Wu-Xing theory is an ancient philosophy that serves as a guiding principle in the traditional Chinese medicine(TCM).It has been used to explain the unbalance among the TCM organ systems in disease states and provide t...Wu-Xing theory is an ancient philosophy that serves as a guiding principle in the traditional Chinese medicine(TCM).It has been used to explain the unbalance among the TCM organ systems in disease states and provide treatment philosophy qualitatively.Until now,it is still a challenge to explore the Wu-Xing theory beyond its philosophical nature.In this study,we established a quantitative framework using the landscape and flux theory to characterize the nature of the WuXing theory from a perspective of a minimal network motif and leave certain specific functional aspects of Wu-Xing theory for future exploration.We uncovered the irregular ring shape of projection landscape for the Wu-Xing network with several local basins and barriers.We found that the dynamics of the self-organized Wu-Xing system was determined by the underlying negative landscape gradient force and the nonequilibrium rotational flux.While the shape of the WuXing landscape determines the stabilities of the states,the rotational flux guarantees the persistent periodic oscillation and the stability of the flow.This provides a physical and quantitative basis for Yin–Yang duality of the driving forces for determining the dynamics and behaviors of the living systems.Applying landscape and flux analysis,we can identify the key parameter for the dynamics/function of Wu-Xing network.These findings allow us to have a deeper understanding of the scientific merits of the ancient Wu-Xing theory from the network motif perspective.展开更多
The United Nations passed two important resolutions,Transforming our World:The 2030 Agenda for Sustainable Development and the Paris Agreement,in 2015 to change our world.The 17 Sustainable Development Goals(SDGs)were...The United Nations passed two important resolutions,Transforming our World:The 2030 Agenda for Sustainable Development and the Paris Agreement,in 2015 to change our world.The 17 Sustainable Development Goals(SDGs)were adopted as the core of the 2030 Agenda for Sustainable Development,which set out a 15-year plan to achieve the goals.展开更多
Wastewater-based epidemiology(WBE)offers a unique window into the health and habits of communities through the analysis of pollutants and biomarkers in sewage.Traditionally focused on small molecules,such as pharmaceu...Wastewater-based epidemiology(WBE)offers a unique window into the health and habits of communities through the analysis of pollutants and biomarkers in sewage.Traditionally focused on small molecules,such as pharmaceuticals and illegal drugs,recent advances in environmental proteomics have expanded WBE to include large biomolecules such as proteins.Notably,novel sampling methods using polymeric probes and high-resolution mass spectrometry have facilitated the detection of human and animal proteins,both soluble and in particulate material,linking them to specific populations and industrial activities.An immunological dimension to this approach is fundamental to include the recognition of host immunoglobulins,immune-response proteins,and pathogen antigens in wastewater,potentially serving as indicators of community immune status,infection prevalence,and vaccination coverage.This review consolidates the latest advancements in environmental proteomics as applied to WBE,emphasizing an immunological perspective as a comprehensive tool for assessing population health and environmental conditions to bridge environmental monitoring,public health,and clinical diagnostics.展开更多
Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health.Despite global efforts to mitigate legacy pollutants,the continuous introduction of new su...Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health.Despite global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the planet.In response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution Prevention.This review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health approach.Strategies for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international levels.Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.21721003)the Fund from the Ministry of Science and Technology of China(Grant No.2016YFA0203200)。
文摘Wu-Xing theory is an ancient philosophy that serves as a guiding principle in the traditional Chinese medicine(TCM).It has been used to explain the unbalance among the TCM organ systems in disease states and provide treatment philosophy qualitatively.Until now,it is still a challenge to explore the Wu-Xing theory beyond its philosophical nature.In this study,we established a quantitative framework using the landscape and flux theory to characterize the nature of the WuXing theory from a perspective of a minimal network motif and leave certain specific functional aspects of Wu-Xing theory for future exploration.We uncovered the irregular ring shape of projection landscape for the Wu-Xing network with several local basins and barriers.We found that the dynamics of the self-organized Wu-Xing system was determined by the underlying negative landscape gradient force and the nonequilibrium rotational flux.While the shape of the WuXing landscape determines the stabilities of the states,the rotational flux guarantees the persistent periodic oscillation and the stability of the flow.This provides a physical and quantitative basis for Yin–Yang duality of the driving forces for determining the dynamics and behaviors of the living systems.Applying landscape and flux analysis,we can identify the key parameter for the dynamics/function of Wu-Xing network.These findings allow us to have a deeper understanding of the scientific merits of the ancient Wu-Xing theory from the network motif perspective.
基金supported by the International ResearchCenter of Big Data for Sustainable Development Goals(CBAS)(CBASYX0906)the Strategic Priority Research Program of the Chinese Academy of Sciences(grant number XDA19090122)+1 种基金key scientific and technological research projects in the Xinjiang Production and Construction Corps(grant number 2023AB074)the Youth Innovation Promotion Association CAS under grant Y2022050.R.B.S.thankfully acknowledges a grant fromthe Swedish ResearchCouncil(Formas)(grant number 2022-02033).
文摘The United Nations passed two important resolutions,Transforming our World:The 2030 Agenda for Sustainable Development and the Paris Agreement,in 2015 to change our world.The 17 Sustainable Development Goals(SDGs)were adopted as the core of the 2030 Agenda for Sustainable Development,which set out a 15-year plan to achieve the goals.
基金supported by the Spanish Ministry of Science and Innovation(MICINN,Spain)(Project nos.PID2020-114065RB-C22 and PID2020-114065RB-C21).
文摘Wastewater-based epidemiology(WBE)offers a unique window into the health and habits of communities through the analysis of pollutants and biomarkers in sewage.Traditionally focused on small molecules,such as pharmaceuticals and illegal drugs,recent advances in environmental proteomics have expanded WBE to include large biomolecules such as proteins.Notably,novel sampling methods using polymeric probes and high-resolution mass spectrometry have facilitated the detection of human and animal proteins,both soluble and in particulate material,linking them to specific populations and industrial activities.An immunological dimension to this approach is fundamental to include the recognition of host immunoglobulins,immune-response proteins,and pathogen antigens in wastewater,potentially serving as indicators of community immune status,infection prevalence,and vaccination coverage.This review consolidates the latest advancements in environmental proteomics as applied to WBE,emphasizing an immunological perspective as a comprehensive tool for assessing population health and environmental conditions to bridge environmental monitoring,public health,and clinical diagnostics.
基金funded by the National Key Research and Development Program of China(2020YFC1807000)the Strategic Priority Research Program of the Chinese Academy of Sciences(no.XDA28030501)+9 种基金the National Natural Science Foundation of China(41991333,41977137,42090060)the International Atomic Energy Agency Research Project(D15022)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2011225[Fang Wang],Y201859[H.Wang],2013201[J.Su],2021309[Y.Song],Y2022084[M.Ye])Chinese Academy of Sciences President’s International Fellowship Initiative(2020DC0005,2022DC0001,2024DC0009)the Institute of Soil Science,Chinese Academy of Sciences(ISSAS2419)the Research Group Linkage project from Alexander von Humboldt foundation,the Center for Health Impacts of Agriculture(CHIA)of Michigan State University,and the URI STEEP Superfund Center(grant#P42ES027706)Fang Wang was partly supported by the fellowship of Alexander von Humboldt for experienced researchers,and Shennong Young Talents of the Ministry of Agriculture and Rural Affairs,China(SNYCQN006-2022)J.P.and T.R.S.were supported by the Canada Research Chair program.B.W.B.was supported by a Royal Society of New Zealand Catalyst International Leaders fellowship.K.K.B.was supported by Innovation Fund Denmark and the European Commission Horizon 2020 financed under the ERA-NET Aquatic Pollutants Joint Transnational Call(REWA,GA no.869178)S.A.H.was partly supported by a grant from the National Institute of Environmental Health Sciences,National Institutes of Health grant number P42ES04911-29(Project 4)T.R.S.thanks CESAM by FCT/MCTES(UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020)。
文摘Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health.Despite global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the planet.In response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution Prevention.This review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health approach.Strategies for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international levels.Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.
