteristics of Aedes albopi...This study projected dengue distribution risk map using representative concentration pathways(RCP2.6,RCP4.5,RCP6.0,RCP8.5)in China in 2020s,2030s,2050s and 2100s.Based on the biological characteristics of Aedes albopictus and the dengue epidemic process,dengue transmission biological model was developed to project the risk epidemic areas.Observational temperature data in 1981-2016 at 740 stations and grid data of 0.5°×0.5°(15°-55.5°N,70°-140.5E)under selected RCPs in 2020s,2030s,2050s and 2100s were used.Relative to 142 counties and 168 million people living in the projected high risk area of dengue in the climate condition of 1981-2016,dengue high risk areas in China would expand under same RCP scenarios in the 21st century with time past except RCP2.6 with a turning down point in 2050s.Especially under RCP8.5 which global mean temperature would increase by 4.9 C till 2100s,the high risk area and population for dengue transmission would expand additional 34 counties(20 million)in 2020s,114 counties(60 million)in 2030s,208 counties(160 million)in 2050 and 456 counties(490 million)in 2100s respectively than those of 1981-2016.For RCP8.5 in 2100s,the population and expanded high risk areas would increase 4.2-fold and 2.9-fold than the 1981-2016 mean.The newly added high risk areas should prepare for controlling and preventing dengue in different period according to projected dengue risk map.展开更多
Dear Editor,In March 2013,the first 3 cases of severe disease dueto a novel avian-origin influenza A(H7N9)virus weredetected in the Chinese provinces of Shanghai and Anhui(Gao R,et al.,2013).A total of 339 laboratory-...Dear Editor,In March 2013,the first 3 cases of severe disease dueto a novel avian-origin influenza A(H7N9)virus weredetected in the Chinese provinces of Shanghai and Anhui(Gao R,et al.,2013).A total of 339 laboratory-confirmedcases with 100 deaths were reported until January 142014(WHO,2014).To the best of our knowledge,thisis the first time that human infection with the avian in-fluenza A H7N9 subtype has been detected.Prior to展开更多
文摘The Chinese government has always attached great importance to disease control and prevention efforts.Recently,the general office of China’s State Council issued the“Guidelines for High-Quality Development of Disease Prevention and Control”(hereinafter referred to as the“Guidelines”)(1).The Guidelines focus on promoting high-quality development of disease control and prevention and the strategic goal of“Healthy China,”providing specific implementation pathways for the development of national disease control and prevention in the new era,including overall planning,restructuring of governance,enhancing core capabilities,strengthening talent development,and improving organizational support.
基金funded by the National Highlevel Talents Special Support Plan of China for Young Talents.
文摘BACKGROUND President Xi Jinping emphasized the paramount importance of bolstering early surveillance and early warning capacities within a robust public health system(1).These elements constitute one of the five major functionalities of the National Bureau of Disease Control and Prevention(2).As an integral division of the National Bureau of Disease Control and Prevention,the Center for Disease Control and Prevention(CDC)is responsible for executing early surveillance and warning procedures in the realm of public health.Nonetheless,a deficiency persists concerning the early warning of public health risk factors.
文摘China is still a high tuberculosis(TB)burden country,and the number of new cases of TB was 833,000 in 2019(1).School campuses are highlycrowded places with potential for close contact,which suggests that a few cases of TB may lead to a large outbreak.Thus,TB prevention and control in schools is an important disease control challenge for educational and health departments at all levels.
基金supported by Public Health Talent Training and Surport Plan(National Administration of Disease Prevention and Control)Research and application of new technology for rapid monitoring and tracing of emergent infectious diseases among entry-exit population(2024YFFK0056)Monitoring,Early warning and Response of Major Infectious Diseases(2022ZDZX0017).
文摘Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.
基金supported by the commissioned project of the Department of Health and Immunization Planning under the National Disease Control and Prevention Administration(No.BX2024100800015)The preliminary study project on standardization of the Chinese Center for Disease Control and Prevention(No.BZ2025-Q155)The National Natural Science Foundation of China(No.82404299).
文摘INTRODUCTION Contemporary human living environments present complex and pervasive health risks,and environmental health challenges are becoming increasingly prominent.These risks encompass diverse domains,such as chemical factors(e.g.,heavy metals,nanomaterials,per-and polyfluoroalkyl substances),physical factors(e.g.,noise,radiation,and extreme weather)biological factors(e.g.,pathogenic microorganisms and parasites),natural disasters(e.g.,earthquakes and floods),and anthropogenic incidents(e.g.,chemical spills,fires,and explosions).
基金supported by the National Natural Science Foundation of China (No.22106154).
文摘Personal care products(PCPs)are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the environment.Biomonitoring data is valuable for insight the levels of PCPs in the human body and can be crucial for identifying potential health hazards.To gain a better understanding of timely exposure profiles and health risk of reproductive-age population to PCPs,we determined six parabens,six benzophenone-type ultraviolet filters,and three disinfectants in 256 urine samples collected from young adults aged 18-44 years in Beijing,China.The urinary levels of benzophenone-3(BP-3)and 4-hydroxybenzophenone(4-OHBP)were significantly higher in summer compared to winter,suggesting these compounds have different seasonal usage patterns.Moreover,the total concentration of 15 PCPs in female was 430 ng/mL,approximately two times higher than that in male.P-chloro-m-xylenol(PCMX),as a new type of antibacterial agent,has the greatest level among all target analytes,indicating the increasingly use of this antibacterial alternative recently.Five potential influencing factors that lead to the elevated exposure level of PCPs were identified.Over 19%of the target population had a high hazard index value(greater than 1)which was attributed to exposure to propyl paraben(PrP),benzophenone-1(BP-1),BP-3 and PCMX,indicating that PCPs may pose a relatively high exposure risk at environmental levels that should be a cause for concern.
基金supported by the National Natural Science Foundation of China(grant nos.82025030,82222063,and 82388102)the National Key Research and Development Program of China(grant no.2023YFC3603400)。
文摘Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involved 4,033 Chinese older adults aged≥65 years from the Healthy Ageing and Biomarkers Cohort Study.Muscle mass and total skeletal muscle mass index(TSMI)were measured by bioelectric impedance analysis.WBC,PLT,and PWR were measured using standard methods.Multivariate linear regression was used to examine the associations of WBC count,PLT count,and PWR with TSMI.Results High WBC count,PLT count,and PWR were associated with low TSMI,with coefficients of-0.0091(95%confidence interval[CI]:-0.0142 to-0.0041),-0.0119(95%CI:-0.0170 to-0.0068),and-0.0051(95%CI:-0.0102 to-0.0001).The associations between the three inflammatory indices and TSMI were linear.Stratified analyses indicated that the relationship between inflammatory markers and TSMI was more evident in male participants and in individuals aged<80 years than in their counterparts.Conclusion Elevated WBC count,PLT count,and PWR correlated with muscle mass loss.This study highlights the importance of regular monitoring of inflammatory markers as a potential strategy for the screening and management of sarcopenia in older adults.
基金supported by the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(YFH,2024-3-028)the National Natural Science Foundation of China(YFH,72061137007)SHV is supported,in part,by U.S.National Institutes of Health(P30CA016359).
文摘Background:Cervical and breast cancers are among the top 4 leading causes of cancer-related mortality in women.This study aimed to examine age-specific temporal trends in mortality for cervical and breast cancers in urban and rural areas of China from 2009 to 2021.Methods:Age-specific mortality data for cervical and breast cancers among Chinese women aged 20-84 years were obtained from China’s National Disease Surveillance Points system spanning the years 2009 to 2021.Negative binomial regression models were utilized to assess urban-rural differences in mortality rate ratios,while Joinpoint models with estimated average annual percent changes(AAPC)and slopes were employed to compare temporal trends and the acceleration of mortality rates within different age groups.Results:From 2009 to 2021,there was a relative increase in age-specific mortality associated with the two cancers observed in rural areas compared with urban areas.A rising trend in the screening age of 35-64[AAPC:4.0%,95%confidence interval(CI)0.5-7.6,P=0.026]for cervical cancer was noted in rural areas,while a stable trend(AAPC:-0.7%,95%CI-5.8 to 4.6,P=0.780)was observed in urban areas.As for breast cancer,a stable trend(AAPC:0.3%,95%CI-0.3 to 0.9,P=0.280)was observed in rural areas compared to a decreasing trend(AAPC:-2.7%,95%CI-4.6 to-0.7,P=0.007)in urban areas.Urban-rural differences in mortality rates increased over time for cervical cancer but decreased for breast cancer.Mortality trends for both cervical and breast cancers showed an increase with age across 4 segments,with the most significant surge in mortality observed among the 35-54 age group across urban and rural areas,periods,and regions in China.Conclusions:Special attention should be given to women aged 35-54 years due to mortality trends and rural-urban disparities.Focusing on vulnerable age groups and addressing rural-urban differences in the delivery of cancer control programs can enhance resource efficiency and promote health equity.
基金supported by the National Natural Science Foundation of China(No.21976169)the National Key Research and Development Program of China(No.2022YFC3702800).
文摘To explore the multicenter characteristics of endocrine-like phthalate esters(PAEs)in household dust and propose effective control strategies for global indoor public health.An on-site observational investigation was conducted in nine Chinese cities from 2018 to 2019.A total of 246 household dust sampleswere collected and analyzed for ten PAE congeners using Gas Chromatography-Mass Spectrometry(GC-MS).Questionnaires were used to gather information on building conditions,indoor behaviors,and ventilation habits.In residential dust from the nine cities,the total concentrations of the ten PAE congeners(PAEs)ranged from 0.921 to 29097.297μg/g.Dicyclohexyl phthalate(DCHP)and di(2-ethylhexyl)phthalate(DEHP)were the dominant congeners inPAEs.Childhood exposure to PAEs through dust ingestion was four orders of magnitude higher than through inhalation,with a carcinogenic risk of 5.47×10^(−6) for DEHP exposure in household dust.HigherPAEs concentrations were associated with higher temperature,double glazing,wall paint usage,television and computer use,and indoor plant growth.This multicenter on-site investigation confirmed PAE pollution characteristics and uncovered the inacceptable risk of daily DEHP exposure in household dust under real living conditions.Effective mitigation measures based on household-related information,residential characteristics,decoration materials,and lifestyle should be taken to build a healthy household environment.
文摘Objective To estimate the burden of cirrhosis and other chronic liver diseases caused by specific etiologies in China.Methods Data from the Global Burden of Disease Study 2016(GBD 2016)were used.We evaluated the burden by analyzing age-sex-province-specific prevalence,mortality,and disability-adjusted lifeyears(DALYs)of 33 provinces in China.Results From 1990 to 2016,prevalence cases in thousands increased by 73.7%from 6833.3(95%UI:6498.0–7180.6)to 11869.6(95%UI:11274.6–12504.7).Age-standardized mortality and DALY rates per100,000 decreased by 51.2%and 53.3%,respectively.Male and elderly people(aged≥60 years)preponderance were found for prevalence,mortality,and DALYs.The number of prevalence cases,deaths,and DALYs due to hepatitis C virus(HCV)increased by 86.6%,8.7%,and 0.9%,respectively.Also,age-standardized prevalence rates decreased in 31 provinces,but increased in Yunnan and Shandong.The Socio-demographic Index(SDI)values were negatively correlated with age-standardized mortality and DALY rates by provinces in 2016;the correlation coefficients were-0.817 and-0.828,respectively.Conclusion Cirrhosis and other chronic liver diseases remain a huge health burden in China,with the increase of population and the aging of population.Hepatitis B virus(HBV)remains the leading cause of the health burden in China.
基金supported by the National Basic Research Program of China(973 Program) 2010CB530200(2010CB530206)the National Natural Science Foundation of China(No.30771854)National Key Science and Technology Projects of China(Project No.2008ZX10004-008)
文摘Objective:To investigate the situation of anaplasmosis in Yiyuan county.Shandong Province. Methods:A total of 26 blood samples from febrile patients suspected of anaplasmosis,48 blood samples from healthy farmers,8 from dogs,and 10 from goats and 170 ticks were collected in the same area during 2005-2007,and detected by serological and molecular methods.Results: Eight confirmed cases and 6 probable cases were determined using serologic and molecular methods.The seroprevalence of Anaplasma phagocytophilum(A.phagocytophilum) was 26.7% in healthy cases.Nine out of 10 sheep samples and 7 out of 8 dog samples reacted positively to the A.phagocytophilum antigen.PCR amplification and sequencing of the 16SrRNA of,4. phagocytophilum gene showed that some samples from patients,goats and ticks were 100% identical.The seroprevalence of Rickettsia typhi was 22.9%,Orientia tsutsugamushi 6.3%, Rickettsia sibirica 27.1%,Coxiella burnetii 18.8%,Bartonella henselae 31.3%,and Borrelia burgdorferi 41.6%.Conclusions:It is important to make differential diagnosis of febrile patients and to apply treatment with specific antibiotics.It is needed to enforce essential prevention and control measures including tick control and to improve sanitation conditions.
文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug naive AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug naive patients. The prevalence rate of drug resistant HIV strains were 13.9%, 45.4% and 62.7% in drug naive patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT＋DDI＋NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continuation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible.
文摘Results of the Global Burden of Disease, Injury and Risk Factor Study 2010 （GBD 2010） were released on December 13, 2012 in London, a series of papers concerning the project have been published in the Lancet[1]. Research findings of the project have been reported in the United States, the United Kingdom, Indonesia, China[2] and Australia, and widely applied across the world. In addition, the GBD 2010 will see more countries report their project research findings and implement these findings in the near future. The GBD 2010 provides researchers, administrators and policymakers with new and critical sources for their research, teaching and policymaking.
基金supported by the China-U.S.Collaborative Program on Emerging and Re-emerging Infectious Diseases(No. IU2GGH000018-01)National Basic Research Program of China(973 Program) 2010CB530200(2010CB530206)the National Natural Science Foundation of China (grant No.30771854)
文摘Objective:To report a training course on the laboratory diagnoses of rickettsioses that 10 provincial/city CDCs participated in laboratory external quality assurance(EQA) based on the serological specific antibodies detection and rapid PCR amplifying targeted genes of rickettsiae. Methods:An EQA program to evaluate the following laboratory procedures was developed to detect rickettsiae:(1) immunofluorescent assay(IFA) to detect specific antibodies of A. phagocytophilum,R.heilongjiangensis and 0.tsutsugamshi respectively.(2) Two sets of nested PCR were used amplifying groEL genes for most members of the family Rickettsiaceae and amplifying 16SrRNA genes for the most members of family anaplasmae,respectively.A scoring scheme based on the distribution of the median antibody titer values of the serologic assays was designed and a ranking list of the scores of the PCR results based on the detected minimal copy numbers of reference DNA was created.Results:Among nine laboratories who reported the results on time,eight laboratories gave acceptable serologic results,the other one provided an unacceptable antibody titer(1:2 vs median 1:64) results for 0.tsutsugamshi.The limits of detection(LOD) for the PCR amplifying for five references DNA ranged from 1copy/μL to 10~6 copy/μL.Conclusions:We successfully trained and popularized modern diagnostic methods of rickettsiae in 10 provincial CDCs in China and first conducted the EQA projects and evaluated the results.
基金supported by the National Science and Technology Major Project of China(2008ZX10003-009)the National Science and Technology Major Project of China(2013ZX10003-015)
文摘We assessed the incidence of adverse drug reactions （ADRs） with anti-TB medications and evaluated the risk factors for developing ADRs in previously treated tuberculosis patients in China. All patients received the first-line anti-TB regimen （2HREZS/6HRE） as recommended by the national guidelines.
文摘This study projected dengue distribution risk map using representative concentration pathways(RCP2.6,RCP4.5,RCP6.0,RCP8.5)in China in 2020s,2030s,2050s and 2100s.Based on the biological characteristics of Aedes albopictus and the dengue epidemic process,dengue transmission biological model was developed to project the risk epidemic areas.Observational temperature data in 1981-2016 at 740 stations and grid data of 0.5°×0.5°(15°-55.5°N,70°-140.5E)under selected RCPs in 2020s,2030s,2050s and 2100s were used.Relative to 142 counties and 168 million people living in the projected high risk area of dengue in the climate condition of 1981-2016,dengue high risk areas in China would expand under same RCP scenarios in the 21st century with time past except RCP2.6 with a turning down point in 2050s.Especially under RCP8.5 which global mean temperature would increase by 4.9 C till 2100s,the high risk area and population for dengue transmission would expand additional 34 counties(20 million)in 2020s,114 counties(60 million)in 2030s,208 counties(160 million)in 2050 and 456 counties(490 million)in 2100s respectively than those of 1981-2016.For RCP8.5 in 2100s,the population and expanded high risk areas would increase 4.2-fold and 2.9-fold than the 1981-2016 mean.The newly added high risk areas should prepare for controlling and preventing dengue in different period according to projected dengue risk map.
基金supported by an Emergency Research Project on human infection with avian influenza H7N9 virus from the National Ministry of Science and Technology(No.KJYJ-201301-01 to Dr.Shu)the National Basic Research Program(973)of China(grant No.2011CB504704 to Dr.Shu)China Mega-Project for Infectious Disease(2013ZX10004-101)
文摘Dear Editor,In March 2013,the first 3 cases of severe disease dueto a novel avian-origin influenza A(H7N9)virus weredetected in the Chinese provinces of Shanghai and Anhui(Gao R,et al.,2013).A total of 339 laboratory-confirmedcases with 100 deaths were reported until January 142014(WHO,2014).To the best of our knowledge,thisis the first time that human infection with the avian in-fluenza A H7N9 subtype has been detected.Prior to
