Objectives: To identify the etiology and source after recognition of diarrhea outbreak is associated with drinking water in suburb of Chengdu. Methods: Both unmatched case control and retrospective cohort study were c...Objectives: To identify the etiology and source after recognition of diarrhea outbreak is associated with drinking water in suburb of Chengdu. Methods: Both unmatched case control and retrospective cohort study were conducted. 131 targets including 56 suspected patients were recruited for case control study, while 463 residents were selected for cohort study. Stool, water and environmental samples were collected for laboratory testing. Results: The proportion of case exposed to well water was 86% in case group compared with 51% in the controls during the epidemic period (OR = 6.14, P P P E. coli and Enterotoxigenic E. coli was positive in stool and river samples. Conclusions: This outbreak of diarrhea might be caused by several mixed opportunistic pathogens in well water contaminated from the river water.展开更多
目的 探索成都市男男性行为(men who have sex with men, MSM)人群人口学特征、行为学特征以及流行病史等对猴痘感染的影响,为猴痘防控提供理论依据。方法 采用病例对照研究方法,收集成都市2023年6月—2024年3月猴痘患者为研究组,以非猴...目的 探索成都市男男性行为(men who have sex with men, MSM)人群人口学特征、行为学特征以及流行病史等对猴痘感染的影响,为猴痘防控提供理论依据。方法 采用病例对照研究方法,收集成都市2023年6月—2024年3月猴痘患者为研究组,以非猴痘MSM人群为对照组,调查猴痘患者和对照组基本信息、性病史性行为、境内外旅居史等信息。用单因素和多因素logistic回归分析方法,探讨猴痘发病的危险因素。结果 共调查猴痘患者128例(其中HIV感染者53例),对照151例(其中HIV感染者50例)。128例猴痘患者年龄(32.48±6.67)岁,均为男性,101例未婚,100例文化程度在大学及以上,60例为商业服务和自由职业,89例为同性恋,116例自述有男男性行为史,109例月均同性性行为≤4次,48例患者每次都用安全套。猴痘患者组中未婚者、文化程度在大学及以上者比例低于对照组、患HIV以外的性病比例高于对照组(P<0.05)。与MSM人群相比,性取向为双性恋者或异性恋(OR=4.65),同性性行为从不使用安全套(OR=3.25)的猴痘风险更高;流行病学史方面两组差异均无统计学意义。多因素logistic回归分析显示,不清楚是否患有其他性传播疾病感染与猴痘感染存在负向关联,感染HIV以外的其他性传播疾病、双性恋或异性恋与猴痘感染存在正向关联。结论 成都市MSM人群中同时患HIV以外的性传播疾病、性取向为双性恋或异性恋是猴痘的危险因素,应加强此类高风险人群的宣传教育,降低疫情传播风险。展开更多
文摘Objectives: To identify the etiology and source after recognition of diarrhea outbreak is associated with drinking water in suburb of Chengdu. Methods: Both unmatched case control and retrospective cohort study were conducted. 131 targets including 56 suspected patients were recruited for case control study, while 463 residents were selected for cohort study. Stool, water and environmental samples were collected for laboratory testing. Results: The proportion of case exposed to well water was 86% in case group compared with 51% in the controls during the epidemic period (OR = 6.14, P P P E. coli and Enterotoxigenic E. coli was positive in stool and river samples. Conclusions: This outbreak of diarrhea might be caused by several mixed opportunistic pathogens in well water contaminated from the river water.
文摘目的 探索成都市男男性行为(men who have sex with men, MSM)人群人口学特征、行为学特征以及流行病史等对猴痘感染的影响,为猴痘防控提供理论依据。方法 采用病例对照研究方法,收集成都市2023年6月—2024年3月猴痘患者为研究组,以非猴痘MSM人群为对照组,调查猴痘患者和对照组基本信息、性病史性行为、境内外旅居史等信息。用单因素和多因素logistic回归分析方法,探讨猴痘发病的危险因素。结果 共调查猴痘患者128例(其中HIV感染者53例),对照151例(其中HIV感染者50例)。128例猴痘患者年龄(32.48±6.67)岁,均为男性,101例未婚,100例文化程度在大学及以上,60例为商业服务和自由职业,89例为同性恋,116例自述有男男性行为史,109例月均同性性行为≤4次,48例患者每次都用安全套。猴痘患者组中未婚者、文化程度在大学及以上者比例低于对照组、患HIV以外的性病比例高于对照组(P<0.05)。与MSM人群相比,性取向为双性恋者或异性恋(OR=4.65),同性性行为从不使用安全套(OR=3.25)的猴痘风险更高;流行病学史方面两组差异均无统计学意义。多因素logistic回归分析显示,不清楚是否患有其他性传播疾病感染与猴痘感染存在负向关联,感染HIV以外的其他性传播疾病、双性恋或异性恋与猴痘感染存在正向关联。结论 成都市MSM人群中同时患HIV以外的性传播疾病、性取向为双性恋或异性恋是猴痘的危险因素,应加强此类高风险人群的宣传教育,降低疫情传播风险。
