The strength and durability of concrete will be significantly reduced at high volume of mineral admixture,and the poor early strength of concrete also still needs to be solved.In this investigation,a highly active alk...The strength and durability of concrete will be significantly reduced at high volume of mineral admixture,and the poor early strength of concrete also still needs to be solved.In this investigation,a highly active alkaline electrolyzed waters was used as mixing water to improve the early strength and enhance the durability of green concrete with high volume mineral admixture,the influences of alkaline electrolyzed water(AEW)on hydration activity of mineral admixture and durability of concrete were determined.The results showed that compared with natural tap water,AEW can accelerate early hydration process of cement in concrete and produce comparatively more hydrated products,leading to a 13.6%higher compressive strength than that of ordinary concrete at early age,but the improvement effect of AEW concrete was relatively reduced at long-term age.Meanwhile,the activity of mineral admixtures could be stimulated by AEW to some extent,the strength and durability performance of AEW concrete after double doping 25%slag and 25%fly ash can still reach the level of ordinary cement concrete without mineral admixtures.The SEM micromorphology of 7 d hydrated natural tap water cement paste was observed to be flaky and tabular,but the AEW cement pastes present obvious cluster and granulation phenomenon.The SEM microstructure of AEW concrete with mineral admixtures is more developed and denser than ordinary tap water concrete with mineral admixtures.Therefore,the AEW probably could realize the effective utilization of about 50%mineral admixture amount of concrete without strength loss,the cement production cost and associated CO_(2) emission reduced,which has a good economic and environmental benefit.展开更多
Purpose: This work presents a study on the female involvement in patent applications in all 23 Ibero-American countries that are WIPO members, in order to measure gender inequalities in institutional collaborations an...Purpose: This work presents a study on the female involvement in patent applications in all 23 Ibero-American countries that are WIPO members, in order to measure gender inequalities in institutional collaborations and technological fields, across time.Design/methodology/approach: The data used in this paper come from EPO Worldwide Patent Statistical Database(PATSTAT). PATSTAT contains bibliographical data relating to more than 100 million patent documents from leading industrialized and developing countries, as well as legal event data from more than 40 patent authorities contained in the EPO worldwide legal event data(INPADOC). The extracted subset is composed of 150,863 patent applications with priority years between 2007 and 2016.Findings: Our observations indicate that even in more dynamic economies such as Portugal and Spain, the participation of women per patent applications does not exceed 30%. Additionally, the distribution of female participation among institutional sectors and technological fields is consistent with previous studies in other regions and indicate a socio-cultural divide.Research limitations: Unisex names were not considered and were counted as gender unknown, and patent applications for which no inventor information was available were discarded, but further effort of data analysis may provide more information about gender inequalities.Practical implications: While patents are imperfect variables of inventive step and therefore should be considered as a variable proxy of innovation, our findings may help to guide the implementation of policies for balancing gender participation in innovative activities, as well as instigating research into the issues causing divisive participation along gender lines.Originality/value: While there is a widespread effort into evaluating and improving the participation of groups recognized as minorities within state-of-the-art activities, research about women participation in the innovation sector is fragmented due to differing regional characteristics: industrial and academic segmentation, socio-economic disparities, and cultural factors. Thus, localized studies present an opportunity of filling the gaps of knowledge on societal participation in innovation activities.展开更多
Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biologic...Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium（ll） arene compounds bearing thiosemicarba- zone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium（ll） arene compounds has been evaluated in several cell lines （Molt 4/C8, LI 210, CEM, HL60 and BEL7402）. Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range.展开更多
Purpose Upon verification of the article and discussion with other researchers,we became concerned about the reproducibility of our results as we did not include information on a baseline date for the data collection....Purpose Upon verification of the article and discussion with other researchers,we became concerned about the reproducibility of our results as we did not include information on a baseline date for the data collection.In this corrigendum,we seek to amend the article,adding this information and adjusting the data presented in the tables and figures to be accurate to this baseline.Those are minor changes,but they impact on the ability of a researcher to reproduce our results without consulting us.We apologize for any previous inconsistencies and hope this improves the correctness and completeness of this work.展开更多
Dear Editor,The severe coronavirus disease 2019(COVID-19)is associated with coagulopathy.Anticoagulants,such as low-molecular-weight heparin,warfarin,thrombin inhibitors,and factor Xa(FXa)inhibitors,are thus recommend...Dear Editor,The severe coronavirus disease 2019(COVID-19)is associated with coagulopathy.Anticoagulants,such as low-molecular-weight heparin,warfarin,thrombin inhibitors,and factor Xa(FXa)inhibitors,are thus recommended by the American Society of Hematology and National Institutes of Health for COVID-19 patients(Wenzler et al.,2020;Adam et al.,2021).Clinical trials with anticoagulants have shown the increased survival of critically ill COVID-19 patients under non-invasive and invasive ventilatory assistance(Wenzler et al.,2020;Adam et al.,2021),along with decreased consumption of platelets and clotting factors and a reduced risk of hemorrhage(Adam et al.,2021).Among the anti-clotting agents,early use of orally available FXa and thrombin inhibitors(Chowdhury et al.,2020;Rentsch et al.,2021)prevented high levels of D-dimer,which is the final product from the clotting/fibrinolysis cascade and is directly implicated with severe COVID-19(Rentsch et al.,2021).展开更多
基金funded by National Natural Science Foundation of China(Grant Nos.51808310,51878366)Natural Science Foundation of Shandong Province(Grant Nos.ZR2019PEE007,ZR2020ME036)High-level Scientific Research Foundation for the introduction of talent of Qingdao Agricultural University(Grant No.1118034).
文摘The strength and durability of concrete will be significantly reduced at high volume of mineral admixture,and the poor early strength of concrete also still needs to be solved.In this investigation,a highly active alkaline electrolyzed waters was used as mixing water to improve the early strength and enhance the durability of green concrete with high volume mineral admixture,the influences of alkaline electrolyzed water(AEW)on hydration activity of mineral admixture and durability of concrete were determined.The results showed that compared with natural tap water,AEW can accelerate early hydration process of cement in concrete and produce comparatively more hydrated products,leading to a 13.6%higher compressive strength than that of ordinary concrete at early age,but the improvement effect of AEW concrete was relatively reduced at long-term age.Meanwhile,the activity of mineral admixtures could be stimulated by AEW to some extent,the strength and durability performance of AEW concrete after double doping 25%slag and 25%fly ash can still reach the level of ordinary cement concrete without mineral admixtures.The SEM micromorphology of 7 d hydrated natural tap water cement paste was observed to be flaky and tabular,but the AEW cement pastes present obvious cluster and granulation phenomenon.The SEM microstructure of AEW concrete with mineral admixtures is more developed and denser than ordinary tap water concrete with mineral admixtures.Therefore,the AEW probably could realize the effective utilization of about 50%mineral admixture amount of concrete without strength loss,the cement production cost and associated CO_(2) emission reduced,which has a good economic and environmental benefit.
基金supported by CAPES/Brazil-FIOCRUZ scholarshipwithin the cooperation of the project co-financed by the European Union under the Erasmus+ Program, New Quality in Education for Gender Equality Strategic Partnership for the Development of Master’s Study Program LAW AND GENDER, (LAWGEM), 2019-1-RS01-KA203-000880。
文摘Purpose: This work presents a study on the female involvement in patent applications in all 23 Ibero-American countries that are WIPO members, in order to measure gender inequalities in institutional collaborations and technological fields, across time.Design/methodology/approach: The data used in this paper come from EPO Worldwide Patent Statistical Database(PATSTAT). PATSTAT contains bibliographical data relating to more than 100 million patent documents from leading industrialized and developing countries, as well as legal event data from more than 40 patent authorities contained in the EPO worldwide legal event data(INPADOC). The extracted subset is composed of 150,863 patent applications with priority years between 2007 and 2016.Findings: Our observations indicate that even in more dynamic economies such as Portugal and Spain, the participation of women per patent applications does not exceed 30%. Additionally, the distribution of female participation among institutional sectors and technological fields is consistent with previous studies in other regions and indicate a socio-cultural divide.Research limitations: Unisex names were not considered and were counted as gender unknown, and patent applications for which no inventor information was available were discarded, but further effort of data analysis may provide more information about gender inequalities.Practical implications: While patents are imperfect variables of inventive step and therefore should be considered as a variable proxy of innovation, our findings may help to guide the implementation of policies for balancing gender participation in innovative activities, as well as instigating research into the issues causing divisive participation along gender lines.Originality/value: While there is a widespread effort into evaluating and improving the participation of groups recognized as minorities within state-of-the-art activities, research about women participation in the innovation sector is fragmented due to differing regional characteristics: industrial and academic segmentation, socio-economic disparities, and cultural factors. Thus, localized studies present an opportunity of filling the gaps of knowledge on societal participation in innovation activities.
基金supported by National Council for Scientific and Technological Development (CNPq)Coordenao de Aperfeioamento de Pessoal de Nível Superior (CAPES)+1 种基金Oswaldo Cruz Foundation (Fiocruz)Department of Science and Technology,New Delhi,India [No.SR/WOS-A/LS-562/2011) dated 27/03/2012]
文摘Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium（ll） arene compounds bearing thiosemicarba- zone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium（ll） arene compounds has been evaluated in several cell lines （Molt 4/C8, LI 210, CEM, HL60 and BEL7402）. Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range.
文摘Purpose Upon verification of the article and discussion with other researchers,we became concerned about the reproducibility of our results as we did not include information on a baseline date for the data collection.In this corrigendum,we seek to amend the article,adding this information and adjusting the data presented in the tables and figures to be accurate to this baseline.Those are minor changes,but they impact on the ability of a researcher to reproduce our results without consulting us.We apologize for any previous inconsistencies and hope this improves the correctness and completeness of this work.
文摘Dear Editor,The severe coronavirus disease 2019(COVID-19)is associated with coagulopathy.Anticoagulants,such as low-molecular-weight heparin,warfarin,thrombin inhibitors,and factor Xa(FXa)inhibitors,are thus recommended by the American Society of Hematology and National Institutes of Health for COVID-19 patients(Wenzler et al.,2020;Adam et al.,2021).Clinical trials with anticoagulants have shown the increased survival of critically ill COVID-19 patients under non-invasive and invasive ventilatory assistance(Wenzler et al.,2020;Adam et al.,2021),along with decreased consumption of platelets and clotting factors and a reduced risk of hemorrhage(Adam et al.,2021).Among the anti-clotting agents,early use of orally available FXa and thrombin inhibitors(Chowdhury et al.,2020;Rentsch et al.,2021)prevented high levels of D-dimer,which is the final product from the clotting/fibrinolysis cascade and is directly implicated with severe COVID-19(Rentsch et al.,2021).
