Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance...Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance of homeostasis,and orchestrating immune responses.With the rapid exploitation and development of new technologies,there is a deeper understanding of macrophages in the brain barrier system.Here we review the origin,development,important molecules,and functions of macrophages,mainly focusing on microglia and border-associated macrophages.We also highlight some advances in single-cell sequencing and significant cell markers.We anticipate that more advanced methods will emerge to study resident and recruited macrophages in the future,opening new horizons for neuroimmunology and related peripheral immune fields.展开更多
Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective...Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective of this work is to contribute to the management of OF cases in CAR. Patients and Methods: This was a retrospective, descriptive and analytical study, including data from several OF care services. The study included 245 cases of OF, operated on from 2009 to 2018. The parameters studied were maternal and obstetrical data, sociodemographic data, the specific characteristics of the fistulas as well as the modalities and outcome of surgical treatment. The data collected came from six (6) OF surgical repair campaigns organized by the Ministry of Health and Population with the support of UNFPA. Results: We recorded 245 patients, representing a prevalence of 0.77% of OF per year. Among these patients, almost half (45.3%) were treated at the Sino-Central African Friendship University Hospital Center (CHUASC). The average age of the patients was 30 years (range 14 to 78 years). They were unschooled (53.9%) and primigravidas (35%). The fistulas had an average duration of evolution of 7.58 years. They were vesicovaginal in 25.3%. Types V and I dominated in 17.4% and 9.2%, respectively. In 85.9% of cases, fistulorrhaphy was performed, half of which (50.2%) via the upper route. The cure rate was 83.3%. Note that our study reveals statistically significant links between the evolution after surgery with age (p = 0.04 Conclusion: OF mainly affected women of childbearing age, uneducated, primiparous. Vesicovaginal fistula was the frequently encountered type and was manifested by urine loss clinically with a positive methylene blue test.展开更多
Located at the intersection of the east,west,south and north,Central Asia has attracted the attention of major international actors due to its unique geographical location.On one hand,major powers and actors outside t...Located at the intersection of the east,west,south and north,Central Asia has attracted the attention of major international actors due to its unique geographical location.On one hand,major powers and actors outside the region such as the European Union(EU)and the Gulf Cooperation Council have strengthened their ties with Central Asian countries,significantly intensifying the power struggles and institutional competition in the region.On the other hand,Central Asian countries have become increasingly active,developing their foreign relations while seeking strategic autonomy and promoting regional cooperation.展开更多
Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially av...Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially available FDA-approved product for patients with relapsed or refractory(R/R)large B-cell lymphoma(LBCL).However,axi-cel has not been approved by the FDA for use in patients with R/R BL.展开更多
Agriculture is one of the core areas of economic development in Central and Eastern European countries(CEEC).Since the launch of the cooperation between China and Central and Eastern European countries(China-CEEC Coop...Agriculture is one of the core areas of economic development in Central and Eastern European countries(CEEC).Since the launch of the cooperation between China and Central and Eastern European countries(China-CEEC Cooperation)in 2012,agricultural trade has become a pillar of bilateral pragmatic cooperation.Expanding agricultural exports to China has always been the key demand of CEEC.展开更多
As one of the core visual symbols of Chinese traditional culture,the communication history of auspicious cloud patterns on Central Plains ancient ceramics has great significance.Its contemporary value can be summarize...As one of the core visual symbols of Chinese traditional culture,the communication history of auspicious cloud patterns on Central Plains ancient ceramics has great significance.Its contemporary value can be summarized into four aspects,namely the carrier of cultural inheritance and national identity,the innovative resources of modern design,the media of international cultural exchange and the enlightenment of ecological philosophy.展开更多
Transthyretin amyloidosis(ATTR),a rare systemic disorder characterized by misfolded transthyretin(TTR)protein aggregation,predominantly affects the heart and peripheral nervous system.Central nervous system(CNS)involv...Transthyretin amyloidosis(ATTR),a rare systemic disorder characterized by misfolded transthyretin(TTR)protein aggregation,predominantly affects the heart and peripheral nervous system.Central nervous system(CNS)involvement in ATTR,especially widespread leptomeningeal amyloidosis(LA),is exceedingly rare.Early diagnosis of CNS‐predominant ATTR is difficult due to nonspecific symptoms and low awareness.This study adopted a dual‐methodology:A single‐case analysis of a CNSpredominant hereditary ATTR(CNS‐ATTR)patient at a tertiary referral center and a systematic literature review following PRISMA guidelines.PubMed and Embase were systematically searched from the start to March 2025 using controlled vocabulary(MeSH/Emtree terms)and Boolean operators for reported CNS‐involved ATTR cases.A systematic review of 79 CNSATTR cases revealed universal leptomeningeal enhancement on magnetic resonance imaging(MRI)(77/79,97%)and cerebrospinal fluid(CSF)protein elevation(66/79,84%).The index case(p.Gly73Ala)showed diffuse leptomeningeal enhancement,grade 3 PYP uptake,and CSF protein 1.88 g/L.In summary,LA associated with ATTR is extremely scarce.A four‐tiered,protocolbased diagnostic algorithm is crucial for patients with unexplained leptomeningeal disorders.展开更多
In sub-Saharan Africa, foodborne Salmonella infections cause around 680,000 deaths per year. The evolutionary aspects of the incidence of antibiotic resistance in Salmonella strains no longer seem to attract much inte...In sub-Saharan Africa, foodborne Salmonella infections cause around 680,000 deaths per year. The evolutionary aspects of the incidence of antibiotic resistance in Salmonella strains no longer seem to attract much interest in the Central African Republic (CAR), although salmonellosis remains a health problem requiring national and international surveillance. Methodology: The study conducted at the National Laboratory of Clinical Biology and Public Health, Bangui, Central African Republic (LNBCSP) was a retrospective descriptive study. The study duration was five years (January 2019 to December 2023). The study sample consisted of patients who underwent bacteriological testing of stool, blood and urine samples for Salmonella at the LNBCSP in Bangui during this period. Study variables were age, sex, year and bacteriological test results. Statistical tests were used to compare incidences. Relative risks (RR) were calculated to measure the degree of association. Results: From 2019 to 2023, we recorded 353 Salmonella strains, of which 5% were found in blood, 37% in urine and 58% in stool. Patient age ranged from 1 to 86 years, with a mean of 27 ± 22.05 years and a mode of 5 years. Children aged 0 to 14 years (34%) and females (55.81%) predominated. The highest rate of contamination by Salmonella strains was 1.69% in 2022. The overall incidence of salmonellosis was 6.72 in 2019, 7.05 in 2020, 6.91 in 2021, 16.9 in 2022 and 6.26 in 2023 per 1000 samples. Resistance was 30.47% to β_lactam antibiotics, 24.22% to fluroquinolones and 37.97% to Salmonella spp. For Salmonella arizonae strains, resistance was 20.25% to aminoglycosides, 43.67% to chloramphenicol and 7.59% to imipenem. Conclusion: Laboratory-based surveillance of antibiotic resistance in Salmonella strains is needed in both human and veterinary medicine. Another study based on molecular characterization will identify new antibiotic-resistant variants circulating in CAR.展开更多
Background: Chronic low back pain is a leading cause of morbidity and disability globally. Low and Middle-Income Countries (LMICs) tend to be more affected, with chronic low back pain (CLBP) being among the leading pr...Background: Chronic low back pain is a leading cause of morbidity and disability globally. Low and Middle-Income Countries (LMICs) tend to be more affected, with chronic low back pain (CLBP) being among the leading presenting complaints at specialist consultation. The exact burden of this disease is sparingly known in our setting. Objective: To evaluate the burden of chronic low back pain at the Yaounde Central Hospital. Methods: This was a descriptive cross-sectional study for a period of 3 months, from March 2022 to May 2022. After obtaining ethical clearance and research authorisations, data was collected using structured questionnaires from patients with chronic low back pain presenting at the Yaounde Central Hospital during the aforementioned time frame. This data was then tabulated with the Statistical Package for Social Sciences (SPSS 23.0), and disability was assessed using the modified Roland Morris Disability Questionnaire and the Oswestry Disability Index. Data analysis was done using the International Business Machines Statistical Package for Social Sciences (IBM-SPSS) VERSION 23.0. Results: 115 cases of CLBP were included. The mean age was 52.62 years, and the sex ratio was 0.3. The average monthly income was less than 50,000 frs CFA, in 37.4% of cases. In 57.9%, patients had a job that involved physical labour. The patients had a secondary level of education in 40.9%, and alcohol consumption was observed in 36%. The average number of days of a work stoppage due to LBP was 12.75 days (±12SD), and the median duration of CLBP was 7.15 (7.5SD) years. The median pain intensity was 7 (±2SD), with leg pain and sensory neuropathy observed in 67.8% and 63.5% respectively. Lumbar X-ray was done in 45.2% and revealed lumbar osteoarthrosis in 62.4%. Hypertension as a comorbidity was observed in 26.1%. Medical treatment was used at least once in 98.3% of cases. The average cost of management per month was assessed, and the median was 52,000 FCFA (±20,876 SD). Using the Oswestry Disability Questionnaire, 46 patients, that is 40% of the study population, were classified as severely disabled with a median ODI score of 40%. The factors which were independently associated with disability were level of education, alcohol consumption, treatment modality, pain intensity, body mass index (BMI), psychological wellbeing and number of sick leave days. Conclusion: Chronic low back pain is common in our setting. There is a female predominance with the mean age of the study population situated in the 5th decade. Low-income earners and patients with a job involving physical labour were the most affected. Medical treatment was the main therapeutic modality, with the average cost of management per month being above the average monthly income of the greater majority of the patients. Several factors influenced disability, some of which were independently associated with it, such as level of education, alcohol consumption and treatment modality.展开更多
A P-wave velocity model was built in the central southern of the Tanlu Fault based on double-difference tomography.The results suggest the presence of a low-velocity anomaly extending from the surface to a depth of 25...A P-wave velocity model was built in the central southern of the Tanlu Fault based on double-difference tomography.The results suggest the presence of a low-velocity anomaly extending from the surface to a depth of 25 km around the Tanlu and Feixi Faults,representing fault-related fluids caused by partial melting.The relocated earthquakes indicate a significant concentration of seismic activity above 20 km around the Tanlu and Feixi Faults,suggesting that prominent fault systems possibly serve as conduits for the upward migration of deep minerals.The proposed geodynamic model,supported by geological and geophysical data,suggests that the migration of deep mineralized materials extends along the Tanlu Fault.The obtained results serve as a crucial foundation for elucidating the intricate process of mineralization in the central southern segment of the Tanlu Fault,thereby enhancing comprehension regarding the interaction among ore body formation,fault fluids,localized melting,and seismic activity.展开更多
Objective: To evaluate the application effect of ultrasound-guided central venous catheterization in the teaching of anesthesia residents. Methods: Forty anesthesia resident companions who received standardized reside...Objective: To evaluate the application effect of ultrasound-guided central venous catheterization in the teaching of anesthesia residents. Methods: Forty anesthesia resident companions who received standardized residency training in our department from July 2018 to July 2020 were randomly divided into an ultrasound group and a control group, with 20 participants in each group. The ultrasound group was taught by ultrasound-guided central venipuncture, while the control group was taught by traditional anatomy. After ten training punctures, all trainees were assessed twice. Results: Both groups could master the technique of central venipuncture. The success rate of first puncture and the overall success rate of puncture in the ultrasound group were significantly higher than those in the control group (p p < 0.05). Conclusion: Compared with the traditional anatomical localization teaching, the use of ultrasound-guided technology can improve the success rate of puncture, save puncture time, reduce related complications, and have a better training effect.展开更多
AIM:To investigate the choroidal vascular index(CVI)and the choroidal structural changes beyond the subfoveal area(analyzed across a 20 mm×24 mm scanning area)in eyes with chronic central serous chorioretinopathy...AIM:To investigate the choroidal vascular index(CVI)and the choroidal structural changes beyond the subfoveal area(analyzed across a 20 mm×24 mm scanning area)in eyes with chronic central serous chorioretinopathy(cCSC)eyes with macular neovascularization(MNV)using ultra-widefield swept-source optical coherence tomography angiography(UWF SS-OCTA).METHODS:This retrospective comparative study included 46 cCSC with MNV eyes(With MNV group),52 cCSC without MNV eyes(Without MNV group),and 40 age-matched healthy controls.UWF SS-OCTA imaging with a 20 mm×24 mm protocol was used to quantify CVI across 9 subfields(superotemporal,superior,superonasal,temporal,central,nasal,inferotemporal,inferior,and inferonasal).The CVI was compared among the groups.RESULTS:With MNV group demonstrated significantly older mean age than Without MNV group(56.2±6.1 vs 47.5±8.6y,P<0.001).The CVI was significantly lower in the With MNV group than in the Without MNV group,except in the superotemporal,superior,and temporal regions(all P<0.05).Notably,despite MNV-associated CVI reductions,the With MNV group maintained a higher CVI than the control group in all 5 subfields(superior,temporal,central,inferior,and inferonasal;all P<0.05).In the central region,CONCLUSION:CVI decreases,and choroidal structural changes extend beyond the subfoveal area in cCSC with MNV eyes,providing with an imaging evidence for the important role of choroidal ischemia in the pathogenesis of MNV in cCSC.展开更多
BACKGROUND Major depressive disorder(MDD)with comorbid anxiety is an intricate psychiatric condition,but limited research is available on the degree centrality(DC)between anxious MDD and nonanxious MDD patients.AIM To...BACKGROUND Major depressive disorder(MDD)with comorbid anxiety is an intricate psychiatric condition,but limited research is available on the degree centrality(DC)between anxious MDD and nonanxious MDD patients.AIM To examine changes in DC values and their use as neuroimaging biomarkers in anxious and non-anxious MDD patients.METHODS We examined 23 anxious MDD patients,30 nonanxious MDD patients,and 28 healthy controls(HCs)using the DC for data analysis.RESULTS Compared with HCs,the anxious MDD group reported markedly reduced DC values in the right fusiform gyrus(FFG)and inferior occipital gyrus,whereas elevated DC values in the left middle frontal gyrus and left inferior parietal angular gyrus.The nonanxious MDD group exhibited surged DC values in the bilateral cerebellum IX,right precuneus,and opercular part of the inferior frontal gyrus.Unlike the nonanxious MDD group,the anxious MDD group exhibited declined DC values in the right FFG and bilateral calcarine(CAL).Besides,declined DC values in the right FFG and bilateral CAL negatively correlated with anxiety scores in the MDD group.CONCLUSION This study shows that abnormal DC patterns in MDD,especially in the left CAL,can distinguish MDD from its anxiety subtype,indicating a potential neuroimaging biomarker.展开更多
In recent years,torrential rain events caused by extratropical cyclones(ETCs)during the boreal midsummer(July-August)in Central and Eastern China have shown an increasing trend.For instence,in August 2024,two ETCs bro...In recent years,torrential rain events caused by extratropical cyclones(ETCs)during the boreal midsummer(July-August)in Central and Eastern China have shown an increasing trend.For instence,in August 2024,two ETCs brought large-scale heavy rainfall to North China,with daily precipitation exceeding 100 mm.Using reanalysis datasets and gridded precipitation data,the ETCs that affected Central and Eastern China during the boreal midsummer from 1981 to 2020 were objectively identified and tracked.ETCs causing precipitation were classified based on maximum daily precipitation,resulting in datasets for ETCs with torrential rain(daily precipitation exceeding 100 mm,referred to as ETC_R100)and heavy rain(daily precipitation exceeding 25 mm,referred to as ETC_R25).Comparative analysis can help highlight the characteristics of ETC_R100.This study compares the spatial distribution,movement paths,weather impacts,large-scale atmospheric circulation,and environmental conditions of these two types of precipitation-related ETCs.The following findings emerged:(1)ETC_R100 is driven by the combined forcing of upper-level troughs and warm-moist airflows at lower levels,exhibiting stronger thermal forcing than ETC_R25.(2)The moisture source for ETC_R100 are the Bay of Bengal and the Northwest Pacific,with moisture transported via the South China Sea.Compared to ETCs with nonextreme rainfall,ETC_R100 is characterized by greater atmospheric instability and better moisture conditions,resulting in higher precipitation intensity.(3)Regardless of the precipitation level,ETCs affected different regions but contributed significantly to precipitation in northern China,accounting for approximately 50%of the total precipitation.The results indicate that ETC_R100 differs significantly from ETCs with varying levels of precipitation in terms of statistical characteristics,weather impact,environmental conditions,and cyclogenesis conditions.展开更多
Central Asia(CA)faces escalating threats from increasing temperature,glacier retreat,biodiversity loss,unsustainable water use,terminal lake shrinkage,and soil salinization,all of which challenge the balance between e...Central Asia(CA)faces escalating threats from increasing temperature,glacier retreat,biodiversity loss,unsustainable water use,terminal lake shrinkage,and soil salinization,all of which challenge the balance between ecological integrity and socio-economic development essential for achieving Sustainable Development Goals.However,a comprehensive understanding of priority areas from a multi-dimensional perspective is lacking,hindering effective conservation and development strategies.To address this,we developed a comprehensive assessment framework with a tailored indicator system,enabling a spatial evaluation of CA’s priority areas by integrating biodiversity,ecosystem services(ESs),and human activities.Combining zonation and geographical detectors,this approach facilitates spatial prioritization and examines ecological and socio-economic heterogeneity.Our findings reveal a heterogeneous distribution of priority areas across CA,with significant concentrations in eastern mountainous regions,river valleys,and oasis agricultural lands.We identified 184 key districts crucial for ecological and societal sustainability.Attribution analysis shows that natural factors like soil types,precipitation,and evapotranspiration significantly shape these areas,influencing human activities and the distribution of biodiversity and ESs.Multi-dimensional analysis indicates existing protected areas cover only 15%of the top 30%priority areas,revealing substantial conservation gaps.Additionally,a 38%overlap between ESs and human activities,along with 63.25%congruence in integrated areas,underscores significant human impacts on ecological systems and their dependency on ESs.Given CA’s limited resources,it is crucial to implement measures that strengthen conservation efforts,align ecological preservation with socio-economic demands,and enhance resource efficiency through sustainable integrated land and water resource management.展开更多
Introduction: Breastfeeding is the best way to provide ideal nutrition for optimal infant growth and development. Objectives: The aim of our work was to assess the knowledge, attitudes and practices of mothers of chil...Introduction: Breastfeeding is the best way to provide ideal nutrition for optimal infant growth and development. Objectives: The aim of our work was to assess the knowledge, attitudes and practices of mothers of children aged 0 - 24 months on exclusive breastfeeding in the Central African Republic. Methods: This was a cross-sectional, descriptive and analytical study conducted from September 15 to October 15, 2024 among mothers of infants aged 0 to 24 months. Sociodemographic, obstetric and breastfeeding-related data were collected through individual interviews conducted during sensitizations on good feeding practices organized by the Tina Touadera Foundation. The chi2 test was used to test for relationships between variables, and the p significance level was set at 0.05. Results: The average age of the mothers surveyed was 27.67 years. 65.69% (n = 247) of mothers lived in urban areas and 55.85% (n = 210) were Muslim. 56.38% (n = 212) were living common-law and 34.04% (n = 128) were poor. Secondary-school mothers (44.42%, n = 167) and housewives (53.72%, n = 202) were in the majority. Exclusive breastfeeding (EBF) was correctly defined by 79.26% (n = 298) of mothers and actually practised in 24.20% (n = 91) of cases. The main source of information was a health professional in 75.36% (n = 304) of cases. Among the 285 mothers who practised mixed breastfeeding, lack of time (33.33%) was the main reason. They acknowledged having given water (100%), corn porridge (75.09%) and/or artificial milk (24.91%) before the first 6 months of life. The average time for introducing water was 2.2 months, and for porridge/formula 2.79 months. More than half the mothers (55.05%) said they did not know their infants’ weaning age. Factors positively influencing the use of EBF were age under 29, residence in an urban area, primiparity, having been informed about AME by a health professional, and being a housewife or shopkeeper (p Conclusion: Mothers’ level of knowledge was heterogeneous but insufficient overall. An effective system of information and education from pregnancy to the first six months of life is needed to promote breastfeeding.展开更多
Obstetric complications are the main cause of mortality and morbidity. Many factors limit women’s access to the quality care they need to reduce this mortality. We proposed to analyse our referral system to identify ...Obstetric complications are the main cause of mortality and morbidity. Many factors limit women’s access to the quality care they need to reduce this mortality. We proposed to analyse our referral system to identify certain factors that may limit its proper functioning and contribute to maternal deaths. This was a 12-month descriptive and analytical cross-sectional study of 259 evacuated women. The average age was 28.8 ± 7 with extremes ranging from 15 to 44 years. Most of the women were single (81.5%), accompanied by medical staff (78.8%), and had a venous approach (81.9%). The means of transfer used were ambulance (78.8%) and motorbike (11.6%). The transfer time was less than one hour (40.9%). The reasons for referral were consistent with the definitive diagnoses (64.5%) and diagnostic errors were noted (35.5%). The majority of patients were treated surgically (77.6%). We recorded maternal death (7.7%), due to unqualified personnel, transfer time, and poor general and haemodynamic condition (P < 0.05). The causes of death were abortion, ectopic pregnancy, arterial hypertension and post-partum haemorrhage (P = 0.014). Fresh stillbirths (14.9%), newborns transferred to neonatology (57.7%). Counter-referrals were assured (46.7%). Reducing diagnostic errors and late evacuations, as well as ongoing training for providers in peripheral health facilities on the signs of serious obstetric and neonatal emergencies will help to reduce the frequency of evacuations.展开更多
As the global economic and trade landscape enters a period of deep adjustment,China is constructing a new development pattern to ensure food security and diversify its agricultural product supply chain.In this process...As the global economic and trade landscape enters a period of deep adjustment,China is constructing a new development pattern to ensure food security and diversify its agricultural product supply chain.In this process,the"Central and Eastern Europe Kitchen"plan represents a vivid practice of China's agricultural product import diversification strategy,and also a new achievement of high-quality joint construction of the Belt and Road in the agriculturalfield.展开更多
The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune surveillance.The recent identification of functional lymphatic vesse...The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune surveillance.The recent identification of functional lymphatic vessels in the meninges of the brain and the spinal cord has provided novel insights into neurophysiology.They emerge as major pathways for fluid exchange.The abundance of immune cells in lymphatic vessels and meninges also suggests that lymphatic vessels are actively involved in neuroimmunity.The lymphatic system,through its role in the clearance of neurotoxic proteins,autoimmune cell infiltration,and the transmission of pro-inflammatory signals,participates in the pathogenesis of a variety of neurological disorders,including neurodegenerative and neuroinflammatory diseases and traumatic injury.Vascular endothelial growth factor C is the master regulator of lymphangiogenesis,a process that is critical for the maintenance of central nervous system homeostasis.In this review,we summarize current knowledge and recent advances relating to the anatomical features and immunological functions of the lymphatic system of the central nervous system and highlight its potential as a therapeutic target for neurological disorders and central nervous system repair.展开更多
The marine-continental transitional shale of the Upper Permian Longtan Formation is widely distributed in Hunan and shows significant exploration potential.Frequent changes in lithofacies have however notably influenc...The marine-continental transitional shale of the Upper Permian Longtan Formation is widely distributed in Hunan and shows significant exploration potential.Frequent changes in lithofacies have however notably influenced the shale gas enrichment.The strata of the Longtan Formation in the Shaoyang Depression,central Hunan,were taken as the study object for this project.Three lithofacies assemblages were identified:shale interbedded with sandstone layer(SAL),sandstone interbedded with shale layer(ASL)and laminated shale layer(LSL).The SAL shale shows significant variability in hydrocarbon generation potential,which leads to shale gas characterized by'hydrocarbon generation in high total organic carbon(TOC)shale,retention in low TOC shale and accumulation in sandstone'.The ASL shale,influenced by the redox conditions of the depositional environment,shows a lower concentration of organic matter.This results in an enrichment model of'hydrocarbon generation and accumulation in shale,with sealing by sandstone'.The laminar structure of LSL shale causes both quartz and clay minerals to control the reservoir.Shale gas is characterized by'hydrocarbon generation in mud laminae,retention and accumulation in silty laminae,with multiple intra-source migration paths'.In the marine-continental transitional shale gas system,the enrichment intervals of different types of shale gas reservoirs exhibit significant variability.展开更多
基金supported by Ministry of Science and Technology China Brain Initiative Grant,No.2022ZD0204702(to ZY)the National Natural Science Foundation of China,No.82371357(to LC)+2 种基金Foundation for Military Medicine,No.16QNP085(to ZY)Navy Medical University Basic Medical College“Yi Zhang”Basic Medical Talent Development and Support Program,Nos.JCYZRC-D-022(to TC)and JCYZRC-D-024(to HD)Science and Technology Innovation Special Fund of Shanghai Baoshan District,No.2023-E-05(to YW).
文摘Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance of homeostasis,and orchestrating immune responses.With the rapid exploitation and development of new technologies,there is a deeper understanding of macrophages in the brain barrier system.Here we review the origin,development,important molecules,and functions of macrophages,mainly focusing on microglia and border-associated macrophages.We also highlight some advances in single-cell sequencing and significant cell markers.We anticipate that more advanced methods will emerge to study resident and recruited macrophages in the future,opening new horizons for neuroimmunology and related peripheral immune fields.
文摘Introduction: Obstetric Fistulas (OF) constitute a major public health problem in developing countries in general and in Central African Republic (CAR) in particular because of its numerous consequences. The objective of this work is to contribute to the management of OF cases in CAR. Patients and Methods: This was a retrospective, descriptive and analytical study, including data from several OF care services. The study included 245 cases of OF, operated on from 2009 to 2018. The parameters studied were maternal and obstetrical data, sociodemographic data, the specific characteristics of the fistulas as well as the modalities and outcome of surgical treatment. The data collected came from six (6) OF surgical repair campaigns organized by the Ministry of Health and Population with the support of UNFPA. Results: We recorded 245 patients, representing a prevalence of 0.77% of OF per year. Among these patients, almost half (45.3%) were treated at the Sino-Central African Friendship University Hospital Center (CHUASC). The average age of the patients was 30 years (range 14 to 78 years). They were unschooled (53.9%) and primigravidas (35%). The fistulas had an average duration of evolution of 7.58 years. They were vesicovaginal in 25.3%. Types V and I dominated in 17.4% and 9.2%, respectively. In 85.9% of cases, fistulorrhaphy was performed, half of which (50.2%) via the upper route. The cure rate was 83.3%. Note that our study reveals statistically significant links between the evolution after surgery with age (p = 0.04 Conclusion: OF mainly affected women of childbearing age, uneducated, primiparous. Vesicovaginal fistula was the frequently encountered type and was manifested by urine loss clinically with a positive methylene blue test.
文摘Located at the intersection of the east,west,south and north,Central Asia has attracted the attention of major international actors due to its unique geographical location.On one hand,major powers and actors outside the region such as the European Union(EU)and the Gulf Cooperation Council have strengthened their ties with Central Asian countries,significantly intensifying the power struggles and institutional competition in the region.On the other hand,Central Asian countries have become increasingly active,developing their foreign relations while seeking strategic autonomy and promoting regional cooperation.
基金supported by the Sponsored by Tianjin Health Research Project(Grant No.TJWJ2023ZD003)the Chinese Society of Clinical Oncology Beijing Xisike Clinical Oncology Research Foundation(Grant Nos.Y-NCJH202201-0027 and Y-2022YMJN/MS-0001).
文摘Because human immunodeficiency virus(HIV)-associated Burkitt lymphoma(BL)has a poor prognosis new therapeutic approaches need to be developed1.Axicabtagene ciloleucel(axi-cel)is an anti-CD19 CAR-T cell commercially available FDA-approved product for patients with relapsed or refractory(R/R)large B-cell lymphoma(LBCL).However,axi-cel has not been approved by the FDA for use in patients with R/R BL.
文摘Agriculture is one of the core areas of economic development in Central and Eastern European countries(CEEC).Since the launch of the cooperation between China and Central and Eastern European countries(China-CEEC Cooperation)in 2012,agricultural trade has become a pillar of bilateral pragmatic cooperation.Expanding agricultural exports to China has always been the key demand of CEEC.
基金Supported by Open Project of Henan Key Laboratory of Research for Central Plains Ancient Ceramics in 2018(ZYGTCXN2018-05).
文摘As one of the core visual symbols of Chinese traditional culture,the communication history of auspicious cloud patterns on Central Plains ancient ceramics has great significance.Its contemporary value can be summarized into four aspects,namely the carrier of cultural inheritance and national identity,the innovative resources of modern design,the media of international cultural exchange and the enlightenment of ecological philosophy.
文摘Transthyretin amyloidosis(ATTR),a rare systemic disorder characterized by misfolded transthyretin(TTR)protein aggregation,predominantly affects the heart and peripheral nervous system.Central nervous system(CNS)involvement in ATTR,especially widespread leptomeningeal amyloidosis(LA),is exceedingly rare.Early diagnosis of CNS‐predominant ATTR is difficult due to nonspecific symptoms and low awareness.This study adopted a dual‐methodology:A single‐case analysis of a CNSpredominant hereditary ATTR(CNS‐ATTR)patient at a tertiary referral center and a systematic literature review following PRISMA guidelines.PubMed and Embase were systematically searched from the start to March 2025 using controlled vocabulary(MeSH/Emtree terms)and Boolean operators for reported CNS‐involved ATTR cases.A systematic review of 79 CNSATTR cases revealed universal leptomeningeal enhancement on magnetic resonance imaging(MRI)(77/79,97%)and cerebrospinal fluid(CSF)protein elevation(66/79,84%).The index case(p.Gly73Ala)showed diffuse leptomeningeal enhancement,grade 3 PYP uptake,and CSF protein 1.88 g/L.In summary,LA associated with ATTR is extremely scarce.A four‐tiered,protocolbased diagnostic algorithm is crucial for patients with unexplained leptomeningeal disorders.
文摘In sub-Saharan Africa, foodborne Salmonella infections cause around 680,000 deaths per year. The evolutionary aspects of the incidence of antibiotic resistance in Salmonella strains no longer seem to attract much interest in the Central African Republic (CAR), although salmonellosis remains a health problem requiring national and international surveillance. Methodology: The study conducted at the National Laboratory of Clinical Biology and Public Health, Bangui, Central African Republic (LNBCSP) was a retrospective descriptive study. The study duration was five years (January 2019 to December 2023). The study sample consisted of patients who underwent bacteriological testing of stool, blood and urine samples for Salmonella at the LNBCSP in Bangui during this period. Study variables were age, sex, year and bacteriological test results. Statistical tests were used to compare incidences. Relative risks (RR) were calculated to measure the degree of association. Results: From 2019 to 2023, we recorded 353 Salmonella strains, of which 5% were found in blood, 37% in urine and 58% in stool. Patient age ranged from 1 to 86 years, with a mean of 27 ± 22.05 years and a mode of 5 years. Children aged 0 to 14 years (34%) and females (55.81%) predominated. The highest rate of contamination by Salmonella strains was 1.69% in 2022. The overall incidence of salmonellosis was 6.72 in 2019, 7.05 in 2020, 6.91 in 2021, 16.9 in 2022 and 6.26 in 2023 per 1000 samples. Resistance was 30.47% to β_lactam antibiotics, 24.22% to fluroquinolones and 37.97% to Salmonella spp. For Salmonella arizonae strains, resistance was 20.25% to aminoglycosides, 43.67% to chloramphenicol and 7.59% to imipenem. Conclusion: Laboratory-based surveillance of antibiotic resistance in Salmonella strains is needed in both human and veterinary medicine. Another study based on molecular characterization will identify new antibiotic-resistant variants circulating in CAR.
文摘Background: Chronic low back pain is a leading cause of morbidity and disability globally. Low and Middle-Income Countries (LMICs) tend to be more affected, with chronic low back pain (CLBP) being among the leading presenting complaints at specialist consultation. The exact burden of this disease is sparingly known in our setting. Objective: To evaluate the burden of chronic low back pain at the Yaounde Central Hospital. Methods: This was a descriptive cross-sectional study for a period of 3 months, from March 2022 to May 2022. After obtaining ethical clearance and research authorisations, data was collected using structured questionnaires from patients with chronic low back pain presenting at the Yaounde Central Hospital during the aforementioned time frame. This data was then tabulated with the Statistical Package for Social Sciences (SPSS 23.0), and disability was assessed using the modified Roland Morris Disability Questionnaire and the Oswestry Disability Index. Data analysis was done using the International Business Machines Statistical Package for Social Sciences (IBM-SPSS) VERSION 23.0. Results: 115 cases of CLBP were included. The mean age was 52.62 years, and the sex ratio was 0.3. The average monthly income was less than 50,000 frs CFA, in 37.4% of cases. In 57.9%, patients had a job that involved physical labour. The patients had a secondary level of education in 40.9%, and alcohol consumption was observed in 36%. The average number of days of a work stoppage due to LBP was 12.75 days (±12SD), and the median duration of CLBP was 7.15 (7.5SD) years. The median pain intensity was 7 (±2SD), with leg pain and sensory neuropathy observed in 67.8% and 63.5% respectively. Lumbar X-ray was done in 45.2% and revealed lumbar osteoarthrosis in 62.4%. Hypertension as a comorbidity was observed in 26.1%. Medical treatment was used at least once in 98.3% of cases. The average cost of management per month was assessed, and the median was 52,000 FCFA (±20,876 SD). Using the Oswestry Disability Questionnaire, 46 patients, that is 40% of the study population, were classified as severely disabled with a median ODI score of 40%. The factors which were independently associated with disability were level of education, alcohol consumption, treatment modality, pain intensity, body mass index (BMI), psychological wellbeing and number of sick leave days. Conclusion: Chronic low back pain is common in our setting. There is a female predominance with the mean age of the study population situated in the 5th decade. Low-income earners and patients with a job involving physical labour were the most affected. Medical treatment was the main therapeutic modality, with the average cost of management per month being above the average monthly income of the greater majority of the patients. Several factors influenced disability, some of which were independently associated with it, such as level of education, alcohol consumption and treatment modality.
基金supported by the National Natural Science Foundation of China(Nos.42574119,42274083,41974049)partly supported by the Urban Geological Survey Project of Linyi,Shandong Province,China(No.SDGP371300202102000468).
文摘A P-wave velocity model was built in the central southern of the Tanlu Fault based on double-difference tomography.The results suggest the presence of a low-velocity anomaly extending from the surface to a depth of 25 km around the Tanlu and Feixi Faults,representing fault-related fluids caused by partial melting.The relocated earthquakes indicate a significant concentration of seismic activity above 20 km around the Tanlu and Feixi Faults,suggesting that prominent fault systems possibly serve as conduits for the upward migration of deep minerals.The proposed geodynamic model,supported by geological and geophysical data,suggests that the migration of deep mineralized materials extends along the Tanlu Fault.The obtained results serve as a crucial foundation for elucidating the intricate process of mineralization in the central southern segment of the Tanlu Fault,thereby enhancing comprehension regarding the interaction among ore body formation,fault fluids,localized melting,and seismic activity.
文摘Objective: To evaluate the application effect of ultrasound-guided central venous catheterization in the teaching of anesthesia residents. Methods: Forty anesthesia resident companions who received standardized residency training in our department from July 2018 to July 2020 were randomly divided into an ultrasound group and a control group, with 20 participants in each group. The ultrasound group was taught by ultrasound-guided central venipuncture, while the control group was taught by traditional anatomy. After ten training punctures, all trainees were assessed twice. Results: Both groups could master the technique of central venipuncture. The success rate of first puncture and the overall success rate of puncture in the ultrasound group were significantly higher than those in the control group (p p < 0.05). Conclusion: Compared with the traditional anatomical localization teaching, the use of ultrasound-guided technology can improve the success rate of puncture, save puncture time, reduce related complications, and have a better training effect.
基金Supported by General Program of National Natural Science Foundation of China(No.82471110)National Key Research and Development Program of China(No.2022YFC2502805)Postdoctoral Foundation of General Hospital of Central Theater Command(No.20210517KY04).
文摘AIM:To investigate the choroidal vascular index(CVI)and the choroidal structural changes beyond the subfoveal area(analyzed across a 20 mm×24 mm scanning area)in eyes with chronic central serous chorioretinopathy(cCSC)eyes with macular neovascularization(MNV)using ultra-widefield swept-source optical coherence tomography angiography(UWF SS-OCTA).METHODS:This retrospective comparative study included 46 cCSC with MNV eyes(With MNV group),52 cCSC without MNV eyes(Without MNV group),and 40 age-matched healthy controls.UWF SS-OCTA imaging with a 20 mm×24 mm protocol was used to quantify CVI across 9 subfields(superotemporal,superior,superonasal,temporal,central,nasal,inferotemporal,inferior,and inferonasal).The CVI was compared among the groups.RESULTS:With MNV group demonstrated significantly older mean age than Without MNV group(56.2±6.1 vs 47.5±8.6y,P<0.001).The CVI was significantly lower in the With MNV group than in the Without MNV group,except in the superotemporal,superior,and temporal regions(all P<0.05).Notably,despite MNV-associated CVI reductions,the With MNV group maintained a higher CVI than the control group in all 5 subfields(superior,temporal,central,inferior,and inferonasal;all P<0.05).In the central region,CONCLUSION:CVI decreases,and choroidal structural changes extend beyond the subfoveal area in cCSC with MNV eyes,providing with an imaging evidence for the important role of choroidal ischemia in the pathogenesis of MNV in cCSC.
基金Supported by Hubei Provincial Department of Science and Technology Natural Fund,No.2024AFC056the Open Fund of the Mental Health Research Institute at Three Gorges University,No.YCXL-23-11.
文摘BACKGROUND Major depressive disorder(MDD)with comorbid anxiety is an intricate psychiatric condition,but limited research is available on the degree centrality(DC)between anxious MDD and nonanxious MDD patients.AIM To examine changes in DC values and their use as neuroimaging biomarkers in anxious and non-anxious MDD patients.METHODS We examined 23 anxious MDD patients,30 nonanxious MDD patients,and 28 healthy controls(HCs)using the DC for data analysis.RESULTS Compared with HCs,the anxious MDD group reported markedly reduced DC values in the right fusiform gyrus(FFG)and inferior occipital gyrus,whereas elevated DC values in the left middle frontal gyrus and left inferior parietal angular gyrus.The nonanxious MDD group exhibited surged DC values in the bilateral cerebellum IX,right precuneus,and opercular part of the inferior frontal gyrus.Unlike the nonanxious MDD group,the anxious MDD group exhibited declined DC values in the right FFG and bilateral calcarine(CAL).Besides,declined DC values in the right FFG and bilateral CAL negatively correlated with anxiety scores in the MDD group.CONCLUSION This study shows that abnormal DC patterns in MDD,especially in the left CAL,can distinguish MDD from its anxiety subtype,indicating a potential neuroimaging biomarker.
基金National Natural Science Foundation of China(42375014,42088101,42030605)Joint Research Project for Meteorological Capacity Improvement(24NLTSZ010)Young Elite Scientists Sponsorship Program by BAST(BYESS2023205)。
文摘In recent years,torrential rain events caused by extratropical cyclones(ETCs)during the boreal midsummer(July-August)in Central and Eastern China have shown an increasing trend.For instence,in August 2024,two ETCs brought large-scale heavy rainfall to North China,with daily precipitation exceeding 100 mm.Using reanalysis datasets and gridded precipitation data,the ETCs that affected Central and Eastern China during the boreal midsummer from 1981 to 2020 were objectively identified and tracked.ETCs causing precipitation were classified based on maximum daily precipitation,resulting in datasets for ETCs with torrential rain(daily precipitation exceeding 100 mm,referred to as ETC_R100)and heavy rain(daily precipitation exceeding 25 mm,referred to as ETC_R25).Comparative analysis can help highlight the characteristics of ETC_R100.This study compares the spatial distribution,movement paths,weather impacts,large-scale atmospheric circulation,and environmental conditions of these two types of precipitation-related ETCs.The following findings emerged:(1)ETC_R100 is driven by the combined forcing of upper-level troughs and warm-moist airflows at lower levels,exhibiting stronger thermal forcing than ETC_R25.(2)The moisture source for ETC_R100 are the Bay of Bengal and the Northwest Pacific,with moisture transported via the South China Sea.Compared to ETCs with nonextreme rainfall,ETC_R100 is characterized by greater atmospheric instability and better moisture conditions,resulting in higher precipitation intensity.(3)Regardless of the precipitation level,ETCs affected different regions but contributed significantly to precipitation in northern China,accounting for approximately 50%of the total precipitation.The results indicate that ETC_R100 differs significantly from ETCs with varying levels of precipitation in terms of statistical characteristics,weather impact,environmental conditions,and cyclogenesis conditions.
基金funded by the Joint CAS-MPG Research Project(HZXM20225001MI)this research was also supported partly by the key program of National Natural Science Foundation of China(42230708)the Tianshan Talent Project of Xinjiang Uygur Autonomous Region,China(2022TSYCLJ0056).
文摘Central Asia(CA)faces escalating threats from increasing temperature,glacier retreat,biodiversity loss,unsustainable water use,terminal lake shrinkage,and soil salinization,all of which challenge the balance between ecological integrity and socio-economic development essential for achieving Sustainable Development Goals.However,a comprehensive understanding of priority areas from a multi-dimensional perspective is lacking,hindering effective conservation and development strategies.To address this,we developed a comprehensive assessment framework with a tailored indicator system,enabling a spatial evaluation of CA’s priority areas by integrating biodiversity,ecosystem services(ESs),and human activities.Combining zonation and geographical detectors,this approach facilitates spatial prioritization and examines ecological and socio-economic heterogeneity.Our findings reveal a heterogeneous distribution of priority areas across CA,with significant concentrations in eastern mountainous regions,river valleys,and oasis agricultural lands.We identified 184 key districts crucial for ecological and societal sustainability.Attribution analysis shows that natural factors like soil types,precipitation,and evapotranspiration significantly shape these areas,influencing human activities and the distribution of biodiversity and ESs.Multi-dimensional analysis indicates existing protected areas cover only 15%of the top 30%priority areas,revealing substantial conservation gaps.Additionally,a 38%overlap between ESs and human activities,along with 63.25%congruence in integrated areas,underscores significant human impacts on ecological systems and their dependency on ESs.Given CA’s limited resources,it is crucial to implement measures that strengthen conservation efforts,align ecological preservation with socio-economic demands,and enhance resource efficiency through sustainable integrated land and water resource management.
文摘Introduction: Breastfeeding is the best way to provide ideal nutrition for optimal infant growth and development. Objectives: The aim of our work was to assess the knowledge, attitudes and practices of mothers of children aged 0 - 24 months on exclusive breastfeeding in the Central African Republic. Methods: This was a cross-sectional, descriptive and analytical study conducted from September 15 to October 15, 2024 among mothers of infants aged 0 to 24 months. Sociodemographic, obstetric and breastfeeding-related data were collected through individual interviews conducted during sensitizations on good feeding practices organized by the Tina Touadera Foundation. The chi2 test was used to test for relationships between variables, and the p significance level was set at 0.05. Results: The average age of the mothers surveyed was 27.67 years. 65.69% (n = 247) of mothers lived in urban areas and 55.85% (n = 210) were Muslim. 56.38% (n = 212) were living common-law and 34.04% (n = 128) were poor. Secondary-school mothers (44.42%, n = 167) and housewives (53.72%, n = 202) were in the majority. Exclusive breastfeeding (EBF) was correctly defined by 79.26% (n = 298) of mothers and actually practised in 24.20% (n = 91) of cases. The main source of information was a health professional in 75.36% (n = 304) of cases. Among the 285 mothers who practised mixed breastfeeding, lack of time (33.33%) was the main reason. They acknowledged having given water (100%), corn porridge (75.09%) and/or artificial milk (24.91%) before the first 6 months of life. The average time for introducing water was 2.2 months, and for porridge/formula 2.79 months. More than half the mothers (55.05%) said they did not know their infants’ weaning age. Factors positively influencing the use of EBF were age under 29, residence in an urban area, primiparity, having been informed about AME by a health professional, and being a housewife or shopkeeper (p Conclusion: Mothers’ level of knowledge was heterogeneous but insufficient overall. An effective system of information and education from pregnancy to the first six months of life is needed to promote breastfeeding.
文摘Obstetric complications are the main cause of mortality and morbidity. Many factors limit women’s access to the quality care they need to reduce this mortality. We proposed to analyse our referral system to identify certain factors that may limit its proper functioning and contribute to maternal deaths. This was a 12-month descriptive and analytical cross-sectional study of 259 evacuated women. The average age was 28.8 ± 7 with extremes ranging from 15 to 44 years. Most of the women were single (81.5%), accompanied by medical staff (78.8%), and had a venous approach (81.9%). The means of transfer used were ambulance (78.8%) and motorbike (11.6%). The transfer time was less than one hour (40.9%). The reasons for referral were consistent with the definitive diagnoses (64.5%) and diagnostic errors were noted (35.5%). The majority of patients were treated surgically (77.6%). We recorded maternal death (7.7%), due to unqualified personnel, transfer time, and poor general and haemodynamic condition (P < 0.05). The causes of death were abortion, ectopic pregnancy, arterial hypertension and post-partum haemorrhage (P = 0.014). Fresh stillbirths (14.9%), newborns transferred to neonatology (57.7%). Counter-referrals were assured (46.7%). Reducing diagnostic errors and late evacuations, as well as ongoing training for providers in peripheral health facilities on the signs of serious obstetric and neonatal emergencies will help to reduce the frequency of evacuations.
文摘As the global economic and trade landscape enters a period of deep adjustment,China is constructing a new development pattern to ensure food security and diversify its agricultural product supply chain.In this process,the"Central and Eastern Europe Kitchen"plan represents a vivid practice of China's agricultural product import diversification strategy,and also a new achievement of high-quality joint construction of the Belt and Road in the agriculturalfield.
基金supported by the Key Program of the National Natural Science Foundation of ChinaNo.82030071+1 种基金the Science and Technology Major Project of ChangshaNo.kh2103008(both to JZH)
文摘The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune surveillance.The recent identification of functional lymphatic vessels in the meninges of the brain and the spinal cord has provided novel insights into neurophysiology.They emerge as major pathways for fluid exchange.The abundance of immune cells in lymphatic vessels and meninges also suggests that lymphatic vessels are actively involved in neuroimmunity.The lymphatic system,through its role in the clearance of neurotoxic proteins,autoimmune cell infiltration,and the transmission of pro-inflammatory signals,participates in the pathogenesis of a variety of neurological disorders,including neurodegenerative and neuroinflammatory diseases and traumatic injury.Vascular endothelial growth factor C is the master regulator of lymphangiogenesis,a process that is critical for the maintenance of central nervous system homeostasis.In this review,we summarize current knowledge and recent advances relating to the anatomical features and immunological functions of the lymphatic system of the central nervous system and highlight its potential as a therapeutic target for neurological disorders and central nervous system repair.
基金financial support from the National Natural Science Foundation of China(Grant Nos.U23B20155 and 42202140)the Science and Technology Innovation Program of Hunan Province(2023RC1021)+1 种基金the China Geological Survey(DD20221659)the Science and Technology Bureau,Changsha,China(kq2208261)。
文摘The marine-continental transitional shale of the Upper Permian Longtan Formation is widely distributed in Hunan and shows significant exploration potential.Frequent changes in lithofacies have however notably influenced the shale gas enrichment.The strata of the Longtan Formation in the Shaoyang Depression,central Hunan,were taken as the study object for this project.Three lithofacies assemblages were identified:shale interbedded with sandstone layer(SAL),sandstone interbedded with shale layer(ASL)and laminated shale layer(LSL).The SAL shale shows significant variability in hydrocarbon generation potential,which leads to shale gas characterized by'hydrocarbon generation in high total organic carbon(TOC)shale,retention in low TOC shale and accumulation in sandstone'.The ASL shale,influenced by the redox conditions of the depositional environment,shows a lower concentration of organic matter.This results in an enrichment model of'hydrocarbon generation and accumulation in shale,with sealing by sandstone'.The laminar structure of LSL shale causes both quartz and clay minerals to control the reservoir.Shale gas is characterized by'hydrocarbon generation in mud laminae,retention and accumulation in silty laminae,with multiple intra-source migration paths'.In the marine-continental transitional shale gas system,the enrichment intervals of different types of shale gas reservoirs exhibit significant variability.
