The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes.Basic helix-loop-helix ARNT-like 1(BMAL 1),als...The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes.Basic helix-loop-helix ARNT-like 1(BMAL 1),also known as aryl hydrocarbon receptor nuclear translocator-like protein 1(ARNTL1),is a key component of the circadian clock.The deletion of BMAL1 alone can abolish the circadian rhythms of the human body.BMAL 1 plays a critical role in immune cell function.Dysregulation of BMAL 1 is linked to immune-related diseases such as autoimmune diseases,infectious diseases,and cancer,and vice versa.This review highlights the significant role of BMAL 1 in governing immune cells,including their development,differentiation,migration,homing,metabolism,and effector functions.This study also explores how dysregulation of BMAL1 can have far-reaching implications and potentially contribute to the onset of immune-related diseases such as autoimmune diseases,infectious diseases,cancer,sepsis,and trauma.Furthermore,this review discusses treatments for immune-related diseases that target BMAL 1 disorders.Understanding the impact of BMAL 1 on immune function can provide insights into the pathogenesis of immune-related diseases and help in the development of more effective treatment strategies.Targeting BMAL 1 has been demonstrated to achieve good efficacy in immune-related diseases,indicating its promising potential as a targetable therapeutic target in these diseases.展开更多
文摘The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes.Basic helix-loop-helix ARNT-like 1(BMAL 1),also known as aryl hydrocarbon receptor nuclear translocator-like protein 1(ARNTL1),is a key component of the circadian clock.The deletion of BMAL1 alone can abolish the circadian rhythms of the human body.BMAL 1 plays a critical role in immune cell function.Dysregulation of BMAL 1 is linked to immune-related diseases such as autoimmune diseases,infectious diseases,and cancer,and vice versa.This review highlights the significant role of BMAL 1 in governing immune cells,including their development,differentiation,migration,homing,metabolism,and effector functions.This study also explores how dysregulation of BMAL1 can have far-reaching implications and potentially contribute to the onset of immune-related diseases such as autoimmune diseases,infectious diseases,cancer,sepsis,and trauma.Furthermore,this review discusses treatments for immune-related diseases that target BMAL 1 disorders.Understanding the impact of BMAL 1 on immune function can provide insights into the pathogenesis of immune-related diseases and help in the development of more effective treatment strategies.Targeting BMAL 1 has been demonstrated to achieve good efficacy in immune-related diseases,indicating its promising potential as a targetable therapeutic target in these diseases.
