Objective Rheumatoid arthritis(RA)is a systemic autoimmune disease that affects the small joints of the whole body and degrades the patients’quality of life.Zhengqing Fengtongning(ZF)is a traditional Chinese medicine...Objective Rheumatoid arthritis(RA)is a systemic autoimmune disease that affects the small joints of the whole body and degrades the patients’quality of life.Zhengqing Fengtongning(ZF)is a traditional Chinese medicine preparation used to treat RA.ZF may cause liver injury.In this study,we aimed to develop a prediction model for abnormal liver function caused by ZF.Methods This retrospective study collected data from multiple centers from January 2018 to April 2023.Abnormal liver function was set as the target variable according to the alanine transaminase(ALT)level.Features were screened through univariate analysis and sequential forward selection for modeling.Ten machine learning and deep learning models were compared to find the model that most effectively predicted liver function from the available data.Results This study included 1,913 eligible patients.The LightGBM model exhibited the best performance(accuracy=0.96)out of the 10 learning models.The predictive metrics of the LightGBM model were as follows:precision=0.99,recall rate=0.97,F1_score=0.98,area under the curve(AUC)=0.98,sensitivity=0.97 and specificity=0.85 for predicting ALT<40 U/L;precision=0.60,recall rate=0.83,F1_score=0.70,AUC=0.98,sensitivity=0.83 and specificity=0.97 for predicting 40≤ALT<80 U/L;and precision=0.83,recall rate=0.63,F1_score=0.71,AUC=0.97,sensitivity=0.63 and specificity=1.00 for predicting ALT≥80 U/L.ZF-induced abnormal liver function was found to be associated with high total cholesterol and triglyceride levels,the combination of TNF-αinhibitors,JAK inhibitors,methotrexate+nonsteroidal anti-inflammatory drugs,leflunomide,smoking,older age,and females in middle-age(45-65 years old).Conclusion This study developed a model for predicting ZF-induced abnormal liver function,which may help improve the safety of integrated administration of ZF and Western medicine.展开更多
Black rice,as a dietary supplement,has received increasing attention because of its beneficial health properties.Although black rice and its major ingredients have been considered a potential therapy for ulcerative co...Black rice,as a dietary supplement,has received increasing attention because of its beneficial health properties.Although black rice and its major ingredients have been considered a potential therapy for ulcerative colitis(UC),its effect and underlying mechanism of action remain obscure.In this study,black rice was demonstrated to improve dextran sulfate sodium salt(DSS)-induced UC and restore intestinal barrier dysfunction.Cyanidin 3-O-glucoside(C3G)is the most abundant ingredient in black rice.Similarly,in vivo and in vitro studies have demonstrated that C3G alleviates colitis and intestinal barrier dysfunction.Proteomic analysis showed that C3G significantly reduced abnormallyelevated swiprosin-1 levels in mice with colitis.Furthermore,the effect of C3G on mitigating colitis was inhibited after swiprosin-1 was overexpressed in intestinal tissue in vivo and Caco-2 cells in vitro.Acyl-CoA synthetase long-chain family member 1(ACSL1)was identified as a potential protein that interacts with swiprosin-1 byco-immunoprecipitation and liquid chromatography-tandem mass spectrometry.By integratingmetabolomics experiments and bioinformatics analysis of single-cell sequencing,ACSL1 was found to selectively bind to swiprosin-1 and regulate downstream linoleic acid metabolism in colitis.Moreover,C3G was observed to prevent the localization of ACSL1 within mitochondria via swiprosin-1,thereby inhibiting the oxidation of linoleic acid.This study demonstrated that C3G targeted swiprosin-1 to ameliorate UC via ASCLl-mediated linoleic acid metabolism,thereby providing a novel potential insight into the mechanism of C3G protection against colitis and establishing the groundwork for its clinical application.展开更多
A synergistic catalytic effect between copper methanesulfonate and acetic acid in tetrahydropyranylation of alcohols and phenol at room temperature under solvent free condition has been described. Both alcohols （prim...A synergistic catalytic effect between copper methanesulfonate and acetic acid in tetrahydropyranylation of alcohols and phenol at room temperature under solvent free condition has been described. Both alcohols （primary, secondary and tertiary） and phenols reacted with 3,4-dihydro-2H-pyran smoothly to afford the corresponding tetrahydropyranyl ethers in good yields.展开更多
Cobalt-manganese nano catalysts were prepared by sol-gel method. This research investigated the effects of different cobalt-manganese （Co/Mn = 1/1） loading, pH and calcination conditions on the catalytic performance...Cobalt-manganese nano catalysts were prepared by sol-gel method. This research investigated the effects of different cobalt-manganese （Co/Mn = 1/1） loading, pH and calcination conditions on the catalytic performance of Co-Mn/TiO2 catalysts for Fischer-Tropsch synthesis （FTS） in a fixed bed reactor. It was found that the catalyst containing 30wt%（Co-Mn）/TiO2 was an optimal catalyst for the conversion of synthesis gas to light olefins especially propylene. The activity and selectivity of optimal catalyst were studied under different operational conditions. The results showed that the best operational conditions were H2/CO = 1/1 molar feed ratio at 250 ℃ and GHSV = 1300 h-1 un- der atmospheric pressure. Characterization of catalysts was carried out by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, N2 adsorption-desorlation measurements.展开更多
Ferrous methanesulfonate catalysing the conversion of aromatic, heteroaromatic, unsaturated, and aliphatic aldehydes to 1,1- diacetates at room temperature under solvent-free condition has been developed. The catalyti...Ferrous methanesulfonate catalysing the conversion of aromatic, heteroaromatic, unsaturated, and aliphatic aldehydes to 1,1- diacetates at room temperature under solvent-free condition has been developed. The catalytic activity of seventeen metal methanesulfonates was compared under the same condition, ferrous methanesufonate proved to be the best. It can be easily recovered and reused for several times without distinct deterioration in catalytic activity. During the competitive protection between a ketone and an aldehyde group with Ac20, 1,1-diacetate formed exclusively with the aldehyde group. 2009 Min Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data ...AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials.展开更多
OBJECTIVE:To study the morphological basis of the role of Siqi(cold as winter,cool as autumn,warm as spring,hot as summer),Wuwei(five flavors:sweet,pungent,salty,sour,and bitter),and Guijing(meridian tropism) through ...OBJECTIVE:To study the morphological basis of the role of Siqi(cold as winter,cool as autumn,warm as spring,hot as summer),Wuwei(five flavors:sweet,pungent,salty,sour,and bitter),and Guijing(meridian tropism) through the use of information integration.METHODS:A14C-2-deoxy-glucose autoradiography method was adopted to determine the overall impact of treatment with 39 herbs on functions of various tissues and organs.Data was measured at 4hs after a single dose and following the last treatment of repeated doses for a week.Least-squares estimation was used and fitted for each herb regression effect of organs and tissues after singleand repeated treatment.The slope of the regression line represented the cumulative trend of the effect of the herbs(β),and the standard deviation of the slope(Sβ) was compared with those of the untreated animals(t 'test).All significantly cumulative effect trends were applied with an artificial neural network,which integrated the relationship among Siqi,Wuwei,and Guijing with tissues and organs.RESULTS:There is a certain relationship among the Siqi,Wuwei,Guijing and the anatomy of organs and tissues,but the different scores indicate that influence of Siqi,Wuwei,Guijing to anatomy of organs and tissues was a nonlinear state.CONCLUSION:Results demonstrated that the effects of Siqi,Wuwei,and Guijing have a morphological basis,and each concept was associated with multiple anatomical structures.展开更多
This paper describes a new interleaver construction technique for turbo code.The technique searches as much as possible pseudo-random interleaving patterns under a certain condition using genetic algorithms(GAs).The n...This paper describes a new interleaver construction technique for turbo code.The technique searches as much as possible pseudo-random interleaving patterns under a certain condition using genetic algorithms(GAs).The new interleavers have the superiority of the S-random interleavers and this interleaver construction technique can reduce the time taken to generate pseudo-random interleaving patterns under a certain condition.The results obtained indicate that the new interleavers yield an equal to or better performance than the S-random interleavers.Compared to the S-random interleaver,this design requires a lower level of computational complexity.展开更多
A three-arm Michelson-Fabry-Perot detector for gravitational waves is designed. It consists of three Michelson Fabry-Perot interferometers, one for each pair of arms. The new detector can be used to confirm whether th...A three-arm Michelson-Fabry-Perot detector for gravitational waves is designed. It consists of three Michelson Fabry-Perot interferometers, one for each pair of arms. The new detector can be used to confirm whether the gravitational waves are in general relativity polarization states and to set the strong constraints on non-GR gravitational wave polarization states. By the new detectors, the angular resolution of sources can be improved significantly. With the new detector, it is easier to search for and confirm a gravitational wave signal in the observation data.展开更多
Azulene, one of representative nonbenzenoid aromatic hydrocarbons, exhibits unique molecular structure and distinctive physical and chemical properties. Herein, azulenoisoindigo(Az II), an azulene-based isoindigo anal...Azulene, one of representative nonbenzenoid aromatic hydrocarbons, exhibits unique molecular structure and distinctive physical and chemical properties. Herein, azulenoisoindigo(Az II), an azulene-based isoindigo analogue, is designed and synthesized, which has a twisted molecular backbone and R/Sisomers in single crystals. Interestingly, Az II shows the characteristics of both isoindigo and azulene,such as reversible redox behavior and reversible proton responsiveness. UV-vis-NIR,^(1)H NMR and electron paramagnetic resonance(EPR) measurements were carried out to get insights into the possible mechanism of the proton-responsive property of Az II. The results demonstrated that only one azulenyl moiety of molecule of Az II was protonated and deprotonated, and the protonated Az II can be further oxidized to form azulenium cation radicals.展开更多
Nanosized Fe-Co catalysts were prepared by co-precipitation method and studied for the conversion of synthesis gas to light olefins.In particular,the effects of a range of preparation variables such as Co/Fe molar rat...Nanosized Fe-Co catalysts were prepared by co-precipitation method and studied for the conversion of synthesis gas to light olefins.In particular,the effects of a range of preparation variables such as Co/Fe molar ratios of the precipitation solution,pH value of precipitate,temperature of precipitation,promoters and loading of optimum promoter on the structure and catalytic performance are investigated.The optimal nano catalyst for light olefins （C2-C4） production was obtained over the catalyst with Co/Fe molar ratio of 3/1 which promoted with 2 wt% K.The results show that the best operational conditions were GHSV=2200 h^-1 （H2/CO=2/1） at 260℃ under atmospheric pressure.Characterization of catalysts were carried out using X-ray diffraction （XRD）,thermal gravimetric analysis （TGA）,differential scanning calorimetry （DSC）,scanning electron microscopy （SEM）,transmission electron microscopy （TEM） and N2 physisorption measurements such as Brunauer-Emmett-Teller （BET） and Barrett-Joyner-Halenda （BJH） methods.展开更多
Mast cells are the main effector cells in IgE-associated allergic disorders,and we have reported that mucosal mast cells(MMCs)play a more important role in the development of food allergy(FA).IgE with antigen or calci...Mast cells are the main effector cells in IgE-associated allergic disorders,and we have reported that mucosal mast cells(MMCs)play a more important role in the development of food allergy(FA).IgE with antigen or calcium ionophore stimulation can lead to the activation of MMCs via a calcium-dependent pathway.The purpose of the present study was to identify gene signatures with IgE/antigen(dinitrophenyl-bovine serum albumin,DNP-BSA)or calcium ionophore(A23187)on the activation of MMCs.Differentially expressed genes between the two types of samples were identified with microarray analysis.Gene ontology functional and pathway enrichment analyses of differentially expressed genes were performed using the database for annotation,visualization,and integrated discovery software.The results showed that IgE/antigen and A23187 could induce degranulation,increase vacuoles,and elevate the cytosolic calcium concentration in MMCs.Furthermore,GeneChip analysis showed that the same 134 mRNAs were altered with IgE/DNP-BSA and A23187,suggesting that DNP-BSA/IgE and A23187 affect the same signal pathway partly in degranulation.KEGG analysis showed that the data were enriched in NF-κB,TNF,MAPK,transcription factor activity,DNA binding,and nucleic acid binding,suggesting that activation of MMCs is a complex process.The results provide new insights on MMCs activation.展开更多
Verlinde has suggested that the gravity has an entropic origin, and a gravitational system could be regarded as a thermodynarnical system. It is well-known that the equipartition law of energy is invalid at very low t...Verlinde has suggested that the gravity has an entropic origin, and a gravitational system could be regarded as a thermodynarnical system. It is well-known that the equipartition law of energy is invalid at very low temperature. Therefore, entropic force should be modified while the temperature of the holographic screen is very low. It is shown that the modified entropic force is proportional to the square of the acceleration, while the temperature of the holographic screen is much lower than the Debye temperature TD. The modified entropic force returns to the Newton＇s law of gravitation while the temperature of the holographic screen is much higher than the Debye temperature. The modified entropic force is connected with modified Newtonian dynamics （MOND）. The constant ao involved in MOND is linear in the Debye frequency WD, which can be regarded as the largest frequency of the bits in screen. We find that there do have a strong connection between MOND and cosmology in the framework of Verlinde＇s entropic force, if the holographic screen is taken to be bound of the Universe. The Debye frequency is linear in the Hubble constant Ho.展开更多
In Verlinde＇s entropic force scenario of gravity, Newton＇s laws and Einstein equations can be obtained from the first principles and general assumptions. However, the equipartition law of energy is invalid at very l...In Verlinde＇s entropic force scenario of gravity, Newton＇s laws and Einstein equations can be obtained from the first principles and general assumptions. However, the equipartition law of energy is invalid at very low temperatures. We show clearly that the threshold of the equipartition law of energy is related with horizon of the universe. Thus, a one-dimensional Debye （ODD） model in the direction of radius of the modified entropic force （MEF） may be suitable in description of the accelerated expanding universe. We present a Friedmann cosmic dynamical model in the ODD-MEF framework. We examine carefully constraints on the ODD-MEF model from the Union2 compilation of the Supernova Cosmology Project （SCP） collaboration, the data from the observation of the large-scale structure （LSS） and the cosmic microwave background （CMB）, i.e. SNe Ia＋LSS＋CMB. The combined numerical analysis gives the best-fit value of the model parameters （ -10^-9 and Ωm0= 0.224, with 2 = Xmin= 591.156. The corresponding age of the universe agrees with the result of D. Spergel et al. [J.M. Bardeen, B. Carter, and S.W. Hawking, Commun. Math. Phys. 31 （1973） 161] at 95% confidence level. The numerical result also yields an accelerated expanding universe without invoking any kind of dark energy. Taking ζ（= 2πωD/ H0 ） as a running parameter associated with the structure scale r, we obtain a possible unified scenario of the asymptotic flatness of the radial velocity dispersion of spiral galaxies, the accelerated expanding universe and the Pioneer 10/11 anomaly in the entropic force framework of Verlinde.展开更多
This study aims to investigate the efficacy of journal cumulative impact factors(CIFs)and annual impact factors(AIFs)in the evaluation of science journals.We screened U.S.ophthalmological journals based on the SCI dat...This study aims to investigate the efficacy of journal cumulative impact factors(CIFs)and annual impact factors(AIFs)in the evaluation of science journals.We screened U.S.ophthalmological journals based on the SCI database by the inclusive and exclusive criteria.The CIFs and AIFs were calculated based on the citation data of the screened SCI-indexed ophthalmological journals in Web of Science ranging from 1-y to 10-y data,year by year.The peer review scores of these journals were obtained through questionnaire surveys issued to U.S.ophthalmologists,which were recognised as the golden standard for journal evaluation.The effects of CIFs and AIFs on journal evaluation were analyzed and compared,followed by the assessment of the correlation of peer review scores with journal CIFs and AIFs.We found that both AIFs and CIFs were positively correlated with the peer review score,but the correlation coefficient of CIFs with peer review score outweighed that of AIFs with peer review score in the same time window excluding 3-y and 6-y CIF.From the correlation analysis,the 7-y CIF had the strongest correlation with peer review score(r=0.706,P=0.000),so CIF at the 7-y time window was the optimum parameter with regards to U.S.ophthalmologic journal evaluation in this study.Finally,there were four journals which were indexed in Web of Science over a long time period,of which the CIFs did not grow persistently.Therefore,we thought that more attention should be paid to the cumulative citation counts made from the first year when the source items were published.The optimum time window was still a controversial issue as research areas have variable citation characteristics.展开更多
A mild and efficient method for diacetylation reaction was developed,by which diacetate could be achieved through the reaction of aldehyde with acetic anhydride,in the presence of cobalt sulfate,with an admirable yiel...A mild and efficient method for diacetylation reaction was developed,by which diacetate could be achieved through the reaction of aldehyde with acetic anhydride,in the presence of cobalt sulfate,with an admirable yield,at room temperature,without solvent.The catalyst could be recycled six times without a distinct loss of activity.展开更多
The QCD deconfinement phase transition in pure SU（3） gauge theory is studied on an anlsotropic lattice. The critical temperature is determined to be Tc ≈ 285 MeV. The relation between the deconfinement phase transi...The QCD deconfinement phase transition in pure SU（3） gauge theory is studied on an anlsotropic lattice. The critical temperature is determined to be Tc ≈ 285 MeV. The relation between the deconfinement phase transition and the breakdown of Z（3） center symmetry is also discussed.展开更多
We present Finslerian perturbation for the ∧CDM model, which breaks the isotropic symmetry of the universe. The analysis on the Killing vectors shows that the Randers-Finsler spacetime breaks the isotropic symmetry e...We present Finslerian perturbation for the ∧CDM model, which breaks the isotropic symmetry of the universe. The analysis on the Killing vectors shows that the Randers-Finsler spacetime breaks the isotropic symmetry even ff the scalar perturbations of the FRW metric vanish. In Randers-Finsler spacetime, the modified geodesic equation deduces a modified Boltzmann equation. We propose a perturbational version of the gravitational field equation in Randers-Finsler spacetime, where we have omitted the curvature tensor that does not belong to the base space of the tangent bundle. The gravitational field equations for the gravitational wave are also presented. The primordial power spectrum of the gravitational wave is investigated. We show that the primordial power spectrum for super-horizon perturbations is unchanged. For sub-horizon perturbations, however, the power spectrum is modified.展开更多
基金supported by the Budgeted Fund of Shanghai University of Traditional Chinese Medicine(Natural Science)(No.2021LK037)the Open Project of Qinghai Province Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation(No.2021-ZY-03).
文摘Objective Rheumatoid arthritis(RA)is a systemic autoimmune disease that affects the small joints of the whole body and degrades the patients’quality of life.Zhengqing Fengtongning(ZF)is a traditional Chinese medicine preparation used to treat RA.ZF may cause liver injury.In this study,we aimed to develop a prediction model for abnormal liver function caused by ZF.Methods This retrospective study collected data from multiple centers from January 2018 to April 2023.Abnormal liver function was set as the target variable according to the alanine transaminase(ALT)level.Features were screened through univariate analysis and sequential forward selection for modeling.Ten machine learning and deep learning models were compared to find the model that most effectively predicted liver function from the available data.Results This study included 1,913 eligible patients.The LightGBM model exhibited the best performance(accuracy=0.96)out of the 10 learning models.The predictive metrics of the LightGBM model were as follows:precision=0.99,recall rate=0.97,F1_score=0.98,area under the curve(AUC)=0.98,sensitivity=0.97 and specificity=0.85 for predicting ALT<40 U/L;precision=0.60,recall rate=0.83,F1_score=0.70,AUC=0.98,sensitivity=0.83 and specificity=0.97 for predicting 40≤ALT<80 U/L;and precision=0.83,recall rate=0.63,F1_score=0.71,AUC=0.97,sensitivity=0.63 and specificity=1.00 for predicting ALT≥80 U/L.ZF-induced abnormal liver function was found to be associated with high total cholesterol and triglyceride levels,the combination of TNF-αinhibitors,JAK inhibitors,methotrexate+nonsteroidal anti-inflammatory drugs,leflunomide,smoking,older age,and females in middle-age(45-65 years old).Conclusion This study developed a model for predicting ZF-induced abnormal liver function,which may help improve the safety of integrated administration of ZF and Western medicine.
基金supported by grants from the National Natural Science Foundation of China(81973551,82204737,82204686)the Science and Technology Commission of Shanghai Municipality(19ZR1451800,21ZR1460400,and 21140905300)+4 种基金Guoyiqiangyou foundation of Shanghai Hongkou(HGY-KY-2018-03 and HGYMGB-2018-01-05)the Health Commission of Shanghai Municipality(ZY(2021-2023)-0203-04)Shanghai Natural Science Foundation(22ZR1455900)Future Plan for Traditional Chinese Medicine Inheritance and Development of Shanghai Municipal Hospital of TraditionalChineseMedicine(WLJH2021ZY-ZYY007,WL-HBBD-2021001K)Shanghai Putuo District Health System Special Disease Construction Project(2023tszb01).
文摘Black rice,as a dietary supplement,has received increasing attention because of its beneficial health properties.Although black rice and its major ingredients have been considered a potential therapy for ulcerative colitis(UC),its effect and underlying mechanism of action remain obscure.In this study,black rice was demonstrated to improve dextran sulfate sodium salt(DSS)-induced UC and restore intestinal barrier dysfunction.Cyanidin 3-O-glucoside(C3G)is the most abundant ingredient in black rice.Similarly,in vivo and in vitro studies have demonstrated that C3G alleviates colitis and intestinal barrier dysfunction.Proteomic analysis showed that C3G significantly reduced abnormallyelevated swiprosin-1 levels in mice with colitis.Furthermore,the effect of C3G on mitigating colitis was inhibited after swiprosin-1 was overexpressed in intestinal tissue in vivo and Caco-2 cells in vitro.Acyl-CoA synthetase long-chain family member 1(ACSL1)was identified as a potential protein that interacts with swiprosin-1 byco-immunoprecipitation and liquid chromatography-tandem mass spectrometry.By integratingmetabolomics experiments and bioinformatics analysis of single-cell sequencing,ACSL1 was found to selectively bind to swiprosin-1 and regulate downstream linoleic acid metabolism in colitis.Moreover,C3G was observed to prevent the localization of ACSL1 within mitochondria via swiprosin-1,thereby inhibiting the oxidation of linoleic acid.This study demonstrated that C3G targeted swiprosin-1 to ameliorate UC via ASCLl-mediated linoleic acid metabolism,thereby providing a novel potential insight into the mechanism of C3G protection against colitis and establishing the groundwork for its clinical application.
文摘A synergistic catalytic effect between copper methanesulfonate and acetic acid in tetrahydropyranylation of alcohols and phenol at room temperature under solvent free condition has been described. Both alcohols （primary, secondary and tertiary） and phenols reacted with 3,4-dihydro-2H-pyran smoothly to afford the corresponding tetrahydropyranyl ethers in good yields.
基金supported by the International Center for Science, High Technology & Environmental Sciences
文摘Cobalt-manganese nano catalysts were prepared by sol-gel method. This research investigated the effects of different cobalt-manganese （Co/Mn = 1/1） loading, pH and calcination conditions on the catalytic performance of Co-Mn/TiO2 catalysts for Fischer-Tropsch synthesis （FTS） in a fixed bed reactor. It was found that the catalyst containing 30wt%（Co-Mn）/TiO2 was an optimal catalyst for the conversion of synthesis gas to light olefins especially propylene. The activity and selectivity of optimal catalyst were studied under different operational conditions. The results showed that the best operational conditions were H2/CO = 1/1 molar feed ratio at 250 ℃ and GHSV = 1300 h-1 un- der atmospheric pressure. Characterization of catalysts was carried out by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, N2 adsorption-desorlation measurements.
文摘Ferrous methanesulfonate catalysing the conversion of aromatic, heteroaromatic, unsaturated, and aliphatic aldehydes to 1,1- diacetates at room temperature under solvent-free condition has been developed. The catalytic activity of seventeen metal methanesulfonates was compared under the same condition, ferrous methanesufonate proved to be the best. It can be easily recovered and reused for several times without distinct deterioration in catalytic activity. During the competitive protection between a ketone and an aldehyde group with Ac20, 1,1-diacetate formed exclusively with the aldehyde group. 2009 Min Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials.
基金Support by National Natural Science Foundation Grant(Correlation Analysis Among Herb's Properties affecting the Multiple Parameters of the Blood and the Morphology of the Organism Structure,No.81473366)
文摘OBJECTIVE:To study the morphological basis of the role of Siqi(cold as winter,cool as autumn,warm as spring,hot as summer),Wuwei(five flavors:sweet,pungent,salty,sour,and bitter),and Guijing(meridian tropism) through the use of information integration.METHODS:A14C-2-deoxy-glucose autoradiography method was adopted to determine the overall impact of treatment with 39 herbs on functions of various tissues and organs.Data was measured at 4hs after a single dose and following the last treatment of repeated doses for a week.Least-squares estimation was used and fitted for each herb regression effect of organs and tissues after singleand repeated treatment.The slope of the regression line represented the cumulative trend of the effect of the herbs(β),and the standard deviation of the slope(Sβ) was compared with those of the untreated animals(t 'test).All significantly cumulative effect trends were applied with an artificial neural network,which integrated the relationship among Siqi,Wuwei,and Guijing with tissues and organs.RESULTS:There is a certain relationship among the Siqi,Wuwei,Guijing and the anatomy of organs and tissues,but the different scores indicate that influence of Siqi,Wuwei,Guijing to anatomy of organs and tissues was a nonlinear state.CONCLUSION:Results demonstrated that the effects of Siqi,Wuwei,and Guijing have a morphological basis,and each concept was associated with multiple anatomical structures.
基金Supported by the National Natural Science Foundation of China(60372057) the Key Open laboratory on Information Science and Engineering of Railway Transportation Ministry of Beijing Jiaotong University of China(KLISAE-0103)
文摘This paper describes a new interleaver construction technique for turbo code.The technique searches as much as possible pseudo-random interleaving patterns under a certain condition using genetic algorithms(GAs).The new interleavers have the superiority of the S-random interleavers and this interleaver construction technique can reduce the time taken to generate pseudo-random interleaving patterns under a certain condition.The results obtained indicate that the new interleavers yield an equal to or better performance than the S-random interleavers.Compared to the S-random interleaver,this design requires a lower level of computational complexity.
基金Supported by the National Natural Science Foundation of China under Grant No 11275207
文摘A three-arm Michelson-Fabry-Perot detector for gravitational waves is designed. It consists of three Michelson Fabry-Perot interferometers, one for each pair of arms. The new detector can be used to confirm whether the gravitational waves are in general relativity polarization states and to set the strong constraints on non-GR gravitational wave polarization states. By the new detectors, the angular resolution of sources can be improved significantly. With the new detector, it is easier to search for and confirm a gravitational wave signal in the observation data.
基金financially supported by the National Natural Science Foundation of China (Nos. 21790362, 22075310 and21522209)the “Strategic Priority Research Program of Chinese Academy of Sciences”(No. XDB12010100)+1 种基金the Science and Technology Commission of Shanghai Municipality (Nos. 19XD1424700 and18JC1410600)SIOC. An early preprint of this work appeared on Chem Rxiv [47]。
文摘Azulene, one of representative nonbenzenoid aromatic hydrocarbons, exhibits unique molecular structure and distinctive physical and chemical properties. Herein, azulenoisoindigo(Az II), an azulene-based isoindigo analogue, is designed and synthesized, which has a twisted molecular backbone and R/Sisomers in single crystals. Interestingly, Az II shows the characteristics of both isoindigo and azulene,such as reversible redox behavior and reversible proton responsiveness. UV-vis-NIR,^(1)H NMR and electron paramagnetic resonance(EPR) measurements were carried out to get insights into the possible mechanism of the proton-responsive property of Az II. The results demonstrated that only one azulenyl moiety of molecule of Az II was protonated and deprotonated, and the protonated Az II can be further oxidized to form azulenium cation radicals.
基金supported by the International Center for Science,High Technology & Environmental Sciences
文摘Nanosized Fe-Co catalysts were prepared by co-precipitation method and studied for the conversion of synthesis gas to light olefins.In particular,the effects of a range of preparation variables such as Co/Fe molar ratios of the precipitation solution,pH value of precipitate,temperature of precipitation,promoters and loading of optimum promoter on the structure and catalytic performance are investigated.The optimal nano catalyst for light olefins （C2-C4） production was obtained over the catalyst with Co/Fe molar ratio of 3/1 which promoted with 2 wt% K.The results show that the best operational conditions were GHSV=2200 h^-1 （H2/CO=2/1） at 260℃ under atmospheric pressure.Characterization of catalysts were carried out using X-ray diffraction （XRD）,thermal gravimetric analysis （TGA）,differential scanning calorimetry （DSC）,scanning electron microscopy （SEM）,transmission electron microscopy （TEM） and N2 physisorption measurements such as Brunauer-Emmett-Teller （BET） and Barrett-Joyner-Halenda （BJH） methods.
基金This work was supported by the“Xinlin Young Talent Program”(A1-U1820502040237)from Shanghai University of Traditional Chinese Medicine“Sasakawa Scientific Research Grant”(23-401)from the Japan Science Society.
文摘Mast cells are the main effector cells in IgE-associated allergic disorders,and we have reported that mucosal mast cells(MMCs)play a more important role in the development of food allergy(FA).IgE with antigen or calcium ionophore stimulation can lead to the activation of MMCs via a calcium-dependent pathway.The purpose of the present study was to identify gene signatures with IgE/antigen(dinitrophenyl-bovine serum albumin,DNP-BSA)or calcium ionophore(A23187)on the activation of MMCs.Differentially expressed genes between the two types of samples were identified with microarray analysis.Gene ontology functional and pathway enrichment analyses of differentially expressed genes were performed using the database for annotation,visualization,and integrated discovery software.The results showed that IgE/antigen and A23187 could induce degranulation,increase vacuoles,and elevate the cytosolic calcium concentration in MMCs.Furthermore,GeneChip analysis showed that the same 134 mRNAs were altered with IgE/DNP-BSA and A23187,suggesting that DNP-BSA/IgE and A23187 affect the same signal pathway partly in degranulation.KEGG analysis showed that the data were enriched in NF-κB,TNF,MAPK,transcription factor activity,DNA binding,and nucleic acid binding,suggesting that activation of MMCs is a complex process.The results provide new insights on MMCs activation.
基金Supported by the National Natural Science Foundation of China under Grant Nos.10525522 and 10875129
文摘Verlinde has suggested that the gravity has an entropic origin, and a gravitational system could be regarded as a thermodynarnical system. It is well-known that the equipartition law of energy is invalid at very low temperature. Therefore, entropic force should be modified while the temperature of the holographic screen is very low. It is shown that the modified entropic force is proportional to the square of the acceleration, while the temperature of the holographic screen is much lower than the Debye temperature TD. The modified entropic force returns to the Newton＇s law of gravitation while the temperature of the holographic screen is much higher than the Debye temperature. The modified entropic force is connected with modified Newtonian dynamics （MOND）. The constant ao involved in MOND is linear in the Debye frequency WD, which can be regarded as the largest frequency of the bits in screen. We find that there do have a strong connection between MOND and cosmology in the framework of Verlinde＇s entropic force, if the holographic screen is taken to be bound of the Universe. The Debye frequency is linear in the Hubble constant Ho.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 10525522 and 10875129
文摘In Verlinde＇s entropic force scenario of gravity, Newton＇s laws and Einstein equations can be obtained from the first principles and general assumptions. However, the equipartition law of energy is invalid at very low temperatures. We show clearly that the threshold of the equipartition law of energy is related with horizon of the universe. Thus, a one-dimensional Debye （ODD） model in the direction of radius of the modified entropic force （MEF） may be suitable in description of the accelerated expanding universe. We present a Friedmann cosmic dynamical model in the ODD-MEF framework. We examine carefully constraints on the ODD-MEF model from the Union2 compilation of the Supernova Cosmology Project （SCP） collaboration, the data from the observation of the large-scale structure （LSS） and the cosmic microwave background （CMB）, i.e. SNe Ia＋LSS＋CMB. The combined numerical analysis gives the best-fit value of the model parameters （ -10^-9 and Ωm0= 0.224, with 2 = Xmin= 591.156. The corresponding age of the universe agrees with the result of D. Spergel et al. [J.M. Bardeen, B. Carter, and S.W. Hawking, Commun. Math. Phys. 31 （1973） 161] at 95% confidence level. The numerical result also yields an accelerated expanding universe without invoking any kind of dark energy. Taking ζ（= 2πωD/ H0 ） as a running parameter associated with the structure scale r, we obtain a possible unified scenario of the asymptotic flatness of the radial velocity dispersion of spiral galaxies, the accelerated expanding universe and the Pioneer 10/11 anomaly in the entropic force framework of Verlinde.
文摘This study aims to investigate the efficacy of journal cumulative impact factors(CIFs)and annual impact factors(AIFs)in the evaluation of science journals.We screened U.S.ophthalmological journals based on the SCI database by the inclusive and exclusive criteria.The CIFs and AIFs were calculated based on the citation data of the screened SCI-indexed ophthalmological journals in Web of Science ranging from 1-y to 10-y data,year by year.The peer review scores of these journals were obtained through questionnaire surveys issued to U.S.ophthalmologists,which were recognised as the golden standard for journal evaluation.The effects of CIFs and AIFs on journal evaluation were analyzed and compared,followed by the assessment of the correlation of peer review scores with journal CIFs and AIFs.We found that both AIFs and CIFs were positively correlated with the peer review score,but the correlation coefficient of CIFs with peer review score outweighed that of AIFs with peer review score in the same time window excluding 3-y and 6-y CIF.From the correlation analysis,the 7-y CIF had the strongest correlation with peer review score(r=0.706,P=0.000),so CIF at the 7-y time window was the optimum parameter with regards to U.S.ophthalmologic journal evaluation in this study.Finally,there were four journals which were indexed in Web of Science over a long time period,of which the CIFs did not grow persistently.Therefore,we thought that more attention should be paid to the cumulative citation counts made from the first year when the source items were published.The optimum time window was still a controversial issue as research areas have variable citation characteristics.
文摘A mild and efficient method for diacetylation reaction was developed,by which diacetate could be achieved through the reaction of aldehyde with acetic anhydride,in the presence of cobalt sulfate,with an admirable yield,at room temperature,without solvent.The catalyst could be recycled six times without a distinct loss of activity.
基金Supported by NSFC under Grant Nos.10347110,10575107,10421003,10835002CAS under Grant No.KJCX3-SYW-N2the Numerical Calculations were Performed on DeepComp 6800 Supercomputer of the Supercomputing Center of Chinese Academy of Sciences,Dawning 4000A Supercomputer of Shanghai Supercomputing Center,and NKstar 2 Supercomputer of Nankai University
文摘The QCD deconfinement phase transition in pure SU（3） gauge theory is studied on an anlsotropic lattice. The critical temperature is determined to be Tc ≈ 285 MeV. The relation between the deconfinement phase transition and the breakdown of Z（3） center symmetry is also discussed.
基金Supported by National Natural Science Foundation of China under Grant Nos.11375203 and 11305181
文摘We present Finslerian perturbation for the ∧CDM model, which breaks the isotropic symmetry of the universe. The analysis on the Killing vectors shows that the Randers-Finsler spacetime breaks the isotropic symmetry even ff the scalar perturbations of the FRW metric vanish. In Randers-Finsler spacetime, the modified geodesic equation deduces a modified Boltzmann equation. We propose a perturbational version of the gravitational field equation in Randers-Finsler spacetime, where we have omitted the curvature tensor that does not belong to the base space of the tangent bundle. The gravitational field equations for the gravitational wave are also presented. The primordial power spectrum of the gravitational wave is investigated. We show that the primordial power spectrum for super-horizon perturbations is unchanged. For sub-horizon perturbations, however, the power spectrum is modified.
