The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 d...The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this relationship.Peripheral lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory regions.Ceramide and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting gliosis.Peripheral insulin resistance further exacerbates brain insulin resistance and neuroinflammation.Preclinical interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal models.However,translating these findings to clinical practice requires further investigation into human subjects.In conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and neurodegeneration.Understanding these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.展开更多
通过对引种的哈萨克斯坦桦树开展多点区域试验,分析其适应性,筛选出优良家系,为引种桦树家系的选择和应用提供理论依据。以定植在黑龙江省大庆市、黑龙江省尚志市及辽宁省锦州市11年生23个哈萨克斯坦桦树家系及2个帽儿山种源的中国白桦...通过对引种的哈萨克斯坦桦树开展多点区域试验,分析其适应性,筛选出优良家系,为引种桦树家系的选择和应用提供理论依据。以定植在黑龙江省大庆市、黑龙江省尚志市及辽宁省锦州市11年生23个哈萨克斯坦桦树家系及2个帽儿山种源的中国白桦家系为研究对象,分析其树高、胸径、材积和通直度等性状的遗传变异规律,采用R语言ASReml4.0软件包,拟合具有异质方差的混合线性模型,通过最佳线性无偏预测法(best linear unbiased prediction,BLUP)获得不同试验地点各家系的育种值,并结合GGE(Genotype main effects and genotype×environment interaction)双标图对各参试点和家系进行综合评价及选择。在以地点为固定效应的混合效应模型中,发现地点间环境影响显著,生长性状在不同地点间及同一试验地点内家系间均达到显著差异(P<0.05,方差分量估计值与其标准误差的比值(Z ratio)大于1.5);大庆试验点中17号家系的保存率和育种值最高,具有较好的耐盐性;基于BLUP法的GGE双标图显示,引种桦树3号家系速生性最优,9号家系稳定性最强。基于各家系稳定性及速生性综合排序,按照30%入选率,并结合各家系材积遗传增益,选出20号、9号、7号、24号共4个优良家系。展开更多
主要对小区玉米收获机气力输送系统中的旋风分离器的设计进行仿真分析,运用EDEM-Fluent软件对旋风分离器内部流场进行了仿真模拟。通过EDEM软件模拟颗粒的仿真运动,观察模拟中颗粒的运动轨迹,再通过Fluent软件对旋风分离器中的气流流场...主要对小区玉米收获机气力输送系统中的旋风分离器的设计进行仿真分析,运用EDEM-Fluent软件对旋风分离器内部流场进行了仿真模拟。通过EDEM软件模拟颗粒的仿真运动,观察模拟中颗粒的运动轨迹,再通过Fluent软件对旋风分离器中的气流流场进行模拟分析,将两者进行耦合,以观察玉米籽粒在气流作用下的运动情况,并对玉米籽粒在运动过程中的受力情况和玉米籽粒碰撞特性进行分析。结合旋风分离器的结构参数和对玉米籽粒的运动分析,以气流流速、下锥体高度和入料口横截面积作为试验因素,以玉米籽粒破损率为指标进行试验,对多目标变量进行方法优化并建立优化模型,得出旋风分离器最佳结构参数:气流流速为30 m/s、下锥体高度为400 mm、入料口横截面积为0.08 m 2,玉米籽粒破损率为0.782%,优于传统同类装置。进行了10组台架试验,验证结果与仿真结果相符,表明改进的旋风分离器能够满足玉米收获机的收获要求。展开更多
基金supported by a Presidential Postdoctoral Fellowship (021229-00001) from Nanyang Technological University,Singapore (to JZ)a Lee Kong Chian School of Medicine Dean’s Postdoctoral Fellowship (021207-00001) from NTU Singaporea Mistletoe Research Fellowship (022522-00001) from the Momental Foundaton,USA (to CHL)
文摘The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this relationship.Peripheral lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory regions.Ceramide and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting gliosis.Peripheral insulin resistance further exacerbates brain insulin resistance and neuroinflammation.Preclinical interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal models.However,translating these findings to clinical practice requires further investigation into human subjects.In conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and neurodegeneration.Understanding these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.
文摘通过对引种的哈萨克斯坦桦树开展多点区域试验,分析其适应性,筛选出优良家系,为引种桦树家系的选择和应用提供理论依据。以定植在黑龙江省大庆市、黑龙江省尚志市及辽宁省锦州市11年生23个哈萨克斯坦桦树家系及2个帽儿山种源的中国白桦家系为研究对象,分析其树高、胸径、材积和通直度等性状的遗传变异规律,采用R语言ASReml4.0软件包,拟合具有异质方差的混合线性模型,通过最佳线性无偏预测法(best linear unbiased prediction,BLUP)获得不同试验地点各家系的育种值,并结合GGE(Genotype main effects and genotype×environment interaction)双标图对各参试点和家系进行综合评价及选择。在以地点为固定效应的混合效应模型中,发现地点间环境影响显著,生长性状在不同地点间及同一试验地点内家系间均达到显著差异(P<0.05,方差分量估计值与其标准误差的比值(Z ratio)大于1.5);大庆试验点中17号家系的保存率和育种值最高,具有较好的耐盐性;基于BLUP法的GGE双标图显示,引种桦树3号家系速生性最优,9号家系稳定性最强。基于各家系稳定性及速生性综合排序,按照30%入选率,并结合各家系材积遗传增益,选出20号、9号、7号、24号共4个优良家系。
文摘主要对小区玉米收获机气力输送系统中的旋风分离器的设计进行仿真分析,运用EDEM-Fluent软件对旋风分离器内部流场进行了仿真模拟。通过EDEM软件模拟颗粒的仿真运动,观察模拟中颗粒的运动轨迹,再通过Fluent软件对旋风分离器中的气流流场进行模拟分析,将两者进行耦合,以观察玉米籽粒在气流作用下的运动情况,并对玉米籽粒在运动过程中的受力情况和玉米籽粒碰撞特性进行分析。结合旋风分离器的结构参数和对玉米籽粒的运动分析,以气流流速、下锥体高度和入料口横截面积作为试验因素,以玉米籽粒破损率为指标进行试验,对多目标变量进行方法优化并建立优化模型,得出旋风分离器最佳结构参数:气流流速为30 m/s、下锥体高度为400 mm、入料口横截面积为0.08 m 2,玉米籽粒破损率为0.782%,优于传统同类装置。进行了10组台架试验,验证结果与仿真结果相符,表明改进的旋风分离器能够满足玉米收获机的收获要求。
