Brain science accelerates the study of intelligence and behavior,contributes fundamental insights into human cognition,and offers prospective treatments for brain disease.Faced with the challenges posed by imaging tec...Brain science accelerates the study of intelligence and behavior,contributes fundamental insights into human cognition,and offers prospective treatments for brain disease.Faced with the challenges posed by imaging technologies and deep learning computational models,big data and high-performance computing(HPC)play essential roles in studying brain function,brain diseases,and large-scale brain models or connectomes.We review the driving forces behind big data and HPC methods applied to brain science,including deep learning,powerful data analysis capabilities,and computational performance solutions,each of which can be used to improve diagnostic accuracy and research output.This work reinforces predictions that big data and HPC will continue to improve brain science by making ultrahigh-performance analysis possible,by improving data standardization and sharing,and by providing new neuromorphic insights.展开更多
The accelerating growth of the public microbial genomic data imposes substantial burden on the research community that uses such resources.Building databases for non-redundant reference sequences from massive microbia...The accelerating growth of the public microbial genomic data imposes substantial burden on the research community that uses such resources.Building databases for non-redundant reference sequences from massive microbial genomic data based on clustering analysis is essential.However,existing clustering algorithms perform poorly on long genomic sequences.In this article,we present Gclust,a parallel program for clustering complete or draft genomic sequences,where clustering is accelerated with a novel parallelization strategy and a fast sequence comparison algorithm using sparse suffix arrays(SSAs).Moreover,genome identity measures between two sequences are calculated based on their maximal exact matches(MEMs).In this paper,we demonstrate the high speed and clustering quality of Gclust by examining four genome sequence datasets.Gclust is freely available for non-commercial use at https://github.com/niu-lab/gclust.We also introduce a web server for clustering user-uploaded genomes at http://niulab.scgrid.cn/gclust.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.31771466)the National Key R&D Program of China(Grant Nos.2018YFB0203903,2016YFC0503607,and 2016YFB0200300)+3 种基金the Transformation Project in Scientific and Technological Achievements of Qinghai,China(Grant No.2016-SF-127)the Special Project of Informatization of Chinese Academy of Sciences,China(Grant No.XXH13504-08)the Strategic Pilot Science and Technology Project of Chinese Academy of Sciences,China(Grant No.XDA12010000)the 100-Talents Program of Chinese Academy of Sciences,China(awarded to BN)
文摘Brain science accelerates the study of intelligence and behavior,contributes fundamental insights into human cognition,and offers prospective treatments for brain disease.Faced with the challenges posed by imaging technologies and deep learning computational models,big data and high-performance computing(HPC)play essential roles in studying brain function,brain diseases,and large-scale brain models or connectomes.We review the driving forces behind big data and HPC methods applied to brain science,including deep learning,powerful data analysis capabilities,and computational performance solutions,each of which can be used to improve diagnostic accuracy and research output.This work reinforces predictions that big data and HPC will continue to improve brain science by making ultrahigh-performance analysis possible,by improving data standardization and sharing,and by providing new neuromorphic insights.
基金the National Key R&D Program of China(Grant Nos.2018YFB0203903,2016YFC0503607,and 2016YFB0200300)the National Natural Science Foundation of China(Grant Nos.31771466 and 61702476)+3 种基金the Transformation Project in Scientific and Technological Achievements of Qinghai Province,China(Grant No.2016-SF-127)the Special Project of Informatization(Grant No.XXH13504-08)the Strategic Pilot Science and Technology Project(Grant No.XDA12010000)the 100-Talents Program(awarded to BN)of the Chinese Academy of Sciences,China.
文摘The accelerating growth of the public microbial genomic data imposes substantial burden on the research community that uses such resources.Building databases for non-redundant reference sequences from massive microbial genomic data based on clustering analysis is essential.However,existing clustering algorithms perform poorly on long genomic sequences.In this article,we present Gclust,a parallel program for clustering complete or draft genomic sequences,where clustering is accelerated with a novel parallelization strategy and a fast sequence comparison algorithm using sparse suffix arrays(SSAs).Moreover,genome identity measures between two sequences are calculated based on their maximal exact matches(MEMs).In this paper,we demonstrate the high speed and clustering quality of Gclust by examining four genome sequence datasets.Gclust is freely available for non-commercial use at https://github.com/niu-lab/gclust.We also introduce a web server for clustering user-uploaded genomes at http://niulab.scgrid.cn/gclust.
