AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24...AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies.展开更多
AIM: To estimate the prevalence and risk factors for vitreous floaters in the general population. ·METHODS: An electronic survey was administered through a smartphone app asking various demographic and health que...AIM: To estimate the prevalence and risk factors for vitreous floaters in the general population. ·METHODS: An electronic survey was administered through a smartphone app asking various demographic and health questions, including whether users experience floaters in their field of vision. Multivariate logistic regression analysis was used to determine risk factors. ·RESULTS: A total of 603 individuals completed the survey, with 76% reporting that they see floaters, and 33% reporting that floaters caused noticeable impairment in vision. Myopes were 3.5 times more likely (P =0.0004), and hyperopes 4.4 times more likely (P =0.0069) to report moderate to severe floaters compared to those with normal vision. Floater prevalence was not significantly affected by respondent age, race, gender, and eye color. ·CONCLUSION: Vitreous floaters were found to be a very common phenomenon in this non -clinical general population sample, and more likely to be impairing in myopes and hyperopes.展开更多
Preterm infants are vulnerable to brain injuries,and have a greater chance of experiencing neurodevelopmental disorders throughout development. Early screening for motor and cognitive functions is critical to assessin...Preterm infants are vulnerable to brain injuries,and have a greater chance of experiencing neurodevelopmental disorders throughout development. Early screening for motor and cognitive functions is critical to assessing the developmental trajectory in preterm infants, especially those who may have motor or cognitive deficits. The brain imaging technology functional near-infrared spectroscopy(fNIRS) is a portable and low-cost method of assessing cerebral hemodynamics, making it suitable for large-scale use even in remote and underdeveloped areas. In this article, we review peer-reviewed, scientific f NIRS studies of motor performance, speech perception, and facial recognition in preterm infants. f NIRS provides a link between hemodynamic activity and the development of brain functions in preterm infants. Research using fNIRS has shown different patterns of hemoglobin change during some behavioral tasks in early infancy. fNIRS helps to promote our understanding of the developmental mechanisms of brain function in preterm infants when performing motor or cognitive tasks in a less-restricted environment.展开更多
Suicide risk constitutes a complex set of interacting demographic, clinical, psychobiological and environmental variables. Impulsivity is a long-known risk factor for suicide attempts. However, research based on clear...Suicide risk constitutes a complex set of interacting demographic, clinical, psychobiological and environmental variables. Impulsivity is a long-known risk factor for suicide attempts. However, research based on clearer conceptual refinement in this area is imperative. One emerging field of study is that of decision-making. Impulsivity involves a failure of higher-order control, including decision-making. Using standardized operational definitions that take into consideration relevant aspects of impulsivity, including state- and trait-components and a deeper understanding of the process of decision-making in the suicidal mind, we may come a step closer to understanding suicidality and winning the fight in this scourge of human suffering.展开更多
BACKGROUND Global education in psychiatry is heavily influenced by knowledge from Western,high-income countries,which obscures local voices and expertise.AIM To adapt a human simulation model to psychiatric education ...BACKGROUND Global education in psychiatry is heavily influenced by knowledge from Western,high-income countries,which obscures local voices and expertise.AIM To adapt a human simulation model to psychiatric education in a context that is specific to local languages and cultures.METHODS We conducted an observational study consisting of six human simulation sessions with standardized patients from two host countries,speaking their native languages,and following an adaptation of the co-constructive patient simulation(CCPS)model.As local faculty became increasingly familiar with the CCPS approach,they took on the role of facilitators—in their country’s native language.RESULTS Fifty-three learners participated:19 child and adolescent psychiatry trainees and 3 faculty members in Türkiye(as a group that met online during 3 consecutive months);and 24 trainees and 7 faculty in Israel(divided into 3 groups,in parallel in-person sessions during a single training day).Each of the six cases reflected local realities and clinical challenges,and was associated with specific learning goals identified by each case-writing trainee.CONCLUSION Human simulation has not been fully incorporated into psychiatric education:The creation of immersive clinical experiences and the strengthening of reflective practice are two areas ripe for development.Our adaptations of CCPS can also strengthen local and regional networks and psychiatric communities of practice.Finally,the model can help question and press against hegemonies in psychiatric training that overshadow local expertise.展开更多
Tremor occurs in about half of multiple sclerosis(MS)patients.MS tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tre...Tremor occurs in about half of multiple sclerosis(MS)patients.MS tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tremor may affect the upper and lower extremities,head,and trunk,and may even affect the vocal cords in isolated cases of palatal tremor.MS tremor is classically attributed to lesions of the brain stem,cerebellum,or cerebellar peduncles,and tremor intensity has been shown to correlate with the number of lesions or their functional connections.However,recent work has demonstrated that inflammatory damage to the cerebello-thalamic and cortico-thalamic pathways might also play an important role in causing tremor,as it co-occurs with other signs and symptoms of MS such as dysarthria,dysmetria,dysdiadochokinesia,and dystonia(Alusi et al.,2001).展开更多
Background: Tourette syndrome (TS) is a childhood-onset neuropsychiatric diso rder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete res...Background: Tourette syndrome (TS) is a childhood-onset neuropsychiatric diso rder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic sympto ms during adolescence. At least one third of adults with TS have comorbid obsess ive-compulsive disorder (OCD). Objectives: To clarify the clinical course of ti c and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolesce nce and early adulthood. Design: Prospective cohort study. Setting: Yale Child Study Center tic and OCD outpatient specialty clinic. Participants: Forty-six children with TS who received a structured clinical evaluation prior to age 14 years. Main Outcome Measures: Expert-rated tic and OCD symptom sever ity at follow-up interview an average of 7.6 years later (range, 3.8-12.8 year s). Results: Eighty-five percent of subjects reported a reduction in tic sympto ms during adolescence. Only increased tic severity in childhood was associated w ith increased tic severity at follow-up. The average age at worst-ever tic sev erity was 10.6 years. Forty-one percent of patients with TS reported at one tim e experiencing at least moderate OCD symptoms. Worst-ever OCD symptoms occurred approximately 2 years later than worst-ever tic symptoms. Increased childhood IQ was strongly associated with increased OCD severity at followup. Conclusion: Obsessive-compulsive disorder symptoms in children with TS became more severe a t a later age and were more likely to persist than tic symptoms.展开更多
Objectives:Problematic use of the internet(PUI)has been increasingly associated with various mental health issues,highlighting the need for accurate assessment tools.The Assessment of Criteria for Specific Internet-us...Objectives:Problematic use of the internet(PUI)has been increasingly associated with various mental health issues,highlighting the need for accurate assessment tools.The Assessment of Criteria for Specific Internet-use Disorder(ACSID-11)is a validated psychometric instrument designed to measure distinct forms of PUI across multiple online activities.However,its applicability and validity have not yet been established within the Indonesian context.Therefore,this study aimed to translate and validate the ACSID-11 for use among Indonesian populations.Methods:The translation procedure of the ACSID-11 involved forward translation,back translation,and expert panel discussions.This research involved 600 undergraduate and post-graduate students from universities in Indonesia(mean[SD]age=21.60[2.74]years;409[68%]females).Cronbach’s Alpha(α)and McDonald’s Omega(ω)were used to measure the internal consistency of the ACSID-11.Confirmatory factor analysis(CFA)was used in testing the construct validity of the ACSID-11.Results:The ACSID-11 demonstrated validity and reliability in assessing different types of PUI in the present Indonesian sample(α=0.67–0.96;ω=0.68–0.96).The CFA results supported a four-factor structure for the Indonesian version of the ACSID-11.Conclusion:The findings suggest that the Indonesian version of the ACSID-11 is a valid and reliable tool for assessing specific forms of PUI among Indonesian students.Future research and clinical applications are encouraged to utilize the ACSID-11 for early identification,intervention,and prevention strategies targeting PUI within this population.展开更多
Multiple sclerosis(MS)is the most common inflammatory demyelinating brain disease.The occurrence of psychiatric disorders,especially for major depression,in the course of MS is high.Reports concerning bipolar disorder...Multiple sclerosis(MS)is the most common inflammatory demyelinating brain disease.The occurrence of psychiatric disorders,especially for major depression,in the course of MS is high.Reports concerning bipolar disorder(BD)remain rather scarce although early descriptions were found in the old neurological literature.The purpose of this article is to provide a critical review of the epidemiology,comorbidity,and treatment findings regarding BD preceding the onset of MS.展开更多
A pathophysiological relationship has been reported between inflammatory processes,decreased levels of neurotrophins,increased oxidative stress and psychiatric disorders in both juvenile and adult ages.Moreover,this r...A pathophysiological relationship has been reported between inflammatory processes,decreased levels of neurotrophins,increased oxidative stress and psychiatric disorders in both juvenile and adult ages.Moreover,this relationship remains unclear in juvenile bipolar disorder(BD).We performed a systematic literature review of studies reporting measurements of inflammatory markers,oxidative stress markers or neurotrophins in juvenile and young adult subjects with BD.Concordant findings showed that inflammatory markers are increased since the earlier stages of BD.A positive correlation between decreased levels of a peripheral brain-derived neurotrophic factor and juvenile BD is controversial suggesting that those changes might occur only during the late stage of BD.No changes in central glutathione levels were reported in young adult age BD indicating that oxidative stress may be an outcome of long illness duration and repeated affective episodes.In conclusion,preliminary findings indicate that a certain relationship exists between inflammatory process and juvenile BD but evidence are insufficient to support a causal relationship.Adequately powered and prospective studies are warranted to clarify the role of inflammation,neurotrophins and oxidative stress in juvenile BD.展开更多
Background:Problems with emotional processing are widely reported in individuals with attentiondeficit/hyperactivity disorder(ADHD).Although methylphenidate(MPH)effectively alleviates inattention and hyperactivity sym...Background:Problems with emotional processing are widely reported in individuals with attentiondeficit/hyperactivity disorder(ADHD).Although methylphenidate(MPH)effectively alleviates inattention and hyperactivity symptoms in ADHD,its effects on emotional processing and internalizing symptoms have remained elusive.While we previously found that acute MPH administration modulated neural mechanisms underlying emotional processing in an age-dependent manner,the effects of prolonged administration remained unknown.Objectives:Therefore,we investigated:(i)whether prolonged MPH treatment influences neural substrates(amygdala reactivity and connectivity)of emotional processing,and(ii)whether these effects are modulated by age.Methods:The“effects of Psychotropic drugs On Developing brain-MPH”(“ePOD-MPH”)randomized controlled trial was a 16-week double-blind,placebo-controlled,multi-center trial with MPH in 50 boys(10–12 years of age)and 49 men(23–40 years of age),all stimulant treatment-naive and diagnosed with ADHD.Participants performed an emotional face-matching task during functional magnetic resonance imaging.We assessed their symptoms of ADHD and internalizing symptoms at baseline,during the trial(8 weeks),and 1 week after the trial end(17 weeks).Results and Conclusions:We did not find effects of prolonged MPH treatment on emotional processing,as measured by amygdala reactivity and connectivity and internalizing symptoms in this trial with stimulant treatment-naive participants.This differs from our findings on emotional processing following acute MPH administration and the effects of prolonged MPH treatment on the dopamine system,which were both modulated by age.Interestingly,prolonged MPH treatment did improve ADHD symptoms,although depressive and anxiety symptoms showed a medication-independent decrease.Furthermore,our data indicate that baseline internalizing symptoms may be used to predict MPH treatment effects on ADHD symptoms,particularly in(male)adults with ADHD.展开更多
文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies.
文摘AIM: To estimate the prevalence and risk factors for vitreous floaters in the general population. ·METHODS: An electronic survey was administered through a smartphone app asking various demographic and health questions, including whether users experience floaters in their field of vision. Multivariate logistic regression analysis was used to determine risk factors. ·RESULTS: A total of 603 individuals completed the survey, with 76% reporting that they see floaters, and 33% reporting that floaters caused noticeable impairment in vision. Myopes were 3.5 times more likely (P =0.0004), and hyperopes 4.4 times more likely (P =0.0069) to report moderate to severe floaters compared to those with normal vision. Floater prevalence was not significantly affected by respondent age, race, gender, and eye color. ·CONCLUSION: Vitreous floaters were found to be a very common phenomenon in this non -clinical general population sample, and more likely to be impairing in myopes and hyperopes.
基金the Key Laboratory of Biomedical Spectroscopy of Xi’an Municipality,China(Y839S11D0Z)an Autonomous Deployment Project of Xi’an Institute of Optics and Precision Mechanics of the Chinese Academy of Sciences(Y855W31213).
文摘Preterm infants are vulnerable to brain injuries,and have a greater chance of experiencing neurodevelopmental disorders throughout development. Early screening for motor and cognitive functions is critical to assessing the developmental trajectory in preterm infants, especially those who may have motor or cognitive deficits. The brain imaging technology functional near-infrared spectroscopy(fNIRS) is a portable and low-cost method of assessing cerebral hemodynamics, making it suitable for large-scale use even in remote and underdeveloped areas. In this article, we review peer-reviewed, scientific f NIRS studies of motor performance, speech perception, and facial recognition in preterm infants. f NIRS provides a link between hemodynamic activity and the development of brain functions in preterm infants. Research using fNIRS has shown different patterns of hemoglobin change during some behavioral tasks in early infancy. fNIRS helps to promote our understanding of the developmental mechanisms of brain function in preterm infants when performing motor or cognitive tasks in a less-restricted environment.
基金following grants:HD042608, NICHD, NIDA, and the Office of the Director, U.S. PHS (PI Years 1–5: David Reiss, MD PI Years 6–10: Leslie Leve, PhD)DA020585, NIDA, NIMH, and the Office of the Director, U.S. PHS (PI:Jenae Neiderhiser, PhD)
文摘Suicide risk constitutes a complex set of interacting demographic, clinical, psychobiological and environmental variables. Impulsivity is a long-known risk factor for suicide attempts. However, research based on clearer conceptual refinement in this area is imperative. One emerging field of study is that of decision-making. Impulsivity involves a failure of higher-order control, including decision-making. Using standardized operational definitions that take into consideration relevant aspects of impulsivity, including state- and trait-components and a deeper understanding of the process of decision-making in the suicidal mind, we may come a step closer to understanding suicidality and winning the fight in this scourge of human suffering.
文摘BACKGROUND Global education in psychiatry is heavily influenced by knowledge from Western,high-income countries,which obscures local voices and expertise.AIM To adapt a human simulation model to psychiatric education in a context that is specific to local languages and cultures.METHODS We conducted an observational study consisting of six human simulation sessions with standardized patients from two host countries,speaking their native languages,and following an adaptation of the co-constructive patient simulation(CCPS)model.As local faculty became increasingly familiar with the CCPS approach,they took on the role of facilitators—in their country’s native language.RESULTS Fifty-three learners participated:19 child and adolescent psychiatry trainees and 3 faculty members in Türkiye(as a group that met online during 3 consecutive months);and 24 trainees and 7 faculty in Israel(divided into 3 groups,in parallel in-person sessions during a single training day).Each of the six cases reflected local realities and clinical challenges,and was associated with specific learning goals identified by each case-writing trainee.CONCLUSION Human simulation has not been fully incorporated into psychiatric education:The creation of immersive clinical experiences and the strengthening of reflective practice are two areas ripe for development.Our adaptations of CCPS can also strengthen local and regional networks and psychiatric communities of practice.Finally,the model can help question and press against hegemonies in psychiatric training that overshadow local expertise.
基金supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Project-ID 424778381-TRR 295(to MM)the Fondazione Grigioni per il Morbo di Parkinson(to IUI).
文摘Tremor occurs in about half of multiple sclerosis(MS)patients.MS tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tremor may affect the upper and lower extremities,head,and trunk,and may even affect the vocal cords in isolated cases of palatal tremor.MS tremor is classically attributed to lesions of the brain stem,cerebellum,or cerebellar peduncles,and tremor intensity has been shown to correlate with the number of lesions or their functional connections.However,recent work has demonstrated that inflammatory damage to the cerebello-thalamic and cortico-thalamic pathways might also play an important role in causing tremor,as it co-occurs with other signs and symptoms of MS such as dysarthria,dysmetria,dysdiadochokinesia,and dystonia(Alusi et al.,2001).
文摘Background: Tourette syndrome (TS) is a childhood-onset neuropsychiatric diso rder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic sympto ms during adolescence. At least one third of adults with TS have comorbid obsess ive-compulsive disorder (OCD). Objectives: To clarify the clinical course of ti c and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolesce nce and early adulthood. Design: Prospective cohort study. Setting: Yale Child Study Center tic and OCD outpatient specialty clinic. Participants: Forty-six children with TS who received a structured clinical evaluation prior to age 14 years. Main Outcome Measures: Expert-rated tic and OCD symptom sever ity at follow-up interview an average of 7.6 years later (range, 3.8-12.8 year s). Results: Eighty-five percent of subjects reported a reduction in tic sympto ms during adolescence. Only increased tic severity in childhood was associated w ith increased tic severity at follow-up. The average age at worst-ever tic sev erity was 10.6 years. Forty-one percent of patients with TS reported at one tim e experiencing at least moderate OCD symptoms. Worst-ever OCD symptoms occurred approximately 2 years later than worst-ever tic symptoms. Increased childhood IQ was strongly associated with increased OCD severity at followup. Conclusion: Obsessive-compulsive disorder symptoms in children with TS became more severe a t a later age and were more likely to persist than tic symptoms.
基金support from Universitas Airlangga,in part by Higher Education Sprout Project,Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University(NCKU),and by the National Science and Technology Council,Taiwan(NSTC 112-2410-H-006-089-SS2).
文摘Objectives:Problematic use of the internet(PUI)has been increasingly associated with various mental health issues,highlighting the need for accurate assessment tools.The Assessment of Criteria for Specific Internet-use Disorder(ACSID-11)is a validated psychometric instrument designed to measure distinct forms of PUI across multiple online activities.However,its applicability and validity have not yet been established within the Indonesian context.Therefore,this study aimed to translate and validate the ACSID-11 for use among Indonesian populations.Methods:The translation procedure of the ACSID-11 involved forward translation,back translation,and expert panel discussions.This research involved 600 undergraduate and post-graduate students from universities in Indonesia(mean[SD]age=21.60[2.74]years;409[68%]females).Cronbach’s Alpha(α)and McDonald’s Omega(ω)were used to measure the internal consistency of the ACSID-11.Confirmatory factor analysis(CFA)was used in testing the construct validity of the ACSID-11.Results:The ACSID-11 demonstrated validity and reliability in assessing different types of PUI in the present Indonesian sample(α=0.67–0.96;ω=0.68–0.96).The CFA results supported a four-factor structure for the Indonesian version of the ACSID-11.Conclusion:The findings suggest that the Indonesian version of the ACSID-11 is a valid and reliable tool for assessing specific forms of PUI among Indonesian students.Future research and clinical applications are encouraged to utilize the ACSID-11 for early identification,intervention,and prevention strategies targeting PUI within this population.
文摘Multiple sclerosis(MS)is the most common inflammatory demyelinating brain disease.The occurrence of psychiatric disorders,especially for major depression,in the course of MS is high.Reports concerning bipolar disorder(BD)remain rather scarce although early descriptions were found in the old neurological literature.The purpose of this article is to provide a critical review of the epidemiology,comorbidity,and treatment findings regarding BD preceding the onset of MS.
基金It was supported by the Research Fellowship from Sapienza University of Rome to Dr.Giulia Serra.
文摘A pathophysiological relationship has been reported between inflammatory processes,decreased levels of neurotrophins,increased oxidative stress and psychiatric disorders in both juvenile and adult ages.Moreover,this relationship remains unclear in juvenile bipolar disorder(BD).We performed a systematic literature review of studies reporting measurements of inflammatory markers,oxidative stress markers or neurotrophins in juvenile and young adult subjects with BD.Concordant findings showed that inflammatory markers are increased since the earlier stages of BD.A positive correlation between decreased levels of a peripheral brain-derived neurotrophic factor and juvenile BD is controversial suggesting that those changes might occur only during the late stage of BD.No changes in central glutathione levels were reported in young adult age BD indicating that oxidative stress may be an outcome of long illness duration and repeated affective episodes.In conclusion,preliminary findings indicate that a certain relationship exists between inflammatory process and juvenile BD but evidence are insufficient to support a causal relationship.Adequately powered and prospective studies are warranted to clarify the role of inflammation,neurotrophins and oxidative stress in juvenile BD.
基金This study was funded by a personal research grant awarded to L.R.by the Academic Medical Center,University of Amsterdam,and 11.32050.26 ERA-NET PRIOMEDCHILD FP 6(EU)and a grant from Amsterdam Brain and Cognition(ABC)Suffugium,a Dutch nonprofit organization,financially supported M.B.as well as A.K.A.K.and L.R.were financially supported by EUROSTARS(E!113351 DEPREDICT)+1 种基金A.S.was supported by an NWOVeni(016.196.153)A.S.and P.J.L.are supported by the Urban Mental Health program of the University of Amsterdam.
文摘Background:Problems with emotional processing are widely reported in individuals with attentiondeficit/hyperactivity disorder(ADHD).Although methylphenidate(MPH)effectively alleviates inattention and hyperactivity symptoms in ADHD,its effects on emotional processing and internalizing symptoms have remained elusive.While we previously found that acute MPH administration modulated neural mechanisms underlying emotional processing in an age-dependent manner,the effects of prolonged administration remained unknown.Objectives:Therefore,we investigated:(i)whether prolonged MPH treatment influences neural substrates(amygdala reactivity and connectivity)of emotional processing,and(ii)whether these effects are modulated by age.Methods:The“effects of Psychotropic drugs On Developing brain-MPH”(“ePOD-MPH”)randomized controlled trial was a 16-week double-blind,placebo-controlled,multi-center trial with MPH in 50 boys(10–12 years of age)and 49 men(23–40 years of age),all stimulant treatment-naive and diagnosed with ADHD.Participants performed an emotional face-matching task during functional magnetic resonance imaging.We assessed their symptoms of ADHD and internalizing symptoms at baseline,during the trial(8 weeks),and 1 week after the trial end(17 weeks).Results and Conclusions:We did not find effects of prolonged MPH treatment on emotional processing,as measured by amygdala reactivity and connectivity and internalizing symptoms in this trial with stimulant treatment-naive participants.This differs from our findings on emotional processing following acute MPH administration and the effects of prolonged MPH treatment on the dopamine system,which were both modulated by age.Interestingly,prolonged MPH treatment did improve ADHD symptoms,although depressive and anxiety symptoms showed a medication-independent decrease.Furthermore,our data indicate that baseline internalizing symptoms may be used to predict MPH treatment effects on ADHD symptoms,particularly in(male)adults with ADHD.
